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The map label for this gene is gyaR [H]

Identifier: 85859682

GI number: 85859682

Start: 1911536

End: 1912516

Strand: Direct

Name: gyaR [H]

Synonym: SYN_01083

Alternate gene names: 85859682

Gene position: 1911536-1912516 (Clockwise)

Preceding gene: 85859681

Following gene: 85859683

Centisome position: 60.12

GC content: 57.29

Gene sequence:

>981_bases
GTGCCGCAACAAAGAAATTTCCATCACATGAATAAAAAAGGAACTTCGTTGATGAACATCCGCGTACTTGCCACCTCTAC
ACTGGTCGGTCCATACATCGACGAATTAGGACTGCGCTTTCCTGAATTATGTGTCGCTCCCTGTCGGTCTTCTGCCTGGA
AAGCGGGGCTCGCCAGCGCGGAAGCCCTCATCGTTCTTTTATCCGAGCCACTGACCGAAGCGGACCTGGACCTTTGTCCG
AACTTGAGGGTCATCGGCACGTACTCTGTGGGAATCAACCACCTTCCCATCACCTCTTGCCAGTCCCGCGGCATCCGCAT
AGTAAACACACAGGGAGTCTTAACGGATGCCACGGCCGATCTGGCCTTGACACTCCTTTTGTCCCTTACCCGACGGGTAC
GGGAAGGTGAAGCACTCGTGCGGTCCGGTCATTGGAAGGGCTGGGCTCCCGATCTCCTCCTGGGAACCGGTCTTACAGGA
AAGACGTGTGGAATTCTCGGCTCCGGTCCTATCGGCCGGGCTTTTGCGCGGCGAGTCTGGGCCATAGGCATGAAGGTCAT
CTTCTGGAACCGGGAAGGCAATCAGAAACCGGTGGATTTCGGAGTGGATATCGCTGCGCGTCTGCCTCTTGATGAGCTGC
TGCGCCAAAGCGATGTGCTCTCCCTGCACTGCCCGCTGACGGATACGACTCGCGGCCTTCTCAACCGCGAGAAGCTGGAT
CTGCTGCCCCATGGAGCCTTTCTCATCAACACGGCCCGGGGCGGAATACTCGATGAACAGGCGGTTATGGAACTTCTTCA
CCAGGGAAAGATCGGTGGTGTCGGTCTGGACGTCTACGAGAATGAACCGGATCTGGATCCCCAGTGGCTTGTGGCACCGC
GAACCGTGCTCCTTCCCCACCTTGGTTCTGCGACTCTCGAGACGAGGGAAGCGATGGCGAAGTTGCTCTGCGATGGGATC
GCTGAATCCCTGCTGACCTGA

Upstream 100 bases:

>100_bases
GGCAAATGTAAAAATAGAGAGGCCTGAAATTCAACTTTCATCCCTTCCATATCCTTCATGAGTATTATCTTGACAGGAAA
AACTGTTATTAATAAACTCC

Downstream 100 bases:

>100_bases
AACGAAGCCGAACCGGGCATTGGATGCAATACCAGGGGAGATTCTCGATCTGCCAAGATTATCGCACATGATCATACAGG
CTGCTGTTGCCCTGATAACG

Product: 2-hydroxyacid dehydrogenase, D-isomer specific

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MPQQRNFHHMNKKGTSLMNIRVLATSTLVGPYIDELGLRFPELCVAPCRSSAWKAGLASAEALIVLLSEPLTEADLDLCP
NLRVIGTYSVGINHLPITSCQSRGIRIVNTQGVLTDATADLALTLLLSLTRRVREGEALVRSGHWKGWAPDLLLGTGLTG
KTCGILGSGPIGRAFARRVWAIGMKVIFWNREGNQKPVDFGVDIAARLPLDELLRQSDVLSLHCPLTDTTRGLLNREKLD
LLPHGAFLINTARGGILDEQAVMELLHQGKIGGVGLDVYENEPDLDPQWLVAPRTVLLPHLGSATLETREAMAKLLCDGI
AESLLT

Sequences:

>Translated_326_residues
MPQQRNFHHMNKKGTSLMNIRVLATSTLVGPYIDELGLRFPELCVAPCRSSAWKAGLASAEALIVLLSEPLTEADLDLCP
NLRVIGTYSVGINHLPITSCQSRGIRIVNTQGVLTDATADLALTLLLSLTRRVREGEALVRSGHWKGWAPDLLLGTGLTG
KTCGILGSGPIGRAFARRVWAIGMKVIFWNREGNQKPVDFGVDIAARLPLDELLRQSDVLSLHCPLTDTTRGLLNREKLD
LLPHGAFLINTARGGILDEQAVMELLHQGKIGGVGLDVYENEPDLDPQWLVAPRTVLLPHLGSATLETREAMAKLLCDGI
AESLLT
>Mature_325_residues
PQQRNFHHMNKKGTSLMNIRVLATSTLVGPYIDELGLRFPELCVAPCRSSAWKAGLASAEALIVLLSEPLTEADLDLCPN
LRVIGTYSVGINHLPITSCQSRGIRIVNTQGVLTDATADLALTLLLSLTRRVREGEALVRSGHWKGWAPDLLLGTGLTGK
TCGILGSGPIGRAFARRVWAIGMKVIFWNREGNQKPVDFGVDIAARLPLDELLRQSDVLSLHCPLTDTTRGLLNREKLDL
LPHGAFLINTARGGILDEQAVMELLHQGKIGGVGLDVYENEPDLDPQWLVAPRTVLLPHLGSATLETREAMAKLLCDGIA
ESLLT

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=277, Percent_Identity=38.2671480144404, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI23308577, Length=256, Percent_Identity=32.421875, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI145580578, Length=284, Percent_Identity=31.6901408450704, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4557499, Length=284, Percent_Identity=31.6901408450704, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI145580575, Length=272, Percent_Identity=33.0882352941176, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI61743967, Length=257, Percent_Identity=32.6848249027237, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4557497, Length=257, Percent_Identity=32.6848249027237, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI87082289, Length=273, Percent_Identity=35.8974358974359, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1787645, Length=204, Percent_Identity=31.8627450980392, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1789279, Length=245, Percent_Identity=30.2040816326531, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI87081824, Length=195, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788660, Length=285, Percent_Identity=28.4210526315789, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=246, Percent_Identity=30.4878048780488, Blast_Score=130, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI25147481, Length=269, Percent_Identity=28.2527881040892, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=239, Percent_Identity=32.6359832635983, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6320925, Length=260, Percent_Identity=29.2307692307692, Blast_Score=109, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=260, Percent_Identity=29.2307692307692, Blast_Score=109, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6324964, Length=220, Percent_Identity=29.0909090909091, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321253, Length=195, Percent_Identity=32.3076923076923, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=139, Percent_Identity=32.3741007194245, Blast_Score=72, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=167, Percent_Identity=28.1437125748503, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28571528, Length=307, Percent_Identity=35.8306188925081, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24585514, Length=260, Percent_Identity=33.8461538461538, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI28574282, Length=260, Percent_Identity=33.8461538461538, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI28574284, Length=260, Percent_Identity=33.8461538461538, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI45552429, Length=260, Percent_Identity=33.8461538461538, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI45551003, Length=260, Percent_Identity=33.8461538461538, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24585516, Length=260, Percent_Identity=31.1538461538462, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI28574286, Length=249, Percent_Identity=32.1285140562249, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19921140, Length=236, Percent_Identity=31.7796610169492, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646446, Length=285, Percent_Identity=31.5789473684211, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646448, Length=285, Percent_Identity=31.5789473684211, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646452, Length=285, Percent_Identity=31.5789473684211, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646450, Length=285, Percent_Identity=31.5789473684211, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI62472511, Length=285, Percent_Identity=31.5789473684211, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35408; Mature: 35276

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQQRNFHHMNKKGTSLMNIRVLATSTLVGPYIDELGLRFPELCVAPCRSSAWKAGLASA
CCCCCCCCCCCCCCCEEEEEEEEEEHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHCCCCH
EALIVLLSEPLTEADLDLCPNLRVIGTYSVGINHLPITSCQSRGIRIVNTQGVLTDATAD
HEEEEEECCCCCCCCHHHCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCEECHHHH
LALTLLLSLTRRVREGEALVRSGHWKGWAPDLLLGTGLTGKTCGILGSGPIGRAFARRVW
HHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHH
AIGMKVIFWNREGNQKPVDFGVDIAARLPLDELLRQSDVLSLHCPLTDTTRGLLNREKLD
HCCEEEEEECCCCCCCCCCCCCCEEEECCHHHHHCCCCCEEEECCCCHHHHHHHCHHHHH
LLPHGAFLINTARGGILDEQAVMELLHQGKIGGVGLDVYENEPDLDPQWLVAPRTVLLPH
CCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEECCHHHHHCC
LGSATLETREAMAKLLCDGIAESLLT
CCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PQQRNFHHMNKKGTSLMNIRVLATSTLVGPYIDELGLRFPELCVAPCRSSAWKAGLASA
CCCCCCCCCCCCCCEEEEEEEEEEHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHCCCCH
EALIVLLSEPLTEADLDLCPNLRVIGTYSVGINHLPITSCQSRGIRIVNTQGVLTDATAD
HEEEEEECCCCCCCCHHHCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCEECHHHH
LALTLLLSLTRRVREGEALVRSGHWKGWAPDLLLGTGLTGKTCGILGSGPIGRAFARRVW
HHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHH
AIGMKVIFWNREGNQKPVDFGVDIAARLPLDELLRQSDVLSLHCPLTDTTRGLLNREKLD
HCCEEEEEECCCCCCCCCCCCCCEEEECCHHHHHCCCCCEEEECCCCHHHHHHHCHHHHH
LLPHGAFLINTARGGILDEQAVMELLHQGKIGGVGLDVYENEPDLDPQWLVAPRTVLLPH
CCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEECCHHHHHCC
LGSATLETREAMAKLLCDGIAESLLT
CCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA