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The map label for this gene is fhuD

Identifier: 86361194

GI number: 86361194

Start: 523112

End: 523942

Strand: Direct

Name: fhuD

Synonym: RHE_PF00464

Alternate gene names: 86361194

Gene position: 523112-523942 (Clockwise)

Preceding gene: 86361193

Following gene: 86361195

Centisome position: 81.42

GC content: 63.06

Gene sequence:

>831_bases
ATGACCGGCGGCCCCGCCATCGCACGCGCTGGCGATGCCAACGTCGTTTCACTCGATTACGGACTGGCATCGACGATGCT
GGCGCTCGGCAGCGTGCCGCGCGCAATCGCTTCCCTCAGGAACTGGTCGGAATGGGTGGTCGAGCCGGCGATGCCCTCAG
GCGTCGTCGATATCGGCACCACAGCCGAGATCAATCTCGAAGTCCTTACAAGCCTCAGGCCATCGCTCATCCTCACTACG
CCTTTCCTTGCGGCGCTGGACGAAAAACTATCCCGGATCGCGCCAGTGGAAATCTTCACCGTCTATGCCGAGAATGGCGA
AGCGCTCGACCGCTCCTACGCCGAAACACTGCGTCTCGGCGCCATGATCGGGCGGCAGAGGGAAGCGGAGGCATATCTCG
CCCGCGCCGACGCCACCTTCGGCCGGCTGCGCGACCGAATGAAAGGCCTGTCCACGCGCCCGGTCGCCGTCATCAACTTC
ATCGACCAGAGGCATGCGCGCATCTATGGCGGCCCCGGACTTTACGGCGGCGCGATGCGCCGGATCGGCATCGAGAACGC
CTGGAAAGGCGAGGCGAGCTACTGGGGATTTCAGACGATCGGCCTAGAACAGCTCGCCGAACTCGATGAAGAGGCGCATC
TTGTTGTCGTTTCGCCACTGCTTCCGCCCGATGTCCTGACCCGGCTTTCCGAAAGCCCGCTCTGGACCAGCCTTCCCTTC
GTCCGGCGGCAGCGGATCTCGGTCGTTCCAGGCGTGCTGATGTTTGGAATGGTCCAGGAAGCCCTGCGCTTTTCGACTTT
GATGGTCGGCGTTCTGGAGACTGCTGCCTGA

Upstream 100 bases:

>100_bases
AGGATCATCCGTGCCTGTTCATGGTCAAACCGCTCATGGAGACGCAGCTGAGCAGGACCGCGCTTTGAGACGACGAGACT
TTCTTCTTGGCGCGTTGGCA

Downstream 100 bases:

>100_bases
TGAAAGCGCAAATTTCCGGCTTTGGCGCGCCCGCCCTCGCGGCGCTGCTGCTGTTTTCCGGCCTCGGCCTGGCTCTCCTC
GACCTGCTGCCGGCGTTGCC

Product: ferrichrome-iron ABC transporter, substrate-binding protein

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein D; Ferrichrome-binding periplasmic protein; Iron(III)-hydroxamate-binding protein fhuD [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MTGGPAIARAGDANVVSLDYGLASTMLALGSVPRAIASLRNWSEWVVEPAMPSGVVDIGTTAEINLEVLTSLRPSLILTT
PFLAALDEKLSRIAPVEIFTVYAENGEALDRSYAETLRLGAMIGRQREAEAYLARADATFGRLRDRMKGLSTRPVAVINF
IDQRHARIYGGPGLYGGAMRRIGIENAWKGEASYWGFQTIGLEQLAELDEEAHLVVVSPLLPPDVLTRLSESPLWTSLPF
VRRQRISVVPGVLMFGMVQEALRFSTLMVGVLETAA

Sequences:

>Translated_276_residues
MTGGPAIARAGDANVVSLDYGLASTMLALGSVPRAIASLRNWSEWVVEPAMPSGVVDIGTTAEINLEVLTSLRPSLILTT
PFLAALDEKLSRIAPVEIFTVYAENGEALDRSYAETLRLGAMIGRQREAEAYLARADATFGRLRDRMKGLSTRPVAVINF
IDQRHARIYGGPGLYGGAMRRIGIENAWKGEASYWGFQTIGLEQLAELDEEAHLVVVSPLLPPDVLTRLSESPLWTSLPF
VRRQRISVVPGVLMFGMVQEALRFSTLMVGVLETAA
>Mature_275_residues
TGGPAIARAGDANVVSLDYGLASTMLALGSVPRAIASLRNWSEWVVEPAMPSGVVDIGTTAEINLEVLTSLRPSLILTTP
FLAALDEKLSRIAPVEIFTVYAENGEALDRSYAETLRLGAMIGRQREAEAYLARADATFGRLRDRMKGLSTRPVAVINFI
DQRHARIYGGPGLYGGAMRRIGIENAWKGEASYWGFQTIGLEQLAELDEEAHLVVVSPLLPPDVLTRLSESPLWTSLPFV
RRQRISVVPGVLMFGMVQEALRFSTLMVGVLETAA

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrich

COG id: COG0614

COG function: function code P; ABC-type Fe3+-hydroxamate transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe/B12 periplasmic-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786346, Length=271, Percent_Identity=30.9963099630996, Blast_Score=134, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008091
- InterPro:   IPR002491 [H]

Pfam domain/function: PF01497 Peripla_BP_2 [H]

EC number: NA

Molecular weight: Translated: 29998; Mature: 29867

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS50983 FE_B12_PBP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGGPAIARAGDANVVSLDYGLASTMLALGSVPRAIASLRNWSEWVVEPAMPSGVVDIGT
CCCCCCCEECCCCCEEEECHHHHHHHHHHCCHHHHHHHHHCHHHHHCCCCCCCCCEECCC
TAEINLEVLTSLRPSLILTTPFLAALDEKLSRIAPVEIFTVYAENGEALDRSYAETLRLG
CCEEHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHH
AMIGRQREAEAYLARADATFGRLRDRMKGLSTRPVAVINFIDQRHARIYGGPGLYGGAMR
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEECCCCCHHHHHH
RIGIENAWKGEASYWGFQTIGLEQLAELDEEAHLVVVSPLLPPDVLTRLSESPLWTSLPF
HCCCCCCCCCCCCCCCHHHHCHHHHHHCCCCCEEEEEECCCCHHHHHHCCCCCCCCCCHH
VRRQRISVVPGVLMFGMVQEALRFSTLMVGVLETAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TGGPAIARAGDANVVSLDYGLASTMLALGSVPRAIASLRNWSEWVVEPAMPSGVVDIGT
CCCCCCEECCCCCEEEECHHHHHHHHHHCCHHHHHHHHHCHHHHHCCCCCCCCCEECCC
TAEINLEVLTSLRPSLILTTPFLAALDEKLSRIAPVEIFTVYAENGEALDRSYAETLRLG
CCEEHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHH
AMIGRQREAEAYLARADATFGRLRDRMKGLSTRPVAVINFIDQRHARIYGGPGLYGGAMR
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEECCCCCHHHHHH
RIGIENAWKGEASYWGFQTIGLEQLAELDEEAHLVVVSPLLPPDVLTRLSESPLWTSLPF
HCCCCCCCCCCCCCCCHHHHCHHHHHHCCCCCEEEEEECCCCHHHHHHCCCCCCCCCCHH
VRRQRISVVPGVLMFGMVQEALRFSTLMVGVLETAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3301821; 2823072; 8202364; 9278503; 7651325; 10742172 [H]