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The map label for this gene is thrS [H]

Identifier: 85858497

GI number: 85858497

Start: 652895

End: 654832

Strand: Direct

Name: thrS [H]

Synonym: SYN_01717

Alternate gene names: 85858497

Gene position: 652895-654832 (Clockwise)

Preceding gene: 85858496

Following gene: 85858498

Centisome position: 20.54

GC content: 49.48

Gene sequence:

>1938_bases
TTGGATCTGGGCTTTTTAGTTATGAAAGAAATTAAAATTGTTTTACCTGATGGGTCGGAAAGATCACACAATGAAGGCGT
TACTGTACGGGACGTTCTTTCTTCCTGGAATCCCGCCCTGCTGGCTACGACCGCCGCTGCCAGATATAATCAGAATCTTC
TTGACTTGAGCCGCTCGCTGCATGACGACGGTGTTCTGGAACCGATCGATATTCATTCCCGGGAAGGTCTTGAAATCCTC
AGGCACAGCATATCCCACATCATGGCCCAGGCCGTTCAGGATATTTTCCCCGGCGTGCTGGTCAGCATAGGACCGGCGAT
TGAAGATGGTTTCTATTATGACTTTGAATATGGGAACACATTTACCCCGGAGGAGCTTGAAAAGATAGAGGCCCGGATGC
AGGAAATTGTGAAGGAGGATCATCCTTTTGTTCGAGAGGAGGTTTCCCGTGAAGAGGCTGTAGCTTTCTTTCAGGGTAAA
GGTGAGTCTTATAAAGTCGAACTTTTAAATGATCTGCCTGGCAATATAAAAACAGTCAGTCTTTACCGGCAGGGCCATTA
TACTGATCTTTGCCGGGGGCCTCATGTCCCATCGACCTCGATGATCCGTGCCTTCAAGCTTCTCAATGTTGCCGGCGCAT
ACTGGCGCGGCGATGAACGCAACAAGATGCTGCAACGCATCTATGGAACGGGTTTCGCGTCCCGGGAAGAGCTGGATGAA
TACCTGAAAATCCTCGAAGAGGCGAAAAAGCGGGATCACCGGAAACTGGGTAAGGATCTTGATCTATTCCAGGTCAGTGA
AGAAGCGGGTGCCGGTTTGATCATCTTTCATCCCAAAGGAACGATCCTGCGCACGATCATTGAAGATTGGGAAAAGAAGG
AACATCTGCGACGCGGGTATGACATGGTCATGGGTCCGCAGATCCTGAAGGTTGATCTGTGGAAAAAATCAGGACATTTC
GATCACTATCGCGAAAACATGTATTTCACGGAAGTAGAGGGGCAATCTTATGGGATCAAGCCGATGAACTGCCTTTCCCA
TATGCTCATCTATAAAACCAAAATCAGGAGTTATCGGGATCTGCCAATACGGTACTTTGAACTCGGTACAGTTCATCGTC
ATGAAAAAACGGGGGTTCTGCATGGTCTGCTGCGGGCCCGGCAGTTTACCCAGGATGATGCCCACATTCTCTGCACGCCG
GAGCAGTTGAATTCAGAAATTCGGGCTATTGCTGATTTTGTCGGCTATGCCATGAAGATCTTTGGATTTGAATATGAAGT
TGAATTAAGCACAAGGCCTGATAATTCCATCGGTTCCGATCAGGATTGGGAACTGGCAACCAGCGCCCTGGAGAATGCCC
TGAAAGACAATCAGATGACTTATGATATCAATGAGGGCGATGGCGCATTCTATGGTCCCAAGATTGACTTCAAACTGAAG
GATGCGCTCAAACGAAAATGGCAGTGCGCCACCATCCAGTGCGACTTTACGCTGCCGGAGCGGTTTGATCTCACATACGT
TGGGGCGGATGGCGAGAAGCATCGGCCGGTGATGCTGCACCGGGTTATCCTGGGTGCGATCGAGCGGTTCATGGGTGTGC
TGATCGAGCATTACGGAGGAGCTTTCCCTGTCTGGCTTGCACCAGTGCAGGCTATTCTTCTGTCGGTGACCGACAGGCAT
ATCCCGTATGGAAAGACCGTTTATCAGCAATTGATGGATGCGGGAATCAGGGTGGAAGGAGATTTCAGAAACGAAAAGCT
GGGGTATAAAATTCGAGAGGCGCAAACTCAGAAAATACCCTATATGCTGGTTATCGGCGATAAGGAAATGGCTTCGGGAG
AGGTTGCTGTCCGGCAGCGGGGCGGAGACAATCTGGGGACCCTGCCGGTTTCTGCCTTTATTGAACTGGTAAAGGAAAAG
AGCAGTCAGTATCTGTAA

Upstream 100 bases:

>100_bases
AAAGGGCATCCGCAATTGTAACGCGATGATGCCCTTTCTTTAATGAGAGGATATCAAAGAAGGAATACAGATATCCGTCG
TTGCTGTTTTAGACACGGTA

Downstream 100 bases:

>100_bases
TCGGCGCTTGAATCCATCATCAGACCCTGTGAAGCGGGGATGTGGGATTCATCTTACATTTGCAGGAGGTGTCCAATAGT
TAAAGATCTGAAGATCAACA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 645; Mature: 645

Protein sequence:

>645_residues
MDLGFLVMKEIKIVLPDGSERSHNEGVTVRDVLSSWNPALLATTAAARYNQNLLDLSRSLHDDGVLEPIDIHSREGLEIL
RHSISHIMAQAVQDIFPGVLVSIGPAIEDGFYYDFEYGNTFTPEELEKIEARMQEIVKEDHPFVREEVSREEAVAFFQGK
GESYKVELLNDLPGNIKTVSLYRQGHYTDLCRGPHVPSTSMIRAFKLLNVAGAYWRGDERNKMLQRIYGTGFASREELDE
YLKILEEAKKRDHRKLGKDLDLFQVSEEAGAGLIIFHPKGTILRTIIEDWEKKEHLRRGYDMVMGPQILKVDLWKKSGHF
DHYRENMYFTEVEGQSYGIKPMNCLSHMLIYKTKIRSYRDLPIRYFELGTVHRHEKTGVLHGLLRARQFTQDDAHILCTP
EQLNSEIRAIADFVGYAMKIFGFEYEVELSTRPDNSIGSDQDWELATSALENALKDNQMTYDINEGDGAFYGPKIDFKLK
DALKRKWQCATIQCDFTLPERFDLTYVGADGEKHRPVMLHRVILGAIERFMGVLIEHYGGAFPVWLAPVQAILLSVTDRH
IPYGKTVYQQLMDAGIRVEGDFRNEKLGYKIREAQTQKIPYMLVIGDKEMASGEVAVRQRGGDNLGTLPVSAFIELVKEK
SSQYL

Sequences:

>Translated_645_residues
MDLGFLVMKEIKIVLPDGSERSHNEGVTVRDVLSSWNPALLATTAAARYNQNLLDLSRSLHDDGVLEPIDIHSREGLEIL
RHSISHIMAQAVQDIFPGVLVSIGPAIEDGFYYDFEYGNTFTPEELEKIEARMQEIVKEDHPFVREEVSREEAVAFFQGK
GESYKVELLNDLPGNIKTVSLYRQGHYTDLCRGPHVPSTSMIRAFKLLNVAGAYWRGDERNKMLQRIYGTGFASREELDE
YLKILEEAKKRDHRKLGKDLDLFQVSEEAGAGLIIFHPKGTILRTIIEDWEKKEHLRRGYDMVMGPQILKVDLWKKSGHF
DHYRENMYFTEVEGQSYGIKPMNCLSHMLIYKTKIRSYRDLPIRYFELGTVHRHEKTGVLHGLLRARQFTQDDAHILCTP
EQLNSEIRAIADFVGYAMKIFGFEYEVELSTRPDNSIGSDQDWELATSALENALKDNQMTYDINEGDGAFYGPKIDFKLK
DALKRKWQCATIQCDFTLPERFDLTYVGADGEKHRPVMLHRVILGAIERFMGVLIEHYGGAFPVWLAPVQAILLSVTDRH
IPYGKTVYQQLMDAGIRVEGDFRNEKLGYKIREAQTQKIPYMLVIGDKEMASGEVAVRQRGGDNLGTLPVSAFIELVKEK
SSQYL
>Mature_645_residues
MDLGFLVMKEIKIVLPDGSERSHNEGVTVRDVLSSWNPALLATTAAARYNQNLLDLSRSLHDDGVLEPIDIHSREGLEIL
RHSISHIMAQAVQDIFPGVLVSIGPAIEDGFYYDFEYGNTFTPEELEKIEARMQEIVKEDHPFVREEVSREEAVAFFQGK
GESYKVELLNDLPGNIKTVSLYRQGHYTDLCRGPHVPSTSMIRAFKLLNVAGAYWRGDERNKMLQRIYGTGFASREELDE
YLKILEEAKKRDHRKLGKDLDLFQVSEEAGAGLIIFHPKGTILRTIIEDWEKKEHLRRGYDMVMGPQILKVDLWKKSGHF
DHYRENMYFTEVEGQSYGIKPMNCLSHMLIYKTKIRSYRDLPIRYFELGTVHRHEKTGVLHGLLRARQFTQDDAHILCTP
EQLNSEIRAIADFVGYAMKIFGFEYEVELSTRPDNSIGSDQDWELATSALENALKDNQMTYDINEGDGAFYGPKIDFKLK
DALKRKWQCATIQCDFTLPERFDLTYVGADGEKHRPVMLHRVILGAIERFMGVLIEHYGGAFPVWLAPVQAILLSVTDRH
IPYGKTVYQQLMDAGIRVEGDFRNEKLGYKIREAQTQKIPYMLVIGDKEMASGEVAVRQRGGDNLGTLPVSAFIELVKEK
SSQYL

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=636, Percent_Identity=40.4088050314465, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI38570111, Length=602, Percent_Identity=40.0332225913621, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI20070344, Length=639, Percent_Identity=37.245696400626, Blast_Score=395, Evalue=1e-110,
Organism=Escherichia coli, GI1788013, Length=629, Percent_Identity=45.7869634340223, Blast_Score=602, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI71984192, Length=646, Percent_Identity=38.2352941176471, Blast_Score=465, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI71984184, Length=646, Percent_Identity=38.2352941176471, Blast_Score=464, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6322112, Length=629, Percent_Identity=37.9968203497615, Blast_Score=461, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6322654, Length=391, Percent_Identity=37.8516624040921, Blast_Score=276, Evalue=6e-75,
Organism=Drosophila melanogaster, GI24583842, Length=638, Percent_Identity=39.3416927899687, Blast_Score=485, Evalue=1e-137,
Organism=Drosophila melanogaster, GI28574141, Length=638, Percent_Identity=39.3416927899687, Blast_Score=485, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24583839, Length=638, Percent_Identity=39.3416927899687, Blast_Score=484, Evalue=1e-137,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 73755; Mature: 73755

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLGFLVMKEIKIVLPDGSERSHNEGVTVRDVLSSWNPALLATTAAARYNQNLLDLSRSL
CCCHHEEEECEEEEECCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHH
HDDGVLEPIDIHSREGLEILRHSISHIMAQAVQDIFPGVLVSIGPAIEDGFYYDFEYGNT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCEEEEEECCCC
FTPEELEKIEARMQEIVKEDHPFVREEVSREEAVAFFQGKGESYKVELLNDLPGNIKTVS
CCHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHHEECCCCCEEEEEECCCCCCEEEEE
LYRQGHYTDLCRGPHVPSTSMIRAFKLLNVAGAYWRGDERNKMLQRIYGTGFASREELDE
EEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHH
YLKILEEAKKRDHRKLGKDLDLFQVSEEAGAGLIIFHPKGTILRTIIEDWEKKEHLRRGY
HHHHHHHHHHHHHHHHCCCCCCEEEHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCC
DMVMGPQILKVDLWKKSGHFDHYRENMYFTEVEGQSYGIKPMNCLSHMLIYKTKIRSYRD
CHHCCCEEEEEEEECCCCCCHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCC
LPIRYFELGTVHRHEKTGVLHGLLRARQFTQDDAHILCTPEQLNSEIRAIADFVGYAMKI
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHH
FGFEYEVELSTRPDNSIGSDQDWELATSALENALKDNQMTYDINEGDGAFYGPKIDFKLK
HCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEECCEECEEHH
DALKRKWQCATIQCDFTLPERFDLTYVGADGEKHRPVMLHRVILGAIERFMGVLIEHYGG
HHHCCCCEEEEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
AFPVWLAPVQAILLSVTDRHIPYGKTVYQQLMDAGIRVEGDFRNEKLGYKIREAQTQKIP
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEECCCCCCCCCEEHHHHHHCCCC
YMLVIGDKEMASGEVAVRQRGGDNLGTLPVSAFIELVKEKSSQYL
EEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDLGFLVMKEIKIVLPDGSERSHNEGVTVRDVLSSWNPALLATTAAARYNQNLLDLSRSL
CCCHHEEEECEEEEECCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHH
HDDGVLEPIDIHSREGLEILRHSISHIMAQAVQDIFPGVLVSIGPAIEDGFYYDFEYGNT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCEEEEEECCCC
FTPEELEKIEARMQEIVKEDHPFVREEVSREEAVAFFQGKGESYKVELLNDLPGNIKTVS
CCHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHHEECCCCCEEEEEECCCCCCEEEEE
LYRQGHYTDLCRGPHVPSTSMIRAFKLLNVAGAYWRGDERNKMLQRIYGTGFASREELDE
EEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHH
YLKILEEAKKRDHRKLGKDLDLFQVSEEAGAGLIIFHPKGTILRTIIEDWEKKEHLRRGY
HHHHHHHHHHHHHHHHCCCCCCEEEHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCC
DMVMGPQILKVDLWKKSGHFDHYRENMYFTEVEGQSYGIKPMNCLSHMLIYKTKIRSYRD
CHHCCCEEEEEEEECCCCCCHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCC
LPIRYFELGTVHRHEKTGVLHGLLRARQFTQDDAHILCTPEQLNSEIRAIADFVGYAMKI
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHH
FGFEYEVELSTRPDNSIGSDQDWELATSALENALKDNQMTYDINEGDGAFYGPKIDFKLK
HCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEECCEECEEHH
DALKRKWQCATIQCDFTLPERFDLTYVGADGEKHRPVMLHRVILGAIERFMGVLIEHYGG
HHHCCCCEEEEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
AFPVWLAPVQAILLSVTDRHIPYGKTVYQQLMDAGIRVEGDFRNEKLGYKIREAQTQKIP
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEECCCCCCCCCEEHHHHHHCCCC
YMLVIGDKEMASGEVAVRQRGGDNLGTLPVSAFIELVKEKSSQYL
EEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA