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The map label for this gene is 85859770

Identifier: 85859770

GI number: 85859770

Start: 2004410

End: 2005720

Strand: Direct

Name: 85859770

Synonym: SYN_02870

Alternate gene names: NA

Gene position: 2004410-2005720 (Clockwise)

Preceding gene: 85859769

Following gene: 85859771

Centisome position: 63.05

GC content: 54.08

Gene sequence:

>1311_bases
ATGAAAAAAGCACGGAAAACCGGTTTGATTTTCTTCCCGGCTTTTGACTGGGCCATTTCGCCTACTCATCCGGAAAGAGA
AGAACGCCTGCTCTATACCCAGGATCAGGTTTTTGAAGAAGGCCTTCTTGATCTGGAAAACATTATTGAGTATAAACCCT
CCATCGCTTCCTACTCGGACATCAACCGCGTTCATTTCTGCGTTCCCGATGCCCGTGCCGTAACGACGGAGTCTCATCTG
ATTGCAGCCGGCGGGGCGATCACCGCAGCGGAGAAGGTCATGAACAAAGAGGTGGATAACGCCTTTGCCCTTGTCCGCCC
TCCGGGACATCACGCCATGCTTGTCGTTCACGGAGCGAGAGGGTTCTGCAATGTCAACATGGAAGCCATCATGATCGAAT
ACATCCGGCACCATTACGGTCACCGGCGGATTGCCGTCGTGGATACGGACTGCCACCATGGCGACGGCACCCAGGACATT
TACTGGAACGATCCTGATACGCTGTGCATCTCCATCCATCAGGACGGTCGGACCCTGTACCCAGGTTCCGGCTTTCATGA
AGAGTTCGGCGGGCCAAACGCCCTGGGAACCACCCTGAATATTCCCCTGCCTCCCAGAACCTCCGATGAGGGGTTTCTTC
ATGTCCTGGACAAGGCCATCCTGCCCATTCTTTCTGAATTCAAGCCGGATCTGATCATCAATTCGGCCGGTCAGGACAAT
CATTTTTCAGACCCGATCACGGACATGCGCTTCAGCGCACAAGGTTACGCCATACTGAACGATCGACTGTCCCCGGATAT
TGCCGTCCTGGAGGGCGGCTACTCTATCGAGAAGGCGCTTCCCTATGTCAATGTGGGCATCATCCTGGCGATGGCCGGTC
TAGATTACAGTCATGTTCGAGAGCCGGAATACGACCCGTCGCGGTTCAGGCAGTCGGAGGAGATCTCCAGCCAGGTAGCA
CAGGAGGCGGAAGAGATTTATGAGCTCTGGTCGCGTCGGAATGAACTGCGGGAAAGGATGATCGGCGATGCAAAATATAT
GAAACGCCGAAAAGGGGTCTATTACGATACGGACGGCATCAGCGAACAGCAGGAAACGATCGTCCGGATATGCAGCGATT
GCGGCGGCGTTGTAATGGTCAACTCCCGTTCTGATCTGGGAAACCATATCTTCGCCGTGACAATCCCCTGGAACGCCTGT
CGTGAGTGCCGCCGCGAAGGCGAAAGCGCGTATGACAAGGCGCAGAAAAAAGACGGATATCAGCACATCTACCTTCAGGA
TAAGGACAGAGACCTGTACCTGGTTAAATGA

Upstream 100 bases:

>100_bases
TCAACATGGTCAGAGATTTCTATATGACAGGGAAAAATATTCGCGTCAAACTGCAGGTCAAGCCCGGTCTTATTGCGGGG
TTTAAAACAGGAGAATTGTC

Downstream 100 bases:

>100_bases
CCGGCCACACCGGCACATCGTTTCCGGAATCCCGGCAGTTTAAAGATCCGGAAAAGCAAACTCGGCAGAAAGGAGCAATT
TTAACATTGGATGAGGAAGC

Product: histone deacetylase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MKKARKTGLIFFPAFDWAISPTHPEREERLLYTQDQVFEEGLLDLENIIEYKPSIASYSDINRVHFCVPDARAVTTESHL
IAAGGAITAAEKVMNKEVDNAFALVRPPGHHAMLVVHGARGFCNVNMEAIMIEYIRHHYGHRRIAVVDTDCHHGDGTQDI
YWNDPDTLCISIHQDGRTLYPGSGFHEEFGGPNALGTTLNIPLPPRTSDEGFLHVLDKAILPILSEFKPDLIINSAGQDN
HFSDPITDMRFSAQGYAILNDRLSPDIAVLEGGYSIEKALPYVNVGIILAMAGLDYSHVREPEYDPSRFRQSEEISSQVA
QEAEEIYELWSRRNELRERMIGDAKYMKRRKGVYYDTDGISEQQETIVRICSDCGGVVMVNSRSDLGNHIFAVTIPWNAC
RECRREGESAYDKAQKKDGYQHIYLQDKDRDLYLVK

Sequences:

>Translated_436_residues
MKKARKTGLIFFPAFDWAISPTHPEREERLLYTQDQVFEEGLLDLENIIEYKPSIASYSDINRVHFCVPDARAVTTESHL
IAAGGAITAAEKVMNKEVDNAFALVRPPGHHAMLVVHGARGFCNVNMEAIMIEYIRHHYGHRRIAVVDTDCHHGDGTQDI
YWNDPDTLCISIHQDGRTLYPGSGFHEEFGGPNALGTTLNIPLPPRTSDEGFLHVLDKAILPILSEFKPDLIINSAGQDN
HFSDPITDMRFSAQGYAILNDRLSPDIAVLEGGYSIEKALPYVNVGIILAMAGLDYSHVREPEYDPSRFRQSEEISSQVA
QEAEEIYELWSRRNELRERMIGDAKYMKRRKGVYYDTDGISEQQETIVRICSDCGGVVMVNSRSDLGNHIFAVTIPWNAC
RECRREGESAYDKAQKKDGYQHIYLQDKDRDLYLVK
>Mature_436_residues
MKKARKTGLIFFPAFDWAISPTHPEREERLLYTQDQVFEEGLLDLENIIEYKPSIASYSDINRVHFCVPDARAVTTESHL
IAAGGAITAAEKVMNKEVDNAFALVRPPGHHAMLVVHGARGFCNVNMEAIMIEYIRHHYGHRRIAVVDTDCHHGDGTQDI
YWNDPDTLCISIHQDGRTLYPGSGFHEEFGGPNALGTTLNIPLPPRTSDEGFLHVLDKAILPILSEFKPDLIINSAGQDN
HFSDPITDMRFSAQGYAILNDRLSPDIAVLEGGYSIEKALPYVNVGIILAMAGLDYSHVREPEYDPSRFRQSEEISSQVA
QEAEEIYELWSRRNELRERMIGDAKYMKRRKGVYYDTDGISEQQETIVRICSDCGGVVMVNSRSDLGNHIFAVTIPWNAC
RECRREGESAYDKAQKKDGYQHIYLQDKDRDLYLVK

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=228, Percent_Identity=35.9649122807018, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI30795202, Length=208, Percent_Identity=35.5769230769231, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI30795204, Length=208, Percent_Identity=35.5769230769231, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI17158039, Length=208, Percent_Identity=35.5769230769231, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI148539870, Length=207, Percent_Identity=35.2657004830918, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI169234807, Length=207, Percent_Identity=35.2657004830918, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI153085395, Length=208, Percent_Identity=32.6923076923077, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI20070354, Length=215, Percent_Identity=36.7441860465116, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI62750349, Length=209, Percent_Identity=34.9282296650718, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI62750347, Length=209, Percent_Identity=34.9282296650718, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI13128862, Length=287, Percent_Identity=25.4355400696864, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI226529806, Length=129, Percent_Identity=38.7596899224806, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI13128860, Length=203, Percent_Identity=25.1231527093596, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI293336691, Length=180, Percent_Identity=25, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI8923769, Length=200, Percent_Identity=27, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI262073088, Length=162, Percent_Identity=25.9259259259259, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193209491, Length=216, Percent_Identity=34.2592592592593, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17540334, Length=206, Percent_Identity=31.0679611650485, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI193206283, Length=206, Percent_Identity=31.0679611650485, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17540332, Length=206, Percent_Identity=31.0679611650485, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25154020, Length=208, Percent_Identity=32.6923076923077, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25154022, Length=208, Percent_Identity=32.2115384615385, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17537347, Length=231, Percent_Identity=30.3030303030303, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508561, Length=287, Percent_Identity=23.3449477351916, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17534739, Length=220, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17561978, Length=286, Percent_Identity=22.7272727272727, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324307, Length=237, Percent_Identity=31.6455696202532, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321244, Length=293, Percent_Identity=24.9146757679181, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323999, Length=203, Percent_Identity=26.6009852216749, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24642144, Length=272, Percent_Identity=29.7794117647059, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24642142, Length=272, Percent_Identity=29.7794117647059, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24642146, Length=272, Percent_Identity=29.7794117647059, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI281360899, Length=272, Percent_Identity=29.7794117647059, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI281360799, Length=215, Percent_Identity=33.953488372093, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24641720, Length=215, Percent_Identity=33.953488372093, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281360801, Length=215, Percent_Identity=33.953488372093, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24644244, Length=293, Percent_Identity=24.5733788395904, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24657891, Length=201, Percent_Identity=25.8706467661692, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286
- InterPro:   IPR003084 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 49337; Mature: 49337

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKARKTGLIFFPAFDWAISPTHPEREERLLYTQDQVFEEGLLDLENIIEYKPSIASYSD
CCCCCCCCEEEEEEECCEECCCCCCHHHCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
INRVHFCVPDARAVTTESHLIAAGGAITAAEKVMNKEVDNAFALVRPPGHHAMLVVHGAR
CCEEEEECCCCCEEECCCEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCEEEEEEECCC
GFCNVNMEAIMIEYIRHHYGHRRIAVVDTDCHHGDGTQDIYWNDPDTLCISIHQDGRTLY
CEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCCCEEEEEEECCCCEEC
PGSGFHEEFGGPNALGTTLNIPLPPRTSDEGFLHVLDKAILPILSEFKPDLIINSAGQDN
CCCCCHHHCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
HFSDPITDMRFSAQGYAILNDRLSPDIAVLEGGYSIEKALPYVNVGIILAMAGLDYSHVR
CCCCCCHHCEECCCCEEEECCCCCCCEEEEECCCCHHHHCCCHHHHHHHHHHCCCHHHCC
EPEYDPSRFRQSEEISSQVAQEAEEIYELWSRRNELRERMIGDAKYMKRRKGVYYDTDGI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCEECCCCC
SEQQETIVRICSDCGGVVMVNSRSDLGNHIFAVTIPWNACRECRREGESAYDKAQKKDGY
CHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECHHHHHHHHHCCHHHHHHHHHCCCC
QHIYLQDKDRDLYLVK
EEEEEECCCCCEEEEC
>Mature Secondary Structure
MKKARKTGLIFFPAFDWAISPTHPEREERLLYTQDQVFEEGLLDLENIIEYKPSIASYSD
CCCCCCCCEEEEEEECCEECCCCCCHHHCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
INRVHFCVPDARAVTTESHLIAAGGAITAAEKVMNKEVDNAFALVRPPGHHAMLVVHGAR
CCEEEEECCCCCEEECCCEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCEEEEEEECCC
GFCNVNMEAIMIEYIRHHYGHRRIAVVDTDCHHGDGTQDIYWNDPDTLCISIHQDGRTLY
CEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCCCEEEEEEECCCCEEC
PGSGFHEEFGGPNALGTTLNIPLPPRTSDEGFLHVLDKAILPILSEFKPDLIINSAGQDN
CCCCCHHHCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
HFSDPITDMRFSAQGYAILNDRLSPDIAVLEGGYSIEKALPYVNVGIILAMAGLDYSHVR
CCCCCCHHCEECCCCEEEECCCCCCCEEEEECCCCHHHHCCCHHHHHHHHHHCCCHHHCC
EPEYDPSRFRQSEEISSQVAQEAEEIYELWSRRNELRERMIGDAKYMKRRKGVYYDTDGI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCEECCCCC
SEQQETIVRICSDCGGVVMVNSRSDLGNHIFAVTIPWNACRECRREGESAYDKAQKKDGY
CHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECHHHHHHHHHCCHHHHHHHHHCCCC
QHIYLQDKDRDLYLVK
EEEEEECCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]