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The map label for this gene is cysK [H]

Identifier: 85859830

GI number: 85859830

Start: 2066687

End: 2067574

Strand: Direct

Name: cysK [H]

Synonym: SYN_00446

Alternate gene names: 85859830

Gene position: 2066687-2067574 (Clockwise)

Preceding gene: 85859828

Following gene: 85859831

Centisome position: 65.0

GC content: 49.55

Gene sequence:

>888_bases
ATGGACACACATGATGTAATGGAACTGATAGGAAACACGCCTTTAATTCGGCTGAGAAACGAAAATATAATCGCCAAGGC
TGAATTTCTTAATCCTGGAGGAAGTATAAAAGACCGCATTGGCCTGGCAATGATCGAAGCGGCGGAACGGGATGGAACAC
TGAAACCGGGAATGAAAATTGTCGAGCCGACCTCGGGCAATACCGGAATTGGAATAACGCTCGTCGGGGCTGCAAAGGGA
TATGAAGTATTTATTGTCATGCCCGAAGGTATGAGCGAGGAGAGAAAGCATATCATTAAGGTTCTGGGCGGAAATCTCGT
TCTGACTCCGGACAGTGAGAACATAGCCGGCGCGATCAAAAAGGCGGAAGAACTTGTTGAAGAATTCCATGGATATATGC
CGAATCAATTCAAGAACCCTGCTAACGCACTGGCCCACTTCACACATACCGCGCCGGAACTCTGGAAACAGGCGGAACAT
AAAATCGATGCCTTTATTTCGGGAATTGGAAGCGGCGGAACGATTCAGGGGGTTGGCTCTTTTCTGAAGGAGAGGAATCC
GGACGTGACCATTGTGGCCGTGGAGCCCAAAAACGTATCCGCTCTTCTCGGTCATGAGCCGGGTTTACACCAGATCCAGG
GAATCGGGGATGGATTCATCCCTGAAATTCTCAACGTTTCCCTGATCGACAGAATAATTGAAGTCTCTGATGACGATGCA
ATCAGGACAACGCGTGAGCTTGCATCAAATAATTCTCTTTTATGCGGAACTTCATCCGGGGCAAACGTATGGGCCGCGAG
GCAGATAGCCATGGAACATCCGGAATGGACGATAGCCACGGTTCTTGCGGACCGGGCGGAACGGTATTTCAGCACCGGCT
TACTCTGA

Upstream 100 bases:

>100_bases
AAAAGAGGATGTGTTATGGAGTGCTCCAAATCATCGAAGACAGATTTCGTATTCTTGATTTTCAACTGCAAAAATTTAAA
GCTATGGGAAGTAACGGGAT

Downstream 100 bases:

>100_bases
GCGCAAACCGGCAGACGCGGAAACAACCCGTTTCAGACTGGAGCGGCAATCTTCATTTTCCCCTGGACAACTTCAGAGTA
TTAAAATGACAACCACGCTC

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MDTHDVMELIGNTPLIRLRNENIIAKAEFLNPGGSIKDRIGLAMIEAAERDGTLKPGMKIVEPTSGNTGIGITLVGAAKG
YEVFIVMPEGMSEERKHIIKVLGGNLVLTPDSENIAGAIKKAEELVEEFHGYMPNQFKNPANALAHFTHTAPELWKQAEH
KIDAFISGIGSGGTIQGVGSFLKERNPDVTIVAVEPKNVSALLGHEPGLHQIQGIGDGFIPEILNVSLIDRIIEVSDDDA
IRTTRELASNNSLLCGTSSGANVWAARQIAMEHPEWTIATVLADRAERYFSTGLL

Sequences:

