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The map label for this gene is murC

Identifier: 85858527

GI number: 85858527

Start: 680556

End: 681998

Strand: Direct

Name: murC

Synonym: SYN_01747

Alternate gene names: 85858527

Gene position: 680556-681998 (Clockwise)

Preceding gene: 85858526

Following gene: 85858528

Centisome position: 21.41

GC content: 54.26

Gene sequence:

>1443_bases
ATGAGGGGAATGCCATTGAACTCCATGAAGCTTTTCAGAATAACAGACGTCATGCGCAGAAAGGTGCGCCATATTCATTT
TGTCGGCATAGGCGGCATCGGTATGAGCGGGATTGCCGAGGTGCTTCTTAATCTGGGGTATACGGTCAGCGGGTCGGACC
TGAGAACTTCGGATACCACCGAGCATCTGTCATCCCTGGGAGCCACGGTATTTCAGGGGCACAAGGCTTCCAACCTGACC
GATGTCGACGTGGTGGTCACCTCAACGGCCGTGAGGAAGGATAATCCCGAAGTCCTGGAGGCGCACAGACGCTCTGTTCC
CGTCATTCCCCGCGCGGAAATGCTGGCGGAACTGCTGAAAATGAAGGTATCCATTGCCGTATCGGGAAGTCACGGCAAGA
CCACGACAACTTCCATGATTGCAACGGTTATGGCCAGCGGCGGGCTGGATCCTACCATGGTCATCGGGGGCAAGCTGGGC
AGTATCGGGAGCAACGCCCGGATGGGGCATGGGGAGTTTATCGTGGCCGAGGCAGACGAAAGCGATGGCTCTTTTCTTAA
GCTTTCGCCATCCCTGGCCGTCATTACCAACATCGACCGGGAACATCTGGATTTTTACCGGGGCATTGAAGACATAAAGG
ACGCTTTTCTGCAGTTTGCCAACATCGTTCCTTTTTATGGCTCCGCCGTCCTTTGTCTCGATGATCCTCACATCAAAACG
ATTCTTTCGGATATCAAGCGAAAAACAATCACTTACGGGATGGAGCCGGCGGCGGACTATCGGGCGCAAGAGCTCCGTTT
TAATGGAGCCGTTACGGAGTATGAACTCTATTATCGAACGGAATGTCTGGGATCCGTGACTCTTTCTGTTCCGGGGATGT
TTAATGTATACAATTCCCTGGCGACTGTCGCTGTTGCGCGGGAACTGGACATGACTTTCCCTGACATACAGCAGGGTTTG
AAAAGCTATGTTGGTGTGGGGCGTCGATTGGAAGTCAAGGGAAAAATCGCCGGGGTCACAGTGGTGGATGACTATGGCCA
TCATCCCACGGAAATCAGCGCGACGCTGGCGGCAGCTCGACAGGTCTGGAAAAATCGGATGATCGTGGTATTTCAGCCGC
ACCGTTATACGCGGACCCAGGCCCTTTTCCGGGAATTTCTCGGAGCCTTTACCGAAGCGGATCTTCTGATTGTGACAGAC
ATTTACCCTGCCAGTGAGGATCCCATTGAAGGTGTCACGGCGGAGGCGCTTTGCGACGGCATCCGCTCCCTCACGCGCCG
GGAGGTTCGCTATATTCCGAATTTCAGCGACATCACCGACTATTTGATGACCGTGGTGCAGCCGGGAGATACAGTGATCA
CACAGGGGGCGGGAAGTGTCAATTCGGTGGGCGTTTCTCTCTTGAGCCGACTGAAGGAGGTTGAGGATTCCCGTGCTGCA
TGA

Upstream 100 bases:

>100_bases
CCATGATCAGGCTGTAGAAAACTATTTTGTATAGACATGATACAATATATAGTGTATGTATCTGCAATTTATACCACATA
AAGTGTGATATGTTTCACAC

Downstream 100 bases:

>100_bases
TTTTTTTATCAAAGAACAATTGAAGTCCTGTGTTTCGGGGGCTGTGCTTTTCGATGAACCTCTGGATCGTTATACCTCCA
TGGGTGTGGGCGGTCCGGCC

Product: UDP-N-acetylmuramate--alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MRGMPLNSMKLFRITDVMRRKVRHIHFVGIGGIGMSGIAEVLLNLGYTVSGSDLRTSDTTEHLSSLGATVFQGHKASNLT
DVDVVVTSTAVRKDNPEVLEAHRRSVPVIPRAEMLAELLKMKVSIAVSGSHGKTTTTSMIATVMASGGLDPTMVIGGKLG
SIGSNARMGHGEFIVAEADESDGSFLKLSPSLAVITNIDREHLDFYRGIEDIKDAFLQFANIVPFYGSAVLCLDDPHIKT
ILSDIKRKTITYGMEPAADYRAQELRFNGAVTEYELYYRTECLGSVTLSVPGMFNVYNSLATVAVARELDMTFPDIQQGL
KSYVGVGRRLEVKGKIAGVTVVDDYGHHPTEISATLAAARQVWKNRMIVVFQPHRYTRTQALFREFLGAFTEADLLIVTD
IYPASEDPIEGVTAEALCDGIRSLTRREVRYIPNFSDITDYLMTVVQPGDTVITQGAGSVNSVGVSLLSRLKEVEDSRAA

Sequences:

>Translated_480_residues
MRGMPLNSMKLFRITDVMRRKVRHIHFVGIGGIGMSGIAEVLLNLGYTVSGSDLRTSDTTEHLSSLGATVFQGHKASNLT
DVDVVVTSTAVRKDNPEVLEAHRRSVPVIPRAEMLAELLKMKVSIAVSGSHGKTTTTSMIATVMASGGLDPTMVIGGKLG
SIGSNARMGHGEFIVAEADESDGSFLKLSPSLAVITNIDREHLDFYRGIEDIKDAFLQFANIVPFYGSAVLCLDDPHIKT
ILSDIKRKTITYGMEPAADYRAQELRFNGAVTEYELYYRTECLGSVTLSVPGMFNVYNSLATVAVARELDMTFPDIQQGL
KSYVGVGRRLEVKGKIAGVTVVDDYGHHPTEISATLAAARQVWKNRMIVVFQPHRYTRTQALFREFLGAFTEADLLIVTD
IYPASEDPIEGVTAEALCDGIRSLTRREVRYIPNFSDITDYLMTVVQPGDTVITQGAGSVNSVGVSLLSRLKEVEDSRAA
>Mature_480_residues
MRGMPLNSMKLFRITDVMRRKVRHIHFVGIGGIGMSGIAEVLLNLGYTVSGSDLRTSDTTEHLSSLGATVFQGHKASNLT
DVDVVVTSTAVRKDNPEVLEAHRRSVPVIPRAEMLAELLKMKVSIAVSGSHGKTTTTSMIATVMASGGLDPTMVIGGKLG
SIGSNARMGHGEFIVAEADESDGSFLKLSPSLAVITNIDREHLDFYRGIEDIKDAFLQFANIVPFYGSAVLCLDDPHIKT
ILSDIKRKTITYGMEPAADYRAQELRFNGAVTEYELYYRTECLGSVTLSVPGMFNVYNSLATVAVARELDMTFPDIQQGL
KSYVGVGRRLEVKGKIAGVTVVDDYGHHPTEISATLAAARQVWKNRMIVVFQPHRYTRTQALFREFLGAFTEADLLIVTD
IYPASEDPIEGVTAEALCDGIRSLTRREVRYIPNFSDITDYLMTVVQPGDTVITQGAGSVNSVGVSLLSRLKEVEDSRAA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=475, Percent_Identity=43.3684210526316, Blast_Score=367, Evalue=1e-102,
Organism=Escherichia coli, GI1790680, Length=463, Percent_Identity=28.7257019438445, Blast_Score=180, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_SYNAS (Q2LR47)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_460729.1
- ProteinModelPortal:   Q2LR47
- SMR:   Q2LR47
- STRING:   Q2LR47
- GeneID:   3885154
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_01747
- NMPDR:   fig|56780.10.peg.674
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   Q2LR47
- BioCyc:   SACI56780:SYN_01747-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 52376; Mature: 52376

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGMPLNSMKLFRITDVMRRKVRHIHFVGIGGIGMSGIAEVLLNLGYTVSGSDLRTSDTT
CCCCCCCCCHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCHH
EHLSSLGATVFQGHKASNLTDVDVVVTSTAVRKDNPEVLEAHRRSVPVIPRAEMLAELLK
HHHHHHCHHHHCCCCCCCCCEEEEEEEEHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHH
MKVSIAVSGSHGKTTTTSMIATVMASGGLDPTMVIGGKLGSIGSNARMGHGEFIVAEADE
HEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCC
SDGSFLKLSPSLAVITNIDREHLDFYRGIEDIKDAFLQFANIVPFYGSAVLCLDDPHIKT
CCCCEEEECCCEEEEECCCHHHHHHHHCHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHH
ILSDIKRKTITYGMEPAADYRAQELRFNGAVTEYELYYRTECLGSVTLSVPGMFNVYNSL
HHHHHHHHHHHCCCCCCCCHHHHHEEECCCCEEEEEEEEHHHHCEEEEECCCHHHHHHHH
ATVAVARELDMTFPDIQQGLKSYVGVGRRLEVKGKIAGVTVVDDYGHHPTEISATLAAAR
HHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCEEEEEEEEECCCCCCCHHHHHHHHHH
QVWKNRMIVVFQPHRYTRTQALFREFLGAFTEADLLIVTDIYPASEDPIEGVTAEALCDG
HHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHH
IRSLTRREVRYIPNFSDITDYLMTVVQPGDTVITQGAGSVNSVGVSLLSRLKEVEDSRAA
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRGMPLNSMKLFRITDVMRRKVRHIHFVGIGGIGMSGIAEVLLNLGYTVSGSDLRTSDTT
CCCCCCCCCHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCHH
EHLSSLGATVFQGHKASNLTDVDVVVTSTAVRKDNPEVLEAHRRSVPVIPRAEMLAELLK
HHHHHHCHHHHCCCCCCCCCEEEEEEEEHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHH
MKVSIAVSGSHGKTTTTSMIATVMASGGLDPTMVIGGKLGSIGSNARMGHGEFIVAEADE
HEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCC
SDGSFLKLSPSLAVITNIDREHLDFYRGIEDIKDAFLQFANIVPFYGSAVLCLDDPHIKT
CCCCEEEECCCEEEEECCCHHHHHHHHCHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHH
ILSDIKRKTITYGMEPAADYRAQELRFNGAVTEYELYYRTECLGSVTLSVPGMFNVYNSL
HHHHHHHHHHHCCCCCCCCHHHHHEEECCCCEEEEEEEEHHHHCEEEEECCCHHHHHHHH
ATVAVARELDMTFPDIQQGLKSYVGVGRRLEVKGKIAGVTVVDDYGHHPTEISATLAAAR
HHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCEEEEEEEEECCCCCCCHHHHHHHHHH
QVWKNRMIVVFQPHRYTRTQALFREFLGAFTEADLLIVTDIYPASEDPIEGVTAEALCDG
HHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHH
IRSLTRREVRYIPNFSDITDYLMTVVQPGDTVITQGAGSVNSVGVSLLSRLKEVEDSRAA
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA