| Definition | Synechococcus sp. JA-3-3Ab, complete genome. |
|---|---|
| Accession | NC_007775 |
| Length | 2,932,766 |
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The map label for this gene is coaBC
Identifier: 86604890
GI number: 86604890
Start: 157001
End: 158224
Strand: Reverse
Name: coaBC
Synonym: CYA_0161
Alternate gene names: 86604890
Gene position: 158224-157001 (Counterclockwise)
Preceding gene: 86604894
Following gene: 86604889
Centisome position: 5.4
GC content: 66.01
Gene sequence:
>1224_bases ATGGATCCCTTTTGGTCGGGGCGGCGTCTGCTGGTTGGGGTGAGCGGGGGAATTGCTGCCTACAAAACTGCGGTTTTGGT GTCTGCTCTGGCCCAGCAGGGGGCAGAGGTGAGGGTGGTTTTGACGCAAGCTGCACAACAGTTTATCTCCCCGCTGACGT TTGCCACTGTGTCCCGTCAGCCGGCTTTTACAGATGCCGAGTTCTGGCAAGCTGCGCGGGGACGGCCGCTGCACATCGAG CTGGGGGAATGGGCCGAGGCTCTCCTGATTGCGCCGCTTTCGGCCAACACCTTGGGCAAGCTGGCCCAGGGGCTGGCGGA CAATTTGCTCACCAACGTGGTTTTGGCCTCCCACTGTCCGGTGGCCTTGGCGCCGGCCATGAATACCCACATGTGGAAGG CTGAAGCAGTGGCCGAGAATTGGCAGCGGCTGCAACGGGATCCCCGCTTCTGGGCCTTGCCCACGGCCAGGGGCCGCCTG GCCTGCGATGCGGTGGGGGAAGGGCGCCTGCTGGAGCCAGAGGCGCTGCAGGAGTATGTGCGGGCTCTGCTCTGGACAGG GGGGCAAAAAGACTGGCAAGGGAAGCGGGTGTTGGTGACGGCAGGAGGCACCCGCGAGCCCATCGACGCGGTGCGCTTTA TCGGCAACCCGGCCAGTGGGCGGATGGGGGTGGCGCTGGCGGTGGCCGCCGCCTGTCGGGGGGCCGAAGTCACGCTGGTG CATGGGCCGCTGGGGATCCCCTTTGATCCAGCACCCTTCGCCATTCGGGCCATCCCGGTGGAGACAGCAGCCCAACTGGA GCAGGTTTTGCGGGCGGAGTTTCCCCAGGTGGACGTGCTCTGGATGGCAACGGCAGTGGGGGATGTGCGGCCCACGCAGA CCTATGCGGGCAAGCTGGCCAAGGCCGAGCTGCCCCTGCTGCTGCCCTTGGAGCCTGTCCCCGATTTGGTGGCAGCCCTA GCCCGTCACCGACGTCCCGGCCAGCTTCTTATCGGCTTTGCTGCCCAGAGCGGGGATCCTCTCCCCCCGGCCAAGGAGAA GCTGCAGCAGAAAGGGCTGGACGCCATTGTGGCCAACCCCATCGACCAGCCGGAGAGCGGCTTTGGCAGCAGCCACAACC AAGGCTACTGGATCCCGCGGCAGGGCAACCCGGAACTGCTCCCGTTGGCCACCAAATCGACCCTGGCTCACCGGCTGCTG GATCTGGCCCTGCGCCTAGGCTGA
Upstream 100 bases:
>100_bases ATCGGCGGCCTGAGCCCTAGCACTTTGGGCGAGGGATTCCTGTTGTGTTGCTGGCAAAGGCAGGGAAACTGGAAACAGGG CTGTTTGAGTATTCGCTGAT
Downstream 100 bases:
>100_bases CTTGGATAGCCGGCCAAAATCAGGTACCTTTGAGGCTAAGCGCAGAGGGATCCGATGGCGATCATTGTCTTGAGAGCCTG GTATTTGGATTCGGTGTTGT
Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase
Products: NA
Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]
Number of amino acids: Translated: 407; Mature: 407
Protein sequence:
>407_residues MDPFWSGRRLLVGVSGGIAAYKTAVLVSALAQQGAEVRVVLTQAAQQFISPLTFATVSRQPAFTDAEFWQAARGRPLHIE LGEWAEALLIAPLSANTLGKLAQGLADNLLTNVVLASHCPVALAPAMNTHMWKAEAVAENWQRLQRDPRFWALPTARGRL ACDAVGEGRLLEPEALQEYVRALLWTGGQKDWQGKRVLVTAGGTREPIDAVRFIGNPASGRMGVALAVAAACRGAEVTLV HGPLGIPFDPAPFAIRAIPVETAAQLEQVLRAEFPQVDVLWMATAVGDVRPTQTYAGKLAKAELPLLLPLEPVPDLVAAL ARHRRPGQLLIGFAAQSGDPLPPAKEKLQQKGLDAIVANPIDQPESGFGSSHNQGYWIPRQGNPELLPLATKSTLAHRLL DLALRLG
Sequences:
>Translated_407_residues MDPFWSGRRLLVGVSGGIAAYKTAVLVSALAQQGAEVRVVLTQAAQQFISPLTFATVSRQPAFTDAEFWQAARGRPLHIE LGEWAEALLIAPLSANTLGKLAQGLADNLLTNVVLASHCPVALAPAMNTHMWKAEAVAENWQRLQRDPRFWALPTARGRL ACDAVGEGRLLEPEALQEYVRALLWTGGQKDWQGKRVLVTAGGTREPIDAVRFIGNPASGRMGVALAVAAACRGAEVTLV HGPLGIPFDPAPFAIRAIPVETAAQLEQVLRAEFPQVDVLWMATAVGDVRPTQTYAGKLAKAELPLLLPLEPVPDLVAAL ARHRRPGQLLIGFAAQSGDPLPPAKEKLQQKGLDAIVANPIDQPESGFGSSHNQGYWIPRQGNPELLPLATKSTLAHRLL DLALRLG >Mature_407_residues MDPFWSGRRLLVGVSGGIAAYKTAVLVSALAQQGAEVRVVLTQAAQQFISPLTFATVSRQPAFTDAEFWQAARGRPLHIE LGEWAEALLIAPLSANTLGKLAQGLADNLLTNVVLASHCPVALAPAMNTHMWKAEAVAENWQRLQRDPRFWALPTARGRL ACDAVGEGRLLEPEALQEYVRALLWTGGQKDWQGKRVLVTAGGTREPIDAVRFIGNPASGRMGVALAVAAACRGAEVTLV HGPLGIPFDPAPFAIRAIPVETAAQLEQVLRAEFPQVDVLWMATAVGDVRPTQTYAGKLAKAELPLLLPLEPVPDLVAAL ARHRRPGQLLIGFAAQSGDPLPPAKEKLQQKGLDAIVANPIDQPESGFGSSHNQGYWIPRQGNPELLPLATKSTLAHRLL DLALRLG
Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]
COG id: COG0452
COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]
Homologues:
Organism=Homo sapiens, GI71725351, Length=183, Percent_Identity=38.2513661202186, Blast_Score=105, Evalue=6e-23, Organism=Escherichia coli, GI87082301, Length=400, Percent_Identity=37.5, Blast_Score=229, Evalue=3e-61, Organism=Caenorhabditis elegans, GI17560194, Length=204, Percent_Identity=33.8235294117647, Blast_Score=96, Evalue=5e-20, Organism=Saccharomyces cerevisiae, GI6322762, Length=187, Percent_Identity=32.0855614973262, Blast_Score=85, Evalue=3e-17, Organism=Saccharomyces cerevisiae, GI6322925, Length=185, Percent_Identity=28.1081081081081, Blast_Score=69, Evalue=1e-12, Organism=Saccharomyces cerevisiae, GI6324629, Length=89, Percent_Identity=41.5730337078652, Blast_Score=67, Evalue=5e-12, Organism=Drosophila melanogaster, GI24657262, Length=185, Percent_Identity=32.4324324324324, Blast_Score=86, Evalue=3e-17,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005252 - InterPro: IPR007085 - InterPro: IPR003382 [H]
Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]
EC number: =4.1.1.36; =6.3.2.5 [H]
Molecular weight: Translated: 43639; Mature: 43639
Theoretical pI: Translated: 8.49; Mature: 8.49
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 1.2 %Met (Translated Protein) 2.0 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 1.2 %Met (Mature Protein) 2.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDPFWSGRRLLVGVSGGIAAYKTAVLVSALAQQGAEVRVVLTQAAQQFISPLTFATVSRQ CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCHHHHHCCCC PAFTDAEFWQAARGRPLHIELGEWAEALLIAPLSANTLGKLAQGLADNLLTNVVLASHCP CCCCCHHHHHHHCCCEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC VALAPAMNTHMWKAEAVAENWQRLQRDPRFWALPTARGRLACDAVGEGRLLEPEALQEYV EEEECCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEECCCCCCCCCHHHHHHHH RALLWTGGQKDWQGKRVLVTAGGTREPIDAVRFIGNPASGRMGVALAVAAACRGAEVTLV HHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEE HGPLGIPFDPAPFAIRAIPVETAAQLEQVLRAEFPQVDVLWMATAVGDVRPTQTYAGKLA ECCCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCHHHHCCHH KAELPLLLPLEPVPDLVAALARHRRPGQLLIGFAAQSGDPLPPAKEKLQQKGLDAIVANP HCCCCEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCEEECCC IDQPESGFGSSHNQGYWIPRQGNPELLPLATKSTLAHRLLDLALRLG CCCCCCCCCCCCCCCEEECCCCCCCEEEEEHHHHHHHHHHHHHHHCC >Mature Secondary Structure MDPFWSGRRLLVGVSGGIAAYKTAVLVSALAQQGAEVRVVLTQAAQQFISPLTFATVSRQ CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCHHHHHCCCC PAFTDAEFWQAARGRPLHIELGEWAEALLIAPLSANTLGKLAQGLADNLLTNVVLASHCP CCCCCHHHHHHHCCCEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC VALAPAMNTHMWKAEAVAENWQRLQRDPRFWALPTARGRLACDAVGEGRLLEPEALQEYV EEEECCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEECCCCCCCCCHHHHHHHH RALLWTGGQKDWQGKRVLVTAGGTREPIDAVRFIGNPASGRMGVALAVAAACRGAEVTLV HHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEE HGPLGIPFDPAPFAIRAIPVETAAQLEQVLRAEFPQVDVLWMATAVGDVRPTQTYAGKLA ECCCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCHHHHCCHH KAELPLLLPLEPVPDLVAALARHRRPGQLLIGFAAQSGDPLPPAKEKLQQKGLDAIVANP HCCCCEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCEEECCC IDQPESGFGSSHNQGYWIPRQGNPELLPLATKSTLAHRLLDLALRLG CCCCCCCCCCCCCCCEEECCCCCCCEEEEEHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8905231 [H]