Click here to switch to the map view.

The map label for this gene is tatA [H]

Identifier: 86361003

GI number: 86361003

Start: 296366

End: 297562

Strand: Direct

Name: tatA [H]

Synonym: RHE_PF00273

Alternate gene names: 86361003

Gene position: 296366-297562 (Clockwise)

Preceding gene: 86361001

Following gene: 86361004

Centisome position: 46.13

GC content: 61.4

Gene sequence:

>1197_bases
ATGGAACTGGAGGTGACAGTGTTTGACCAACTGAACAGCCGGCCGGCCGATAGCCTGCTCGCACTCATCAAGGCCTTCCA
GGCCGACGATCGTCCCGGAAAGATCGACCTCGGCGTCGGGGTCTATCGCGACGCCATGGGACGCACGCCCGTTATGCGGG
CCGTCAAGGCGGCGGAGCAGTTTCTCCTGGAGACGCAGGACAGCAAGAAATATCTCGGCCCCGAGGGTGATCTGCAATTC
GTGCGCCTGCTTGAGCCGATCATCTTCGGCAACTCGCCGAAATTCGCCCAACGGCTCGCCGGCATTCAAACGCCGGGCGG
CAGCGGCGCGCTCCGTCTCGGCGCGGAACTCATCCAAACGGCAAACCCCTCGGCAAAGGTTCTCTTGGGAACGCCGAGCT
GGCCTAATCATAAGCCGATCTTCGCTTCGGCACGCTTGGACGTAAAGGAATATGCCTTCGTCGACCTGACGTCACAGCAG
GTGACGTTCGAAAGCGTCGTCTCCGCTTTGTCATCCGCCAGGGAAGGCGACGTCGTGCTGCTTCATTGTTGCTGCCATAA
TCCCACGGGTATCGATTTCACCATGGAGCAATGGCGAGAGATTGCCGATCTCCTCGTTGCGCACAGGCTCGTGCCCTTCA
TCGATCTTGCCTATCAGGGGCTCGGCGACGGCCTCGAACAGGATGCCGCCCCGACGCGCATGATTCTCGATGCGGTCGAG
GAAGCGCTGATCGCCTATTCCTGCGACAAGAACTTCGGCCTCTATCGCGAACGCGTCGGCGCGCTTTATGTCGTGGCGCG
CAATGCCGATGACGTCAGAAAGGCAGAAAGCAACATGGCGGGGCTTGCCCGCGTGAACTGGTCCATGCCGCCGGACCATG
GTGCCGCAATCGTCAAGACCATTCTTGAAAGCCCGGAAATGACAGCGATATGGCGTACGGAACTCGAAGAGATGTGCCGG
CGCATCAATGGCAATCGCGCGGCGCTGGCCGCTGCCTCTCCGGAGCTGGCCTTCGTCAGCCGGCAACGTGGGCTGTTCTC
CAATCTCTCCATGCGCAAGGAAACGGCGGTCGCGCTTAGGGCAAACCACGGCATCTACATGGCGGATTCCGGGCGCATGA
ATCTCGCCGGCATGCAGCCCGCCGATGCCGGCGCCATCGTCGCGGCGCTCCGGGCCGAAGGCTGCCTGAAATCATAA

Upstream 100 bases:

>100_bases
TTATACCGATATAACGCAGATTATCTGCACAATTACGTCAAAGCAGGAGGATAATCGCAGAAATTCGTCGCGATAGCTCC
GTTAATCTTCGGCAACTGAC

Downstream 100 bases:

>100_bases
CCGAATGCACCGTTGGAGCCTCCGAATGAGCAGGAAAGAAACGACCGGCCAGGCGATCACCCGTTCGCTTGTCGCCCACG
GAATTGACACGATCTTCGGC

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: TAT; L-tyrosine:2-oxoglutarate aminotransferase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MELEVTVFDQLNSRPADSLLALIKAFQADDRPGKIDLGVGVYRDAMGRTPVMRAVKAAEQFLLETQDSKKYLGPEGDLQF
VRLLEPIIFGNSPKFAQRLAGIQTPGGSGALRLGAELIQTANPSAKVLLGTPSWPNHKPIFASARLDVKEYAFVDLTSQQ
VTFESVVSALSSAREGDVVLLHCCCHNPTGIDFTMEQWREIADLLVAHRLVPFIDLAYQGLGDGLEQDAAPTRMILDAVE
EALIAYSCDKNFGLYRERVGALYVVARNADDVRKAESNMAGLARVNWSMPPDHGAAIVKTILESPEMTAIWRTELEEMCR
RINGNRAALAAASPELAFVSRQRGLFSNLSMRKETAVALRANHGIYMADSGRMNLAGMQPADAGAIVAALRAEGCLKS

Sequences:

>Translated_398_residues
MELEVTVFDQLNSRPADSLLALIKAFQADDRPGKIDLGVGVYRDAMGRTPVMRAVKAAEQFLLETQDSKKYLGPEGDLQF
VRLLEPIIFGNSPKFAQRLAGIQTPGGSGALRLGAELIQTANPSAKVLLGTPSWPNHKPIFASARLDVKEYAFVDLTSQQ
VTFESVVSALSSAREGDVVLLHCCCHNPTGIDFTMEQWREIADLLVAHRLVPFIDLAYQGLGDGLEQDAAPTRMILDAVE
EALIAYSCDKNFGLYRERVGALYVVARNADDVRKAESNMAGLARVNWSMPPDHGAAIVKTILESPEMTAIWRTELEEMCR
RINGNRAALAAASPELAFVSRQRGLFSNLSMRKETAVALRANHGIYMADSGRMNLAGMQPADAGAIVAALRAEGCLKS
>Mature_398_residues
MELEVTVFDQLNSRPADSLLALIKAFQADDRPGKIDLGVGVYRDAMGRTPVMRAVKAAEQFLLETQDSKKYLGPEGDLQF
VRLLEPIIFGNSPKFAQRLAGIQTPGGSGALRLGAELIQTANPSAKVLLGTPSWPNHKPIFASARLDVKEYAFVDLTSQQ
VTFESVVSALSSAREGDVVLLHCCCHNPTGIDFTMEQWREIADLLVAHRLVPFIDLAYQGLGDGLEQDAAPTRMILDAVE
EALIAYSCDKNFGLYRERVGALYVVARNADDVRKAESNMAGLARVNWSMPPDHGAAIVKTILESPEMTAIWRTELEEMCR
RINGNRAALAAASPELAFVSRQRGLFSNLSMRKETAVALRANHGIYMADSGRMNLAGMQPADAGAIVAALRAEGCLKS

Specific function: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate [H]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=388, Percent_Identity=34.020618556701, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI4504067, Length=389, Percent_Identity=33.4190231362468, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI117414139, Length=384, Percent_Identity=24.21875, Blast_Score=119, Evalue=6e-27,
Organism=Escherichia coli, GI1787159, Length=394, Percent_Identity=42.8934010152284, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI1790488, Length=395, Percent_Identity=36.2025316455696, Blast_Score=249, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71981858, Length=386, Percent_Identity=33.6787564766839, Blast_Score=251, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI25147133, Length=386, Percent_Identity=32.6424870466321, Blast_Score=230, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI17569539, Length=397, Percent_Identity=33.2493702770781, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI25147136, Length=209, Percent_Identity=34.4497607655502, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17569537, Length=398, Percent_Identity=25.6281407035176, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17550384, Length=251, Percent_Identity=30.2788844621514, Blast_Score=121, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6323055, Length=405, Percent_Identity=31.358024691358, Blast_Score=212, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6322743, Length=418, Percent_Identity=27.511961722488, Blast_Score=177, Evalue=3e-45,
Organism=Drosophila melanogaster, GI19922362, Length=399, Percent_Identity=33.3333333333333, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24654046, Length=399, Percent_Identity=33.3333333333333, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24580970, Length=388, Percent_Identity=32.4742268041237, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24580972, Length=383, Percent_Identity=32.8981723237598, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI19920542, Length=374, Percent_Identity=33.1550802139037, Blast_Score=206, Evalue=2e-53,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.5 [H]

Molecular weight: Translated: 43317; Mature: 43317

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELEVTVFDQLNSRPADSLLALIKAFQADDRPGKIDLGVGVYRDAMGRTPVMRAVKAAEQ
CCEEEEEHHCCCCCCHHHHHHHHHHHCCCCCCCEEEECCHHHHHHCCCCHHHHHHHHHHH
FLLETQDSKKYLGPEGDLQFVRLLEPIIFGNSPKFAQRLAGIQTPGGSGALRLGAELIQT
HHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHC
ANPSAKVLLGTPSWPNHKPIFASARLDVKEYAFVDLTSQQVTFESVVSALSSAREGDVVL
CCCCCEEEEECCCCCCCCCEEEECCCCHHHEEEEEECCCHHHHHHHHHHHHCCCCCCEEE
LHCCCHNPTGIDFTMEQWREIADLLVAHRLVPFIDLAYQGLGDGLEQDAAPTRMILDAVE
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHH
EALIAYSCDKNFGLYRERVGALYVVARNADDVRKAESNMAGLARVNWSMPPDHGAAIVKT
HHHHHHCCCCCCCHHHHCCCEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCCHHHHHHH
ILESPEMTAIWRTELEEMCRRINGNRAALAAASPELAFVSRQRGLFSNLSMRKETAVALR
HHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCHHHHCHHHHHHEEEEE
ANHGIYMADSGRMNLAGMQPADAGAIVAALRAEGCLKS
ECCCEEEECCCCEEECCCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MELEVTVFDQLNSRPADSLLALIKAFQADDRPGKIDLGVGVYRDAMGRTPVMRAVKAAEQ
CCEEEEEHHCCCCCCHHHHHHHHHHHCCCCCCCEEEECCHHHHHHCCCCHHHHHHHHHHH
FLLETQDSKKYLGPEGDLQFVRLLEPIIFGNSPKFAQRLAGIQTPGGSGALRLGAELIQT
HHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHC
ANPSAKVLLGTPSWPNHKPIFASARLDVKEYAFVDLTSQQVTFESVVSALSSAREGDVVL
CCCCCEEEEECCCCCCCCCEEEECCCCHHHEEEEEECCCHHHHHHHHHHHHCCCCCCEEE
LHCCCHNPTGIDFTMEQWREIADLLVAHRLVPFIDLAYQGLGDGLEQDAAPTRMILDAVE
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHH
EALIAYSCDKNFGLYRERVGALYVVARNADDVRKAESNMAGLARVNWSMPPDHGAAIVKT
HHHHHHCCCCCCCHHHHCCCEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCCHHHHHHH
ILESPEMTAIWRTELEEMCRRINGNRAALAAASPELAFVSRQRGLFSNLSMRKETAVALR
HHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCHHHHCHHHHHHEEEEE
ANHGIYMADSGRMNLAGMQPADAGAIVAALRAEGCLKS
ECCCEEEECCCCEEECCCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2019560; 8096210; 11481430 [H]