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The map label for this gene is pgsA2 [H]

Identifier: 85858496

GI number: 85858496

Start: 651922

End: 652461

Strand: Direct

Name: pgsA2 [H]

Synonym: SYN_01716

Alternate gene names: 85858496

Gene position: 651922-652461 (Clockwise)

Preceding gene: 85858495

Following gene: 85858497

Centisome position: 20.51

GC content: 47.22

Gene sequence:

>540_bases
ATGAATATTCCTAATATTTTAACCCTTCTGCGTATTGTCCTCACGCCTGCCGTTGTCATTTTTCTGATGGAGGGTTCCTA
TTTCAAGGCCCTTATAGTTTTCAGCATTTCCGGTCTGACCGACGGTCTGGACGGCTTTCTGGCCCGCGTCCTGAAGCAGC
AGACCAAACTGGGAGCTTATCTCGATCCCATTGCAGACAAAGCCCTTTTAACCAGCAGTTTTCTGACACTGGCTATTATG
GGGATTATCCCCGGGTGGCTGACGGTCATTGTTATCAGCCGGGACTGTATTATTCTGCTTGGCATAGCGATTTTATCCAT
CATGTCCATATCTTTTGAAATCCGCCCCGCCTTCATCAGTAAGGTGACCACCATGCTTCAACTTATGACGGTACTGACCG
TGCTGGTATTGCAAGGACTGGGAAACGCAATGGATTACAACTGGATGCATCTGCTGTATTGGGTAACGGCTTTGTTTACC
ATTCTATCCGGATTGGGATATCTGGTCAGAGGTATCCGCTTGATTAATACTCAGGGGTAA

Upstream 100 bases:

>100_bases
AGATGATTCCGAGTGATGGCTGCGGGAGGACAGAGTGCCAGTTGTTTTTTCGATCGGATGCTGAACACAGAGAAGACCCG
CATGCATTGATGGTTCGCCG

Downstream 100 bases:

>100_bases
GGACCGCTTTCTATTGATTGAACCGTTGCCGTGGATTGTGAGGAACAGATGGAAAGGATTATAATCAGCTTGTGTTTCAA
CCATTTTAAGAAAGTTTCCC

Product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MNIPNILTLLRIVLTPAVVIFLMEGSYFKALIVFSISGLTDGLDGFLARVLKQQTKLGAYLDPIADKALLTSSFLTLAIM
GIIPGWLTVIVISRDCIILLGIAILSIMSISFEIRPAFISKVTTMLQLMTVLTVLVLQGLGNAMDYNWMHLLYWVTALFT
ILSGLGYLVRGIRLINTQG

Sequences:

>Translated_179_residues
MNIPNILTLLRIVLTPAVVIFLMEGSYFKALIVFSISGLTDGLDGFLARVLKQQTKLGAYLDPIADKALLTSSFLTLAIM
GIIPGWLTVIVISRDCIILLGIAILSIMSISFEIRPAFISKVTTMLQLMTVLTVLVLQGLGNAMDYNWMHLLYWVTALFT
ILSGLGYLVRGIRLINTQG
>Mature_179_residues
MNIPNILTLLRIVLTPAVVIFLMEGSYFKALIVFSISGLTDGLDGFLARVLKQQTKLGAYLDPIADKALLTSSFLTLAIM
GIIPGWLTVIVISRDCIILLGIAILSIMSISFEIRPAFISKVTTMLQLMTVLTVLVLQGLGNAMDYNWMHLLYWVTALFT
ILSGLGYLVRGIRLINTQG

Specific function: This Protein Catalyzes The Committed Step To The Synthesis Of The Acidic Phospholipids. [C]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=190, Percent_Identity=32.6315789473684, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI10092647, Length=190, Percent_Identity=32.6315789473684, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI1788220, Length=173, Percent_Identity=31.7919075144509, Blast_Score=75, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71984834, Length=182, Percent_Identity=34.6153846153846, Blast_Score=83, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71984838, Length=182, Percent_Identity=34.6153846153846, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320059, Length=210, Percent_Identity=31.4285714285714, Blast_Score=76, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24650130, Length=186, Percent_Identity=30.6451612903226, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24650126, Length=186, Percent_Identity=30.6451612903226, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24650128, Length=186, Percent_Identity=30.6451612903226, Blast_Score=83, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 19663; Mature: 19663

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIPNILTLLRIVLTPAVVIFLMEGSYFKALIVFSISGLTDGLDGFLARVLKQQTKLGAY
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LDPIADKALLTSSFLTLAIMGIIPGWLTVIVISRDCIILLGIAILSIMSISFEIRPAFIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVTTMLQLMTVLTVLVLQGLGNAMDYNWMHLLYWVTALFTILSGLGYLVRGIRLINTQG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNIPNILTLLRIVLTPAVVIFLMEGSYFKALIVFSISGLTDGLDGFLARVLKQQTKLGAY
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LDPIADKALLTSSFLTLAIMGIIPGWLTVIVISRDCIILLGIAILSIMSISFEIRPAFIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVTTMLQLMTVLTVLVLQGLGNAMDYNWMHLLYWVTALFTILSGLGYLVRGIRLINTQG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036; 10889206 [H]