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The map label for this gene is dppA [H]

Identifier: 86361081

GI number: 86361081

Start: 393259

End: 394869

Strand: Direct

Name: dppA [H]

Synonym: RHE_PF00351

Alternate gene names: 86361081

Gene position: 393259-394869 (Clockwise)

Preceding gene: 86361080

Following gene: 86361082

Centisome position: 61.21

GC content: 59.03

Gene sequence:

>1611_bases
ATGAACGACAAGATCACCAATTGGACCAGATCGGACAACGCCATGGTCGAAACCGCCATCCGTCGTGGCGCCACCCGCCG
CGAGCTGCTGCATATGATGCTCGCGGGCGGCGTGGCCATGTCCGCCGGCGGGCTCGTGCTCGGCCGCGCCGGCAAGGCGC
TCGCCGCCACGCCCGTTTCCGGCGGGGCGCTGAAGGCGGCCGGCTGGTCGTCCTCCACGGCCGATACGCTCGACCCCGCC
AAGGCATCGCTCTCCACCGACTATGTCCGCTGCTGCGCCTTCTACAACCGTCTCACCTATATCCAGTCGGACGGTACGCC
GCGGATGGAACTCGCCGAATCCATCGAAAGCGGCGATGCCAAAGTCTGGACGATCAAGCTGCGCAGCGGCGTGACCTTCC
ATGACGGCAAGCCGCTCACTGCCGACGATGTGGTCTTCTCGATGAAGCGCCATCTCGACCCGGCGGTCGGCTCCAAGGTT
GCCAAGATCGCCAAGCAAATGACTGGCTTCAAAGCGGTCGACAAACTGACCGTCGAGATTACGCTGGAAAACCCCAATGC
CGATCTGCCGACGATTCTCGGCATGCACCACTTCATGATCGTTGCCGACGGCACAACCGATTTTTCCAAGGGCAATGGCA
CCGGCGCCTTCGTGCGGGAAGTTTTTGAGCCCGGCGTCCGCTCGATCGGGCTGAAGAACAAGAACTACTGGAAGGCCAAC
CACCCGAACGTTGATTCTTTTGAGTTCTTTGCCATCAGCGAAGACAATGCGCGTATCAATGCGCTGCTCTCGGGCGATAT
TCACCTCGCCGCAGCCATCAATCCACGATCCGTGCGTCTGATGGACGGCAAAGACGGCTTCTTTCTCTCCAAAACGACGT
CGGGCAATTACACGGATCTCAACATCCGTCTGGACATGTCTCCCGGCGACAAGAAGGGCTTCGTGGAAGGCATGAAATAT
CTGATCAACCGCGAGCAGATTCAGAAATCTGCCTTGCGCGGCTTCGCCGAAATCGGCAATGACCAACCAATCTCGCCCGC
CAATTTCTATCACAATGCAGACCTGAAGCCGAAGGCATTCGATCCCGAAAAAGCGAAGTTCCTATTCCAGAAGGCGGGCC
TTCTCGGCCAGTCAATCCCTGTCATCGCCTCCGACGCAGCCAATTCCGCGATCGACATGGCGATGATCGTCCAGGCGGCC
GGCGCCGAAATCGGCATGAAGCTCGACGTGCAGCGCGTACCGTCCGACGGCTACTGGGACAATTACTGGCTCAAAGCGCC
GATCCATTTCGGCAATATCAATCCGCGTCCGACACCCGACATATTGTTCTCGCTTCTCTATGCGTCTGACGCGCCTTGGA
ACGAGAGCCAGTACAAGTCAGAGAAGTTCGATCGGATGCTGATCGAGGCCCGCGGCTCGCTCGATCAGGCCAAGCGCCGG
GAGATCTACAACGAGATGCAGGTCATGGTGTCGGAAGAAGCCGGCACCATCATACCGGCCTATCTCTCCAACGTCGATGC
GGTGTCGTCCAAAGTCAAGGGGCTCGAATCCAACCCGCTCGGCGGCATGATGGGCTATTCCTTCCCGGAATATATCTGGT
TGGAATCCTGA

Upstream 100 bases:

