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The map label for this gene is hbd [H]

Identifier: 85859759

GI number: 85859759

Start: 1994999

End: 1995850

Strand: Direct

Name: hbd [H]

Synonym: SYN_01310

Alternate gene names: 85859759

Gene position: 1994999-1995850 (Clockwise)

Preceding gene: 85859756

Following gene: 85859760

Centisome position: 62.75

GC content: 49.06

Gene sequence:

>852_bases
ATGCAGGTGAAAAAACTGGGTGTTCTTGGCGCAGGCGCCATGGGCGCGGGTATTGCCCATTTAGCTGCTCAACGAGGCAT
TGAAGTTGTTCTTTGTGATATTGATATGAAATTTGTCGATGGCGGTGTTGCTCGGATGGAAAAGCTGATGGCCGGCTCCA
TCAAAAAAGGGAAAATGACCGAAGACGAAGCAAAGGCCGTTCTCGGAAGAATAAAGAAAACCGTACAGATGGAAGACTTT
GCCGACTGCGATTTCATCGTTGAGGCCATTATCGAAAACCTGAAAATCAAGCAGGATGCCTTTTCAAAACTGGATACGAT
TACACGGCCTGAAGTCATTCTGGCCTCGAATACCTCATCCATGTCCCTGACTGAAATCGCCGCCGCCACGAAACGGCCGG
AAAAGGTCGTCGGCATGCATTTCTTCAATCCTCCCCAGGTCATGAAACTCGTTGAAATCATCAGAGGTTATTATACTTCC
GACGAAACCTTCAAGGCGACGGAGGAATTTTCCAAGCAGCTGGGCAAGATCACCGTAGAAATCAAAAAGGATGCCCCGGG
CTTTGTCGTCAACAGAGTCATGATGGCCTCTGCCATGGAAGCCATGAAGCTCTACGAAGAAGGCGTCGCCAGTATGGAAG
ATATCGATCAGGCCGTCAAGCTGGGTCTGAACGCTCCCATGGGACCTTTTGAATTGATGGATTTTGTCGGCATCGATATC
AACAAATCAATCCTTGACTATTTAGCCGATGAAACAATGGACGTCCGCTGGAATCCCCCTCTATCCATCAAACTGCTGCT
GAAATCAGGCAGGCTGGGTCGCAAAAACGGCGCCGGCTGGTACAAGTACTAA

Upstream 100 bases:

>100_bases
CGCGTCATCCCGCGCCGATTTTCGGATAAAAGCCTTGACAGCGTCATTTCTATAAATGTATAAACCCGTTAAAATATCAG
CTTAGAGGAGGATTATACAG

Downstream 100 bases:

>100_bases
GTGACAGGGGGACAAAATCTCATGGCATATGAAACGATACTCCTCAAAATCGAGGGTAATATTGCAACGATAACGATCAA
TCGCCCCCCCATGAATCCCC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MQVKKLGVLGAGAMGAGIAHLAAQRGIEVVLCDIDMKFVDGGVARMEKLMAGSIKKGKMTEDEAKAVLGRIKKTVQMEDF
ADCDFIVEAIIENLKIKQDAFSKLDTITRPEVILASNTSSMSLTEIAAATKRPEKVVGMHFFNPPQVMKLVEIIRGYYTS
DETFKATEEFSKQLGKITVEIKKDAPGFVVNRVMMASAMEAMKLYEEGVASMEDIDQAVKLGLNAPMGPFELMDFVGIDI
NKSILDYLADETMDVRWNPPLSIKLLLKSGRLGRKNGAGWYKY

Sequences:

>Translated_283_residues
MQVKKLGVLGAGAMGAGIAHLAAQRGIEVVLCDIDMKFVDGGVARMEKLMAGSIKKGKMTEDEAKAVLGRIKKTVQMEDF
ADCDFIVEAIIENLKIKQDAFSKLDTITRPEVILASNTSSMSLTEIAAATKRPEKVVGMHFFNPPQVMKLVEIIRGYYTS
DETFKATEEFSKQLGKITVEIKKDAPGFVVNRVMMASAMEAMKLYEEGVASMEDIDQAVKLGLNAPMGPFELMDFVGIDI
NKSILDYLADETMDVRWNPPLSIKLLLKSGRLGRKNGAGWYKY
>Mature_283_residues
MQVKKLGVLGAGAMGAGIAHLAAQRGIEVVLCDIDMKFVDGGVARMEKLMAGSIKKGKMTEDEAKAVLGRIKKTVQMEDF
ADCDFIVEAIIENLKIKQDAFSKLDTITRPEVILASNTSSMSLTEIAAATKRPEKVVGMHFFNPPQVMKLVEIIRGYYTS
DETFKATEEFSKQLGKITVEIKKDAPGFVVNRVMMASAMEAMKLYEEGVASMEDIDQAVKLGLNAPMGPFELMDFVGIDI
NKSILDYLADETMDVRWNPPLSIKLLLKSGRLGRKNGAGWYKY

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=294, Percent_Identity=44.2176870748299, Blast_Score=215, Evalue=4e-56,
Organism=Homo sapiens, GI296179427, Length=311, Percent_Identity=41.8006430868167, Blast_Score=204, Evalue=8e-53,
Organism=Homo sapiens, GI20127408, Length=284, Percent_Identity=33.4507042253521, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI261878539, Length=295, Percent_Identity=31.5254237288136, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI68989263, Length=295, Percent_Identity=31.5254237288136, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI115430219, Length=238, Percent_Identity=30.2521008403361, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI1787661, Length=284, Percent_Identity=36.9718309859155, Blast_Score=193, Evalue=9e-51,
Organism=Escherichia coli, GI1790281, Length=283, Percent_Identity=36.3957597173145, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1788682, Length=264, Percent_Identity=35.2272727272727, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17549919, Length=293, Percent_Identity=39.5904436860068, Blast_Score=212, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17553560, Length=289, Percent_Identity=39.4463667820069, Blast_Score=204, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI25144276, Length=289, Percent_Identity=32.8719723183391, Blast_Score=162, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17508951, Length=289, Percent_Identity=32.8719723183391, Blast_Score=162, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17508953, Length=289, Percent_Identity=32.8719723183391, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17563036, Length=290, Percent_Identity=34.4827586206897, Blast_Score=158, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17558304, Length=284, Percent_Identity=31.6901408450704, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71985923, Length=282, Percent_Identity=30.4964539007092, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71985930, Length=282, Percent_Identity=29.4326241134752, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI115533614, Length=179, Percent_Identity=28.4916201117318, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI193203623, Length=179, Percent_Identity=28.4916201117318, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI19921000, Length=282, Percent_Identity=34.7517730496454, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24583077, Length=282, Percent_Identity=34.7517730496454, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24583079, Length=282, Percent_Identity=34.7517730496454, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI45549573, Length=236, Percent_Identity=30.5084745762712, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI20129993, Length=256, Percent_Identity=25.78125, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31185; Mature: 31185

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVKKLGVLGAGAMGAGIAHLAAQRGIEVVLCDIDMKFVDGGVARMEKLMAGSIKKGKMT
CCCHHCCCCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHCCHHHHHHHHHHCCCCCCCCC
EDEAKAVLGRIKKTVQMEDFADCDFIVEAIIENLKIKQDAFSKLDTITRPEVILASNTSS
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCCC
MSLTEIAAATKRPEKVVGMHFFNPPQVMKLVEIIRGYYTSDETFKATEEFSKQLGKITVE
CHHHHHHHHHCCCHHEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEE
IKKDAPGFVVNRVMMASAMEAMKLYEEGVASMEDIDQAVKLGLNAPMGPFELMDFVGIDI
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
NKSILDYLADETMDVRWNPPLSIKLLLKSGRLGRKNGAGWYKY
CHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MQVKKLGVLGAGAMGAGIAHLAAQRGIEVVLCDIDMKFVDGGVARMEKLMAGSIKKGKMT
CCCHHCCCCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHCCHHHHHHHHHHCCCCCCCCC
EDEAKAVLGRIKKTVQMEDFADCDFIVEAIIENLKIKQDAFSKLDTITRPEVILASNTSS
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCCC
MSLTEIAAATKRPEKVVGMHFFNPPQVMKLVEIIRGYYTSDETFKATEEFSKQLGKITVE
CHHHHHHHHHCCCHHEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEE
IKKDAPGFVVNRVMMASAMEAMKLYEEGVASMEDIDQAVKLGLNAPMGPFELMDFVGIDI
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
NKSILDYLADETMDVRWNPPLSIKLLLKSGRLGRKNGAGWYKY
CHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]