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The map label for this gene is dcm [C]

Identifier: 86360841

GI number: 86360841

Start: 117472

End: 118986

Strand: Direct

Name: dcm [C]

Synonym: RHE_PF00108

Alternate gene names: 86360841

Gene position: 117472-118986 (Clockwise)

Preceding gene: 86360836

Following gene: 86360842

Centisome position: 18.28

GC content: 60.73

Gene sequence:

>1515_bases
ATGAGCGTTGATCCGAAACTTATCCGCCAGAAAATCCAGCGATTAGACGCCGGCGCTCGCCCTCGTGTGCTGGATCTCTT
CTCAGGCTGTGGTGGGATCTCGCTTGGTTTTCAGTCGGCGGGTTTTGAGATCGTCGCAGCGGTCGAGAATGATCCCGACG
CGGCCCGCTCGCACGGCCTCAACTTCCATCATGGCGAGGACCGCCATAGTATCCCACGCAACATCACCGTAACGTCGCCA
GCCGCCCTTGCCACGGCGCTCGGCCTCGGCGCCGCGGCAAGCGCGTTCGATGTGATCGTTGGCGGCCCTCCCTGCCAGGC
ATTTGCGCGTGTCGGGCGCTCAAAACTGCGCGAGATCGCCGAACATCCGGAGGCCTTTCGACATGATTCTCGCGCCCGGC
TCTATATCGAGTATCTGGCGTACGTAGAAGCTTGTGCACCACTCGCCGTGGTGATCGAAAACGTGCCAGACATGCTCAAT
CATGGGGGACACAACCTCGCCGCAGAGATCGGTGAGATCCTAGCGAGTAAGGATTATGTCGTTCGCTACACGCTGCTCAA
CGCAGCATTCTACGGTGTGCCGCAGATGCGTGAGCGGATGATCCTCATCGCAATCCGCAAAGAACTTGCGGACGATGTCG
AATTTCCCGCACCGACACACTGGATTGACCTGCCGTCCGGCTATCAGGGTTCGCGCGCTGTAGCGCTCAAACTGGCGACA
GGAAGGGATCTGCTCACCGAAGCAACCGGCGGCAGTGCATACAAGGCCGCTCCGGAAGCTGTTGAAACACTGGCGCCCGC
GGTGTCCACCCAACAGGCCATCGGGGATCTTCCGGAAATAATGGCGCGAGAATTACTTGCCGAAGGGGCGCTTCGACGTG
GCACGCGTCGTCTCGACGCCATGCTCCCTTATGGCGGGCACAATCAGCAGAACGACTATGTGAAGGAGATGCGAACCTGG
CCCGGGTTCGAGGGTAGCTCGCATGTGCGTGACCATGTGATCCGATATCTCCCGCGCGACTATCGTATCTTCGCCGGCCT
GAAGCCGGGCGATCAATATCCTGAGGCACATCGCTATGCGCTGAGCCTGTTCGAAGCGGAGCTCGAACGACTTCATGCCC
AGGGTAAACGCCCGGAAGACGGCAGTTCCGAATGGGACGCGCTCAAGGCAGCTTTCGTGCCTCCATACGATGCTGGGAAG
TTTCCGAACAAGTGGCGCAAAATGGAAGCAACTACGCCTGCCCGCACCCTCCTCGCGCATCTCGGCAAGGATGGCTACAG
TCACATTCATTACGATAGCCGGCAGGCGCGGCCGATCTCGGTACGCGAGGCAGCGCGCCTGCAGTCGTTTCCTGATGGCT
TCCGCTTTGCCGGAACGATGAACCCGGCATTCCGTCAGATTGGCAACGCGGTCCCGCCGCTGCTCGCTCGCGCGATCGCC
CAGACCCTGCGCAGTCAGCTTGTCCGAGGAGTGGCAACAGAGGACCTGCCGCGCGTGGCAGGTGCAGGTCGCTGA

Upstream 100 bases:

>100_bases
CTAATGATGTATCAGCTGCCTGGGTGATTCGGCAGGCAGTTCTCCATTATCTTGCCACGAAAGCCGGCCAAGCCGAGCTG
CCGTTGGGAAGCGATCGGTC

Downstream 100 bases:

>100_bases
TGAGCCGGCGCGAGGAGATTATCGTCGTCAGGTCACTTGCGGAATCGGACCTGGGTCTCTTCTCGGCGCACCGCCTTAGC
GCCACCAGCAAGCAGCGCGC

Product: DNA (cytosine-5-)-methyltransferase protein

Products: NA

Alternate protein names: Cytosine-specific methyltransferase; M.OihORF3336P [H]

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MSVDPKLIRQKIQRLDAGARPRVLDLFSGCGGISLGFQSAGFEIVAAVENDPDAARSHGLNFHHGEDRHSIPRNITVTSP
AALATALGLGAAASAFDVIVGGPPCQAFARVGRSKLREIAEHPEAFRHDSRARLYIEYLAYVEACAPLAVVIENVPDMLN
HGGHNLAAEIGEILASKDYVVRYTLLNAAFYGVPQMRERMILIAIRKELADDVEFPAPTHWIDLPSGYQGSRAVALKLAT
GRDLLTEATGGSAYKAAPEAVETLAPAVSTQQAIGDLPEIMARELLAEGALRRGTRRLDAMLPYGGHNQQNDYVKEMRTW
PGFEGSSHVRDHVIRYLPRDYRIFAGLKPGDQYPEAHRYALSLFEAELERLHAQGKRPEDGSSEWDALKAAFVPPYDAGK
FPNKWRKMEATTPARTLLAHLGKDGYSHIHYDSRQARPISVREAARLQSFPDGFRFAGTMNPAFRQIGNAVPPLLARAIA
QTLRSQLVRGVATEDLPRVAGAGR

Sequences:

>Translated_504_residues
MSVDPKLIRQKIQRLDAGARPRVLDLFSGCGGISLGFQSAGFEIVAAVENDPDAARSHGLNFHHGEDRHSIPRNITVTSP
AALATALGLGAAASAFDVIVGGPPCQAFARVGRSKLREIAEHPEAFRHDSRARLYIEYLAYVEACAPLAVVIENVPDMLN
HGGHNLAAEIGEILASKDYVVRYTLLNAAFYGVPQMRERMILIAIRKELADDVEFPAPTHWIDLPSGYQGSRAVALKLAT
GRDLLTEATGGSAYKAAPEAVETLAPAVSTQQAIGDLPEIMARELLAEGALRRGTRRLDAMLPYGGHNQQNDYVKEMRTW
PGFEGSSHVRDHVIRYLPRDYRIFAGLKPGDQYPEAHRYALSLFEAELERLHAQGKRPEDGSSEWDALKAAFVPPYDAGK
FPNKWRKMEATTPARTLLAHLGKDGYSHIHYDSRQARPISVREAARLQSFPDGFRFAGTMNPAFRQIGNAVPPLLARAIA
QTLRSQLVRGVATEDLPRVAGAGR
>Mature_503_residues
SVDPKLIRQKIQRLDAGARPRVLDLFSGCGGISLGFQSAGFEIVAAVENDPDAARSHGLNFHHGEDRHSIPRNITVTSPA
ALATALGLGAAASAFDVIVGGPPCQAFARVGRSKLREIAEHPEAFRHDSRARLYIEYLAYVEACAPLAVVIENVPDMLNH
GGHNLAAEIGEILASKDYVVRYTLLNAAFYGVPQMRERMILIAIRKELADDVEFPAPTHWIDLPSGYQGSRAVALKLATG
RDLLTEATGGSAYKAAPEAVETLAPAVSTQQAIGDLPEIMARELLAEGALRRGTRRLDAMLPYGGHNQQNDYVKEMRTWP
GFEGSSHVRDHVIRYLPRDYRIFAGLKPGDQYPEAHRYALSLFEAELERLHAQGKRPEDGSSEWDALKAAFVPPYDAGKF
PNKWRKMEATTPARTLLAHLGKDGYSHIHYDSRQARPISVREAARLQSFPDGFRFAGTMNPAFRQIGNAVPPLLARAIAQ
TLRSQLVRGVATEDLPRVAGAGR

Specific function: This methylase recognizes the double-stranded sequence ACCGGT, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by a specific endonuclease (Potential) [H]

COG id: COG0270

COG function: function code L; Site-specific DNA methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C5-methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4503351, Length=507, Percent_Identity=25.2465483234714, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI195927037, Length=507, Percent_Identity=25.2465483234714, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI1788271, Length=208, Percent_Identity=27.4038461538462, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018117
- InterPro:   IPR001525 [H]

Pfam domain/function: PF00145 DNA_methylase [H]

EC number: =2.1.1.37 [H]

Molecular weight: Translated: 55184; Mature: 55053

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS00095 C5_MTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVDPKLIRQKIQRLDAGARPRVLDLFSGCGGISLGFQSAGFEIVAAVENDPDAARSHGL
CCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHCCC
NFHHGEDRHSIPRNITVTSPAALATALGLGAAASAFDVIVGGPPCQAFARVGRSKLREIA
CCCCCCCCCCCCCCEEECCHHHHHHHHHCCHHHHHHHEEECCCCHHHHHHHHHHHHHHHH
EHPEAFRHDSRARLYIEYLAYVEACAPLAVVIENVPDMLNHGGHNLAAEIGEILASKDYV
HCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCE
VRYTLLNAAFYGVPQMRERMILIAIRKELADDVEFPAPTHWIDLPSGYQGSRAVALKLAT
EHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCEEEEEEEC
GRDLLTEATGGSAYKAAPEAVETLAPAVSTQQAIGDLPEIMARELLAEGALRRGTRRLDA
CCHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
MLPYGGHNQQNDYVKEMRTWPGFEGSSHVRDHVIRYLPRDYRIFAGLKPGDQYPEAHRYA
HCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHH
LSLFEAELERLHAQGKRPEDGSSEWDALKAAFVPPYDAGKFPNKWRKMEATTPARTLLAH
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHHHH
LGKDGYSHIHYDSRQARPISVREAARLQSFPDGFRFAGTMNPAFRQIGNAVPPLLARAIA
HCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCCCCHHHHHHCCCCHHHHHHHHH
QTLRSQLVRGVATEDLPRVAGAGR
HHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SVDPKLIRQKIQRLDAGARPRVLDLFSGCGGISLGFQSAGFEIVAAVENDPDAARSHGL
CCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHCCC
NFHHGEDRHSIPRNITVTSPAALATALGLGAAASAFDVIVGGPPCQAFARVGRSKLREIA
CCCCCCCCCCCCCCEEECCHHHHHHHHHCCHHHHHHHEEECCCCHHHHHHHHHHHHHHHH
EHPEAFRHDSRARLYIEYLAYVEACAPLAVVIENVPDMLNHGGHNLAAEIGEILASKDYV
HCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCE
VRYTLLNAAFYGVPQMRERMILIAIRKELADDVEFPAPTHWIDLPSGYQGSRAVALKLAT
EHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCEEEEEEEC
GRDLLTEATGGSAYKAAPEAVETLAPAVSTQQAIGDLPEIMARELLAEGALRRGTRRLDA
CCHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
MLPYGGHNQQNDYVKEMRTWPGFEGSSHVRDHVIRYLPRDYRIFAGLKPGDQYPEAHRYA
HCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHH
LSLFEAELERLHAQGKRPEDGSSEWDALKAAFVPPYDAGKFPNKWRKMEATTPARTLLAH
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHHHH
LGKDGYSHIHYDSRQARPISVREAARLQSFPDGFRFAGTMNPAFRQIGNAVPPLLARAIA
HCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCCCCHHHHHHCCCCHHHHHHHHH
QTLRSQLVRGVATEDLPRVAGAGR
HHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]