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The map label for this gene is ndhD2

Identifier: 86606561

GI number: 86606561

Start: 1924290

End: 1925897

Strand: Reverse

Name: ndhD2

Synonym: CYA_1915

Alternate gene names: 86606561

Gene position: 1925897-1924290 (Counterclockwise)

Preceding gene: 86606563

Following gene: 86606560

Centisome position: 65.67

GC content: 60.82

Gene sequence:

>1608_bases
ATGGCGCTGCCCAGCTTGCACGAGTTTCCCTGGCTGACCACGGTCATCGTCTATCCGGTGGTGGCCGCCCTCTTCATCCC
CTTGATCCCGGCGCCCGCTGGGGATCCCACTACCCGGGTCTACGCGCAAAAGTTGGCAGAACGGGTTCGCTGGTTTGCCC
TCTTCATCGCGGTTACCGACCTGCTCATTTTGCTGGCTGGCTTCTATGTCGGCTATGACCCCAGCCAGACAAGCTTACAA
CTGCTGGAGCGCTACACCTGGGTGCCGCAGGTGGGGCTGAGCTGGTCGGTGGGGGCCGATGGCCTTTCCATGCCGCTGAT
CCTGCTCACGGCTTTTGTGACCACGCTTGCCATCTTGGCCGCCTGGCCGGTCACCCTCAAGCCGCGCCTGTTTTATTTTC
TGATGTTGGCCATGTACGGCGGGCAGATCGGGGTGTTCGCCGTGCAGGACATGTTGCTCTTCTTCCTGATGTGGGAGCTG
GAGCTGATCCCGGTGTATTTGCTCCTCTCCATTTGGGGGGGGTACAACCGCCTCTATGCGGCCACCAAGTTCATTCTCTA
CACCGCCCTCAGCTCCCTGTTTATCCTGGTGGCGGGCCTGGCCATGGCCTTCTACGGGGATCCCATCAGCTTTGACATGA
CGGATCTGGCCCACAAGGCCTATCCGCTGAGCTTCCAATTGCTGCTGTATGGGGCCTTCCTCATCGCCTACGGGGTGAAG
CTGCCCGTCTTCCCTTTGCACACCTGGCTGCCCGATGCCCACGGCGAAGCCACGGCGCCGGTTCACATGTTGCTGGCCGG
GATCTTGCTTAAGATGGGGGGCTATGCCCTGATGCGCATGAATGTGGGCATGCTGCCGGATGCCCACCTCTACTTTGCGC
CGGTGCTGATCGTGCTGGGGGTGGTGAACATCATCTTTGCCGCCCTTACCTCCTTTGCCCAGCGCAACCTCAAGCGCAAG
ATCGCCTACTCTTCCATCAGCCACATGGGCTTTGTCCTCATCGGGATCGGATCCCTGACCGAAATCGGCATGAGCGGCGC
CATGCTGCAGATGATCTCCCACGGGCTGATCGGGGCCAGCCTGTTCTTCTTGGTGGGGGCCACCTACGACCGCACCCACA
CGCTGGAGCTGGAGGAAATGGGCGGCGTCGGCCTGAAGATGCCCAAGATTTTCTCCATGTTCACCGCTTGCTCGCTGGCC
TCTCTGGCTCTGCCGGGGATGAGCGGCTTTGTGGCGGAGCTGATGGTGTTCATCGGCATGGCCACCACCGATGCCTACTC
CCTCCCCTTCCGGCTGGTGGTGGTCTTTCTGGCGGCGGTTGGGGTGATCCTGACTCCTATCTACCTGCTGTCGATGTTGC
GGCAGATCTTCTTTGGCCCGGAAAACAAAGAGCTGACCGAACACGAGGAACTGGTGGATGCCGAGCCGCGGGAGGTGTTC
ATCATCGCCTGCCTGCTGATCCCCATCATCGGCATTGGGCTCTATCCCAAGCTGGTCACTAGCCTCTACGACCAGTCCAC
CAATGCCCTGGTGGCGCTGCTGCGCCAAGAACTCTCCTCTATTGGAGCGACGGTTGCCCAAGCTCCTGCTCTCTACAGCG
CCGACTGA

Upstream 100 bases:

>100_bases
AGATACTCAGGAGCGATTCTGGTAAAAGGCTGTTGGCTGTAGCCGACGGCAATCCCCCTGGAAGGGTGTGGTATGAACTT
AGCGTAACGAGGTTATCTTC

Downstream 100 bases:

>100_bases
AGTGACATCCTCTCCCGCTAAGCCCTGACGGGCTGTAGACGGGAGCTTCCGAGAATCACTTCCCGGAGTTGCTGCTTCAA
CGGACTGGTAAACCAGGATC

Product: NAD(P)H-quinone oxidoreductase subunit 4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 2; NDH-1, chain 4 2

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MALPSLHEFPWLTTVIVYPVVAALFIPLIPAPAGDPTTRVYAQKLAERVRWFALFIAVTDLLILLAGFYVGYDPSQTSLQ
LLERYTWVPQVGLSWSVGADGLSMPLILLTAFVTTLAILAAWPVTLKPRLFYFLMLAMYGGQIGVFAVQDMLLFFLMWEL
ELIPVYLLLSIWGGYNRLYAATKFILYTALSSLFILVAGLAMAFYGDPISFDMTDLAHKAYPLSFQLLLYGAFLIAYGVK
LPVFPLHTWLPDAHGEATAPVHMLLAGILLKMGGYALMRMNVGMLPDAHLYFAPVLIVLGVVNIIFAALTSFAQRNLKRK
IAYSSISHMGFVLIGIGSLTEIGMSGAMLQMISHGLIGASLFFLVGATYDRTHTLELEEMGGVGLKMPKIFSMFTACSLA
SLALPGMSGFVAELMVFIGMATTDAYSLPFRLVVVFLAAVGVILTPIYLLSMLRQIFFGPENKELTEHEELVDAEPREVF
IIACLLIPIIGIGLYPKLVTSLYDQSTNALVALLRQELSSIGATVAQAPALYSAD

Sequences:

>Translated_535_residues
MALPSLHEFPWLTTVIVYPVVAALFIPLIPAPAGDPTTRVYAQKLAERVRWFALFIAVTDLLILLAGFYVGYDPSQTSLQ
LLERYTWVPQVGLSWSVGADGLSMPLILLTAFVTTLAILAAWPVTLKPRLFYFLMLAMYGGQIGVFAVQDMLLFFLMWEL
ELIPVYLLLSIWGGYNRLYAATKFILYTALSSLFILVAGLAMAFYGDPISFDMTDLAHKAYPLSFQLLLYGAFLIAYGVK
LPVFPLHTWLPDAHGEATAPVHMLLAGILLKMGGYALMRMNVGMLPDAHLYFAPVLIVLGVVNIIFAALTSFAQRNLKRK
IAYSSISHMGFVLIGIGSLTEIGMSGAMLQMISHGLIGASLFFLVGATYDRTHTLELEEMGGVGLKMPKIFSMFTACSLA
SLALPGMSGFVAELMVFIGMATTDAYSLPFRLVVVFLAAVGVILTPIYLLSMLRQIFFGPENKELTEHEELVDAEPREVF
IIACLLIPIIGIGLYPKLVTSLYDQSTNALVALLRQELSSIGATVAQAPALYSAD
>Mature_534_residues
ALPSLHEFPWLTTVIVYPVVAALFIPLIPAPAGDPTTRVYAQKLAERVRWFALFIAVTDLLILLAGFYVGYDPSQTSLQL
LERYTWVPQVGLSWSVGADGLSMPLILLTAFVTTLAILAAWPVTLKPRLFYFLMLAMYGGQIGVFAVQDMLLFFLMWELE
LIPVYLLLSIWGGYNRLYAATKFILYTALSSLFILVAGLAMAFYGDPISFDMTDLAHKAYPLSFQLLLYGAFLIAYGVKL
PVFPLHTWLPDAHGEATAPVHMLLAGILLKMGGYALMRMNVGMLPDAHLYFAPVLIVLGVVNIIFAALTSFAQRNLKRKI
AYSSISHMGFVLIGIGSLTEIGMSGAMLQMISHGLIGASLFFLVGATYDRTHTLELEEMGGVGLKMPKIFSMFTACSLAS
LALPGMSGFVAELMVFIGMATTDAYSLPFRLVVVFLAAVGVILTPIYLLSMLRQIFFGPENKELTEHEELVDAEPREVFI
IACLLIPIIGIGLYPKLVTSLYDQSTNALVALLRQELSSIGATVAQAPALYSAD

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family

Homologues:

Organism=Homo sapiens, GI251831116, Length=380, Percent_Identity=31.0526315789474, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI251831117, Length=373, Percent_Identity=25.7372654155496, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1788613, Length=490, Percent_Identity=35.9183673469388, Blast_Score=279, Evalue=4e-76,
Organism=Escherichia coli, GI1788827, Length=284, Percent_Identity=25.7042253521127, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1788831, Length=307, Percent_Identity=27.6872964169381, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI2367154, Length=224, Percent_Identity=27.6785714285714, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788829, Length=296, Percent_Identity=27.027027027027, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788614, Length=461, Percent_Identity=22.7765726681128, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI145693160, Length=228, Percent_Identity=31.5789473684211, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NU4C2_SYNJA (Q2JTD6)

Other databases:

- EMBL:   CP000239
- RefSeq:   YP_475324.1
- STRING:   Q2JTD6
- GeneID:   3899778
- GenomeReviews:   CP000239_GR
- KEGG:   cya:CYA_1915
- TIGR:   CYA_1915
- eggNOG:   COG1008
- HOGENOM:   HBG643593
- OMA:   TSFAQRN
- ProtClustDB:   PRK02546
- BioCyc:   SSP321327:CYA_1915-MONOMER
- HAMAP:   MF_00491
- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- PRINTS:   PR01437
- TIGRFAMs:   TIGR01972

Pfam domain/function: PF00361 Oxidored_q1

EC number: 1.6.5.3

Molecular weight: Translated: 58575; Mature: 58444

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x95f64c0)-; HASH(0x14f7e77c)-; HASH(0x15e1eb0c)-; HASH(0x12047104)-; HASH(0x15e06a04)-; HASH(0x15ecc6c4)-; HASH(0x15e21978)-; HASH(0x15f59878)-; HASH(0x13e72ab0)-; HASH(0x15e31bf8)-; HASH(0x14f7e7e8)-; HASH(0x14f7e4dc)-; HASH(0x154ffe28)-; HASH(0x15e1e9ec)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
>Mature Secondary Structure 
ALPSLHEFPWLTTVIVYPVVAALFIPLIPAPAGDPTTRVYAQKLAERVRWFALFIAVTD
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LLILLAGFYVGYDPSQTSLQLLERYTWVPQVGLSWSVGADGLSMPLILLTAFVTTLAILA
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AWPVTLKPRLFYFLMLAMYGGQIGVFAVQDMLLFFLMWELELIPVYLLLSIWGGYNRLYA
HCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ATKFILYTALSSLFILVAGLAMAFYGDPISFDMTDLAHKAYPLSFQLLLYGAFLIAYGVK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCC
LPVFPLHTWLPDAHGEATAPVHMLLAGILLKMGGYALMRMNVGMLPDAHLYFAPVLIVLG
CCCEEHHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHEEEECCCCCCCHHHHHHHHHHHHH
VVNIIFAALTSFAQRNLKRKIAYSSISHMGFVLIGIGSLTEIGMSGAMLQMISHGLIGAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHCCCHHHHHHHHHHHHHHH
LFFLVGATYDRTHTLELEEMGGVGLKMPKIFSMFTACSLASLALPGMSGFVAELMVFIGM
HHHHHCCCCCCCEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ATTDAYSLPFRLVVVFLAAVGVILTPIYLLSMLRQIFFGPENKELTEHEELVDAEPREVF
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHH
IIACLLIPIIGIGLYPKLVTSLYDQSTNALVALLRQELSSIGATVAQAPALYSAD
HHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA