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The map label for this gene is gcvT

Identifier: 86605926

GI number: 86605926

Start: 1255463

End: 1256599

Strand: Reverse

Name: gcvT

Synonym: CYA_1242

Alternate gene names: 86605926

Gene position: 1256599-1255463 (Counterclockwise)

Preceding gene: 86605928

Following gene: 86605923

Centisome position: 42.85

GC content: 63.15

Gene sequence:

>1137_bases
ATGAGCTCAACTCCCCTGCAACGCACCCCCCTGTTTCCCCTGCACCAAGCCTTGGGGGCGCGGTTTGTCTCCTTTGCCGG
CTGGGAAATGCCGCTGCAGTATCAGGGGGTGGTGGCTGAGCATCGGGCGGTGCGGGAGCGGGCAGGCGTCTTCGACATCT
CCCACATGGGCAAGTTCGACCTCTGGGGGCCGGAGCTGGGATCCCACCTCAGCCGTCTGGTGCCCAGCGATCTGGGCGCT
GTGGCGGTGGGATCCGCTCGCTACACGGTTTTGCTAAACCCCCTAGGGGGCATTGTGGACGATGTCATCTTCTACCGGCA
CCCACCAGAAGGCGAGCTGGAGCACTGGAGCCTGATCGTCAACGCGGCCACCCGCCAAAAGGACTGGGAGTGGCTCCATC
AGCAGGGGATCCCCGGCCTGGAACTTCAAGATCACACCGAGTCTCAGGTGTTGCTGGCGGTGCAGGGGCCGGCAGCCGAA
GAGGTTTTGCAGCCTTTTTTGGCGGGATCCCTGAGGGCTTTGCGCCGGTTTCAACACGGGCAGTTTGCGACTCGAAAAGA
GAGATCCTCAGGGGCAGGGGTCTTTGTGGCCCGCACCGGCTACACCGGAGAGGATGGCTTTGAGCTCCTGCTCGGCCCTG
CCGACGGGCTTTGGCTCTGGGAGCAACTGGTGCAGGCGGGGGTACAGCCTTGTGGACTGGGCTGCCGCGATACGCTGCGC
CTGGAGGCCGCTTTCTGTCTCTACGGGCAAGACATAGATGAGAGCACCACCCCCCTGGAAGCCGACCTGGGCTGGTTGGT
CAGCAATCCAGGGGACTACATCGGCAAGCCTGCCCTCGAAAGCCAACGCCAGCAAGGGATCCCGCGCCGTCTGGTGGGGT
TTCGGCTGTTGGAGCGAGCCATTCCCCGCCGCGGCTATGCCATCTACGCTCCCAACTCCCCTGAGCCGATCGGCCGGGTA
ACCAGCGGCACCCATTCTCCCACTTTGGGCTATGGCATCGGCCTGGGATATGTGGATTCAACTTGGGCTAAGGTGGGATC
CCGGCTAGAGATTGAGATTCGGGGCCAGCGCCGTCCTGCTGAAGTGGTGAAGAAGCCGTTCTACAGAGGGCAGGCTCCAG
TTAGCTTGGGGAGTTGA

Upstream 100 bases:

>100_bases
TGCCAACGCGGATCATGGTGTGGAGAAGACGCATGGGACGAGCTCCAAGAAATGGGCGACGTTGCGTTTATTCTAGTCCT
TGACTCCTAGAGATCCGTGG

Downstream 100 bases:

>100_bases
GCTGTCTGCCGGCCTTGGGGGTGGAGTATTCCTGCTGTAGCCGCCGCAATTTCCGCAGGGCCCGCCGCTCAATTTGCCGG
ACTCGCTCCCGCGAAAGACC

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MSSTPLQRTPLFPLHQALGARFVSFAGWEMPLQYQGVVAEHRAVRERAGVFDISHMGKFDLWGPELGSHLSRLVPSDLGA
VAVGSARYTVLLNPLGGIVDDVIFYRHPPEGELEHWSLIVNAATRQKDWEWLHQQGIPGLELQDHTESQVLLAVQGPAAE
EVLQPFLAGSLRALRRFQHGQFATRKERSSGAGVFVARTGYTGEDGFELLLGPADGLWLWEQLVQAGVQPCGLGCRDTLR
LEAAFCLYGQDIDESTTPLEADLGWLVSNPGDYIGKPALESQRQQGIPRRLVGFRLLERAIPRRGYAIYAPNSPEPIGRV
TSGTHSPTLGYGIGLGYVDSTWAKVGSRLEIEIRGQRRPAEVVKKPFYRGQAPVSLGS

Sequences:

>Translated_378_residues
MSSTPLQRTPLFPLHQALGARFVSFAGWEMPLQYQGVVAEHRAVRERAGVFDISHMGKFDLWGPELGSHLSRLVPSDLGA
VAVGSARYTVLLNPLGGIVDDVIFYRHPPEGELEHWSLIVNAATRQKDWEWLHQQGIPGLELQDHTESQVLLAVQGPAAE
EVLQPFLAGSLRALRRFQHGQFATRKERSSGAGVFVARTGYTGEDGFELLLGPADGLWLWEQLVQAGVQPCGLGCRDTLR
LEAAFCLYGQDIDESTTPLEADLGWLVSNPGDYIGKPALESQRQQGIPRRLVGFRLLERAIPRRGYAIYAPNSPEPIGRV
TSGTHSPTLGYGIGLGYVDSTWAKVGSRLEIEIRGQRRPAEVVKKPFYRGQAPVSLGS
>Mature_377_residues
SSTPLQRTPLFPLHQALGARFVSFAGWEMPLQYQGVVAEHRAVRERAGVFDISHMGKFDLWGPELGSHLSRLVPSDLGAV
AVGSARYTVLLNPLGGIVDDVIFYRHPPEGELEHWSLIVNAATRQKDWEWLHQQGIPGLELQDHTESQVLLAVQGPAAEE
VLQPFLAGSLRALRRFQHGQFATRKERSSGAGVFVARTGYTGEDGFELLLGPADGLWLWEQLVQAGVQPCGLGCRDTLRL
EAAFCLYGQDIDESTTPLEADLGWLVSNPGDYIGKPALESQRQQGIPRRLVGFRLLERAIPRRGYAIYAPNSPEPIGRVT
SGTHSPTLGYGIGLGYVDSTWAKVGSRLEIEIRGQRRPAEVVKKPFYRGQAPVSLGS

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=376, Percent_Identity=34.8404255319149, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI257796258, Length=362, Percent_Identity=34.5303867403315, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI257796254, Length=368, Percent_Identity=32.3369565217391, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI257796256, Length=320, Percent_Identity=33.75, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI24797151, Length=348, Percent_Identity=28.735632183908, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI197927446, Length=330, Percent_Identity=27.5757575757576, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI21361378, Length=330, Percent_Identity=27.5757575757576, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI194306651, Length=412, Percent_Identity=26.9417475728155, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1789272, Length=376, Percent_Identity=38.563829787234, Blast_Score=240, Evalue=8e-65,
Organism=Caenorhabditis elegans, GI17560118, Length=376, Percent_Identity=33.7765957446808, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI32563613, Length=349, Percent_Identity=25.5014326647564, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71994052, Length=377, Percent_Identity=23.6074270557029, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71994045, Length=377, Percent_Identity=23.6074270557029, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320222, Length=387, Percent_Identity=36.4341085271318, Blast_Score=235, Evalue=1e-62,
Organism=Drosophila melanogaster, GI20129441, Length=382, Percent_Identity=34.5549738219895, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI28571104, Length=281, Percent_Identity=30.6049822064057, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI20130091, Length=363, Percent_Identity=26.9972451790634, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 41548; Mature: 41417

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTPLQRTPLFPLHQALGARFVSFAGWEMPLQYQGVVAEHRAVRERAGVFDISHMGKFD
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHCCEEEHHCCCCCC
LWGPELGSHLSRLVPSDLGAVAVGSARYTVLLNPLGGIVDDVIFYRHPPEGELEHWSLIV
CCCHHHHHHHHHHCCCCCCCEEECCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCEEEEE
NAATRQKDWEWLHQQGIPGLELQDHTESQVLLAVQGPAAEEVLQPFLAGSLRALRRFQHG
EHHHCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
QFATRKERSSGAGVFVARTGYTGEDGFELLLGPADGLWLWEQLVQAGVQPCGLGCRDTLR
CCHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHH
LEAAFCLYGQDIDESTTPLEADLGWLVSNPGDYIGKPALESQRQQGIPRRLVGFRLLERA
HEEEEEEECCCCCCCCCCCCCCCCEEECCCCHHCCCCHHHHHHHCCCHHHHHHHHHHHHH
IPRRGYAIYAPNSPEPIGRVTSGTHSPTLGYGIGLGYVDSTWAKVGSRLEIEIRGQRRPA
CCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEEECCCCCCH
EVVKKPFYRGQAPVSLGS
HHHHCCHHCCCCCCCCCC
>Mature Secondary Structure 
SSTPLQRTPLFPLHQALGARFVSFAGWEMPLQYQGVVAEHRAVRERAGVFDISHMGKFD
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHCCEEEHHCCCCCC
LWGPELGSHLSRLVPSDLGAVAVGSARYTVLLNPLGGIVDDVIFYRHPPEGELEHWSLIV
CCCHHHHHHHHHHCCCCCCCEEECCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCEEEEE
NAATRQKDWEWLHQQGIPGLELQDHTESQVLLAVQGPAAEEVLQPFLAGSLRALRRFQHG
EHHHCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
QFATRKERSSGAGVFVARTGYTGEDGFELLLGPADGLWLWEQLVQAGVQPCGLGCRDTLR
CCHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHH
LEAAFCLYGQDIDESTTPLEADLGWLVSNPGDYIGKPALESQRQQGIPRRLVGFRLLERA
HEEEEEEECCCCCCCCCCCCCCCCEEECCCCHHCCCCHHHHHHHCCCHHHHHHHHHHHHH
IPRRGYAIYAPNSPEPIGRVTSGTHSPTLGYGIGLGYVDSTWAKVGSRLEIEIRGQRRPA
CCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEEECCCCCCH
EVVKKPFYRGQAPVSLGS
HHHHCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA