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The map label for this gene is ispA [C]

Identifier: 85859630

GI number: 85859630

Start: 1858783

End: 1859709

Strand: Direct

Name: ispA [C]

Synonym: SYN_02457

Alternate gene names: 85859630

Gene position: 1858783-1859709 (Clockwise)

Preceding gene: 85859629

Following gene: 85859631

Centisome position: 58.47

GC content: 55.12

Gene sequence:

>927_bases
ATGGAGAGAAAAATGAATCCTGAATCCGGGCTGGATCTGAATGCCTACATCAAGGAAAAAAAGCTGCGGATCGATGAAGC
CATCGACCGCTACCTGCCCGGCGAGGAGGAATCCCCGGGTGAACTTTTTAAAGCGATGCGGTACAGCCTTTTTGCAGGCG
GGAAGAGGATCCGTCCCATTCTCTGTCTTGCGGCTGCAGAAGCTGTTGGAACTTCAGTCTCTTCCGATTGCCTTCTTCCG
GTGGCCTGCGCCCTCGAATACATCCATACCTATTCATTGATTCATGACGATCTTCCCGCCATGGACAATGACGACTACCG
CCGGGGAAAGCCCACCAGCCACAAGGTTTTCGGTGATGCTCTGGCCATTCTCGCCGGGGACGCTCTGCTCACGGAGGCCT
TTGAACTGATGACCCGAACCGATTTTCATACCGGCCTGGCCCCGGAAATTCTCCTGAGAGTCATCAGGGAAATCGCTGCT
GCTGCCGGGGCTTTCGGCATGGTGGGAGGACAGGTGGAAGATTTGCGTGCGGAAGGAAAACCCGGAAATCTGGACACGCT
GAACCGAATTCATAATCGGAAAACAGGGGCAATGATCGTCGTTTCCCTTAGAGCAGGGGCGATACTTTCCGGAGGATCGG
AGCAGGCCGTTTCGGCATTGACAGATTACGGCCACAAGATCGGCCTGGTTTTCCAGATTGCCGACGACATTCTCAACGTG
GAGGGAGACCGGACTGTGCTGGGTAAAAGCACGGGGAGTGACGCGAGCCGTGGTAAAATGACCTTCCCTCTCCTTATGGG
ATTGGAACCATCCCGTCAGAAGGCCTTTGCCCTGGTTGAGGAGGCTCTGCGCGATCTTGACGGTTTTGACAACCGGGCGA
CTCCTCTGCGGCTGATGGCCAGATATTTTGTGGAGCGCCGACTTTAA

Upstream 100 bases:

>100_bases
CTTTCACGGCTGTGTGCGTCCCGCCTGGATGATGCCGAACGGCGCGTGGAGATGTTGATTGCTGAAAATTCGAATGTGAC
GGTGCAGCCCTTACGGGAAA

Downstream 100 bases:

>100_bases
GGGAAACGCACTGGCGCGACATCGTTATATAAATAAAATTATAATGGATGTTTATCTCTTCTATGAACCCGGTAAAAAAG
AATAATTCCGGCGGCATTCT

Product: dimethylallyltransferase / geranyltranstransferase / geranylgeranyl pyrophosphate synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MERKMNPESGLDLNAYIKEKKLRIDEAIDRYLPGEEESPGELFKAMRYSLFAGGKRIRPILCLAAAEAVGTSVSSDCLLP
VACALEYIHTYSLIHDDLPAMDNDDYRRGKPTSHKVFGDALAILAGDALLTEAFELMTRTDFHTGLAPEILLRVIREIAA
AAGAFGMVGGQVEDLRAEGKPGNLDTLNRIHNRKTGAMIVVSLRAGAILSGGSEQAVSALTDYGHKIGLVFQIADDILNV
EGDRTVLGKSTGSDASRGKMTFPLLMGLEPSRQKAFALVEEALRDLDGFDNRATPLRLMARYFVERRL

Sequences:

>Translated_308_residues
MERKMNPESGLDLNAYIKEKKLRIDEAIDRYLPGEEESPGELFKAMRYSLFAGGKRIRPILCLAAAEAVGTSVSSDCLLP
VACALEYIHTYSLIHDDLPAMDNDDYRRGKPTSHKVFGDALAILAGDALLTEAFELMTRTDFHTGLAPEILLRVIREIAA
AAGAFGMVGGQVEDLRAEGKPGNLDTLNRIHNRKTGAMIVVSLRAGAILSGGSEQAVSALTDYGHKIGLVFQIADDILNV
EGDRTVLGKSTGSDASRGKMTFPLLMGLEPSRQKAFALVEEALRDLDGFDNRATPLRLMARYFVERRL
>Mature_308_residues
MERKMNPESGLDLNAYIKEKKLRIDEAIDRYLPGEEESPGELFKAMRYSLFAGGKRIRPILCLAAAEAVGTSVSSDCLLP
VACALEYIHTYSLIHDDLPAMDNDDYRRGKPTSHKVFGDALAILAGDALLTEAFELMTRTDFHTGLAPEILLRVIREIAA
AAGAFGMVGGQVEDLRAEGKPGNLDTLNRIHNRKTGAMIVVSLRAGAILSGGSEQAVSALTDYGHKIGLVFQIADDILNV
EGDRTVLGKSTGSDASRGKMTFPLLMGLEPSRQKAFALVEEALRDLDGFDNRATPLRLMARYFVERRL

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=238, Percent_Identity=29.4117647058824, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786623, Length=302, Percent_Identity=43.3774834437086, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1789578, Length=242, Percent_Identity=31.8181818181818, Blast_Score=120, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17505681, Length=267, Percent_Identity=25.4681647940075, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325188, Length=252, Percent_Identity=25.7936507936508, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24651612, Length=249, Percent_Identity=28.1124497991968, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 33611; Mature: 33611

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERKMNPESGLDLNAYIKEKKLRIDEAIDRYLPGEEESPGELFKAMRYSLFAGGKRIRPI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHH
LCLAAAEAVGTSVSSDCLLPVACALEYIHTYSLIHDDLPAMDNDDYRRGKPTSHKVFGDA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
LAILAGDALLTEAFELMTRTDFHTGLAPEILLRVIREIAAAAGAFGMVGGQVEDLRAEGK
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCC
PGNLDTLNRIHNRKTGAMIVVSLRAGAILSGGSEQAVSALTDYGHKIGLVFQIADDILNV
CCCHHHHHHHHCCCCCEEEEEEECCCEEECCCHHHHHHHHHHCCCHHHHHHEEHHHHHCC
EGDRTVLGKSTGSDASRGKMTFPLLMGLEPSRQKAFALVEEALRDLDGFDNRATPLRLMA
CCCCEEECCCCCCCCCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
RYFVERRL
HHHHHHCC
>Mature Secondary Structure
MERKMNPESGLDLNAYIKEKKLRIDEAIDRYLPGEEESPGELFKAMRYSLFAGGKRIRPI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHH
LCLAAAEAVGTSVSSDCLLPVACALEYIHTYSLIHDDLPAMDNDDYRRGKPTSHKVFGDA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
LAILAGDALLTEAFELMTRTDFHTGLAPEILLRVIREIAAAAGAFGMVGGQVEDLRAEGK
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCC
PGNLDTLNRIHNRKTGAMIVVSLRAGAILSGGSEQAVSALTDYGHKIGLVFQIADDILNV
CCCHHHHHHHHCCCCCEEEEEEECCCEEECCCHHHHHHHHHHCCCHHHHHHEEHHHHHCC
EGDRTVLGKSTGSDASRGKMTFPLLMGLEPSRQKAFALVEEALRDLDGFDNRATPLRLMA
CCCCEEECCCCCCCCCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
RYFVERRL
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]