The gene/protein map for NC_007759 is currently unavailable.
Definition Syntrophus aciditrophicus SB chromosome, complete genome.
Accession NC_007759
Length 3,179,300

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The map label for this gene is hemC

Identifier: 85858418

GI number: 85858418

Start: 568362

End: 569282

Strand: Direct

Name: hemC

Synonym: SYN_02273

Alternate gene names: 85858418

Gene position: 568362-569282 (Clockwise)

Preceding gene: 85858417

Following gene: 85858419

Centisome position: 17.88

GC content: 63.3

Gene sequence:

>921_bases
TTGAAAATCGGAACAAGGGGAAGCGCCCTGGCCCTGACGCAGACACGCCAGATCGCGGCGCGTCTGCAGGGCCAATATCC
CGAAATGCATCTTGAGATCGTGGTGATCAAGACCAGCGGTGACATCCAGAAGGACGTGCCGCTGGCGAAAATCGGGGGGA
AAGGGCTGTTTATCAAGGAGATCGAAGAGGCCCTGCTGGCCGGAACGGTTGATCTGGCCGTCCACAGCATGAAGGATCTG
CCGGCGGAGCTTCCAGAGGGACTTCAGATTGCCGCCGTCCCGAGACGAGAGGATCCTCGGGATGTGCTGATTTCCGGGAT
ATGCCGGGAATTTGATAATCTGCCTGCGGGGGCGCGGATCGGGACAGGCTCCCTGCGCCGGAGCGTGCAGCTTCGGGACT
GGCGGCCCGATCTGGAGATCGTGCCGCTCCGGGGCAATCTGGACACCCGGATCCGGAAGGTGGCGCAGGCGGCACTGGAT
GGGGTCGTCGTCGCCGCGGCGGGAATCCGCCGGATGGGCTGGGCGGAGAAGGTGACGCAGTTTATCCCAACGGAGAAGAT
GCTGCCGGCGGTGGGGCAGGGGGTCCTCTGTCTGGAAACCCGCGAAGAGGATGAGGACCTGAAAGCGGGGCTGGCCTTTC
TGGAAGACAAGAGGACACGGAGGGAAGTTACGGCGGAGCGCGCCTTCCTGCGGCGTCTGGGCGGCGGTTGTACCCTGCCC
GTAGCCGCCTTTGCGGAACAGCGGGGGGATGTCCTGACGATTCGGGGGATGGTGGGAAGCCTGAACGAACGGACGATGAT
CCGGCAGGAAATTTATGGGTCGGTGGAACAAGCCGTGGATCTTGGGACGGAACTGGCTGAGCGTCTGCTGGACGGAGGCG
GGCGCATTCTTCTGGAACACCTGGAGGATGGGCAGCCCTGA

Upstream 100 bases:

>100_bases
GCAGAGCCGGAACCGGAACGGAAAGGCTTACGCCGCCGCACTCCGGAAGCTCTTCAAACTGGAAAGGTAGAAGGAGAGGG
ACGAACTCATTCGACAGTCA

Downstream 100 bases:

>100_bases
TCAATCCATTTCAATATAGCAGAATCGCCGCATTCCGTGGTGGGAGCGCATTTTCAATAAAGGCCTCAAAATGGGGCAGG
GGACGGATTCGATGAGCAAA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKIGTRGSALALTQTRQIAARLQGQYPEMHLEIVVIKTSGDIQKDVPLAKIGGKGLFIKEIEEALLAGTVDLAVHSMKDL
PAELPEGLQIAAVPRREDPRDVLISGICREFDNLPAGARIGTGSLRRSVQLRDWRPDLEIVPLRGNLDTRIRKVAQAALD
GVVVAAAGIRRMGWAEKVTQFIPTEKMLPAVGQGVLCLETREEDEDLKAGLAFLEDKRTRREVTAERAFLRRLGGGCTLP
VAAFAEQRGDVLTIRGMVGSLNERTMIRQEIYGSVEQAVDLGTELAERLLDGGGRILLEHLEDGQP

Sequences:

>Translated_306_residues
MKIGTRGSALALTQTRQIAARLQGQYPEMHLEIVVIKTSGDIQKDVPLAKIGGKGLFIKEIEEALLAGTVDLAVHSMKDL
PAELPEGLQIAAVPRREDPRDVLISGICREFDNLPAGARIGTGSLRRSVQLRDWRPDLEIVPLRGNLDTRIRKVAQAALD
GVVVAAAGIRRMGWAEKVTQFIPTEKMLPAVGQGVLCLETREEDEDLKAGLAFLEDKRTRREVTAERAFLRRLGGGCTLP
VAAFAEQRGDVLTIRGMVGSLNERTMIRQEIYGSVEQAVDLGTELAERLLDGGGRILLEHLEDGQP
>Mature_306_residues
MKIGTRGSALALTQTRQIAARLQGQYPEMHLEIVVIKTSGDIQKDVPLAKIGGKGLFIKEIEEALLAGTVDLAVHSMKDL
PAELPEGLQIAAVPRREDPRDVLISGICREFDNLPAGARIGTGSLRRSVQLRDWRPDLEIVPLRGNLDTRIRKVAQAALD
GVVVAAAGIRRMGWAEKVTQFIPTEKMLPAVGQGVLCLETREEDEDLKAGLAFLEDKRTRREVTAERAFLRRLGGGCTLP
VAAFAEQRGDVLTIRGMVGSLNERTMIRQEIYGSVEQAVDLGTELAERLLDGGGRILLEHLEDGQP

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=280, Percent_Identity=40.7142857142857, Blast_Score=213, Evalue=1e-55,
Organism=Homo sapiens, GI66933009, Length=280, Percent_Identity=40.7142857142857, Blast_Score=213, Evalue=1e-55,
Organism=Escherichia coli, GI48994974, Length=304, Percent_Identity=43.0921052631579, Blast_Score=244, Evalue=7e-66,
Organism=Saccharomyces cerevisiae, GI6319996, Length=316, Percent_Identity=32.9113924050633, Blast_Score=170, Evalue=3e-43,
Organism=Drosophila melanogaster, GI20130425, Length=309, Percent_Identity=39.8058252427184, Blast_Score=206, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_SYNAS (Q2LQU2)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_460620.1
- ProteinModelPortal:   Q2LQU2
- SMR:   Q2LQU2
- STRING:   Q2LQU2
- GeneID:   3885136
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_02273
- NMPDR:   fig|56780.10.peg.565
- eggNOG:   COG0181
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- PhylomeDB:   Q2LQU2
- BioCyc:   SACI56780:SYN_02273-MONOMER
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 33436; Mature: 33436

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MKIGTRGSALALTQTRQIAARLQGQYPEMHLEIVVIKTSGDIQKDVPLAKIGGKGLFIKE
CCCCCCCCEEEHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCEEECCCCEEHHH
IEEALLAGTVDLAVHSMKDLPAELPEGLQIAAVPRREDPRDVLISGICREFDNLPAGARI
HHHHHHHHHHHHHHHHHHHCHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEE
GTGSLRRSVQLRDWRPDLEIVPLRGNLDTRIRKVAQAALDGVVVAAAGIRRMGWAEKVTQ
CCHHHHHCEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FIPTEKMLPAVGQGVLCLETREEDEDLKAGLAFLEDKRTRREVTAERAFLRRLGGGCTLP
HCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
VAAFAEQRGDVLTIRGMVGSLNERTMIRQEIYGSVEQAVDLGTELAERLLDGGGRILLEH
HHHHHHHCCCEEEEECHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHH
LEDGQP
HCCCCC
>Mature Secondary Structure
MKIGTRGSALALTQTRQIAARLQGQYPEMHLEIVVIKTSGDIQKDVPLAKIGGKGLFIKE
CCCCCCCCEEEHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCEEECCCCEEHHH
IEEALLAGTVDLAVHSMKDLPAELPEGLQIAAVPRREDPRDVLISGICREFDNLPAGARI
HHHHHHHHHHHHHHHHHHHCHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEE
GTGSLRRSVQLRDWRPDLEIVPLRGNLDTRIRKVAQAALDGVVVAAAGIRRMGWAEKVTQ
CCHHHHHCEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FIPTEKMLPAVGQGVLCLETREEDEDLKAGLAFLEDKRTRREVTAERAFLRRLGGGCTLP
HCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
VAAFAEQRGDVLTIRGMVGSLNERTMIRQEIYGSVEQAVDLGTELAERLLDGGGRILLEH
HHHHHHHCCCEEEEECHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHH
LEDGQP
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA