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The map label for this gene is rnc

Identifier: 85860141

GI number: 85860141

Start: 2348037

End: 2348759

Strand: Direct

Name: rnc

Synonym: SYN_00796

Alternate gene names: 85860141

Gene position: 2348037-2348759 (Clockwise)

Preceding gene: 85860140

Following gene: 85860142

Centisome position: 73.85

GC content: 53.39

Gene sequence:

>723_bases
ATGACGGAAGAACGACAAACGGCCCTGAAGAAACTGGAATCACATCTTTCCTGTGCGTTCCGCGACATCACTCTGCTTGA
TAACGCCCTGGTCCATCGCTCCTATGTCAATGAGAATCCATCCTTGTCCTTCGCGGACAATGAAAGGCTGGAATTCCTGG
GAGACGCTGTTCTCGAACTGTGCATCAGCGACCTGCTCATGAAGGCTTTTCCGGATTATTCTGAAGGGCAGTTGTCCAAG
CTGAGGGCCTCTGTCGTCAACGAACAGCCTCTAGCCGAACTGGCCAAAAAATGCCGAATCGGCAGTTTTATTCTCCTGGG
AAAAGGGGAAGAAAGTTCCGGCGGCCGTTCCAAACCATCGATCCTTGCCAATACGATGGAAGCCATCACGGCCGCGGTGT
TCCTGGACGGTGGGTTTGACCGGGCCTACGAATTCGTCCGTCGCCTTTTCACCCCCCTCATCGAGGAAGGAAACCGCAGC
GCCACCTATAAGGATTACAAAACGACCCTCCAGGAGCTCAGCCAGAACCGTTTCAGGGAAATTCCCCGATACAGGCTGAT
CGGCGAATACGGCCCCGACCATGACAAACTCTTCGAAAGCGGCCTTTCCATTCCCGGGATCATCGAAACAACCGGAAAAG
GAAAGAGCAAAAAAGAAGCGGAACAGCACGCGGCACACAAAGCGCTGGACGAACTGCTGAAGAATACCCATGAAGGAGAG
TGA

Upstream 100 bases:

>100_bases
TTCTCATGACCAATGCCGACGCCTCGCAGGTCAATCAACTGGTGCAGGTCCAGATTGAAAACATCGATGGCACAAGAATT
TCTGGAAGGATCATGACCCC

Downstream 100 bases:

>100_bases
ATTTTCCGTGGCATCCCCCCTGATTATCCCCGTTTTTCTGCCCTGGCAGGGCTGTCGGCAACGCTGCATCTTCTGCAACG
AAAGCATTACCACGGGAACA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MTEERQTALKKLESHLSCAFRDITLLDNALVHRSYVNENPSLSFADNERLEFLGDAVLELCISDLLMKAFPDYSEGQLSK
LRASVVNEQPLAELAKKCRIGSFILLGKGEESSGGRSKPSILANTMEAITAAVFLDGGFDRAYEFVRRLFTPLIEEGNRS
ATYKDYKTTLQELSQNRFREIPRYRLIGEYGPDHDKLFESGLSIPGIIETTGKGKSKKEAEQHAAHKALDELLKNTHEGE

Sequences:

>Translated_240_residues
MTEERQTALKKLESHLSCAFRDITLLDNALVHRSYVNENPSLSFADNERLEFLGDAVLELCISDLLMKAFPDYSEGQLSK
LRASVVNEQPLAELAKKCRIGSFILLGKGEESSGGRSKPSILANTMEAITAAVFLDGGFDRAYEFVRRLFTPLIEEGNRS
ATYKDYKTTLQELSQNRFREIPRYRLIGEYGPDHDKLFESGLSIPGIIETTGKGKSKKEAEQHAAHKALDELLKNTHEGE
>Mature_239_residues
TEERQTALKKLESHLSCAFRDITLLDNALVHRSYVNENPSLSFADNERLEFLGDAVLELCISDLLMKAFPDYSEGQLSKL
RASVVNEQPLAELAKKCRIGSFILLGKGEESSGGRSKPSILANTMEAITAAVFLDGGFDRAYEFVRRLFTPLIEEGNRSA
TYKDYKTTLQELSQNRFREIPRYRLIGEYGPDHDKLFESGLSIPGIIETTGKGKSKKEAEQHAAHKALDELLKNTHEGE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=229, Percent_Identity=28.82096069869, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI155030234, Length=229, Percent_Identity=28.82096069869, Blast_Score=98, Evalue=6e-21,
Organism=Escherichia coli, GI1788920, Length=226, Percent_Identity=36.7256637168142, Blast_Score=124, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI193202651, Length=223, Percent_Identity=30.0448430493274, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17506883, Length=223, Percent_Identity=30.0448430493274, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323895, Length=183, Percent_Identity=30.6010928961749, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17137682, Length=229, Percent_Identity=27.5109170305677, Blast_Score=88, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 26886; Mature: 26755

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2 ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEERQTALKKLESHLSCAFRDITLLDNALVHRSYVNENPSLSFADNERLEFLGDAVLEL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHH
CISDLLMKAFPDYSEGQLSKLRASVVNEQPLAELAKKCRIGSFILLGKGEESSGGRSKPS
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCHH
ILANTMEAITAAVFLDGGFDRAYEFVRRLFTPLIEEGNRSATYKDYKTTLQELSQNRFRE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
IPRYRLIGEYGPDHDKLFESGLSIPGIIETTGKGKSKKEAEQHAAHKALDELLKNTHEGE
CCHHHHHCCCCCCHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TEERQTALKKLESHLSCAFRDITLLDNALVHRSYVNENPSLSFADNERLEFLGDAVLEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHH
CISDLLMKAFPDYSEGQLSKLRASVVNEQPLAELAKKCRIGSFILLGKGEESSGGRSKPS
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCHH
ILANTMEAITAAVFLDGGFDRAYEFVRRLFTPLIEEGNRSATYKDYKTTLQELSQNRFRE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
IPRYRLIGEYGPDHDKLFESGLSIPGIIETTGKGKSKKEAEQHAAHKALDELLKNTHEGE
CCHHHHHCCCCCCHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA