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The map label for this gene is msrA [H]

Identifier: 86607734

GI number: 86607734

Start: 244559

End: 245227

Strand: Direct

Name: msrA [H]

Synonym: CYB_0235

Alternate gene names: 86607734

Gene position: 244559-245227 (Clockwise)

Preceding gene: 86607733

Following gene: 86607745

Centisome position: 8.03

GC content: 60.09

Gene sequence:

>669_bases
ATGGTGCTCTTTGGCTTTGGCAAACTTGGCAAGAAACTGTCCCTGCCCAAACCGGAAGAAGCCTTGCCGGGCCGGGCCGA
GCCGATGGTGATCGTGAATCGGCATTTTGTCAATGGCCATCCGCTGCAGCCGCCTTTTCCCGAGGGCATGGAGCTGGCCA
TGTTCGGCATGGGCTGCTTCTGGGGGGCAGAGCGCAAGTTTTGGCAGGTGCCAGGGGTGTTCAGCACAGCGGTGGGCTAC
GCTGGCGGGTTTACCCCCAACCCCACCTATGAAGAGGTCTGTACTGGCCTGACTGGCCACAACGAGGTGGTGCGGGTGGT
TTACGACCCAGCTCAGGTCAGCTATGCCCAACTGCTGAAGGTGTTTTGGGAAAATCACGACCCTACCCAGGGGATGCGCC
AAGGCAATGATGTGGGCACCCAATACCGCTCCGGCATCTATGTGTATTCTCCGGCGCAGCGGGAGCTGGCGGAAAAAACC
CGCGATCTCTATCAGCAGGCCCTGACCGCCCACGGCTACGGCCAGATCACCACCGAGATCTTAGACGCGCCTGAGTTTTA
CTACGCCGAAGACTACCACCAGCAATATCTGGCCAAGAATCCGCGCGGCTACTGCGGCCTGCGGGGCACTAGGGTTTGTC
TGCCAGAGATCCTCACCGAGCCTGCCTAG

Upstream 100 bases:

>100_bases
TTTTGAATCGGTGAGCTGACCCGATCAAGGATTTTTCCAACACATGAGGAGCCAACTGAGCTAGGCTGGTAAGTGTTAAC
GAATGTATCGGGCTGTCCCT

Downstream 100 bases:

>100_bases
CCCCAACCCAACCGTCAAAAGACTCGGCGGGAATGGGATCCCCGCTCAAGGAACTCCCTAGCCACTAGGGTTACCACCGC
CAGCAAGGAGAGCACCACCG

Product: methionine-S-sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MVLFGFGKLGKKLSLPKPEEALPGRAEPMVIVNRHFVNGHPLQPPFPEGMELAMFGMGCFWGAERKFWQVPGVFSTAVGY
AGGFTPNPTYEEVCTGLTGHNEVVRVVYDPAQVSYAQLLKVFWENHDPTQGMRQGNDVGTQYRSGIYVYSPAQRELAEKT
RDLYQQALTAHGYGQITTEILDAPEFYYAEDYHQQYLAKNPRGYCGLRGTRVCLPEILTEPA

Sequences:

>Translated_222_residues
MVLFGFGKLGKKLSLPKPEEALPGRAEPMVIVNRHFVNGHPLQPPFPEGMELAMFGMGCFWGAERKFWQVPGVFSTAVGY
AGGFTPNPTYEEVCTGLTGHNEVVRVVYDPAQVSYAQLLKVFWENHDPTQGMRQGNDVGTQYRSGIYVYSPAQRELAEKT
RDLYQQALTAHGYGQITTEILDAPEFYYAEDYHQQYLAKNPRGYCGLRGTRVCLPEILTEPA
>Mature_222_residues
MVLFGFGKLGKKLSLPKPEEALPGRAEPMVIVNRHFVNGHPLQPPFPEGMELAMFGMGCFWGAERKFWQVPGVFSTAVGY
AGGFTPNPTYEEVCTGLTGHNEVVRVVYDPAQVSYAQLLKVFWENHDPTQGMRQGNDVGTQYRSGIYVYSPAQRELAEKT
RDLYQQALTAHGYGQITTEILDAPEFYYAEDYHQQYLAKNPRGYCGLRGTRVCLPEILTEPA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=214, Percent_Identity=61.214953271028, Blast_Score=275, Evalue=2e-74,
Organism=Homo sapiens, GI208609995, Length=182, Percent_Identity=65.3846153846154, Blast_Score=257, Evalue=7e-69,
Organism=Homo sapiens, GI208609993, Length=214, Percent_Identity=47.196261682243, Blast_Score=187, Evalue=9e-48,
Organism=Escherichia coli, GI1790665, Length=209, Percent_Identity=61.244019138756, Blast_Score=250, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI17533973, Length=174, Percent_Identity=33.9080459770115, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320881, Length=167, Percent_Identity=37.7245508982036, Blast_Score=100, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24664627, Length=166, Percent_Identity=37.9518072289157, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24664631, Length=166, Percent_Identity=37.3493975903614, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=40, Blast_Score=91, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 24889; Mature: 24889

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLFGFGKLGKKLSLPKPEEALPGRAEPMVIVNRHFVNGHPLQPPFPEGMELAMFGMGCF
CEEECCCCCCCCCCCCCCHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
WGAERKFWQVPGVFSTAVGYAGGFTPNPTYEEVCTGLTGHNEVVRVVYDPAQVSYAQLLK
CCCCCCEEECCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCEEEEEEECCHHHHHHHHHH
VFWENHDPTQGMRQGNDVGTQYRSGIYVYSPAQRELAEKTRDLYQQALTAHGYGQITTEI
HHHCCCCCHHHHHCCCHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LDAPEFYYAEDYHQQYLAKNPRGYCGLRGTRVCLPEILTEPA
HCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MVLFGFGKLGKKLSLPKPEEALPGRAEPMVIVNRHFVNGHPLQPPFPEGMELAMFGMGCF
CEEECCCCCCCCCCCCCCHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
WGAERKFWQVPGVFSTAVGYAGGFTPNPTYEEVCTGLTGHNEVVRVVYDPAQVSYAQLLK
CCCCCCEEECCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCEEEEEEECCHHHHHHHHHH
VFWENHDPTQGMRQGNDVGTQYRSGIYVYSPAQRELAEKTRDLYQQALTAHGYGQITTEI
HHHCCCCCHHHHHCCCHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LDAPEFYYAEDYHQQYLAKNPRGYCGLRGTRVCLPEILTEPA
HCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]