Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 85860890

GI number: 85860890

Start: 3057027

End: 3058379

Strand: Direct

Name: atoC [H]

Synonym: SYN_01635

Alternate gene names: 85860890

Gene position: 3057027-3058379 (Clockwise)

Preceding gene: 85860889

Following gene: 85860891

Centisome position: 96.15

GC content: 47.45

Gene sequence:

>1353_bases
ATGTGTAAGAAGAAAATTTTAATTATAGATGATGATGCCTCTCAACTGGAACTGCTCAATATATTTTTCAGTGGAAGAGG
TTATGCCGTTCATTGCTCCGCCACCGCGATGGCTGGTCTGGAGGCCCGTGCAACTTTTCACCCGGATGTAATCGTCCTTG
ATATTCGACTGCCGGACATGGATGGAATCGAAGTTCTACGCAGTCTTGATACAGGGAAATCTTCAATTAATGTGATCATG
ATTACGGCCTATCATGACATGGAAACAACGGTTAAGGCGATGAAGCTGGGGGCCTACGAATACATCACAAAGCCAATCGA
TGTTGACGAGTTGGAAGACGCGGTCTGCAGGGCCTTAAAGAACTCGGAGCTCCGTGAAGCCAAAGAATTACCTGCGGTCA
AGACCTTTCTTCAAAAAGGGCCCATGATCGGCAACAGCAAACCGATGAAAGAAGTCTTCAAGATGATCGGTGTGCTCAGC
GAAAATAATGTTACGGTCCTCATAGAAGGAGAAACGGGAACGGGAAAAGAACTTATTGCAAGAGCGATCCACGACTACGG
TCCACACAAGGATCATCCTTTTATTCCCATCAACTGTTCGGCTATTGTGGGAACACTACTTGAGAGTGAACTTTTCGGCC
ATGAGAAAGGGGCCTTTACAGGCGCATTCGCCACGAAAAAGGGGAAATTCGAGCTTGCAGGAGAGGGAACGATCTTTCTT
GATGAGATGGGTGAAATTCCCATCGAACTACAGGCCAAACTCCTTCGTTTTCTGCAGGATAAGGCATTTCAACGCGTCGG
CGGTGAAAAATTCCTGCATTCAAAGGCCAGGGTGATTGTAGCAACCAATAAAGACCTGCTTCAGATGGTCAGAGCAGGCA
CTTTCAGAGAAGATCTCTATTATCGGTTGAGTGCAGCGAAAATAAACGTGCCGCCGCTGAGAAAGCGCAGGGAGGATATC
CCTTTCCTCCTTGATCATATGGTTAAAGAGATCAATGCCGAACTGGGCAAACGCATCGATAGGGTCGATAAGAAAGCGCT
TTTGAGAATGATGGAATACGATTGGCCGGGCAATGTAAGGGAACTCAGGAACGTTCTTACCGGTGCGGCCATTTCGACGC
GGGGTGAAACCTTATTGGATGACGCAATACTCCCTTTCTTAGGGGCGGGAACCGTACAGGACATCTTCCCGCCGGGGGCC
GCCCTCAGTCTTCGGGAAGTTGAAAGGGAGCATATTCTGAAGATTCTTCATTATACGAATGGAAACATTACAAGCAGCGC
ACAGATCCTTGGAATATCTCGACCGACGCTTCGACAAAAAATAAGGCAGTACAAGATATTGCCACAGCAATAA

Upstream 100 bases:

>100_bases
AATGTGAAAAAAGTCGTGGATGCCCATGGAGGGAAGATTGCCGCTTCGGCTACCTCAAAAGGTTTTTCCATTTCTTTTAC
GATCCCTGTAAGGAAGGATC

Downstream 100 bases:

>100_bases
AAGAAGGAACGGTTCTCTATTACGGTATTGAAAAAGACAATAAATTTGGAAAAATTTTGTTCGAACGTACGAGGAAAGAA
GCAGAAAGTGAAAAGAAAAT

Product: sigma-54 dependent transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MCKKKILIIDDDASQLELLNIFFSGRGYAVHCSATAMAGLEARATFHPDVIVLDIRLPDMDGIEVLRSLDTGKSSINVIM
ITAYHDMETTVKAMKLGAYEYITKPIDVDELEDAVCRALKNSELREAKELPAVKTFLQKGPMIGNSKPMKEVFKMIGVLS
ENNVTVLIEGETGTGKELIARAIHDYGPHKDHPFIPINCSAIVGTLLESELFGHEKGAFTGAFATKKGKFELAGEGTIFL
DEMGEIPIELQAKLLRFLQDKAFQRVGGEKFLHSKARVIVATNKDLLQMVRAGTFREDLYYRLSAAKINVPPLRKRREDI
PFLLDHMVKEINAELGKRIDRVDKKALLRMMEYDWPGNVRELRNVLTGAAISTRGETLLDDAILPFLGAGTVQDIFPPGA
ALSLREVEREHILKILHYTNGNITSSAQILGISRPTLRQKIRQYKILPQQ

Sequences:

>Translated_450_residues
MCKKKILIIDDDASQLELLNIFFSGRGYAVHCSATAMAGLEARATFHPDVIVLDIRLPDMDGIEVLRSLDTGKSSINVIM
ITAYHDMETTVKAMKLGAYEYITKPIDVDELEDAVCRALKNSELREAKELPAVKTFLQKGPMIGNSKPMKEVFKMIGVLS
ENNVTVLIEGETGTGKELIARAIHDYGPHKDHPFIPINCSAIVGTLLESELFGHEKGAFTGAFATKKGKFELAGEGTIFL
DEMGEIPIELQAKLLRFLQDKAFQRVGGEKFLHSKARVIVATNKDLLQMVRAGTFREDLYYRLSAAKINVPPLRKRREDI
PFLLDHMVKEINAELGKRIDRVDKKALLRMMEYDWPGNVRELRNVLTGAAISTRGETLLDDAILPFLGAGTVQDIFPPGA
ALSLREVEREHILKILHYTNGNITSSAQILGISRPTLRQKIRQYKILPQQ
>Mature_450_residues
MCKKKILIIDDDASQLELLNIFFSGRGYAVHCSATAMAGLEARATFHPDVIVLDIRLPDMDGIEVLRSLDTGKSSINVIM
ITAYHDMETTVKAMKLGAYEYITKPIDVDELEDAVCRALKNSELREAKELPAVKTFLQKGPMIGNSKPMKEVFKMIGVLS
ENNVTVLIEGETGTGKELIARAIHDYGPHKDHPFIPINCSAIVGTLLESELFGHEKGAFTGAFATKKGKFELAGEGTIFL
DEMGEIPIELQAKLLRFLQDKAFQRVGGEKFLHSKARVIVATNKDLLQMVRAGTFREDLYYRLSAAKINVPPLRKRREDI
PFLLDHMVKEINAELGKRIDRVDKKALLRMMEYDWPGNVRELRNVLTGAAISTRGETLLDDAILPFLGAGTVQDIFPPGA
ALSLREVEREHILKILHYTNGNITSSAQILGISRPTLRQKIRQYKILPQQ

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=456, Percent_Identity=42.5438596491228, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1790437, Length=443, Percent_Identity=42.4379232505643, Blast_Score=325, Evalue=5e-90,
Organism=Escherichia coli, GI1790299, Length=467, Percent_Identity=36.830835117773, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI87082117, Length=321, Percent_Identity=43.613707165109, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1788905, Length=442, Percent_Identity=33.9366515837104, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI1789087, Length=315, Percent_Identity=44.7619047619048, Blast_Score=261, Evalue=4e-71,
Organism=Escherichia coli, GI87082152, Length=302, Percent_Identity=41.3907284768212, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1786524, Length=334, Percent_Identity=39.2215568862275, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1789233, Length=320, Percent_Identity=36.875, Blast_Score=204, Evalue=9e-54,
Organism=Escherichia coli, GI87081872, Length=324, Percent_Identity=37.037037037037, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1787583, Length=309, Percent_Identity=37.5404530744337, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI87081858, Length=290, Percent_Identity=31.0344827586207, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789828, Length=265, Percent_Identity=33.9622641509434, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1789809, Length=133, Percent_Identity=33.0827067669173, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786911, Length=175, Percent_Identity=29.7142857142857, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1787487, Length=132, Percent_Identity=30.3030303030303, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87082052, Length=190, Percent_Identity=28.4210526315789, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1786784, Length=107, Percent_Identity=31.7757009345794, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787229, Length=106, Percent_Identity=31.1320754716981, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1790552, Length=115, Percent_Identity=33.0434782608696, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50237; Mature: 50237

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCKKKILIIDDDASQLELLNIFFSGRGYAVHCSATAMAGLEARATFHPDVIVLDIRLPDM
CCCCEEEEEECCCHHEEEEEEEECCCCEEEEECHHHHCCCCCCEEECCCEEEEEEECCCC
DGIEVLRSLDTGKSSINVIMITAYHDMETTVKAMKLGAYEYITKPIDVDELEDAVCRALK
CHHHHHHHHCCCCCCEEEEEEEEECCHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHC
NSELREAKELPAVKTFLQKGPMIGNSKPMKEVFKMIGVLSENNVTVLIEGETGTGKELIA
CCHHHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHCEECCCCEEEEEECCCCCCHHHHH
RAIHDYGPHKDHPFIPINCSAIVGTLLESELFGHEKGAFTGAFATKKGKFELAGEGTIFL
HHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEECCCCEEEE
DEMGEIPIELQAKLLRFLQDKAFQRVGGEKFLHSKARVIVATNKDLLQMVRAGTFREDLY
ECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEECCHHHHHHHHHCCHHHHHH
YRLSAAKINVPPLRKRREDIPFLLDHMVKEINAELGKRIDRVDKKALLRMMEYDWPGNVR
EEEEECEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ELRNVLTGAAISTRGETLLDDAILPFLGAGTVQDIFPPGAALSLREVEREHILKILHYTN
HHHHHHHCCHHCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
GNITSSAQILGISRPTLRQKIRQYKILPQQ
CCCCCCEEEEECCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MCKKKILIIDDDASQLELLNIFFSGRGYAVHCSATAMAGLEARATFHPDVIVLDIRLPDM
CCCCEEEEEECCCHHEEEEEEEECCCCEEEEECHHHHCCCCCCEEECCCEEEEEEECCCC
DGIEVLRSLDTGKSSINVIMITAYHDMETTVKAMKLGAYEYITKPIDVDELEDAVCRALK
CHHHHHHHHCCCCCCEEEEEEEEECCHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHC
NSELREAKELPAVKTFLQKGPMIGNSKPMKEVFKMIGVLSENNVTVLIEGETGTGKELIA
CCHHHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHCEECCCCEEEEEECCCCCCHHHHH
RAIHDYGPHKDHPFIPINCSAIVGTLLESELFGHEKGAFTGAFATKKGKFELAGEGTIFL
HHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEECCCCEEEE
DEMGEIPIELQAKLLRFLQDKAFQRVGGEKFLHSKARVIVATNKDLLQMVRAGTFREDLY
ECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEECCHHHHHHHHHCCHHHHHH
YRLSAAKINVPPLRKRREDIPFLLDHMVKEINAELGKRIDRVDKKALLRMMEYDWPGNVR
EEEEECEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ELRNVLTGAAISTRGETLLDDAILPFLGAGTVQDIFPPGAALSLREVEREHILKILHYTN
HHHHHHHCCHHCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
GNITSSAQILGISRPTLRQKIRQYKILPQQ
CCCCCCEEEEECCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]