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The map label for this gene is gloB

Identifier: 86605820

GI number: 86605820

Start: 1157890

End: 1158648

Strand: Reverse

Name: gloB

Synonym: CYA_1132

Alternate gene names: 86605820

Gene position: 1158648-1157890 (Counterclockwise)

Preceding gene: 86605821

Following gene: 86605819

Centisome position: 39.51

GC content: 63.9

Gene sequence:

>759_bases
ATGCGCATTCTGCAACTGCCTGCCCTGCGCGACAACTACATCTATCTGCTGCACGATCCCGAGACGGCCACGGCAGCGGT
GGTGGATCCGACAGTGGCCGAGCCGGTGCTGGATAAACTGGCTGAGCTAGGGGCGGAGCTGGTGGCCATCTTCAACACCC
ACCACCACCACGACCATGTGGGGGGCAACCTGCAACTTTTGGCCCGCTACCCCCGTGCCGTCGTCTACGGCAGCCAGGCG
GATCGGGGACGGATCCCGGGCCAGACGGTGGAGCTGCAGGCGGGAGAGACGGTGGCATTTGCGGGCCGGCAGGCGAAGGT
GCTGTTTGTGCCCGGCCATACGCGGGGACATGTTGCCTACTACTTTCCCGAAAGCGGGGATCTCTTCTGCGGCGATACCC
TGTTTGCCGGGGGATGCGGGCGCCTCTTTGAGGGCACCCCGGAGCAGATGCTGGGATCCCTGGATCAACTGCGGCAGTTG
CCGGAAGCCACGCGGGTCTGGTGTGCCCACGAATACACCTTGAACAATCTCAAGTTTGCCCTGACGGTGGATGGGGACAA
CCCCGACTTGCAGGCGCGCTACCAACAGGTGGTGGCCCTGCGCCAGGCGGGATCCCCAACTGTCCCCAGCACCATCGGCG
AAGAGCGCCGCACCAATCCTTTTTTGCGCTGGGATCAGCCGGCTTTGCGGGCGGCTACGGGCGCTCAAGATCCGGTGCGG
GTTTTTGCCCGGCTGCGGGGTATGAAGGATCAATTCTAA

Upstream 100 bases:

>100_bases
GCGCTATACCTATCCTGATGGCAACACCAAAACTCTGTCTTTTCCCTATTCGCTAAGCCGCCAGGATGTAGAGCAGGCCA
TTTTTGAGGACTAGCCGGCT

Downstream 100 bases:

>100_bases
GGCTGGCCGGAACGCGAACGGGGCCGAGTTGTGATTGGGATCCTGTCCTGACGCTGGGGATTCCCAGTTTGCTTTCCGTA
AGATTGGCTTCTTTTTTCGG

Product: glyoxalase II family protein

Products: NA

Alternate protein names: Glyoxalase II; Glx II

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MRILQLPALRDNYIYLLHDPETATAAVVDPTVAEPVLDKLAELGAELVAIFNTHHHHDHVGGNLQLLARYPRAVVYGSQA
DRGRIPGQTVELQAGETVAFAGRQAKVLFVPGHTRGHVAYYFPESGDLFCGDTLFAGGCGRLFEGTPEQMLGSLDQLRQL
PEATRVWCAHEYTLNNLKFALTVDGDNPDLQARYQQVVALRQAGSPTVPSTIGEERRTNPFLRWDQPALRAATGAQDPVR
VFARLRGMKDQF

Sequences:

>Translated_252_residues
MRILQLPALRDNYIYLLHDPETATAAVVDPTVAEPVLDKLAELGAELVAIFNTHHHHDHVGGNLQLLARYPRAVVYGSQA
DRGRIPGQTVELQAGETVAFAGRQAKVLFVPGHTRGHVAYYFPESGDLFCGDTLFAGGCGRLFEGTPEQMLGSLDQLRQL
PEATRVWCAHEYTLNNLKFALTVDGDNPDLQARYQQVVALRQAGSPTVPSTIGEERRTNPFLRWDQPALRAATGAQDPVR
VFARLRGMKDQF
>Mature_252_residues
MRILQLPALRDNYIYLLHDPETATAAVVDPTVAEPVLDKLAELGAELVAIFNTHHHHDHVGGNLQLLARYPRAVVYGSQA
DRGRIPGQTVELQAGETVAFAGRQAKVLFVPGHTRGHVAYYFPESGDLFCGDTLFAGGCGRLFEGTPEQMLGSLDQLRQL
PEATRVWCAHEYTLNNLKFALTVDGDNPDLQARYQQVVALRQAGSPTVPSTIGEERRTNPFLRWDQPALRAATGAQDPVR
VFARLRGMKDQF

Specific function: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family

Homologues:

Organism=Homo sapiens, GI94538320, Length=258, Percent_Identity=39.922480620155, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI94538322, Length=258, Percent_Identity=39.922480620155, Blast_Score=188, Evalue=3e-48,
Organism=Homo sapiens, GI14150041, Length=257, Percent_Identity=38.1322957198444, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI116642887, Length=264, Percent_Identity=40.9090909090909, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI21703352, Length=264, Percent_Identity=40.9090909090909, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI46361987, Length=204, Percent_Identity=37.7450980392157, Blast_Score=137, Evalue=9e-33,
Organism=Homo sapiens, GI41327741, Length=199, Percent_Identity=28.1407035175879, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1786406, Length=256, Percent_Identity=44.53125, Blast_Score=190, Evalue=8e-50,
Organism=Escherichia coli, GI1787158, Length=245, Percent_Identity=26.9387755102041, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17536925, Length=252, Percent_Identity=36.9047619047619, Blast_Score=165, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17538952, Length=171, Percent_Identity=29.2397660818713, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320478, Length=265, Percent_Identity=31.6981132075472, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324614, Length=245, Percent_Identity=33.0612244897959, Blast_Score=102, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21356335, Length=260, Percent_Identity=44.6153846153846, Blast_Score=210, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24667711, Length=260, Percent_Identity=44.6153846153846, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24667703, Length=260, Percent_Identity=44.6153846153846, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI221330176, Length=209, Percent_Identity=29.6650717703349, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLO2_SYNJA (Q2JVC3)

Other databases:

- EMBL:   CP000239
- RefSeq:   YP_474583.1
- HSSP:   Q9C8L4
- ProteinModelPortal:   Q2JVC3
- SMR:   Q2JVC3
- STRING:   Q2JVC3
- GeneID:   3898821
- GenomeReviews:   CP000239_GR
- KEGG:   cya:CYA_1132
- TIGR:   CYA_1132
- eggNOG:   COG0491
- HOGENOM:   HBG753931
- OMA:   WCAHEYT
- ProtClustDB:   CLSK750337
- BioCyc:   SSP321327:CYA_1132-MONOMER
- HAMAP:   MF_01374
- InterPro:   IPR001279
- InterPro:   IPR017782
- SMART:   SM00849
- TIGRFAMs:   TIGR03413

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.2.6

Molecular weight: Translated: 27825; Mature: 27825

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILQLPALRDNYIYLLHDPETATAAVVDPTVAEPVLDKLAELGAELVAIFNTHHHHDHV
CCEEECCCCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GGNLQLLARYPRAVVYGSQADRGRIPGQTVELQAGETVAFAGRQAKVLFVPGHTRGHVAY
CCCEEEEEECCEEEEECCCCCCCCCCCCEEEEECCCEEEECCCCEEEEEECCCCCCCEEE
YFPESGDLFCGDTLFAGGCGRLFEGTPEQMLGSLDQLRQLPEATRVWCAHEYTLNNLKFA
EECCCCCEEECCCEECCCCCHHCCCCHHHHHHHHHHHHHCHHHHHEEEEEEEEECCEEEE
LTVDGDNPDLQARYQQVVALRQAGSPTVPSTIGEERRTNPFLRWDQPALRAATGAQDPVR
EEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCEEECCHHHHHHCCCCCHHH
VFARLRGMKDQF
HHHHHHCCCCCC
>Mature Secondary Structure
MRILQLPALRDNYIYLLHDPETATAAVVDPTVAEPVLDKLAELGAELVAIFNTHHHHDHV
CCEEECCCCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GGNLQLLARYPRAVVYGSQADRGRIPGQTVELQAGETVAFAGRQAKVLFVPGHTRGHVAY
CCCEEEEEECCEEEEECCCCCCCCCCCCEEEEECCCEEEECCCCEEEEEECCCCCCCEEE
YFPESGDLFCGDTLFAGGCGRLFEGTPEQMLGSLDQLRQLPEATRVWCAHEYTLNNLKFA
EECCCCCEEECCCEECCCCCHHCCCCHHHHHHHHHHHHHCHHHHHEEEEEEEEECCEEEE
LTVDGDNPDLQARYQQVVALRQAGSPTVPSTIGEERRTNPFLRWDQPALRAATGAQDPVR
EEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCEEECCHHHHHHCCCCCHHH
VFARLRGMKDQF
HHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA