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The map label for this gene is hemA [H]

Identifier: 85858417

GI number: 85858417

Start: 566913

End: 568331

Strand: Direct

Name: hemA [H]

Synonym: SYN_02274

Alternate gene names: 85858417

Gene position: 566913-568331 (Clockwise)

Preceding gene: 85858416

Following gene: 85858418

Centisome position: 17.83

GC content: 56.8

Gene sequence:

>1419_bases
ATGCTGTTTTGCTCCATCAGCGCCTGGCCATTGGCTGGAAGGGTCATAAAACCGCCGTTTTTTCACTTCTGGCTTTTCTC
CTCTTTCTTGCGGCCTTTCTTGTGGAAAGGGCTTTTTTTACCACGTTTCACCGGTTTCTCTGAGATCATGGGCATTCTTC
TTATCGGCATGAGCCATAAAACCTCACCCCTGGCCGTTCGGGAGCGGTTTTCCCTTTCCTGCGAAAACCGGGATCATCCT
CTGGATCGAATCCGGCAGATGCCGTCGATCCGGGAAGCCCTGTATCTGGCTACATGCAACCGGGTGGAGGTGCTGGTCAG
CGCCGCGGAAGAAGCGGAACAGGCGGTTGAAGAAGGACTGAAAGCTCTGATGGCCGAACGGGGGGGGATATCCGGGCAGG
AACTGGAACGCTGCCTTTATACGCTGAGCGGGGCGGAGGCTGTACGGCATCTGTTCCGGGTGGCTTCCAGTCTGGATTCC
CTGGTCATGGGGGAACCGCAGATTCTCGGTCAGGTCAAGGAAGCTTACCGGGAAGCCGTGGAACATGGTGTCACGGGGAT
CCTGCTGAACCGGATTCTTCATCATGCCTTTCAGGTGGCCAAACGGGTGAGAACGGAGACCGGCATTGCCGATAACGCGG
TGTCCGTCGGGTATGCCGCGGTCGAACTGGCGAAGAAGATCTTCGGGAGGCTTGATGGGAAAGTAATTCTCCTGGTGGGG
GCGGGGGAGATGTCCGAACTGGCGGCCCGCCATCTGCTGAAGCAGGGCATCAAATCCATTTTCGTCGCCAACCGGACCCA
TGCCCGGGCATTGGAGATGGCGGAACAGTTTGAGGGAAAGGCGGTCGTTCTGGAGCAGGTGCCCGAGGTTTTGAAATCGG
TGGACATCGTGATCAGCTCCACGGGCGCGTCCAACTATGTCCTGACCCGTGACATGGTCGCCGCGGCCCTGCGCCGGAGA
AAAAACCGTTTTCTCTTTCTCATCGATATTGCCGTTCCCCGGGATATCGAGCCGGCGGCGGGAGACATAGACAACGTTTA
CCTTTACAATATCGACCACCTTCAGGAACTGGTGGATGAGAACCGAAACCATCGTCTGCGGGAAGCGGAAAAGGCCGAGG
CGATCATTGAAGAAGAGGTGGGCAATCATACAGCCTGGCTTTCCACTCTGGATGTGGTGCCCACCATTGTGGAATTCCGG
GAAAAGATCGAGGGAATCATGAAAGCGGAGCTGGGAAAATCAGCCTCATGGCGGCACTCGCTGAGCGAGATTGACCAGCG
TCATGTTGAAAGCCTGATGGCTTCCATCGTCAACAAAATCCTTCATGAGCCCACGGCCTGCCTGCGGGAGCAGAGCCGGA
ACCGGAACGGAAAGGCTTACGCCGCCGCACTCCGGAAGCTCTTCAAACTGGAAAGGTAG

Upstream 100 bases:

>100_bases
ATGGGGGTGCTGACAGGTTCCCTCTGGGCCCGACTGGCCCTGGGGAACTCCTGGCTCTGGGATCCCAAACAGGTCTGGAC
CTTTACGGTCTGGGGAACTT

Downstream 100 bases:

>100_bases
AAGGAGAGGGACGAACTCATTCGACAGTCATTGAAAATCGGAACAAGGGGAAGCGCCCTGGCCCTGACGCAGACACGCCA
GATCGCGGCGCGTCTGCAGG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MLFCSISAWPLAGRVIKPPFFHFWLFSSFLRPFLWKGLFLPRFTGFSEIMGILLIGMSHKTSPLAVRERFSLSCENRDHP
LDRIRQMPSIREALYLATCNRVEVLVSAAEEAEQAVEEGLKALMAERGGISGQELERCLYTLSGAEAVRHLFRVASSLDS
LVMGEPQILGQVKEAYREAVEHGVTGILLNRILHHAFQVAKRVRTETGIADNAVSVGYAAVELAKKIFGRLDGKVILLVG
AGEMSELAARHLLKQGIKSIFVANRTHARALEMAEQFEGKAVVLEQVPEVLKSVDIVISSTGASNYVLTRDMVAAALRRR
KNRFLFLIDIAVPRDIEPAAGDIDNVYLYNIDHLQELVDENRNHRLREAEKAEAIIEEEVGNHTAWLSTLDVVPTIVEFR
EKIEGIMKAELGKSASWRHSLSEIDQRHVESLMASIVNKILHEPTACLREQSRNRNGKAYAAALRKLFKLER

Sequences:

>Translated_472_residues
MLFCSISAWPLAGRVIKPPFFHFWLFSSFLRPFLWKGLFLPRFTGFSEIMGILLIGMSHKTSPLAVRERFSLSCENRDHP
LDRIRQMPSIREALYLATCNRVEVLVSAAEEAEQAVEEGLKALMAERGGISGQELERCLYTLSGAEAVRHLFRVASSLDS
LVMGEPQILGQVKEAYREAVEHGVTGILLNRILHHAFQVAKRVRTETGIADNAVSVGYAAVELAKKIFGRLDGKVILLVG
AGEMSELAARHLLKQGIKSIFVANRTHARALEMAEQFEGKAVVLEQVPEVLKSVDIVISSTGASNYVLTRDMVAAALRRR
KNRFLFLIDIAVPRDIEPAAGDIDNVYLYNIDHLQELVDENRNHRLREAEKAEAIIEEEVGNHTAWLSTLDVVPTIVEFR
EKIEGIMKAELGKSASWRHSLSEIDQRHVESLMASIVNKILHEPTACLREQSRNRNGKAYAAALRKLFKLER
>Mature_472_residues
MLFCSISAWPLAGRVIKPPFFHFWLFSSFLRPFLWKGLFLPRFTGFSEIMGILLIGMSHKTSPLAVRERFSLSCENRDHP
LDRIRQMPSIREALYLATCNRVEVLVSAAEEAEQAVEEGLKALMAERGGISGQELERCLYTLSGAEAVRHLFRVASSLDS
LVMGEPQILGQVKEAYREAVEHGVTGILLNRILHHAFQVAKRVRTETGIADNAVSVGYAAVELAKKIFGRLDGKVILLVG
AGEMSELAARHLLKQGIKSIFVANRTHARALEMAEQFEGKAVVLEQVPEVLKSVDIVISSTGASNYVLTRDMVAAALRRR
KNRFLFLIDIAVPRDIEPAAGDIDNVYLYNIDHLQELVDENRNHRLREAEKAEAIIEEEVGNHTAWLSTLDVVPTIVEFR
EKIEGIMKAELGKSASWRHSLSEIDQRHVESLMASIVNKILHEPTACLREQSRNRNGKAYAAALRKLFKLER

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=409, Percent_Identity=38.1418092909535, Blast_Score=270, Evalue=1e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR003462
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 52937; Mature: 52937

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFCSISAWPLAGRVIKPPFFHFWLFSSFLRPFLWKGLFLPRFTGFSEIMGILLIGMSHK
CEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCCCC
TSPLAVRERFSLSCENRDHPLDRIRQMPSIREALYLATCNRVEVLVSAAEEAEQAVEEGL
CCCHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KALMAERGGISGQELERCLYTLSGAEAVRHLFRVASSLDSLVMGEPQILGQVKEAYREAV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
EHGVTGILLNRILHHAFQVAKRVRTETGIADNAVSVGYAAVELAKKIFGRLDGKVILLVG
HHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEC
AGEMSELAARHLLKQGIKSIFVANRTHARALEMAEQFEGKAVVLEQVPEVLKSVDIVISS
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHEEC
TGASNYVLTRDMVAAALRRRKNRFLFLIDIAVPRDIEPAAGDIDNVYLYNIDHLQELVDE
CCCCCEEHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHHC
NRNHRLREAEKAEAIIEEEVGNHTAWLSTLDVVPTIVEFREKIEGIMKAELGKSASWRHS
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LSEIDQRHVESLMASIVNKILHEPTACLREQSRNRNGKAYAAALRKLFKLER
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLFCSISAWPLAGRVIKPPFFHFWLFSSFLRPFLWKGLFLPRFTGFSEIMGILLIGMSHK
CEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCCCC
TSPLAVRERFSLSCENRDHPLDRIRQMPSIREALYLATCNRVEVLVSAAEEAEQAVEEGL
CCCHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KALMAERGGISGQELERCLYTLSGAEAVRHLFRVASSLDSLVMGEPQILGQVKEAYREAV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
EHGVTGILLNRILHHAFQVAKRVRTETGIADNAVSVGYAAVELAKKIFGRLDGKVILLVG
HHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEC
AGEMSELAARHLLKQGIKSIFVANRTHARALEMAEQFEGKAVVLEQVPEVLKSVDIVISS
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHEEC
TGASNYVLTRDMVAAALRRRKNRFLFLIDIAVPRDIEPAAGDIDNVYLYNIDHLQELVDE
CCCCCEEHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHHC
NRNHRLREAEKAEAIIEEEVGNHTAWLSTLDVVPTIVEFREKIEGIMKAELGKSASWRHS
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LSEIDQRHVESLMASIVNKILHEPTACLREQSRNRNGKAYAAALRKLFKLER
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA