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The map label for this gene is ubiH

Identifier: 86604894

GI number: 86604894

Start: 161686

End: 162930

Strand: Reverse

Name: ubiH

Synonym: CYA_0164

Alternate gene names: 86604894

Gene position: 162930-161686 (Counterclockwise)

Preceding gene: 86604895

Following gene: 86604890

Centisome position: 5.56

GC content: 65.62

Gene sequence:

>1245_bases
ATGACAACCCTTGCTCCCACTCCGACTACCTTGGCAGCCGTTTACGACGTGATCATCGTCGGCGGCGGCATTGCGGGCTT
GACCCTAGCTTGTGCCCTGCAGGGATCCGGCCTGCGCTTGGCCCTCATTGAGGCCCAGTCGGCTGAGGCAGTCAGGCAGC
GCCCCTTGGCCTATGCCCTTTCGCCGTTGTCGATCCGCATCTTTCGGGCCATCGGGGTGTGGGAGGCGCTGGCTCCCCAC
ATCACACCCTTTGCCCAGGTGATTCTGACCGACGCCGACGCTCCCCAGCGGGTGACGTTTAGGCCGGAGGATGTGGGGGA
AACGGCAGTTTTCTACTGCGGCGAACATGCTCGGCTGCAGCAGGTGCTCCAGGAGCGGGTGGCTGCCGATCCCCAGATCA
CCTGCCACTACGAAGCCAGGGTGGAGAGCGTAACCTACGGGGAGGCTGCGGCTGAGGTAGAGCTGGAAACGACCCAAGGC
CGCCGCCGGCTGGCCGCCTCCCTGGTGGTAGCCGCCGATGGCCTGCGCTCCCAAGTGCGCCAGCGGGCAGGGATCCCGAG
CGACGGCTGGGACTACTGGCAGTCGTGTATCACCGCCCTGGTGGCCCCTGCCCAAGACCACCAAAACGTCGCCTACGAGC
GCTTTTGGCCTGCCGGCCCCTTCGCCATCCTGCCCCTGCCCGGCAACCGCTGCCAGGTGGTCTGGATCCTGCCCCACGAG
CAGGCCAAGGCCACGCTGGCCCTTTCCCAGGCCGACTTCTTGGCCGAGATGCAGCGCTACTACGGCGACCAGGGCGGCTA
CCTTACCTTGCTGAACCCGCCCCAAGTCTTCCCGGCCCGCCTGCGCCAGAGCCGCCGCTACTATCAGCACCGCCTGGCTT
TGGTGGGGGACGCCGCTCACCACTGTCATCCCGTAGCTGGCCAAGGGCTGAACCTCGGCATCCGCGATGCCGCTGCCTTG
GCCCAAGTGTTGCTGGACGCCTGGAGACGACAGGAGGATTTGGGAGAGGTCCAAGTCCTGCGGCGCTACGGTCGCCGTCG
CCGCTGGGAAAACTGGGTGGTGTTGCTCTTTACGGATCTCCTCACCCGCACTTTCTCCAACTCCTACTGGCCCCTGGTGG
TCTTGCGGCGCTTGGTTTTGATAGGGATGATACGCTTTCCGCCGCTGCGGCGCTTTTTGCTGCGCCTGATGACCGGGCTG
TGGGGCAGCCCTCCCTACAGCCCCAGTTCCTCCTTGGCCTTCTGA

Upstream 100 bases:

>100_bases
CTGGCCTCTGCCGCTTTGGCATGTTCCGAGCGGTGCGGGCCGCCACGCCGGCAAACTCCGCCCGCCCAGAAGTAGTTGCC
CACAGCACTCAGCACTAGAA

Downstream 100 bases:

>100_bases
GCTGCCCAAAGCACCTCCGCATCGGCGGCCTCTGACCAATCGGGATCGGCGATCTCGGCGTAGAACCTCTGGTCGTAGGA
GCGGGTTTGCACCACCACCG

Product: 2-octaprenyl-6-methoxyphenyl hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MTTLAPTPTTLAAVYDVIIVGGGIAGLTLACALQGSGLRLALIEAQSAEAVRQRPLAYALSPLSIRIFRAIGVWEALAPH
ITPFAQVILTDADAPQRVTFRPEDVGETAVFYCGEHARLQQVLQERVAADPQITCHYEARVESVTYGEAAAEVELETTQG
RRRLAASLVVAADGLRSQVRQRAGIPSDGWDYWQSCITALVAPAQDHQNVAYERFWPAGPFAILPLPGNRCQVVWILPHE
QAKATLALSQADFLAEMQRYYGDQGGYLTLLNPPQVFPARLRQSRRYYQHRLALVGDAAHHCHPVAGQGLNLGIRDAAAL
AQVLLDAWRRQEDLGEVQVLRRYGRRRRWENWVVLLFTDLLTRTFSNSYWPLVVLRRLVLIGMIRFPPLRRFLLRLMTGL
WGSPPYSPSSSLAF

Sequences:

>Translated_414_residues
MTTLAPTPTTLAAVYDVIIVGGGIAGLTLACALQGSGLRLALIEAQSAEAVRQRPLAYALSPLSIRIFRAIGVWEALAPH
ITPFAQVILTDADAPQRVTFRPEDVGETAVFYCGEHARLQQVLQERVAADPQITCHYEARVESVTYGEAAAEVELETTQG
RRRLAASLVVAADGLRSQVRQRAGIPSDGWDYWQSCITALVAPAQDHQNVAYERFWPAGPFAILPLPGNRCQVVWILPHE
QAKATLALSQADFLAEMQRYYGDQGGYLTLLNPPQVFPARLRQSRRYYQHRLALVGDAAHHCHPVAGQGLNLGIRDAAAL
AQVLLDAWRRQEDLGEVQVLRRYGRRRRWENWVVLLFTDLLTRTFSNSYWPLVVLRRLVLIGMIRFPPLRRFLLRLMTGL
WGSPPYSPSSSLAF
>Mature_413_residues
TTLAPTPTTLAAVYDVIIVGGGIAGLTLACALQGSGLRLALIEAQSAEAVRQRPLAYALSPLSIRIFRAIGVWEALAPHI
TPFAQVILTDADAPQRVTFRPEDVGETAVFYCGEHARLQQVLQERVAADPQITCHYEARVESVTYGEAAAEVELETTQGR
RRLAASLVVAADGLRSQVRQRAGIPSDGWDYWQSCITALVAPAQDHQNVAYERFWPAGPFAILPLPGNRCQVVWILPHEQ
AKATLALSQADFLAEMQRYYGDQGGYLTLLNPPQVFPARLRQSRRYYQHRLALVGDAAHHCHPVAGQGLNLGIRDAAALA
QVLLDAWRRQEDLGEVQVLRRYGRRRRWENWVVLLFTDLLTRTFSNSYWPLVVLRRLVLIGMIRFPPLRRFLLRLMTGLW
GSPPYSPSSSLAF

Specific function: Oxygenase That Introduces The Hydroxyl Group At Carbon Four Of 2-Octaprenyl-6-Methoxyphenol Resulting In The Formation Of 2-Octaprenyl-6-Methoxy-1,4-Benzoquinone. [C]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=432, Percent_Identity=28.4722222222222, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI32967307, Length=383, Percent_Identity=28.7206266318538, Blast_Score=135, Evalue=5e-32,
Organism=Escherichia coli, GI1789274, Length=384, Percent_Identity=35.9375, Blast_Score=197, Evalue=8e-52,
Organism=Escherichia coli, GI1789273, Length=402, Percent_Identity=32.089552238806, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1786883, Length=394, Percent_Identity=33.756345177665, Blast_Score=180, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25146631, Length=436, Percent_Identity=27.0642201834862, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6321694, Length=472, Percent_Identity=25.2118644067797, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19920760, Length=377, Percent_Identity=25.9946949602122, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 46108; Mature: 45976

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLAPTPTTLAAVYDVIIVGGGIAGLTLACALQGSGLRLALIEAQSAEAVRQRPLAYAL
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHCCHHHHH
SPLSIRIFRAIGVWEALAPHITPFAQVILTDADAPQRVTFRPEDVGETAVFYCGEHARLQ
CCHHHHHHHHHHHHHHHHHCCCHHHHHEEECCCCCCEEEECCCCCCCEEEEECCCHHHHH
QVLQERVAADPQITCHYEARVESVTYGEAAAEVELETTQGRRRLAASLVVAADGLRSQVR
HHHHHHHCCCCCEEEEEEHHCCEEECCCHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
QRAGIPSDGWDYWQSCITALVAPAQDHQNVAYERFWPAGPFAILPLPGNRCQVVWILPHE
HHCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCEEEEECCCCCEEEEEEECCC
QAKATLALSQADFLAEMQRYYGDQGGYLTLLNPPQVFPARLRQSRRYYQHRLALVGDAAH
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHH
HCHPVAGQGLNLGIRDAAALAQVLLDAWRRQEDLGEVQVLRRYGRRRRWENWVVLLFTDL
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHH
LTRTFSNSYWPLVVLRRLVLIGMIRFPPLRRFLLRLMTGLWGSPPYSPSSSLAF
HHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTLAPTPTTLAAVYDVIIVGGGIAGLTLACALQGSGLRLALIEAQSAEAVRQRPLAYAL
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHCCHHHHH
SPLSIRIFRAIGVWEALAPHITPFAQVILTDADAPQRVTFRPEDVGETAVFYCGEHARLQ
CCHHHHHHHHHHHHHHHHHCCCHHHHHEEECCCCCCEEEECCCCCCCEEEEECCCHHHHH
QVLQERVAADPQITCHYEARVESVTYGEAAAEVELETTQGRRRLAASLVVAADGLRSQVR
HHHHHHHCCCCCEEEEEEHHCCEEECCCHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
QRAGIPSDGWDYWQSCITALVAPAQDHQNVAYERFWPAGPFAILPLPGNRCQVVWILPHE
HHCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCEEEEECCCCCEEEEEEECCC
QAKATLALSQADFLAEMQRYYGDQGGYLTLLNPPQVFPARLRQSRRYYQHRLALVGDAAH
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHH
HCHPVAGQGLNLGIRDAAALAQVLLDAWRRQEDLGEVQVLRRYGRRRRWENWVVLLFTDL
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHH
LTRTFSNSYWPLVVLRRLVLIGMIRFPPLRRFLLRLMTGLWGSPPYSPSSSLAF
HHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]