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The map label for this gene is 86607745

Identifier: 86607745

GI number: 86607745

Start: 259659

End: 260738

Strand: Direct

Name: 86607745

Synonym: CYB_0246

Alternate gene names: NA

Gene position: 259659-260738 (Clockwise)

Preceding gene: 86607734

Following gene: 86607747

Centisome position: 8.52

GC content: 58.7

Gene sequence:

>1080_bases
ATGAACCAGTCCAATCGAATCGTCCAAGGGATCCATCACCTGCACTTCTATCTTTGGGATCTGCCCCGTTGGCAGGAACA
CTTTTGTCAAGTTTGGGGCTTCCGAATGGAAGGACAGCTCGGCAGTACCCTCTGTCTGCGTCAGGGATCCCTGCGCTTGC
GCCTATCTCAGCCGGCTCACGCCGGGGATGAGGTGGATCGCTATTTGCAGCAACATTCGCCTGGCGTGGTGGATGTGGCC
TTAGCGGTGGTGGAGCAAGAGCTGTTGGGCTTGGCAGAGCTTCTGCAGAGGCGAGGAGCCCAAGTGGAGTGGATCCCGGC
AGAAGAGGAAGGCGGCCCCACTCTGCGCCTGCGCACCCCCTATGGACTTCGGCATTCTTTGCTCCCCGGCTCAGGGATCC
CCGATTCAGCCCCTGCTGAGGAGAACCTGTTTTCCCACTGGGATCACCTGGTATTGAACGTGGAGCAGGGATCCCTGCAG
GCAGCGGCGGATTGGTATGAGCAGGTGCTGGGTTGGCGGTCTCTGTATCGCTATAGCATCCGCACCAACACCTCTGGCCT
AGAAAGTGTGGTGGTGGGAGATCCTGAAGCCGGGATCCAGTTGGCCATCAACGAGCCCACCTGTGCCGCTTCCCAGATCC
AGGAGTTTTTGGATGCCCATCATGGCCCTGGCCTGCAACATGCGGCGTTGCACAGCTCAGATGTCTTCGCCAGTGTGCGC
CGGCTGCGACAGGGAGGCGTAAACTTTCTGCAGGTGCCACCGGAGTACTACACAAACCTGGCAAGGGAGCTGGCTTCTGG
AGCAATACTCCGTTCTGGTGGGTTGCCCCCCGCCATCTCCTGGCACGACTTGGTGGAGCAGCAGCTCCTTTTGGATGCCA
CCTTGCCTGCTTCTGATTCCCCACACCCCCCCCTGTTGTTGCAAACCTTCACTCAGCCTCTGTTTGGTCGGCCCACGTTT
TTTTTCGAGGTCATCCAACGATTGGGTGGAGCCACAGGCTTTGGCGAAGCCAACTTTCAAGCCCTGTTTGAAGCTCTAGA
ACGCCAACAGCGACAACGGCAGCAAGCCCTGGTCTGCTAA

Upstream 100 bases:

>100_bases
CGGCAAATGGCGGGCCTATGCTGAGGTAGGACGGCCCAGGTCGTCTGTTGCCGTGAGAACGTCAGGATACTCGGCCTTTG
CCTTAGCAGTGCCTTGCTCT

Downstream 100 bases:

>100_bases
CACCCTTGTTCTAGGGATCCAGTGGGAGCACCAGGGGAATGTCTCCAGTTAATCAACACGATTGATTGCCCCTGAGTTTC
CAGCCGATATTCGGGTATGC

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MNQSNRIVQGIHHLHFYLWDLPRWQEHFCQVWGFRMEGQLGSTLCLRQGSLRLRLSQPAHAGDEVDRYLQQHSPGVVDVA
LAVVEQELLGLAELLQRRGAQVEWIPAEEEGGPTLRLRTPYGLRHSLLPGSGIPDSAPAEENLFSHWDHLVLNVEQGSLQ
AAADWYEQVLGWRSLYRYSIRTNTSGLESVVVGDPEAGIQLAINEPTCAASQIQEFLDAHHGPGLQHAALHSSDVFASVR
RLRQGGVNFLQVPPEYYTNLARELASGAILRSGGLPPAISWHDLVEQQLLLDATLPASDSPHPPLLLQTFTQPLFGRPTF
FFEVIQRLGGATGFGEANFQALFEALERQQRQRQQALVC

Sequences:

>Translated_359_residues
MNQSNRIVQGIHHLHFYLWDLPRWQEHFCQVWGFRMEGQLGSTLCLRQGSLRLRLSQPAHAGDEVDRYLQQHSPGVVDVA
LAVVEQELLGLAELLQRRGAQVEWIPAEEEGGPTLRLRTPYGLRHSLLPGSGIPDSAPAEENLFSHWDHLVLNVEQGSLQ
AAADWYEQVLGWRSLYRYSIRTNTSGLESVVVGDPEAGIQLAINEPTCAASQIQEFLDAHHGPGLQHAALHSSDVFASVR
RLRQGGVNFLQVPPEYYTNLARELASGAILRSGGLPPAISWHDLVEQQLLLDATLPASDSPHPPLLLQTFTQPLFGRPTF
FFEVIQRLGGATGFGEANFQALFEALERQQRQRQQALVC
>Mature_359_residues
MNQSNRIVQGIHHLHFYLWDLPRWQEHFCQVWGFRMEGQLGSTLCLRQGSLRLRLSQPAHAGDEVDRYLQQHSPGVVDVA
LAVVEQELLGLAELLQRRGAQVEWIPAEEEGGPTLRLRTPYGLRHSLLPGSGIPDSAPAEENLFSHWDHLVLNVEQGSLQ
AAADWYEQVLGWRSLYRYSIRTNTSGLESVVVGDPEAGIQLAINEPTCAASQIQEFLDAHHGPGLQHAALHSSDVFASVR
RLRQGGVNFLQVPPEYYTNLARELASGAILRSGGLPPAISWHDLVEQQLLLDATLPASDSPHPPLLLQTFTQPLFGRPTF
FFEVIQRLGGATGFGEANFQALFEALERQQRQRQQALVC

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=376, Percent_Identity=28.7234042553192, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI285002264, Length=334, Percent_Identity=30.8383233532934, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI14249394, Length=305, Percent_Identity=29.5081967213115, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17555220, Length=316, Percent_Identity=33.2278481012658, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17550752, Length=373, Percent_Identity=26.5415549597855, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24667510, Length=379, Percent_Identity=28.2321899736148, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI21356105, Length=312, Percent_Identity=30.1282051282051, Blast_Score=121, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 40031; Mature: 40031

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQSNRIVQGIHHLHFYLWDLPRWQEHFCQVWGFRMEGQLGSTLCLRQGSLRLRLSQPAH
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHEECCCEEEEECCCCC
AGDEVDRYLQQHSPGVVDVALAVVEQELLGLAELLQRRGAQVEWIPAEEEGGPTLRLRTP
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEECC
YGLRHSLLPGSGIPDSAPAEENLFSHWDHLVLNVEQGSLQAAADWYEQVLGWRSLYRYSI
CCCHHCCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
RTNTSGLESVVVGDPEAGIQLAINEPTCAASQIQEFLDAHHGPGLQHAALHSSDVFASVR
CCCCCCCCEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
RLRQGGVNFLQVPPEYYTNLARELASGAILRSGGLPPAISWHDLVEQQLLLDATLPASDS
HHHHCCCCEEECCHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCC
PHPPLLLQTFTQPLFGRPTFFFEVIQRLGGATGFGEANFQALFEALERQQRQRQQALVC
CCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNQSNRIVQGIHHLHFYLWDLPRWQEHFCQVWGFRMEGQLGSTLCLRQGSLRLRLSQPAH
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHEECCCEEEEECCCCC
AGDEVDRYLQQHSPGVVDVALAVVEQELLGLAELLQRRGAQVEWIPAEEEGGPTLRLRTP
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEECC
YGLRHSLLPGSGIPDSAPAEENLFSHWDHLVLNVEQGSLQAAADWYEQVLGWRSLYRYSI
CCCHHCCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
RTNTSGLESVVVGDPEAGIQLAINEPTCAASQIQEFLDAHHGPGLQHAALHSSDVFASVR
CCCCCCCCEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
RLRQGGVNFLQVPPEYYTNLARELASGAILRSGGLPPAISWHDLVEQQLLLDATLPASDS
HHHHCCCCEEECCHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCC
PHPPLLLQTFTQPLFGRPTFFFEVIQRLGGATGFGEANFQALFEALERQQRQRQQALVC
CCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]