Click here to switch to the map view.

The map label for this gene is trxB

Identifier: 86606033

GI number: 86606033

Start: 1371802

End: 1373232

Strand: Reverse

Name: trxB

Synonym: CYA_1362

Alternate gene names: 86606033

Gene position: 1373232-1371802 (Counterclockwise)

Preceding gene: 86606038

Following gene: 86606031

Centisome position: 46.82

GC content: 61.29

Gene sequence:

>1431_bases
ATGACAGAGCAAAGTCGGGTTGAGAACGTGGTGATTATTGGTTCTGGCCCTGCTGGGTTTACGGCGGCCATTTATGCCGG
GCGTGCCAACCTGAAGCCGGTTGTGTTTGAGGGGTTTCAGGTGGGCGGGATCCCGGGCGGGCAGTTGATGACCACCACCG
AGGTGGAGAACTTTCCGGGTTTTCCCGAGGGCATCAGTGGCCCCCAACTCATGAAAAACATGCGTGCCCAGGCGCAGCGG
TGGGGGGCAGAGCTTTACCCCGAGGACGTCACCTTTGTGGATCTGAGCCAGCGGCCTTTTGTGGTTCGCTCTGACGAACG
GGAAGTGCGCACCCACAGCCTGATTATTGCCACCGGGGCCACGGCCAAGCGCCTGCACTTGCCCGGAGAGGAGATCTACT
GGAACCGGGGCATGTCGGCCTGCGCCGTCTGCGATGGGGCCATGCCCATGTTTAGGGGGGTGGAGCTGGTGGTCATTGGC
GGCGGCGATACCGCCTGTGAGGAGGCCACCTACCTGACCAAGTTTGGATCCCATATCCACATGCTGGTGCGCAGTGGCAA
GATGCGGGCCAGCAAGGCCATGCAAGACCGGGTGCTCAACCACCCCAAGATTACCGTCCACTGGCACACGGAGGCGGTGG
AGGTTCTGGGCGACGGCCTGCGCCTGACGGGGGTGAAGGTGCGCAACAACCAGACGGGCGAGATCCGGGAGATGGCAGTG
GGCGGCCTGTTCTACGCCATCGGCCACAAGCCCAACACCGACTTGTTCAAAGGGCAACTGGAACTGGATGAAGTGGGCTA
CATTGTCACCCGCCCAGGATCTGTAGCCACCAGTGTAGAGGGCGTGTTTGCCGCCGGGGATGTGCAGGATCACGAGTTTC
GCCAGGCCATCACCGCTGCCGGCACCGGCTGTATGGCGGCCATGCTGGCGGAGCGCTGGCTCTCCGAACACGGCCTGGCA
CAGGAGTATCACGTCGTCCCTCAAAGCCATCTTGAGCCCGCTTCTGCCTCTGCTGTCGAGGTAGAGCCGGAGGGAGACTC
GGCTGTTGAGGAGGCCAGTTTTGAGCAGGAGGTGCAAGATGACCTCGACTTCAGCCAGACCTGCCACGAGGGGAGCTATG
CCCTGCGGCGGCTCTACCACGAAAGCGATCGCCTGCTGATGGTCAAGTACACCGCCCCCACCTGTGCCCCTTGTCATGCC
CTCAAGCTGATCTTGAACAAGGTCATCGAAGAGTTTGCCGACAAGCTGCATGTGGTGGAGATCGACATCGAGAAAGACCC
GGAGATCGCCGAGGCAGGGGGGGTCACCTGCACGCCGACGGTGCAGTTTTTCAAAAACAAGGAGCTGGTGGCTCAGGTGG
TGGGTGTCAAGCCCAAGTCCCACTACCGGGAGGTGATCCAGGCCAATTTGTCTGAGGCAAAATCAGCTTGA

Upstream 100 bases:

>100_bases
ACAAGCTCCAGCCTCGCCGAGGGTACCAGCTCGTGTTAGGCTAAAACGTAGTCGTTATGAGTTTGGTTTAGTTTTCAGCA
ACAGCAAGGAGCGACATCGG

Downstream 100 bases:

>100_bases
GGTAGTCCCCCTCACCCCCGGCCCCTCTCCCAGCCCCTCTCCCTGAGGGAGAGGGGAGCTAGGCGGCTAGTCGGCAAAGG
CGCTGTAGTATGCACCCTGC

Product: thioredoxin-disulfide reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MTEQSRVENVVIIGSGPAGFTAAIYAGRANLKPVVFEGFQVGGIPGGQLMTTTEVENFPGFPEGISGPQLMKNMRAQAQR
WGAELYPEDVTFVDLSQRPFVVRSDEREVRTHSLIIATGATAKRLHLPGEEIYWNRGMSACAVCDGAMPMFRGVELVVIG
GGDTACEEATYLTKFGSHIHMLVRSGKMRASKAMQDRVLNHPKITVHWHTEAVEVLGDGLRLTGVKVRNNQTGEIREMAV
GGLFYAIGHKPNTDLFKGQLELDEVGYIVTRPGSVATSVEGVFAAGDVQDHEFRQAITAAGTGCMAAMLAERWLSEHGLA
QEYHVVPQSHLEPASASAVEVEPEGDSAVEEASFEQEVQDDLDFSQTCHEGSYALRRLYHESDRLLMVKYTAPTCAPCHA
LKLILNKVIEEFADKLHVVEIDIEKDPEIAEAGGVTCTPTVQFFKNKELVAQVVGVKPKSHYREVIQANLSEAKSA

Sequences:

>Translated_476_residues
MTEQSRVENVVIIGSGPAGFTAAIYAGRANLKPVVFEGFQVGGIPGGQLMTTTEVENFPGFPEGISGPQLMKNMRAQAQR
WGAELYPEDVTFVDLSQRPFVVRSDEREVRTHSLIIATGATAKRLHLPGEEIYWNRGMSACAVCDGAMPMFRGVELVVIG
GGDTACEEATYLTKFGSHIHMLVRSGKMRASKAMQDRVLNHPKITVHWHTEAVEVLGDGLRLTGVKVRNNQTGEIREMAV
GGLFYAIGHKPNTDLFKGQLELDEVGYIVTRPGSVATSVEGVFAAGDVQDHEFRQAITAAGTGCMAAMLAERWLSEHGLA
QEYHVVPQSHLEPASASAVEVEPEGDSAVEEASFEQEVQDDLDFSQTCHEGSYALRRLYHESDRLLMVKYTAPTCAPCHA
LKLILNKVIEEFADKLHVVEIDIEKDPEIAEAGGVTCTPTVQFFKNKELVAQVVGVKPKSHYREVIQANLSEAKSA
>Mature_475_residues
TEQSRVENVVIIGSGPAGFTAAIYAGRANLKPVVFEGFQVGGIPGGQLMTTTEVENFPGFPEGISGPQLMKNMRAQAQRW
GAELYPEDVTFVDLSQRPFVVRSDEREVRTHSLIIATGATAKRLHLPGEEIYWNRGMSACAVCDGAMPMFRGVELVVIGG
GDTACEEATYLTKFGSHIHMLVRSGKMRASKAMQDRVLNHPKITVHWHTEAVEVLGDGLRLTGVKVRNNQTGEIREMAVG
GLFYAIGHKPNTDLFKGQLELDEVGYIVTRPGSVATSVEGVFAAGDVQDHEFRQAITAAGTGCMAAMLAERWLSEHGLAQ
EYHVVPQSHLEPASASAVEVEPEGDSAVEEASFEQEVQDDLDFSQTCHEGSYALRRLYHESDRLLMVKYTAPTCAPCHAL
KLILNKVIEEFADKLHVVEIDIEKDPEIAEAGGVTCTPTVQFFKNKELVAQVVGVKPKSHYREVIQANLSEAKSA

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787114, Length=320, Percent_Identity=48.75, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI87081763, Length=320, Percent_Identity=31.5625, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87082331, Length=91, Percent_Identity=32.967032967033, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320560, Length=312, Percent_Identity=55.1282051282051, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6321898, Length=311, Percent_Identity=54.6623794212219, Blast_Score=354, Evalue=2e-98,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 51978; Mature: 51846

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00573 PYRIDINE_REDOX_2 ; PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQSRVENVVIIGSGPAGFTAAIYAGRANLKPVVFEGFQVGGIPGGQLMTTTEVENFPG
CCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCEEEECEEECCCCCCCEEEEEECCCCCC
FPEGISGPQLMKNMRAQAQRWGAELYPEDVTFVDLSQRPFVVRSDEREVRTHSLIIATGA
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEECCCCCCEEEEEEEEECC
TAKRLHLPGEEIYWNRGMSACAVCDGAMPMFRGVELVVIGGGDTACEEATYLTKFGSHIH
CEEEEECCCHHEEECCCCCHHHHCCCCCHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHE
MLVRSGKMRASKAMQDRVLNHPKITVHWHTEAVEVLGDGLRLTGVKVRNNQTGEIREMAV
EHHHCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHCCCEEEEEEEEECCCCCHHHHHHH
GGLFYAIGHKPNTDLFKGQLELDEVGYIVTRPGSVATSVEGVFAAGDVQDHEFRQAITAA
CEEEEEECCCCCCCCEECEEEHHHCCEEEECCCCCCCCCCCEEEECCCCHHHHHHHHHHC
GTGCMAAMLAERWLSEHGLAQEYHVVPQSHLEPASASAVEVEPEGDSAVEEASFEQEVQD
CCHHHHHHHHHHHHHHCCCCCCEECCCHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHH
DLDFSQTCHEGSYALRRLYHESDRLLMVKYTAPTCAPCHALKLILNKVIEEFADKLHVVE
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEEE
IDIEKDPEIAEAGGVTCTPTVQFFKNKELVAQVVGVKPKSHYREVIQANLSEAKSA
EEECCCCCHHHCCCCEECCHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEQSRVENVVIIGSGPAGFTAAIYAGRANLKPVVFEGFQVGGIPGGQLMTTTEVENFPG
CCCCCCCEEEEEECCCCCCEEEEEECCCCCCCEEEECEEECCCCCCCEEEEEECCCCCC
FPEGISGPQLMKNMRAQAQRWGAELYPEDVTFVDLSQRPFVVRSDEREVRTHSLIIATGA
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEECCCCCCEEEEEEEEECC
TAKRLHLPGEEIYWNRGMSACAVCDGAMPMFRGVELVVIGGGDTACEEATYLTKFGSHIH
CEEEEECCCHHEEECCCCCHHHHCCCCCHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHE
MLVRSGKMRASKAMQDRVLNHPKITVHWHTEAVEVLGDGLRLTGVKVRNNQTGEIREMAV
EHHHCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHCCCEEEEEEEEECCCCCHHHHHHH
GGLFYAIGHKPNTDLFKGQLELDEVGYIVTRPGSVATSVEGVFAAGDVQDHEFRQAITAA
CEEEEEECCCCCCCCEECEEEHHHCCEEEECCCCCCCCCCCEEEECCCCHHHHHHHHHHC
GTGCMAAMLAERWLSEHGLAQEYHVVPQSHLEPASASAVEVEPEGDSAVEEASFEQEVQD
CCHHHHHHHHHHHHHHCCCCCCEECCCHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHH
DLDFSQTCHEGSYALRRLYHESDRLLMVKYTAPTCAPCHALKLILNKVIEEFADKLHVVE
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEEE
IDIEKDPEIAEAGGVTCTPTVQFFKNKELVAQVVGVKPKSHYREVIQANLSEAKSA
EEECCCCCHHHCCCCEECCHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]