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The map label for this gene is 86361121

Identifier: 86361121

GI number: 86361121

Start: 443586

End: 444584

Strand: Reverse

Name: 86361121

Synonym: RHE_PF00391

Alternate gene names: NA

Gene position: 444584-443586 (Counterclockwise)

Preceding gene: 86361122

Following gene: 86361120

Centisome position: 69.19

GC content: 61.96

Gene sequence:

>999_bases
ATGAGAAACAGCTTCTTCTGCATCGATGCCCATACCTGCGGCAACCCGGTCCGTCTCGTCGCCGGAGGCGGCCCGCTGCT
TCCACATCTGCCGATGGGCGAGCGCCGGGAAATCTTTGTCCGCGACCATGACTGGGTCCGCAAGGCGCTGATGTTCGAGC
CGAGGGGGCATGACATTATGTCGGGCTCGATCATCTATCCGCCCTATCGGGAAGATTGTGATTTCGCCGTTCTTTTCATC
GAGGTGAGTGGCTGCCTGCCGATGTGCGGCGCAGGCACGATCGGCACCGTCACCGCCGCGATCGAAGAGGGCCTGGTCAA
GCCCCGTGAAGCCGGAAGGGTCGCCATCGAAACCCCGGCCGGCAGGGTCGACGTCACCTATGAGGAGAAGGGCGGCTATG
TCGATTCCGTTCGCCTCCACAATGTGGCGAGCTATCTGCACGAGGCGGATGTCGAAGTCGATGTGCCTGAGATGGGCCGG
CTGCGTGTCGATATCTCCTATGGCGGCAACTATTATGCAGTCGTCGAGCCGCAGGAGAATTGGAGCGGGCTCGACGGCAT
GAGCGCCTCCGACATCGTCGCCTGCAGCCAGCGGCTCAGGCATGCGCTTGCCGATATCTGCAATCCTGTTCATCCCGACG
ATGCCAGGATATCGGGCGTGCATCACGCGATCTGGTGCGATCGTCCCGTCAACGACGTGTCTGACGGGCGCTGCGCGGTC
TTCTACGGCGAGAAGGCGATAGATCGCTCGCCGGGCGGCACCGGCACATCGGCGCGCATGGCGCAGTTGCATGGAAAGGG
ACGGCTTACCGTCGGGTCGAGCTACCGTCATGAAAGCCTAATCGGAACCATCTTCCAGGGCCGTGTAGAGGCCGAGGCAA
ACATCGGGTCTTATCGCGGCATCCTCCCGAGCATTGGAGGCTGGGCGCGGGTCATCGGCCACAACGCCATTTTTGTTGAC
GACCGCGATCCCCTGGCGCACGGTTTTCAGATCAGATGA

Upstream 100 bases:

>100_bases
CTGGCGATCGTTGCCGTCGCCCTGCTGCTCGACCGGCTGACCCGCGGTCTGTTCGACCGCGGCCGGCTGGCGAAGGCGCG
GTGAGCCGGGATATGAAAAG

Downstream 100 bases:

>100_bases
GCGCATTCAGGAATGGTGATGAGATGAATATGCGACCTGGGCAGCATCGGCAGGCAGACGGCGCCGCAAAACCCGCCGCC
CGGCTCAAGGTTGGCTTCGT

Product: hydroxyproline-2-epimerase

Products: NA

Alternate protein names: Hydroxyproline-2-epimerase; HyPRE [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MRNSFFCIDAHTCGNPVRLVAGGGPLLPHLPMGERREIFVRDHDWVRKALMFEPRGHDIMSGSIIYPPYREDCDFAVLFI
EVSGCLPMCGAGTIGTVTAAIEEGLVKPREAGRVAIETPAGRVDVTYEEKGGYVDSVRLHNVASYLHEADVEVDVPEMGR
LRVDISYGGNYYAVVEPQENWSGLDGMSASDIVACSQRLRHALADICNPVHPDDARISGVHHAIWCDRPVNDVSDGRCAV
FYGEKAIDRSPGGTGTSARMAQLHGKGRLTVGSSYRHESLIGTIFQGRVEAEANIGSYRGILPSIGGWARVIGHNAIFVD
DRDPLAHGFQIR

Sequences:

>Translated_332_residues
MRNSFFCIDAHTCGNPVRLVAGGGPLLPHLPMGERREIFVRDHDWVRKALMFEPRGHDIMSGSIIYPPYREDCDFAVLFI
EVSGCLPMCGAGTIGTVTAAIEEGLVKPREAGRVAIETPAGRVDVTYEEKGGYVDSVRLHNVASYLHEADVEVDVPEMGR
LRVDISYGGNYYAVVEPQENWSGLDGMSASDIVACSQRLRHALADICNPVHPDDARISGVHHAIWCDRPVNDVSDGRCAV
FYGEKAIDRSPGGTGTSARMAQLHGKGRLTVGSSYRHESLIGTIFQGRVEAEANIGSYRGILPSIGGWARVIGHNAIFVD
DRDPLAHGFQIR
>Mature_332_residues
MRNSFFCIDAHTCGNPVRLVAGGGPLLPHLPMGERREIFVRDHDWVRKALMFEPRGHDIMSGSIIYPPYREDCDFAVLFI
EVSGCLPMCGAGTIGTVTAAIEEGLVKPREAGRVAIETPAGRVDVTYEEKGGYVDSVRLHNVASYLHEADVEVDVPEMGR
LRVDISYGGNYYAVVEPQENWSGLDGMSASDIVACSQRLRHALADICNPVHPDDARISGVHHAIWCDRPVNDVSDGRCAV
FYGEKAIDRSPGGTGTSARMAQLHGKGRLTVGSSYRHESLIGTIFQGRVEAEANIGSYRGILPSIGGWARVIGHNAIFVD
DRDPLAHGFQIR

Specific function: Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4- hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell

COG id: COG3938

COG function: function code E; Proline racemase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the proline racemase family. 4- hydroxyproline epimerase subfamily [H]

Homologues:

Organism=Homo sapiens, GI21389361, Length=339, Percent_Identity=33.0383480825959, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008794 [H]

Pfam domain/function: PF05544 Pro_racemase [H]

EC number: =5.1.1.8 [H]

Molecular weight: Translated: 36224; Mature: 36224

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNSFFCIDAHTCGNPVRLVAGGGPLLPHLPMGERREIFVRDHDWVRKALMFEPRGHDIM
CCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCEEEEECHHHHHHHHEECCCCCCCC
SGSIIYPPYREDCDFAVLFIEVSGCLPMCGAGTIGTVTAAIEEGLVKPREAGRVAIETPA
CCCEECCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCHHCCEEEEECCC
GRVDVTYEEKGGYVDSVRLHNVASYLHEADVEVDVPEMGRLRVDISYGGNYYAVVEPQEN
CEEEEEECCCCCEEEHHHHHHHHHHHHHCCCEECCCCCCEEEEEEEECCCEEEEECCCCC
WSGLDGMSASDIVACSQRLRHALADICNPVHPDDARISGVHHAIWCDRPVNDVSDGRCAV
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCEEEEEECCCCCCCCCCCEEEE
FYGEKAIDRSPGGTGTSARMAQLHGKGRLTVGSSYRHESLIGTIFQGRVEAEANIGSYRG
EECCHHHCCCCCCCCCCHHHHHHCCCCEEEECCCCCHHHHHHHHHHCEEEECCCCCCCCC
ILPSIGGWARVIGHNAIFVDDRDPLAHGFQIR
CCCCCCCHHHHHCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MRNSFFCIDAHTCGNPVRLVAGGGPLLPHLPMGERREIFVRDHDWVRKALMFEPRGHDIM
CCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCEEEEECHHHHHHHHEECCCCCCCC
SGSIIYPPYREDCDFAVLFIEVSGCLPMCGAGTIGTVTAAIEEGLVKPREAGRVAIETPA
CCCEECCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCHHCCEEEEECCC
GRVDVTYEEKGGYVDSVRLHNVASYLHEADVEVDVPEMGRLRVDISYGGNYYAVVEPQEN
CEEEEEECCCCCEEEHHHHHHHHHHHHHCCCEECCCCCCEEEEEEEECCCEEEEECCCCC
WSGLDGMSASDIVACSQRLRHALADICNPVHPDDARISGVHHAIWCDRPVNDVSDGRCAV
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCEEEEEECCCCCCCCCCCEEEE
FYGEKAIDRSPGGTGTSARMAQLHGKGRLTVGSSYRHESLIGTIFQGRVEAEANIGSYRG
EECCHHHCCCCCCCCCCHHHHHHCCCCEEEECCCCCHHHHHHHHHHCEEEECCCCCCCCC
ILPSIGGWARVIGHNAIFVDDRDPLAHGFQIR
CCCCCCCHHHHHCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA