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The map label for this gene is fba [H]

Identifier: 85858603

GI number: 85858603

Start: 769105

End: 770130

Strand: Direct

Name: fba [H]

Synonym: SYN_02954

Alternate gene names: 85858603

Gene position: 769105-770130 (Clockwise)

Preceding gene: 85858602

Following gene: 85858604

Centisome position: 24.19

GC content: 57.89

Gene sequence:

>1026_bases
ATGCCGGTAGCCGACTATGAAACGTTTTGCAGAATGATCGAAAGGGCCCGGAAAAATTCTTTTGCGTATCCCGCTATCAA
CGTGACATCGCTTACGACGGCCAACGCGGTTCTGAAAGGGCTGGCAGAGAGCGGAAGCGATGGAATTCTTCAGGTTTCTA
CGGGCGGAGCCGCCTTTGCCTCGGGTTCCGCGGTCAAGGACATGGCTCTCGGCGCCATCTCGATTGCCGAACATGTCCAC
CGCGTTGCAGACCGATATCCCATTTACATAGCCCTGAACACGGACCATTGCACGGCGGGCAATCTCGAAAAATTCGTGAT
TCCGCTGGTGGAGGAAACGGAGAAGCGGCGTGCGGCAGGAAAACCGAACCTGTTCACGGCTCACATGTTCGACGGGAGCG
TCCTCCCGCTGAAGGAGAATCTGGATATCGCGGAGAAACTGCTCGAACGCTTCCGGAAAAGCGACCTGATCCTTGAAATC
GAAGCGGGTGTGGTCGGCGGCGAGGAAGACGGCGTCAAGGCCAGTGCCGCCGCCAAACTTTACACCACCCCCGAGGATAC
CCTCGCGGTCGCCCGCCGGCTGAACGCAATTTCGGGTGCGCGCTACCTGCTGGCGGCGACCTTCGGCAATGTTCACGGTG
TCTACAAGCCCGGTCACGTTCAGCTGAAGCCTTCCATCCTGAAGGAGTGCCAGGATGCGGTGGTGAAGACATACGGAGAA
GAGGCCCGCTTCTATTTTGTGTTTCACGGCGGTTCAGGATCTTCGATTGAAGACATTCATGCCGCCGTCGATTACGGCGT
GGTCAAGATGAACATCGATACGGACACGCAGTACGCCTTTACCCGGGCCATTGCCGATCACCTGTTCCGGAATTACAGCG
GCGCATTGAAAGTGGACGGCGATGTGGGCGACAAGAAAGTCTATGATCCGCGGGTTTATCTGGGCCTGGCCGAGGCCGCC
ATGGCACAGCGGGTCAGGCAGGCCGTGACCGAACTGCGAAGCCGGAACACGACGCTGATGAAATGA

Upstream 100 bases:

>100_bases
ACTCCTCAAGCATTATGGATGCGGGCCGGACCCGCTACTCTGGCGACGATGAACGGATCACCCGATCCCTTAACCAGGAA
GTATAGATAAGGAGGATTCC

Downstream 100 bases:

>100_bases
GACAGGAGGGTGACATGGGGAATACGGAGCTTGATTTCACGATTGAACGGCTTGGCGAGTGCCATATCCCTTCCCCGGTG
AAGGGGATCCGCTTTGTGGA

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MPVADYETFCRMIERARKNSFAYPAINVTSLTTANAVLKGLAESGSDGILQVSTGGAAFASGSAVKDMALGAISIAEHVH
RVADRYPIYIALNTDHCTAGNLEKFVIPLVEETEKRRAAGKPNLFTAHMFDGSVLPLKENLDIAEKLLERFRKSDLILEI
EAGVVGGEEDGVKASAAAKLYTTPEDTLAVARRLNAISGARYLLAATFGNVHGVYKPGHVQLKPSILKECQDAVVKTYGE
EARFYFVFHGGSGSSIEDIHAAVDYGVVKMNIDTDTQYAFTRAIADHLFRNYSGALKVDGDVGDKKVYDPRVYLGLAEAA
MAQRVRQAVTELRSRNTTLMK

Sequences:

>Translated_341_residues
MPVADYETFCRMIERARKNSFAYPAINVTSLTTANAVLKGLAESGSDGILQVSTGGAAFASGSAVKDMALGAISIAEHVH
RVADRYPIYIALNTDHCTAGNLEKFVIPLVEETEKRRAAGKPNLFTAHMFDGSVLPLKENLDIAEKLLERFRKSDLILEI
EAGVVGGEEDGVKASAAAKLYTTPEDTLAVARRLNAISGARYLLAATFGNVHGVYKPGHVQLKPSILKECQDAVVKTYGE
EARFYFVFHGGSGSSIEDIHAAVDYGVVKMNIDTDTQYAFTRAIADHLFRNYSGALKVDGDVGDKKVYDPRVYLGLAEAA
MAQRVRQAVTELRSRNTTLMK
>Mature_340_residues
PVADYETFCRMIERARKNSFAYPAINVTSLTTANAVLKGLAESGSDGILQVSTGGAAFASGSAVKDMALGAISIAEHVHR
VADRYPIYIALNTDHCTAGNLEKFVIPLVEETEKRRAAGKPNLFTAHMFDGSVLPLKENLDIAEKLLERFRKSDLILEIE
AGVVGGEEDGVKASAAAKLYTTPEDTLAVARRLNAISGARYLLAATFGNVHGVYKPGHVQLKPSILKECQDAVVKTYGEE
ARFYFVFHGGSGSSIEDIHAAVDYGVVKMNIDTDTQYAFTRAIADHLFRNYSGALKVDGDVGDKKVYDPRVYLGLAEAAM
AQRVRQAVTELRSRNTTLMK

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=342, Percent_Identity=43.5672514619883, Blast_Score=248, Evalue=3e-67,
Organism=Escherichia coli, GI87082041, Length=321, Percent_Identity=26.1682242990654, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1789526, Length=329, Percent_Identity=24.9240121580547, Blast_Score=79, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6322790, Length=336, Percent_Identity=37.797619047619, Blast_Score=207, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 37026; Mature: 36894

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVADYETFCRMIERARKNSFAYPAINVTSLTTANAVLKGLAESGSDGILQVSTGGAAFA
CCCCCHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
SGSAVKDMALGAISIAEHVHRVADRYPIYIALNTDHCTAGNLEKFVIPLVEETEKRRAAG
CCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHEEHHHHHHHHHHHCC
KPNLFTAHMFDGSVLPLKENLDIAEKLLERFRKSDLILEIEAGVVGGEEDGVKASAAAKL
CCCEEEEEECCCEEECCCCCCCHHHHHHHHHCCCCEEEEEECCEECCCCCCCCHHCCEEE
YTTPEDTLAVARRLNAISGARYLLAATFGNVHGVYKPGHVQLKPSILKECQDAVVKTYGE
ECCCHHHHHHHHHHHHHCCCHHEEEEHHCCCCCCCCCCCEEECHHHHHHHHHHHHHHCCC
EARFYFVFHGGSGSSIEDIHAAVDYGVVKMNIDTDTQYAFTRAIADHLFRNYSGALKVDG
CEEEEEEEECCCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEECC
DVGDKKVYDPRVYLGLAEAAMAQRVRQAVTELRSRNTTLMK
CCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PVADYETFCRMIERARKNSFAYPAINVTSLTTANAVLKGLAESGSDGILQVSTGGAAFA
CCCCHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
SGSAVKDMALGAISIAEHVHRVADRYPIYIALNTDHCTAGNLEKFVIPLVEETEKRRAAG
CCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHEEHHHHHHHHHHHCC
KPNLFTAHMFDGSVLPLKENLDIAEKLLERFRKSDLILEIEAGVVGGEEDGVKASAAAKL
CCCEEEEEECCCEEECCCCCCCHHHHHHHHHCCCCEEEEEECCEECCCCCCCCHHCCEEE
YTTPEDTLAVARRLNAISGARYLLAATFGNVHGVYKPGHVQLKPSILKECQDAVVKTYGE
ECCCHHHHHHHHHHHHHCCCHHEEEEHHCCCCCCCCCCCEEECHHHHHHHHHHHHHHCCC
EARFYFVFHGGSGSSIEDIHAAVDYGVVKMNIDTDTQYAFTRAIADHLFRNYSGALKVDG
CEEEEEEEECCCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEECC
DVGDKKVYDPRVYLGLAEAAMAQRVRQAVTELRSRNTTLMK
CCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]