Click here to switch to the map view.

The map label for this gene is menA [H]

Identifier: 85859828

GI number: 85859828

Start: 2065344

End: 2066324

Strand: Direct

Name: menA [H]

Synonym: SYN_00445

Alternate gene names: 85859828

Gene position: 2065344-2066324 (Clockwise)

Preceding gene: 85859827

Following gene: 85859830

Centisome position: 64.96

GC content: 51.48

Gene sequence:

>981_bases
GTGTCTGCCATGCCGCTTAAAATAGACTTGACACATGCGAAGGAGGAAAGGGAACCAGGCGTCGTGGATCGATGGATTCA
GGCTTTCCGCCTTCAGTTCGTGCCCACAAGCATCTTCCCCGCCCTGCTGGGAAGCGTCATTGCCTGGGCGACTTTCCGGG
AATTTCATTTTCTATATTTTGTCATGGTCATTTCCGGGGTGGCACTGCATCATATCGGCCTCAACATGATCGATGACGTC
TTTGATTATCTCCACGCGGTGGACCGTTCCCACGGCGGAGAGAAAAATCCCTACACCGGCGGGAGCGGTGTTTTAGCGGG
GCGTCTTCTTTCAGCCAGAAATGTGTTTTGCGTATCGATTTTCTGCTATTTCCTTGCTCTGATCACGGCGGTTTACCTGA
CTCTATCCGTCGGCTGGCCCGTTCTGATCTTCGTGGGCATCGGTCTTTTTTCTTCCGTTTTTTACAGCGTGCCGCCCATA
CGGTACGGCTATCGGGGTTTCGGCGAGTTCAGCCTTCTTATCAATTTCGGCCCGGTAATCTGTCTGGGGGCTTTCTATGC
GCAGACCGGATCGATTGCCTGGGAACCCTTCATCATATCGCTGGTTCCCGGGTTTCTCATGTGGTCCATGATCGTTATCA
ACGAAATACCTGATTATGAAGAGGATCGCCAGGCAGGCAAACTGAACCTCGTTGCCCGCTTCGGGAAAAAAGCCGGTATC
CTCCTGTATTCAGCCGGACTGATCAGCGCTTACGCCACTCTGCTCCTGGCTGTCTTCTTCGGCGTCTCATCGCTCCAGGT
ACTCCTTGGATTCCTGTCGATCCCTGCCGCCTTCAATTCCCTCATAATATTAAGAAAAAATTATCACGACAGACTGAAGA
TGGCCCCTGCCAATCTTGCCGCTATCAAAGTCCACGCGTTTACACTGAGCTTTCTGATTATTGGATATCTGGCAAAAGGA
GTTCAGGTAAACTTGTTGTGA

Upstream 100 bases:

>100_bases
TTTTACTGCCTTCCCTGTCCCATGGAAGACTTCAATGCCAATCCATGGTATTATTAATTTCCGGTCCTCAAATAAAGACA
GAATATCAAGGATATCCGAG

Downstream 100 bases:

>100_bases
TATTGTTGATTTGTAATCAGCATGCAAGCGTGCGTCATCCCTTGATCCGTTCATTCCCGCCTTTCATAAGACCCTGTTGG
CGCAATTGATCTGCAGACCG

Product: 1,4-dihydroxy-2-naphthoate polyprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MSAMPLKIDLTHAKEEREPGVVDRWIQAFRLQFVPTSIFPALLGSVIAWATFREFHFLYFVMVISGVALHHIGLNMIDDV
FDYLHAVDRSHGGEKNPYTGGSGVLAGRLLSARNVFCVSIFCYFLALITAVYLTLSVGWPVLIFVGIGLFSSVFYSVPPI
RYGYRGFGEFSLLINFGPVICLGAFYAQTGSIAWEPFIISLVPGFLMWSMIVINEIPDYEEDRQAGKLNLVARFGKKAGI
LLYSAGLISAYATLLLAVFFGVSSLQVLLGFLSIPAAFNSLIILRKNYHDRLKMAPANLAAIKVHAFTLSFLIIGYLAKG
VQVNLL

Sequences:

>Translated_326_residues
MSAMPLKIDLTHAKEEREPGVVDRWIQAFRLQFVPTSIFPALLGSVIAWATFREFHFLYFVMVISGVALHHIGLNMIDDV
FDYLHAVDRSHGGEKNPYTGGSGVLAGRLLSARNVFCVSIFCYFLALITAVYLTLSVGWPVLIFVGIGLFSSVFYSVPPI
RYGYRGFGEFSLLINFGPVICLGAFYAQTGSIAWEPFIISLVPGFLMWSMIVINEIPDYEEDRQAGKLNLVARFGKKAGI
LLYSAGLISAYATLLLAVFFGVSSLQVLLGFLSIPAAFNSLIILRKNYHDRLKMAPANLAAIKVHAFTLSFLIIGYLAKG
VQVNLL
>Mature_325_residues
SAMPLKIDLTHAKEEREPGVVDRWIQAFRLQFVPTSIFPALLGSVIAWATFREFHFLYFVMVISGVALHHIGLNMIDDVF
DYLHAVDRSHGGEKNPYTGGSGVLAGRLLSARNVFCVSIFCYFLALITAVYLTLSVGWPVLIFVGIGLFSSVFYSVPPIR
YGYRGFGEFSLLINFGPVICLGAFYAQTGSIAWEPFIISLVPGFLMWSMIVINEIPDYEEDRQAGKLNLVARFGKKAGIL
LYSAGLISAYATLLLAVFFGVSSLQVLLGFLSIPAAFNSLIILRKNYHDRLKMAPANLAAIKVHAFTLSFLIIGYLAKGV
QVNLL

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=280, Percent_Identity=25, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1790365, Length=283, Percent_Identity=25.4416961130742, Blast_Score=75, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17737429, Length=288, Percent_Identity=26.3888888888889, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011937
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 36007; Mature: 35876

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAMPLKIDLTHAKEEREPGVVDRWIQAFRLQFVPTSIFPALLGSVIAWATFREFHFLYF
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
VMVISGVALHHIGLNMIDDVFDYLHAVDRSHGGEKNPYTGGSGVLAGRLLSARNVFCVSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHH
FCYFLALITAVYLTLSVGWPVLIFVGIGLFSSVFYSVPPIRYGYRGFGEFSLLINFGPVI
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHH
CLGAFYAQTGSIAWEPFIISLVPGFLMWSMIVINEIPDYEEDRQAGKLNLVARFGKKAGI
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHCCCCCE
LLYSAGLISAYATLLLAVFFGVSSLQVLLGFLSIPAAFNSLIILRKNYHDRLKMAPANLA
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHCCCCCHH
AIKVHAFTLSFLIIGYLAKGVQVNLL
EEHHHHHHHHHHHHHHHHCCCEEECC
>Mature Secondary Structure 
SAMPLKIDLTHAKEEREPGVVDRWIQAFRLQFVPTSIFPALLGSVIAWATFREFHFLYF
CCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
VMVISGVALHHIGLNMIDDVFDYLHAVDRSHGGEKNPYTGGSGVLAGRLLSARNVFCVSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHH
FCYFLALITAVYLTLSVGWPVLIFVGIGLFSSVFYSVPPIRYGYRGFGEFSLLINFGPVI
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHH
CLGAFYAQTGSIAWEPFIISLVPGFLMWSMIVINEIPDYEEDRQAGKLNLVARFGKKAGI
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHCCCCCE
LLYSAGLISAYATLLLAVFFGVSSLQVLLGFLSIPAAFNSLIILRKNYHDRLKMAPANLA
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHCCCCCHH
AIKVHAFTLSFLIIGYLAKGVQVNLL
EEHHHHHHHHHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]