Click here to switch to the map view.

The map label for this gene is cobB1 [H]

Identifier: 85858978

GI number: 85858978

Start: 1159808

End: 1160623

Strand: Direct

Name: cobB1 [H]

Synonym: SYN_01020

Alternate gene names: 85858978

Gene position: 1159808-1160623 (Clockwise)

Preceding gene: 85858976

Following gene: 85858980

Centisome position: 36.48

GC content: 53.68

Gene sequence:

>816_bases
ATGAGAGATTTCAGCATGAGTGACAGGGAATTTATGGAGAAAATCGACGCCGTTGCAGACATGATCTGGATGGCCGGCCG
CGTTGTGGTTTTTACCGGGGCGGGGGTTAGTACGGAATCGGGAATTCCTGACTTTCGCAGTCCGGGGGGATTATGGGATC
GTTTTGATCCTGACGATTTTACAATTGGGAAATTTCTGCGCAGTGCTCAGACGAGGAGGAAACAGTGGCGTATCCTGATC
GCTGGAGGCGCGCTGGCTGAAGCACAGCCTAACCGGGCACATCTGGCTGTGGCCGAACTGGAAAAAATCGGGAAGCTCAA
TTGCGTAATCACTCAGAACATTGACAATCTGCACCAGAAGGCAGGAAACGCGCCGGAAAAGGTATATGAGCTCCATGGCA
ATATGCGGTGGCTTAAATGCCTGAGCTGTGGCGACCGGGTCTCCGTTCCTGAAATGTTCCGGGAGACCGCGTTGCAGGAA
ATGGATGGTTTTCCCTTTTGTGCGAAATGTCAGGGCCTGATGAAACCGGATGTGATCTTCTTCGGAGAGGCTCTTCCGGA
AAAGACGTTGCGGGATGCGACCTGGCAGGCTCGCAACTGTGATCTGCTGCTGGTCATCGGATCTTCCCTCGTGGTTTATC
CGGCAGCTTATATGCCCATGTACGCGAAAGATGCCGGCGCGCGGCTGGTGATCATCAACAGGGATGAAACACCCTATGAC
TCAGAGGCCGATGTCCTTCTGCAGGGATCAGCGGGAGAGATCATGAGCCGTATTCTTGACGCAGTAAAGCATCGAACCGG
CTTCAAACCCGGGTAG

Upstream 100 bases:

>100_bases
TGTTTTAATTTTGCCTGACTGTGTTATGTATTCCGGGATACGCGGCTGGAGAACCTATTGAAAATCTGCAAAATGAGGAC
TTTTTTGTAATTACATAATA

Downstream 100 bases:

>100_bases
AAGCCGACAAAGCGCTGAGTGGATCGAATGTATTCTTGAAGCGCTCTTTCTGAGATAATTGTTGCCGATGTTTTCAGATA
TTCCCGCCGTCGATTCCATT

Product: Sir2 family NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 1 [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MRDFSMSDREFMEKIDAVADMIWMAGRVVVFTGAGVSTESGIPDFRSPGGLWDRFDPDDFTIGKFLRSAQTRRKQWRILI
AGGALAEAQPNRAHLAVAELEKIGKLNCVITQNIDNLHQKAGNAPEKVYELHGNMRWLKCLSCGDRVSVPEMFRETALQE
MDGFPFCAKCQGLMKPDVIFFGEALPEKTLRDATWQARNCDLLLVIGSSLVVYPAAYMPMYAKDAGARLVIINRDETPYD
SEADVLLQGSAGEIMSRILDAVKHRTGFKPG

Sequences:

>Translated_271_residues
MRDFSMSDREFMEKIDAVADMIWMAGRVVVFTGAGVSTESGIPDFRSPGGLWDRFDPDDFTIGKFLRSAQTRRKQWRILI
AGGALAEAQPNRAHLAVAELEKIGKLNCVITQNIDNLHQKAGNAPEKVYELHGNMRWLKCLSCGDRVSVPEMFRETALQE
MDGFPFCAKCQGLMKPDVIFFGEALPEKTLRDATWQARNCDLLLVIGSSLVVYPAAYMPMYAKDAGARLVIINRDETPYD
SEADVLLQGSAGEIMSRILDAVKHRTGFKPG
>Mature_271_residues
MRDFSMSDREFMEKIDAVADMIWMAGRVVVFTGAGVSTESGIPDFRSPGGLWDRFDPDDFTIGKFLRSAQTRRKQWRILI
AGGALAEAQPNRAHLAVAELEKIGKLNCVITQNIDNLHQKAGNAPEKVYELHGNMRWLKCLSCGDRVSVPEMFRETALQE
MDGFPFCAKCQGLMKPDVIFFGEALPEKTLRDATWQARNCDLLLVIGSSLVVYPAAYMPMYAKDAGARLVIINRDETPYD
SEADVLLQGSAGEIMSRILDAVKHRTGFKPG

Specific function: Modulates the activity of chromatin proteins, thereby having an effect on transcription per subunit [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912662, Length=272, Percent_Identity=35.6617647058824, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI300797577, Length=256, Percent_Identity=30.859375, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI300795542, Length=273, Percent_Identity=34.7985347985348, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI6912664, Length=287, Percent_Identity=33.4494773519164, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI300797597, Length=250, Percent_Identity=30, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI13787215, Length=259, Percent_Identity=35.1351351351351, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI7657575, Length=273, Percent_Identity=32.6007326007326, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI7706712, Length=258, Percent_Identity=30.6201550387597, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI13775602, Length=214, Percent_Identity=35.5140186915888, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI6912660, Length=217, Percent_Identity=36.405529953917, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI13775600, Length=214, Percent_Identity=35.5140186915888, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI63054862, Length=212, Percent_Identity=35.377358490566, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI300797705, Length=193, Percent_Identity=35.7512953367876, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI215982798, Length=184, Percent_Identity=34.7826086956522, Blast_Score=88, Evalue=8e-18,
Organism=Escherichia coli, GI308199517, Length=258, Percent_Identity=32.1705426356589, Blast_Score=101, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17567771, Length=267, Percent_Identity=31.0861423220974, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17541892, Length=261, Percent_Identity=31.0344827586207, Blast_Score=121, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71990482, Length=268, Percent_Identity=29.1044776119403, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71990487, Length=270, Percent_Identity=28.8888888888889, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17505510, Length=284, Percent_Identity=26.4084507042254, Blast_Score=91, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6324504, Length=278, Percent_Identity=29.136690647482, Blast_Score=108, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320163, Length=283, Percent_Identity=28.2685512367491, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325242, Length=221, Percent_Identity=32.1266968325792, Blast_Score=99, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6320397, Length=250, Percent_Identity=26, Blast_Score=72, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324599, Length=276, Percent_Identity=22.8260869565217, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28571445, Length=274, Percent_Identity=33.2116788321168, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24645650, Length=262, Percent_Identity=29.0076335877863, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17137536, Length=280, Percent_Identity=32.1428571428571, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24648389, Length=217, Percent_Identity=34.1013824884793, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI28571443, Length=222, Percent_Identity=31.0810810810811, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28571441, Length=222, Percent_Identity=31.0810810810811, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24650933, Length=256, Percent_Identity=27.734375, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 30181; Mature: 30181

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDFSMSDREFMEKIDAVADMIWMAGRVVVFTGAGVSTESGIPDFRSPGGLWDRFDPDDF
CCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCH
TIGKFLRSAQTRRKQWRILIAGGALAEAQPNRAHLAVAELEKIGKLNCVITQNIDNLHQK
HHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHH
AGNAPEKVYELHGNMRWLKCLSCGDRVSVPEMFRETALQEMDGFPFCAKCQGLMKPDVIF
CCCCHHHHHHHHCCHHEEHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEE
FGEALPEKTLRDATWQARNCDLLLVIGSSLVVYPAAYMPMYAKDAGARLVIINRDETPYD
ECCCCCHHHHHHCCCCCCCCCEEEEECCCCEEHHHHHCCEEECCCCCEEEEEECCCCCCC
SEADVLLQGSAGEIMSRILDAVKHRTGFKPG
CCCCEEEECCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRDFSMSDREFMEKIDAVADMIWMAGRVVVFTGAGVSTESGIPDFRSPGGLWDRFDPDDF
CCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCH
TIGKFLRSAQTRRKQWRILIAGGALAEAQPNRAHLAVAELEKIGKLNCVITQNIDNLHQK
HHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHH
AGNAPEKVYELHGNMRWLKCLSCGDRVSVPEMFRETALQEMDGFPFCAKCQGLMKPDVIF
CCCCHHHHHHHHCCHHEEHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEE
FGEALPEKTLRDATWQARNCDLLLVIGSSLVVYPAAYMPMYAKDAGARLVIINRDETPYD
ECCCCCHHHHHHCCCCCCCCCEEEEECCCCEEHHHHHCCEEECCCCCEEEEEECCCCCCC
SEADVLLQGSAGEIMSRILDAVKHRTGFKPG
CCCCEEEECCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792869 [H]