>100_bases
GGCCGGCCTTGCCGATGCCGCGGCCGCACGCGCCTGACTTTTAAAACCGGATCGGGCTCGCCCTGCACTGCCGCCCGCCA
CAGAAGAAAAGGGGAATGAG

Downstream 100 bases:

>100_bases
CGAGGCACCTGGCCGGGAACAGGATTGTTCCCGGTCATCCTCCCCTTTCGTGATAAGCTGTCGGACTTCGGCCGACGGGG
AGCATGAAGATGAACAATCC

Product: oligopeptide ABC transporter, substrate-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Dipeptide-binding protein; DBP [H]

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MNDKITNWTRSDNAMVETAIRRGATRRELLHMMLAGGVAMSAGGLVLGRAGKALAATPVSGGALKAAGWSSSTADTLDPA
KASLSTDYVRCCAFYNRLTYIQSDGTPRMELAESIESGDAKVWTIKLRSGVTFHDGKPLTADDVVFSMKRHLDPAVGSKV
AKIAKQMTGFKAVDKLTVEITLENPNADLPTILGMHHFMIVADGTTDFSKGNGTGAFVREVFEPGVRSIGLKNKNYWKAN
HPNVDSFEFFAISEDNARINALLSGDIHLAAAINPRSVRLMDGKDGFFLSKTTSGNYTDLNIRLDMSPGDKKGFVEGMKY
LINREQIQKSALRGFAEIGNDQPISPANFYHNADLKPKAFDPEKAKFLFQKAGLLGQSIPVIASDAANSAIDMAMIVQAA
GAEIGMKLDVQRVPSDGYWDNYWLKAPIHFGNINPRPTPDILFSLLYASDAPWNESQYKSEKFDRMLIEARGSLDQAKRR
EIYNEMQVMVSEEAGTIIPAYLSNVDAVSSKVKGLESNPLGGMMGYSFPEYIWLES

Sequences:

>Translated_536_residues
MNDKITNWTRSDNAMVETAIRRGATRRELLHMMLAGGVAMSAGGLVLGRAGKALAATPVSGGALKAAGWSSSTADTLDPA
KASLSTDYVRCCAFYNRLTYIQSDGTPRMELAESIESGDAKVWTIKLRSGVTFHDGKPLTADDVVFSMKRHLDPAVGSKV
AKIAKQMTGFKAVDKLTVEITLENPNADLPTILGMHHFMIVADGTTDFSKGNGTGAFVREVFEPGVRSIGLKNKNYWKAN
HPNVDSFEFFAISEDNARINALLSGDIHLAAAINPRSVRLMDGKDGFFLSKTTSGNYTDLNIRLDMSPGDKKGFVEGMKY
LINREQIQKSALRGFAEIGNDQPISPANFYHNADLKPKAFDPEKAKFLFQKAGLLGQSIPVIASDAANSAIDMAMIVQAA
GAEIGMKLDVQRVPSDGYWDNYWLKAPIHFGNINPRPTPDILFSLLYASDAPWNESQYKSEKFDRMLIEARGSLDQAKRR
EIYNEMQVMVSEEAGTIIPAYLSNVDAVSSKVKGLESNPLGGMMGYSFPEYIWLES
>Mature_536_residues
MNDKITNWTRSDNAMVETAIRRGATRRELLHMMLAGGVAMSAGGLVLGRAGKALAATPVSGGALKAAGWSSSTADTLDPA
KASLSTDYVRCCAFYNRLTYIQSDGTPRMELAESIESGDAKVWTIKLRSGVTFHDGKPLTADDVVFSMKRHLDPAVGSKV
AKIAKQMTGFKAVDKLTVEITLENPNADLPTILGMHHFMIVADGTTDFSKGNGTGAFVREVFEPGVRSIGLKNKNYWKAN
HPNVDSFEFFAISEDNARINALLSGDIHLAAAINPRSVRLMDGKDGFFLSKTTSGNYTDLNIRLDMSPGDKKGFVEGMKY
LINREQIQKSALRGFAEIGNDQPISPANFYHNADLKPKAFDPEKAKFLFQKAGLLGQSIPVIASDAANSAIDMAMIVQAA
GAEIGMKLDVQRVPSDGYWDNYWLKAPIHFGNINPRPTPDILFSLLYASDAPWNESQYKSEKFDRMLIEARGSLDQAKRR
EIYNEMQVMVSEEAGTIIPAYLSNVDAVSSKVKGLESNPLGGMMGYSFPEYIWLES

Specific function: Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=497, Percent_Identity=26.5593561368209, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1787052, Length=526, Percent_Identity=25.0950570342205, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787762, Length=478, Percent_Identity=23.8493723849372, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789887, Length=450, Percent_Identity=24.8888888888889, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1789397, Length=515, Percent_Identity=22.3300970873786, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1787495, Length=260, Percent_Identity=26.1538461538462, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87081878, Length=269, Percent_Identity=24.1635687732342, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787551, Length=529, Percent_Identity=23.2514177693762, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 58609; Mature: 58609

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDKITNWTRSDNAMVETAIRRGATRRELLHMMLAGGVAMSAGGLVLGRAGKALAATPVS
CCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCHHCCCCCEEEECCCCEEEECCCC
GGALKAAGWSSSTADTLDPAKASLSTDYVRCCAFYNRLTYIQSDGTPRMELAESIESGDA
CCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHCCCCC
KVWTIKLRSGVTFHDGKPLTADDVVFSMKRHLDPAVGSKVAKIAKQMTGFKAVDKLTVEI
EEEEEEEECCCEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHEEEEEEEEE
TLENPNADLPTILGMHHFMIVADGTTDFSKGNGTGAFVREVFEPGVRSIGLKNKNYWKAN
EEECCCCCCCHHHCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCHHHCCCCCCCCCCCC
HPNVDSFEFFAISEDNARINALLSGDIHLAAAINPRSVRLMDGKDGFFLSKTTSGNYTDL
CCCCCCEEEEEEECCCCEEEEEEECCEEEEEEECCCEEEEEECCCCEEEEECCCCCEEEE
NIRLDMSPGDKKGFVEGMKYLINREQIQKSALRGFAEIGNDQPISPANFYHNADLKPKAF
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCC
DPEKAKFLFQKAGLLGQSIPVIASDAANSAIDMAMIVQAAGAEIGMKLDVQRVPSDGYWD
CCHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCC
NYWLKAPIHFGNINPRPTPDILFSLLYASDAPWNESQYKSEKFDRMLIEARGSLDQAKRR
CEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
EIYNEMQVMVSEEAGTIIPAYLSNVDAVSSKVKGLESNPLGGMMGYSFPEYIWLES
HHHHHHHEEEECCCCCEEHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MNDKITNWTRSDNAMVETAIRRGATRRELLHMMLAGGVAMSAGGLVLGRAGKALAATPVS
CCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCHHCCCCCEEEECCCCEEEECCCC
GGALKAAGWSSSTADTLDPAKASLSTDYVRCCAFYNRLTYIQSDGTPRMELAESIESGDA
CCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHCCCCC
KVWTIKLRSGVTFHDGKPLTADDVVFSMKRHLDPAVGSKVAKIAKQMTGFKAVDKLTVEI
EEEEEEEECCCEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHEEEEEEEEE
TLENPNADLPTILGMHHFMIVADGTTDFSKGNGTGAFVREVFEPGVRSIGLKNKNYWKAN
EEECCCCCCCHHHCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCHHHCCCCCCCCCCCC
HPNVDSFEFFAISEDNARINALLSGDIHLAAAINPRSVRLMDGKDGFFLSKTTSGNYTDL
CCCCCCEEEEEEECCCCEEEEEEECCEEEEEEECCCEEEEEECCCCEEEEECCCCCEEEE
NIRLDMSPGDKKGFVEGMKYLINREQIQKSALRGFAEIGNDQPISPANFYHNADLKPKAF
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCC
DPEKAKFLFQKAGLLGQSIPVIASDAANSAIDMAMIVQAAGAEIGMKLDVQRVPSDGYWD
CCHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCC
NYWLKAPIHFGNINPRPTPDILFSLLYASDAPWNESQYKSEKFDRMLIEARGSLDQAKRR
CEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
EIYNEMQVMVSEEAGTIIPAYLSNVDAVSSKVKGLESNPLGGMMGYSFPEYIWLES
HHHHHHHEEEECCCCCEEHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1702779; 1956284; 7536291; 8041620; 9278503; 9298646; 9600841; 8563629; 8527431 [H]