Click here to switch to the map view.

The map label for this gene is panE-1

Identifier: 86605124

GI number: 86605124

Start: 420789

End: 421748

Strand: Reverse

Name: panE-1

Synonym: CYA_0405

Alternate gene names: NA

Gene position: 421748-420789 (Counterclockwise)

Preceding gene: 86605125

Following gene: 86605123

Centisome position: 14.38

GC content: 61.67

Gene sequence:

>960_bases
ATGGCTGTCTTGCCGGAAACCCGTCGCTACGCTGTCTTGGGCACAGGCGCCCTGGGAGGGTTTTACGGGGCAAAACTGCA
ACAGGCTGGCTTCACGGTGCATTTTCTCTTGCACAGCGACTACGACCACGTGCGCCAGAAAGGGCTGTGGGTAGAGTCCT
GCTGGGGCGACTTTCACTTACCCCAGGTAAATGCCTACGCCGCCGTGGAGGAGATGCCCGTCTGCGAAGGGGTGATCGTG
GCCCTGAAAGCTACCCAAAATCACCTCCTGCCACGGTTGCTGCCGCCTGTGCTGGCGGACAACGGCGTGGTGATCCTGCT
GCAAAACGGCCTGGGGGCGGAGCCGGAGATTGCCAACTGGGTTGGCCCTGAGCGGGTGATCGGCGGGCTGTGCTTTATCA
GCTCCAACAAAGTCGGCCCCGGCCACATCTGTCATCTGGATTATGGCTCGGTGCTGCTGGCGGAATACGGCCCCGGCTAT
GCGCCCCAGGGGATCACGCCTCGCCTTCAACAAGTTCAAGCAGATTTTCAGCGGGCCGGGATCCCGACCTCTCTTTCTCC
GGATCTGATGTTGGCCCGCTGGCAGAAGTTGGTCTGGAACATTCCCTTCAACGGCCTCTCGGTGATCTTCAACGCCGATA
CCCAGCAAATGATCCGCGACCCTGAGGCCCGCGCTTTGGCGGAAACGCTGATGCACGAGGTGATCCAGGGGGCTGCCGCC
TGTGGCCGCCACCTCCCGCAGACCCTGATCTCCGAGATGCTGGCCAGCACCGAGAAGATGGCCCCCTACCGAACCAGCAT
GAAGATCGACTACGAGCGCAAGCGTCCCCTGGAACTGGAGGCTATTTTTGCCAACCCGCTCCGCTATGCCCAGCAAGGCG
GGATTCAGATGCCGCGGGTGGAGATGCTCTACCGGCAGTTGCAGGTGTTGGATCGCCTCAATCGAGGGATCCCGGCCTGA

Upstream 100 bases:

>100_bases
GTTGTTGATCGACGCCAAACTTGAGGAAAACAGCAGAGAGTGAGCCTGAGACGCCCCTGGGGTGCGGTATGGTGGGGATA
ATCTGCCGACTTTTGCCGCT

Downstream 100 bases:

>100_bases
GGGCAAGCTTTTTCCTTCTCCTGCGGCTAGACTCAGCCGCAGCGGAGCGCTGCGCTGGCTTCATGCCTCTAGGATCCACC
CACGATCGCATCACCCTCTG

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MAVLPETRRYAVLGTGALGGFYGAKLQQAGFTVHFLLHSDYDHVRQKGLWVESCWGDFHLPQVNAYAAVEEMPVCEGVIV
ALKATQNHLLPRLLPPVLADNGVVILLQNGLGAEPEIANWVGPERVIGGLCFISSNKVGPGHICHLDYGSVLLAEYGPGY
APQGITPRLQQVQADFQRAGIPTSLSPDLMLARWQKLVWNIPFNGLSVIFNADTQQMIRDPEARALAETLMHEVIQGAAA
CGRHLPQTLISEMLASTEKMAPYRTSMKIDYERKRPLELEAIFANPLRYAQQGGIQMPRVEMLYRQLQVLDRLNRGIPA

Sequences:

>Translated_319_residues
MAVLPETRRYAVLGTGALGGFYGAKLQQAGFTVHFLLHSDYDHVRQKGLWVESCWGDFHLPQVNAYAAVEEMPVCEGVIV
ALKATQNHLLPRLLPPVLADNGVVILLQNGLGAEPEIANWVGPERVIGGLCFISSNKVGPGHICHLDYGSVLLAEYGPGY
APQGITPRLQQVQADFQRAGIPTSLSPDLMLARWQKLVWNIPFNGLSVIFNADTQQMIRDPEARALAETLMHEVIQGAAA
CGRHLPQTLISEMLASTEKMAPYRTSMKIDYERKRPLELEAIFANPLRYAQQGGIQMPRVEMLYRQLQVLDRLNRGIPA
>Mature_318_residues
AVLPETRRYAVLGTGALGGFYGAKLQQAGFTVHFLLHSDYDHVRQKGLWVESCWGDFHLPQVNAYAAVEEMPVCEGVIVA
LKATQNHLLPRLLPPVLADNGVVILLQNGLGAEPEIANWVGPERVIGGLCFISSNKVGPGHICHLDYGSVLLAEYGPGYA
PQGITPRLQQVQADFQRAGIPTSLSPDLMLARWQKLVWNIPFNGLSVIFNADTQQMIRDPEARALAETLMHEVIQGAAAC
GRHLPQTLISEMLASTEKMAPYRTSMKIDYERKRPLELEAIFANPLRYAQQGGIQMPRVEMLYRQLQVLDRLNRGIPA

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320057, Length=344, Percent_Identity=23.8372093023256, Blast_Score=86, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 35284; Mature: 35153

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVLPETRRYAVLGTGALGGFYGAKLQQAGFTVHFLLHSDYDHVRQKGLWVESCWGDFHL
CCCCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEECCHHHHHHCCCEEECCCCCCCC
PQVNAYAAVEEMPVCEGVIVALKATQNHLLPRLLPPVLADNGVVILLQNGLGAEPEIANW
CCCHHHHHHHHCCCCCCEEEEEECHHHHCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHC
VGPERVIGGLCFISSNKVGPGHICHLDYGSVLLAEYGPGYAPQGITPRLQQVQADFQRAG
CCHHHHHCEEEEEECCCCCCCEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCC
IPTSLSPDLMLARWQKLVWNIPFNGLSVIFNADTQQMIRDPEARALAETLMHEVIQGAAA
CCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
CGRHLPQTLISEMLASTEKMAPYRTSMKIDYERKRPLELEAIFANPLRYAQQGGIQMPRV
HHHCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEEEEHHHHHHHHHHCCCCCCHH
EMLYRQLQVLDRLNRGIPA
HHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AVLPETRRYAVLGTGALGGFYGAKLQQAGFTVHFLLHSDYDHVRQKGLWVESCWGDFHL
CCCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEECCHHHHHHCCCEEECCCCCCCC
PQVNAYAAVEEMPVCEGVIVALKATQNHLLPRLLPPVLADNGVVILLQNGLGAEPEIANW
CCCHHHHHHHHCCCCCCEEEEEECHHHHCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHC
VGPERVIGGLCFISSNKVGPGHICHLDYGSVLLAEYGPGYAPQGITPRLQQVQADFQRAG
CCHHHHHCEEEEEECCCCCCCEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCC
IPTSLSPDLMLARWQKLVWNIPFNGLSVIFNADTQQMIRDPEARALAETLMHEVIQGAAA
CCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
CGRHLPQTLISEMLASTEKMAPYRTSMKIDYERKRPLELEAIFANPLRYAQQGGIQMPRV
HHHCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEEEEHHHHHHHHHHCCCCCCHH
EMLYRQLQVLDRLNRGIPA
HHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]