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The map label for this gene is hisC

Identifier: 86607759

GI number: 86607759

Start: 275061

End: 276122

Strand: Reverse

Name: hisC

Synonym: CYB_0260

Alternate gene names: 86607759

Gene position: 276122-275061 (Counterclockwise)

Preceding gene: 86607760

Following gene: 86607754

Centisome position: 9.06

GC content: 62.62

Gene sequence:

>1062_bases
ATGTGTGCCTTGCAGTATCTGCGCCCCGACTTGCTCTACCTCAAGCCCTACGACGCTGTGCCAGCCCCGGCTGCCGACAA
GCTGGATGCCAATGAGTTCCCCCTCGATTGGCCGGCGGGCTTCAAGCAGAAGCTCTCCCTCCTTTGGGAAAAGGGGATCC
CCAGCAACCGCTATCCCGATGCCCACCACCGGGGCCTGAAGCAGGCCATCGCCGCCTATGCCGGAGCGGAGCCAGAGCAG
ATCAGCCTGGGCAATGGGTCGGATGAGCTGATTCGCTCGCTGCTGATTGCCACTTGTTTGGGCGGGCGGGGCGGTATTTT
GGTGGCAGAGCCCACCTTCTCCATGTACGCCATCCTGGCCCAGAGCCTGGGGATCCCAGTGGTGCGGGTTCCCCGCGACC
CGGAGACGTTTGCTCTGGATCTAGAGCGATGTCAACAGGCTTTGAGGGAGCATCCGATTCGGGTGGTGTGCCTGGTGGAT
CCCAACTCGCCGACGGGGAATGGCCTGACGGCTGCAGAGTGGGAGTGGGTGGAAGGGCTGCCCGAAGAGATTCTGGTGAT
TTTGGATGAGGCCTATTTTGAGTTCAGCCGGCACACAGCCCTGCCCAAATTGGCGGAGCATCCCAACTGGGTAATCTTGC
GCACCTTCTCCAAAGCCTTTCGCCTGGCGGCCCACCGGGTGGGCTATGCTGTGGGTCATCCACAGCTTATGCAAGTGCTG
GATGGGATCCGCCTGCCCTACAACCTCACGGCCCTTTCTCAGTGGGCGGTTCAGATGGCTTTGGAGCATGCCGAGGAGCT
TTTGGCCGACGTGACGCTAATTTGTCAGGAGCGGGAAGCCCTTTACCAAGCTCTGCAGGAGCTGCCGGGGGTGCGGGTGT
GGCCCAGCCAAGCCAACTTCCTCTACTTCCGGGTGGCCGGCTGGGATCCCCAAGAGCTGCAGCGGGCCTGGCAGGAGCTG
GGGACTGGTGTGCGCTACACGGGTGGGGGGCTGCGTCTGACGGTGGGCACCCCTGAAGAGAACCGACGGGCCTTGGAGCG
CCTGCGCCAAATCCTGCAATAG

Upstream 100 bases:

>100_bases
GATTGCCCTTTTTGAGGCGCTACGTCAGCAGGGATCCCTGACCAAAGAATAGGGGGTCGGGTTGACCCTGTTATGATAGG
TGTTTCGCCCCGTCAGGAAG

Downstream 100 bases:

>100_bases
GCCTCCCGGCCTGCGTTCGGAGCCAGCCTAGGTGGATGGGTCGGCGCGCGAAAAGCGCTGGATCAAGCTGTGCACCTGCT
GCAAGTGTCGTTCGTCCAGA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MCALQYLRPDLLYLKPYDAVPAPAADKLDANEFPLDWPAGFKQKLSLLWEKGIPSNRYPDAHHRGLKQAIAAYAGAEPEQ
ISLGNGSDELIRSLLIATCLGGRGGILVAEPTFSMYAILAQSLGIPVVRVPRDPETFALDLERCQQALREHPIRVVCLVD
PNSPTGNGLTAAEWEWVEGLPEEILVILDEAYFEFSRHTALPKLAEHPNWVILRTFSKAFRLAAHRVGYAVGHPQLMQVL
DGIRLPYNLTALSQWAVQMALEHAEELLADVTLICQEREALYQALQELPGVRVWPSQANFLYFRVAGWDPQELQRAWQEL
GTGVRYTGGGLRLTVGTPEENRRALERLRQILQ

Sequences:

>Translated_353_residues
MCALQYLRPDLLYLKPYDAVPAPAADKLDANEFPLDWPAGFKQKLSLLWEKGIPSNRYPDAHHRGLKQAIAAYAGAEPEQ
ISLGNGSDELIRSLLIATCLGGRGGILVAEPTFSMYAILAQSLGIPVVRVPRDPETFALDLERCQQALREHPIRVVCLVD
PNSPTGNGLTAAEWEWVEGLPEEILVILDEAYFEFSRHTALPKLAEHPNWVILRTFSKAFRLAAHRVGYAVGHPQLMQVL
DGIRLPYNLTALSQWAVQMALEHAEELLADVTLICQEREALYQALQELPGVRVWPSQANFLYFRVAGWDPQELQRAWQEL
GTGVRYTGGGLRLTVGTPEENRRALERLRQILQ
>Mature_353_residues
MCALQYLRPDLLYLKPYDAVPAPAADKLDANEFPLDWPAGFKQKLSLLWEKGIPSNRYPDAHHRGLKQAIAAYAGAEPEQ
ISLGNGSDELIRSLLIATCLGGRGGILVAEPTFSMYAILAQSLGIPVVRVPRDPETFALDLERCQQALREHPIRVVCLVD
PNSPTGNGLTAAEWEWVEGLPEEILVILDEAYFEFSRHTALPKLAEHPNWVILRTFSKAFRLAAHRVGYAVGHPQLMQVL
DGIRLPYNLTALSQWAVQMALEHAEELLADVTLICQEREALYQALQELPGVRVWPSQANFLYFRVAGWDPQELQRAWQEL
GTGVRYTGGGLRLTVGTPEENRRALERLRQILQ

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=335, Percent_Identity=32.2388059701493, Blast_Score=146, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6322075, Length=327, Percent_Identity=31.4984709480122, Blast_Score=147, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_SYNJB (Q2JPM4)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_476521.1
- ProteinModelPortal:   Q2JPM4
- SMR:   Q2JPM4
- STRING:   Q2JPM4
- GeneID:   3902204
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_0260
- TIGR:   CYB_0260
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   MDEAYQP
- PhylomeDB:   Q2JPM4
- ProtClustDB:   PRK02610
- BioCyc:   SSP321332:CYB_0260-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39544; Mature: 39544

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCALQYLRPDLLYLKPYDAVPAPAADKLDANEFPLDWPAGFKQKLSLLWEKGIPSNRYPD
CCCHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
AHHRGLKQAIAAYAGAEPEQISLGNGSDELIRSLLIATCLGGRGGILVAEPTFSMYAILA
HHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHH
QSLGIPVVRVPRDPETFALDLERCQQALREHPIRVVCLVDPNSPTGNGLTAAEWEWVEGL
HHCCCCEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCHHHHCC
PEEILVILDEAYFEFSRHTALPKLAEHPNWVILRTFSKAFRLAAHRVGYAVGHPQLMQVL
CHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHH
DGIRLPYNLTALSQWAVQMALEHAEELLADVTLICQEREALYQALQELPGVRVWPSQANF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCE
LYFRVAGWDPQELQRAWQELGTGVRYTGGGLRLTVGTPEENRRALERLRQILQ
EEEEECCCCHHHHHHHHHHHCCCCEEECCCEEEEECCCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MCALQYLRPDLLYLKPYDAVPAPAADKLDANEFPLDWPAGFKQKLSLLWEKGIPSNRYPD
CCCHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
AHHRGLKQAIAAYAGAEPEQISLGNGSDELIRSLLIATCLGGRGGILVAEPTFSMYAILA
HHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHH
QSLGIPVVRVPRDPETFALDLERCQQALREHPIRVVCLVDPNSPTGNGLTAAEWEWVEGL
HHCCCCEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCHHHHCC
PEEILVILDEAYFEFSRHTALPKLAEHPNWVILRTFSKAFRLAAHRVGYAVGHPQLMQVL
CHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHH
DGIRLPYNLTALSQWAVQMALEHAEELLADVTLICQEREALYQALQELPGVRVWPSQANF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCE
LYFRVAGWDPQELQRAWQELGTGVRYTGGGLRLTVGTPEENRRALERLRQILQ
EEEEECCCCHHHHHHHHHHHCCCCEEECCCEEEEECCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA