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The map label for this gene is adh [H]

Identifier: 85858110

GI number: 85858110

Start: 280902

End: 281990

Strand: Direct

Name: adh [H]

Synonym: SYN_01269

Alternate gene names: 85858110

Gene position: 280902-281990 (Clockwise)

Preceding gene: 85858108

Following gene: 85858111

Centisome position: 8.84

GC content: 59.23

Gene sequence:

>1089_bases
ATGAAGGAAAAACTGGAGGGTATCAGAATGGACGACACAATGAAAGCGATGGTGTACCGTGGGCCCGGTCGGTACGGCTT
GGAAGATGTCCCGGCGCCCGTCATCCTGGAACCCGATGATGTCATTGGCAGGGTCACGTTATCGTCGATTTCGGGCAGCG
ATGTTCAGATTGTCCATGGCGGCCTGCCGGAAGTTAGAACTCCGCTGATCGTCGGCCACGAATTCTGCGCTGAAATCATG
GAAGTCGGTCCAGCGGTGAAAAGTCTGAATGTCGGAGATCGGGTCGTCGTCTCCTGCGTCGCCTTCTGCGGGGAATGCCG
GTCCTGCAGACAGGGCCTCCATGCCCGCTGCGAAAAGACGGGGTTCGGCTCTTTCGGGATGAATGGGCCGGACGGCGGCC
AGGCGGAATACGTACGCCTCCCGGGGGCCGATCGTTACTGTTTCAAAATTCCCGAATCCCTGACTTTTCAGGATGTCCTG
TTCTGCGGCGATGTCCTGTCGGCGGGCTATTACGGGGCGGAAATGGGGGACATTCAACGCGGTGAAACGGTGGTCGTGGT
GGGCGCCGGTCCGGTCGGTCTGTGCGCCATGGCGTCGGCAAGGCTCCGGGAACCGTCGCGGATTATCGCCGTCGACACCA
ATCCGTACCGGCTGGATGCGGCCCTGAAAGCAGGCGTGGCGGATCTGGCCCTCAACCCAGTGAAGGATCGCGTTGTTGAA
ATCGTCCAGGGACTTACCGATGGGCGGGGCGCCGACAAAACCATCGAATGCGCGGGCATGCAGACCACGTTCGATATCGC
CTTCCAGGCCGTCCGGGGCGGAGGGAAAATCGCTACCGCCAGCATTTTTCAAAAACCGGTGACTGTTCCTCTGGATGCCG
CCTGGGGCAGAAATATCAGCCTGAGCTGGGGGTTCGCGCCGATCGATCGGATTCCGAAACTGATCAGGCTGATCGAAGAG
GGAAAAATCAATACCGGCTTCTTATGCACCCATCAAGCGCCGTTAAACGACATCCTGCGAGGCTACGACATCTTCGGCAA
CAGGAAGGACGGCTGCCTGAAGTGGCTGGTGACGCCATGGGAACATTAG

Upstream 100 bases:

>100_bases
AGGCGTATACAATCCAACCATCGAGGAATCGATCATGAAGACGGCGAAGAGAGCGCTTTGACATGGAATTGCATGACATG
GTCATCCGTCGATCATTTCA

Downstream 100 bases:

>100_bases
AATTTATGCAGAGCTCCTCGATATTTAGAACTCTGTTTCCTGCGTAATTGCCGCCGGATGCCTGTATTTAGCAACTTTCA
ATCGGCTGCCCTTTCAAATC

Product: zinc-binding dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MKEKLEGIRMDDTMKAMVYRGPGRYGLEDVPAPVILEPDDVIGRVTLSSISGSDVQIVHGGLPEVRTPLIVGHEFCAEIM
EVGPAVKSLNVGDRVVVSCVAFCGECRSCRQGLHARCEKTGFGSFGMNGPDGGQAEYVRLPGADRYCFKIPESLTFQDVL
FCGDVLSAGYYGAEMGDIQRGETVVVVGAGPVGLCAMASARLREPSRIIAVDTNPYRLDAALKAGVADLALNPVKDRVVE
IVQGLTDGRGADKTIECAGMQTTFDIAFQAVRGGGKIATASIFQKPVTVPLDAAWGRNISLSWGFAPIDRIPKLIRLIEE
GKINTGFLCTHQAPLNDILRGYDIFGNRKDGCLKWLVTPWEH

Sequences:

>Translated_362_residues
MKEKLEGIRMDDTMKAMVYRGPGRYGLEDVPAPVILEPDDVIGRVTLSSISGSDVQIVHGGLPEVRTPLIVGHEFCAEIM
EVGPAVKSLNVGDRVVVSCVAFCGECRSCRQGLHARCEKTGFGSFGMNGPDGGQAEYVRLPGADRYCFKIPESLTFQDVL
FCGDVLSAGYYGAEMGDIQRGETVVVVGAGPVGLCAMASARLREPSRIIAVDTNPYRLDAALKAGVADLALNPVKDRVVE
IVQGLTDGRGADKTIECAGMQTTFDIAFQAVRGGGKIATASIFQKPVTVPLDAAWGRNISLSWGFAPIDRIPKLIRLIEE
GKINTGFLCTHQAPLNDILRGYDIFGNRKDGCLKWLVTPWEH
>Mature_362_residues
MKEKLEGIRMDDTMKAMVYRGPGRYGLEDVPAPVILEPDDVIGRVTLSSISGSDVQIVHGGLPEVRTPLIVGHEFCAEIM
EVGPAVKSLNVGDRVVVSCVAFCGECRSCRQGLHARCEKTGFGSFGMNGPDGGQAEYVRLPGADRYCFKIPESLTFQDVL
FCGDVLSAGYYGAEMGDIQRGETVVVVGAGPVGLCAMASARLREPSRIIAVDTNPYRLDAALKAGVADLALNPVKDRVVE
IVQGLTDGRGADKTIECAGMQTTFDIAFQAVRGGGKIATASIFQKPVTVPLDAAWGRNISLSWGFAPIDRIPKLIRLIEE
GKINTGFLCTHQAPLNDILRGYDIFGNRKDGCLKWLVTPWEH

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=335, Percent_Identity=28.3582089552239, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI71565152, Length=340, Percent_Identity=25.5882352941176, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI71565154, Length=338, Percent_Identity=24.8520710059172, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI34577061, Length=326, Percent_Identity=26.3803680981595, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4501929, Length=326, Percent_Identity=25.4601226993865, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4501933, Length=332, Percent_Identity=25.3012048192771, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786825, Length=388, Percent_Identity=33.5051546391753, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1790045, Length=336, Percent_Identity=28.8690476190476, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI87082125, Length=256, Percent_Identity=33.203125, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788073, Length=339, Percent_Identity=26.5486725663717, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1787863, Length=349, Percent_Identity=27.5071633237822, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788075, Length=353, Percent_Identity=29.1784702549575, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI226510992, Length=344, Percent_Identity=24.7093023255814, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786552, Length=340, Percent_Identity=28.5294117647059, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788407, Length=362, Percent_Identity=25.414364640884, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790718, Length=319, Percent_Identity=21.0031347962382, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081918, Length=244, Percent_Identity=30.7377049180328, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=339, Percent_Identity=30.9734513274336, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17562878, Length=328, Percent_Identity=28.3536585365854, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17565904, Length=340, Percent_Identity=25.2941176470588, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=341, Percent_Identity=24.9266862170088, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=341, Percent_Identity=24.9266862170088, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=386, Percent_Identity=27.2020725388601, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319955, Length=343, Percent_Identity=26.8221574344023, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6322619, Length=343, Percent_Identity=26.8221574344023, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319257, Length=390, Percent_Identity=24.8717948717949, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6323099, Length=356, Percent_Identity=23.5955056179775, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=350, Percent_Identity=26.5714285714286, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17137530, Length=353, Percent_Identity=26.9121813031161, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI17737897, Length=353, Percent_Identity=27.1954674220963, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17737895, Length=331, Percent_Identity=27.4924471299094, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45550770, Length=327, Percent_Identity=22.9357798165138, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI45551930, Length=327, Percent_Identity=22.9357798165138, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 39002; Mature: 39002

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKLEGIRMDDTMKAMVYRGPGRYGLEDVPAPVILEPDDVIGRVTLSSISGSDVQIVHG
CCCCCCCCCCCCHHEEEEEECCCCCCCCCCCCCEEECCCCCEEEEEEECCCCCCEEEEEC
GLPEVRTPLIVGHEFCAEIMEVGPAVKSLNVGDRVVVSCVAFCGECRSCRQGLHARCEKT
CCCCCCCCEEECHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GFGSFGMNGPDGGQAEYVRLPGADRYCFKIPESLTFQDVLFCGDVLSAGYYGAEMGDIQR
CCCCCCCCCCCCCCEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
GETVVVVGAGPVGLCAMASARLREPSRIIAVDTNPYRLDAALKAGVADLALNPVKDRVVE
CCEEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHCCHHHHHCCHHHHHHHH
IVQGLTDGRGADKTIECAGMQTTFDIAFQAVRGGGKIATASIFQKPVTVPLDAAWGRNIS
HHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEHHHHHCCCCCEEECCCCCCEE
LSWGFAPIDRIPKLIRLIEEGKINTGFLCTHQAPLNDILRGYDIFGNRKDGCLKWLVTPW
EEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCCC
EH
CC
>Mature Secondary Structure
MKEKLEGIRMDDTMKAMVYRGPGRYGLEDVPAPVILEPDDVIGRVTLSSISGSDVQIVHG
CCCCCCCCCCCCHHEEEEEECCCCCCCCCCCCCEEECCCCCEEEEEEECCCCCCEEEEEC
GLPEVRTPLIVGHEFCAEIMEVGPAVKSLNVGDRVVVSCVAFCGECRSCRQGLHARCEKT
CCCCCCCCEEECHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GFGSFGMNGPDGGQAEYVRLPGADRYCFKIPESLTFQDVLFCGDVLSAGYYGAEMGDIQR
CCCCCCCCCCCCCCEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
GETVVVVGAGPVGLCAMASARLREPSRIIAVDTNPYRLDAALKAGVADLALNPVKDRVVE
CCEEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHCCHHHHHCCHHHHHHHH
IVQGLTDGRGADKTIECAGMQTTFDIAFQAVRGGGKIATASIFQKPVTVPLDAAWGRNIS
HHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEHHHHHCCCCCEEECCCCCCEE
LSWGFAPIDRIPKLIRLIEEGKINTGFLCTHQAPLNDILRGYDIFGNRKDGCLKWLVTPW
EEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCCC
EH
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]