>Translated_295_residues
MDTHDVMELIGNTPLIRLRNENIIAKAEFLNPGGSIKDRIGLAMIEAAERDGTLKPGMKIVEPTSGNTGIGITLVGAAKG
YEVFIVMPEGMSEERKHIIKVLGGNLVLTPDSENIAGAIKKAEELVEEFHGYMPNQFKNPANALAHFTHTAPELWKQAEH
KIDAFISGIGSGGTIQGVGSFLKERNPDVTIVAVEPKNVSALLGHEPGLHQIQGIGDGFIPEILNVSLIDRIIEVSDDDA
IRTTRELASNNSLLCGTSSGANVWAARQIAMEHPEWTIATVLADRAERYFSTGLL
>Mature_295_residues
MDTHDVMELIGNTPLIRLRNENIIAKAEFLNPGGSIKDRIGLAMIEAAERDGTLKPGMKIVEPTSGNTGIGITLVGAAKG
YEVFIVMPEGMSEERKHIIKVLGGNLVLTPDSENIAGAIKKAEELVEEFHGYMPNQFKNPANALAHFTHTAPELWKQAEH
KIDAFISGIGSGGTIQGVGSFLKERNPDVTIVAVEPKNVSALLGHEPGLHQIQGIGDGFIPEILNVSLIDRIIEVSDDDA
IRTTRELASNNSLLCGTSSGANVWAARQIAMEHPEWTIATVLADRAERYFSTGLL

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=308, Percent_Identity=37.987012987013, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI295821200, Length=308, Percent_Identity=37.987012987013, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI4557415, Length=308, Percent_Identity=37.987012987013, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI11345492, Length=280, Percent_Identity=26.7857142857143, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI2367138, Length=294, Percent_Identity=38.0952380952381, Blast_Score=222, Evalue=2e-59,
Organism=Escherichia coli, GI1788754, Length=304, Percent_Identity=45.7236842105263, Blast_Score=220, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=45, Blast_Score=251, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI17562970, Length=301, Percent_Identity=43.5215946843854, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI32566674, Length=297, Percent_Identity=43.0976430976431, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI115535073, Length=297, Percent_Identity=44.4444444444444, Blast_Score=225, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=41.7218543046358, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17534315, Length=313, Percent_Identity=38.6581469648562, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI32566672, Length=211, Percent_Identity=42.654028436019, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI25147552, Length=288, Percent_Identity=35.4166666666667, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71996324, Length=330, Percent_Identity=25.7575757575758, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17561716, Length=117, Percent_Identity=39.3162393162393, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321594, Length=317, Percent_Identity=36.2776025236593, Blast_Score=192, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=34.9693251533742, Blast_Score=133, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24643623, Length=262, Percent_Identity=38.1679389312977, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI20129101, Length=262, Percent_Identity=38.1679389312977, Blast_Score=185, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 31819; Mature: 31819

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTHDVMELIGNTPLIRLRNENIIAKAEFLNPGGSIKDRIGLAMIEAAERDGTLKPGMKI
CCHHHHHHHHCCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCEE
VEPTSGNTGIGITLVGAAKGYEVFIVMPEGMSEERKHIIKVLGGNLVLTPDSENIAGAIK
ECCCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCEEECCCCCHHHHHHH
KAEELVEEFHGYMPNQFKNPANALAHFTHTAPELWKQAEHKIDAFISGIGSGGTIQGVGS
HHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
FLKERNPDVTIVAVEPKNVSALLGHEPGLHQIQGIGDGFIPEILNVSLIDRIIEVSDDDA
HHHCCCCCEEEEEECCCCCEEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHH
IRTTRELASNNSLLCGTSSGANVWAARQIAMEHPEWTIATVLADRAERYFSTGLL
HHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDTHDVMELIGNTPLIRLRNENIIAKAEFLNPGGSIKDRIGLAMIEAAERDGTLKPGMKI
CCHHHHHHHHCCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCEE
VEPTSGNTGIGITLVGAAKGYEVFIVMPEGMSEERKHIIKVLGGNLVLTPDSENIAGAIK
ECCCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCEEECCCCCHHHHHHH
KAEELVEEFHGYMPNQFKNPANALAHFTHTAPELWKQAEHKIDAFISGIGSGGTIQGVGS
HHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
FLKERNPDVTIVAVEPKNVSALLGHEPGLHQIQGIGDGFIPEILNVSLIDRIIEVSDDDA
HHHCCCCCEEEEEECCCCCEEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHH
IRTTRELASNNSLLCGTSSGANVWAARQIAMEHPEWTIATVLADRAERYFSTGLL
HHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA