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The map label for this gene is hyuA [H]

Identifier: 85859769

GI number: 85859769

Start: 2002737

End: 2004413

Strand: Direct

Name: hyuA [H]

Synonym: SYN_02869

Alternate gene names: 85859769

Gene position: 2002737-2004413 (Clockwise)

Preceding gene: 85859764

Following gene: 85859770

Centisome position: 62.99

GC content: 52.36

Gene sequence:

>1677_bases
ATGATTCTCGGCATTGACGTTGGAGGAACGCATACGGACGCCGTTCTGATAGAATCCGGTCGGATTCGAAAAACGGCCAA
AGTCACCACTTCTCCGGATCGCATCGTGGATTCACTATCCGGAATCGCACAAGACCTGCTGAAAGGCGAATCCCTTGAAA
AAATCCAGCGCATTGTGCTCAGCACAACACTTTCCACCAACGCCATTGTACAGAACAAAGTGGATCCCGTCGGGCTTCTG
GTCATCAGTGGCCCCGGTCTTTCTCCATCGCATTTTGAAATCGGAGGCAACACCCGTTTTCTGTCCGGCTATGTCAATCA
TCGCGGCATAGAAACGGCACCCATTGATCCGGCTGAAGTTACCCGATTTCATGAAGAGTTCCTGCGGAAGGGATTAAAAC
ATGTCGGCATTGTCGGCAAATTTTCGACCCGCAACCCGAATCAGGAACTACAGGTAGAAAAGAGCATCCACAACGGTCTT
GATCATGTTTCCTTAGGCCACCGGATGTCCGGCCATCTCAATTTCCCGAGACGCGTTGCCACGACCTATCTGAATGAAGC
CGTCTGGGAGCGCTATTCATCTTTTGTCCGGCAGGTCATTTCTTTTTTTCAGGGATTGGGGCTTTCCGTTCCTGTTTACA
TTCTGAAAGCAGATGGCGGCACGTTTGAAATCCAACACTCCGTTGAGTTTCCGGTTTACACCATCCTGTCCGGACCTGCC
GCCAGCATCATGGGCATTCTCAGCATGACGCCGGATAACAAAAATGATGCCATTGCCCTGGACATCGGCGGCACCACGAC
GGACATCGCCGTTTTTGCCGATGGCGTCCCCCTTCTCGAGGCTTTCGGGGTCACAATGGAAAATCACAAGACGCTGATCC
GGGGGCTTCGTTCAAAGCCTGTGGGAATCGGCGGCGACAGTATGGTATATGTCAAAGACGGTCAAATTCTCATTGGGCCC
GAACGAAAAGGCCCAGCCGCTGCCTTTGACGGACCCTGCCCGACCCCTACGGATGCCATGATTTTCCTTGGCTTGACCGA
CATCGGCAACCGTTCAAAGGCCGAAAAGGCCGTTCAGAGCATCGCTGAGATCATGGGGATTACGGTACAGGAAGCGGCAG
AAATCATCTTTGAGAATACCTGCGAAAAAATTGCGCTCCATGTCCATTCTGTCATCGAAGAAATCAACAATCAGCCGGTC
TATACCATCCATGAGCTCCTGGAAGGTAAAAAAATATCCCCCAAAATCCTTTATATTATCGGCGGGCCGGCGAAACCCAT
GTCCACCCGTCTGGGGCAACTGCTGGGATGTCCTGTCTGCGTCCCTTCCTACTATGAAGTGGCCAACGCCATCGGAACCG
CCCTGGCCCGAACGACCGCCGAACTGACGATTCTCGCCGATACCGAACAGGGAACAATGACCATCGGCGAGGAAGGCATC
CAGGAAAAGCTTCCCTCCCGCTTTACCAGAGAAGATGCCATTGAAACCGGCAGGCGCATGCTCAGGGAAAGAGCCCTGCG
CCTCGGCGCGCGGGCGGAGGATCTGGAAATTGAAGTCATTGAAGATCAGGAATTCAACATGGTCAGAGATTTCTATATGA
CAGGGAAAAATATTCGCGTCAAACTGCAGGTCAAGCCCGGTCTTATTGCGGGGTTTAAAACAGGAGAATTGTCATGA

Upstream 100 bases:

>100_bases
TTGAGACGGAAACATACGCCTTTTTTTTGCCTTGTCAAGACAAAAAATTACCAGTATATGAAATGAGTTATTTTTCATTA
CACAGGAGCGAGGTATCCCA

Downstream 100 bases:

>100_bases
AAAAAGCACGGAAAACCGGTTTGATTTTCTTCCCGGCTTTTGACTGGGCCATTTCGCCTACTCATCCGGAAAGAGAAGAA
CGCCTGCTCTATACCCAGGA

Product: hydantoinase/oxoprolinase family protein

Products: NA

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MILGIDVGGTHTDAVLIESGRIRKTAKVTTSPDRIVDSLSGIAQDLLKGESLEKIQRIVLSTTLSTNAIVQNKVDPVGLL
VISGPGLSPSHFEIGGNTRFLSGYVNHRGIETAPIDPAEVTRFHEEFLRKGLKHVGIVGKFSTRNPNQELQVEKSIHNGL
DHVSLGHRMSGHLNFPRRVATTYLNEAVWERYSSFVRQVISFFQGLGLSVPVYILKADGGTFEIQHSVEFPVYTILSGPA
ASIMGILSMTPDNKNDAIALDIGGTTTDIAVFADGVPLLEAFGVTMENHKTLIRGLRSKPVGIGGDSMVYVKDGQILIGP
ERKGPAAAFDGPCPTPTDAMIFLGLTDIGNRSKAEKAVQSIAEIMGITVQEAAEIIFENTCEKIALHVHSVIEEINNQPV
YTIHELLEGKKISPKILYIIGGPAKPMSTRLGQLLGCPVCVPSYYEVANAIGTALARTTAELTILADTEQGTMTIGEEGI
QEKLPSRFTREDAIETGRRMLRERALRLGARAEDLEIEVIEDQEFNMVRDFYMTGKNIRVKLQVKPGLIAGFKTGELS

Sequences:

>Translated_558_residues
MILGIDVGGTHTDAVLIESGRIRKTAKVTTSPDRIVDSLSGIAQDLLKGESLEKIQRIVLSTTLSTNAIVQNKVDPVGLL
VISGPGLSPSHFEIGGNTRFLSGYVNHRGIETAPIDPAEVTRFHEEFLRKGLKHVGIVGKFSTRNPNQELQVEKSIHNGL
DHVSLGHRMSGHLNFPRRVATTYLNEAVWERYSSFVRQVISFFQGLGLSVPVYILKADGGTFEIQHSVEFPVYTILSGPA
ASIMGILSMTPDNKNDAIALDIGGTTTDIAVFADGVPLLEAFGVTMENHKTLIRGLRSKPVGIGGDSMVYVKDGQILIGP
ERKGPAAAFDGPCPTPTDAMIFLGLTDIGNRSKAEKAVQSIAEIMGITVQEAAEIIFENTCEKIALHVHSVIEEINNQPV
YTIHELLEGKKISPKILYIIGGPAKPMSTRLGQLLGCPVCVPSYYEVANAIGTALARTTAELTILADTEQGTMTIGEEGI
QEKLPSRFTREDAIETGRRMLRERALRLGARAEDLEIEVIEDQEFNMVRDFYMTGKNIRVKLQVKPGLIAGFKTGELS
>Mature_558_residues
MILGIDVGGTHTDAVLIESGRIRKTAKVTTSPDRIVDSLSGIAQDLLKGESLEKIQRIVLSTTLSTNAIVQNKVDPVGLL
VISGPGLSPSHFEIGGNTRFLSGYVNHRGIETAPIDPAEVTRFHEEFLRKGLKHVGIVGKFSTRNPNQELQVEKSIHNGL
DHVSLGHRMSGHLNFPRRVATTYLNEAVWERYSSFVRQVISFFQGLGLSVPVYILKADGGTFEIQHSVEFPVYTILSGPA
ASIMGILSMTPDNKNDAIALDIGGTTTDIAVFADGVPLLEAFGVTMENHKTLIRGLRSKPVGIGGDSMVYVKDGQILIGP
ERKGPAAAFDGPCPTPTDAMIFLGLTDIGNRSKAEKAVQSIAEIMGITVQEAAEIIFENTCEKIALHVHSVIEEINNQPV
YTIHELLEGKKISPKILYIIGGPAKPMSTRLGQLLGCPVCVPSYYEVANAIGTALARTTAELTILADTEQGTMTIGEEGI
QEKLPSRFTREDAIETGRRMLRERALRLGARAEDLEIEVIEDQEFNMVRDFYMTGKNIRVKLQVKPGLIAGFKTGELS

Specific function: HyuA and hyuB convert D- and L-substituted hydantoins to corresponding N-carbamyl-amino acids [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI133901900, Length=390, Percent_Identity=25.1282051282051, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322634, Length=456, Percent_Identity=25, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45550492, Length=536, Percent_Identity=24.8134328358209, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: NA

Molecular weight: Translated: 60645; Mature: 60645

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILGIDVGGTHTDAVLIESGRIRKTAKVTTSPDRIVDSLSGIAQDLLKGESLEKIQRIVL
CEEEEECCCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
STTLSTNAIVQNKVDPVGLLVISGPGLSPSHFEIGGNTRFLSGYVNHRGIETAPIDPAEV
HHHCCCCHHECCCCCCEEEEEEECCCCCCCEEEECCCEEEEEEHHCCCCCCCCCCCHHHH
TRFHEEFLRKGLKHVGIVGKFSTRNPNQELQVEKSIHNGLDHVSLGHRMSGHLNFPRRVA
HHHHHHHHHHHHHHCEEEEEECCCCCCHHHEEHHHHHCCCCHHHCCCCCCCCCCCCHHHH
TTYLNEAVWERYSSFVRQVISFFQGLGLSVPVYILKADGGTFEIQHSVEFPVYTILSGPA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCCCCEEEEECCCH
ASIMGILSMTPDNKNDAIALDIGGTTTDIAVFADGVPLLEAFGVTMENHKTLIRGLRSKP
HHHHHHHEECCCCCCCEEEEEECCCCEEEEEEECCCHHHHHHCCCHHHHHHHHHHHHCCC
VGIGGDSMVYVKDGQILIGPERKGPAAAFDGPCPTPTDAMIFLGLTDIGNRSKAEKAVQS
CCCCCCCEEEEECCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHH
IAEIMGITVQEAAEIIFENTCEKIALHVHSVIEEINNQPVYTIHELLEGKKISPKILYII
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEE
GGPAKPMSTRLGQLLGCPVCVPSYYEVANAIGTALARTTAELTILADTEQGTMTIGEEGI
CCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCCEEECHHHH
QEKLPSRFTREDAIETGRRMLRERALRLGARAEDLEIEVIEDQEFNMVRDFYMTGKNIRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHCCCCCEEE
KLQVKPGLIAGFKTGELS
EEEECCCEEECCCCCCCC
>Mature Secondary Structure
MILGIDVGGTHTDAVLIESGRIRKTAKVTTSPDRIVDSLSGIAQDLLKGESLEKIQRIVL
CEEEEECCCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
STTLSTNAIVQNKVDPVGLLVISGPGLSPSHFEIGGNTRFLSGYVNHRGIETAPIDPAEV
HHHCCCCHHECCCCCCEEEEEEECCCCCCCEEEECCCEEEEEEHHCCCCCCCCCCCHHHH
TRFHEEFLRKGLKHVGIVGKFSTRNPNQELQVEKSIHNGLDHVSLGHRMSGHLNFPRRVA
HHHHHHHHHHHHHHCEEEEEECCCCCCHHHEEHHHHHCCCCHHHCCCCCCCCCCCCHHHH
TTYLNEAVWERYSSFVRQVISFFQGLGLSVPVYILKADGGTFEIQHSVEFPVYTILSGPA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCCCCEEEEECCCH
ASIMGILSMTPDNKNDAIALDIGGTTTDIAVFADGVPLLEAFGVTMENHKTLIRGLRSKP
HHHHHHHEECCCCCCCEEEEEECCCCEEEEEEECCCHHHHHHCCCHHHHHHHHHHHHCCC
VGIGGDSMVYVKDGQILIGPERKGPAAAFDGPCPTPTDAMIFLGLTDIGNRSKAEKAVQS
CCCCCCCEEEEECCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHH
IAEIMGITVQEAAEIIFENTCEKIALHVHSVIEEINNQPVYTIHELLEGKKISPKILYII
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEE
GGPAKPMSTRLGQLLGCPVCVPSYYEVANAIGTALARTTAELTILADTEQGTMTIGEEGI
CCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCCEEECHHHH
QEKLPSRFTREDAIETGRRMLRERALRLGARAEDLEIEVIEDQEFNMVRDFYMTGKNIRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHCCCCCEEE
KLQVKPGLIAGFKTGELS
EEEECCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1732229 [H]