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The map label for this gene is moaA [H]

Identifier: 85857996

GI number: 85857996

Start: 159275

End: 160264

Strand: Direct

Name: moaA [H]

Synonym: SYN_01960

Alternate gene names: 85857996

Gene position: 159275-160264 (Clockwise)

Preceding gene: 85857985

Following gene: 85857997

Centisome position: 5.01

GC content: 45.66

Gene sequence:

>990_bases
GTGATAGATATGTTGGATACTTATAACCGGAATATAAATTACCTGCGTATATCCGTGACTGATCGATGTAATTTACGGTG
CCGGTATTGTATGCCCGAAGAGGGTATTTCCAAGCTTGACCACAGGGAAATTTTGAGTCTGGAAGACATCGTCAGGTCGG
TTAAAGTTGCCGCTGGGGTGGGTATTCGTAAGATTCGGCTGACCGGTGGCGAGCCGCTGGTACGTAAAGACATTGCCCGA
CTGATCGGCTTTATTTCTGAAGTCCCGGAAATTGACGATATTGCCATGACTACCAATGGGGTTTTATTTGCAGATATGGC
AGAGCAATTAAAAGCCGCTGGATTGGATCGGGTAAATTTCAGCATGGATACGATGGTATCTGAAAAATTCAGATATATTT
CACGTCGGGATCATCTGGCAGATGTGAGGAAGGCCATTTTCAAAGCCCTGGAACTCGGGCTGGAACCGGTTAAAATCAAT
ACCGTGGTCATCAGGGGATTCAATGATGATGAGCTTCTGGATTTTGCGGATCTTGCCTTTGATTTTCCGCTGCACATCCG
GTTCATTGAATTCATGCCGATTGGAGATTTGTTATTCTGGAAAAAGGACCGCATGATTACTTCTGAGCAGATTAAAGAAA
AGATTGAACAACGCTATGAGCTGACCCCGACGAAGTTAGTTAAAGGAAGCGGTCCTGCCCGATATTTCAAGCTTGCCGGC
GGACGGGGCACGATCGGATTCATCACCCCCATGAGTCATAAATTCTGTTCTGAATGCAACCGGTTACGTATGACTGCCGA
TGGAAAACTGCGAGGCTGTTTATACGATAAGCGAGAAATCGATTTAAAAAAAGCCCTTCAGAGCAAGCCCAGTGATGAAG
ATCTTAAACAGCTTTTTATTGAAGCGATCCTTCTCAAGCCCTATGAACATCATATGGATGCTGGGTGGGGGAAGGACAAC
CCTCGTAAAATGAGCCAGATAGGGGGCTAA

Upstream 100 bases:

>100_bases
TTATTCATATCTTGACATAAGAAGGTGCGCTGCATATATTTTATTCAGTTACATCCTCGGTGTTAAATCTTCAAAATAGA
GGCATGATAGGTGAAAGAAA

Downstream 100 bases:

>100_bases
ACCCGGGAAAAATAAGTTTCTGTTCATGATCAGGAAAATCAGGATCTCTTATCCGCTGCAACATTCAGACAGAACACCCG
GCTTCCGGGAGTCATAGCCC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MIDMLDTYNRNINYLRISVTDRCNLRCRYCMPEEGISKLDHREILSLEDIVRSVKVAAGVGIRKIRLTGGEPLVRKDIAR
LIGFISEVPEIDDIAMTTNGVLFADMAEQLKAAGLDRVNFSMDTMVSEKFRYISRRDHLADVRKAIFKALELGLEPVKIN
TVVIRGFNDDELLDFADLAFDFPLHIRFIEFMPIGDLLFWKKDRMITSEQIKEKIEQRYELTPTKLVKGSGPARYFKLAG
GRGTIGFITPMSHKFCSECNRLRMTADGKLRGCLYDKREIDLKKALQSKPSDEDLKQLFIEAILLKPYEHHMDAGWGKDN
PRKMSQIGG

Sequences:

>Translated_329_residues
MIDMLDTYNRNINYLRISVTDRCNLRCRYCMPEEGISKLDHREILSLEDIVRSVKVAAGVGIRKIRLTGGEPLVRKDIAR
LIGFISEVPEIDDIAMTTNGVLFADMAEQLKAAGLDRVNFSMDTMVSEKFRYISRRDHLADVRKAIFKALELGLEPVKIN
TVVIRGFNDDELLDFADLAFDFPLHIRFIEFMPIGDLLFWKKDRMITSEQIKEKIEQRYELTPTKLVKGSGPARYFKLAG
GRGTIGFITPMSHKFCSECNRLRMTADGKLRGCLYDKREIDLKKALQSKPSDEDLKQLFIEAILLKPYEHHMDAGWGKDN
PRKMSQIGG
>Mature_329_residues
MIDMLDTYNRNINYLRISVTDRCNLRCRYCMPEEGISKLDHREILSLEDIVRSVKVAAGVGIRKIRLTGGEPLVRKDIAR
LIGFISEVPEIDDIAMTTNGVLFADMAEQLKAAGLDRVNFSMDTMVSEKFRYISRRDHLADVRKAIFKALELGLEPVKIN
TVVIRGFNDDELLDFADLAFDFPLHIRFIEFMPIGDLLFWKKDRMITSEQIKEKIEQRYELTPTKLVKGSGPARYFKLAG
GRGTIGFITPMSHKFCSECNRLRMTADGKLRGCLYDKREIDLKKALQSKPSDEDLKQLFIEAILLKPYEHHMDAGWGKDN
PRKMSQIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=326, Percent_Identity=40.7975460122699, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI22027536, Length=326, Percent_Identity=40.7975460122699, Blast_Score=261, Evalue=6e-70,
Organism=Escherichia coli, GI1786999, Length=327, Percent_Identity=31.8042813455657, Blast_Score=178, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI32566329, Length=329, Percent_Identity=40.7294832826748, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI32566331, Length=325, Percent_Identity=39.3846153846154, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17561210, Length=331, Percent_Identity=39.5770392749245, Blast_Score=220, Evalue=9e-58,
Organism=Drosophila melanogaster, GI28574488, Length=330, Percent_Identity=38.1818181818182, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI28574490, Length=315, Percent_Identity=38.0952380952381, Blast_Score=235, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37670; Mature: 37670

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDMLDTYNRNINYLRISVTDRCNLRCRYCMPEEGISKLDHREILSLEDIVRSVKVAAGV
CCCCCHHCCCCCEEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GIRKIRLTGGEPLVRKDIARLIGFISEVPEIDDIAMTTNGVLFADMAEQLKAAGLDRVNF
CEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCEEHHHHHHHHHHCCCCCCCC
SMDTMVSEKFRYISRRDHLADVRKAIFKALELGLEPVKINTVVIRGFNDDELLDFADLAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHHHHH
DFPLHIRFIEFMPIGDLLFWKKDRMITSEQIKEKIEQRYELTPTKLVKGSGPARYFKLAG
CCCEEEEEEEEEECCHHHEECCCCCCCHHHHHHHHHHHHCCCHHHEECCCCCCEEEEECC
GRGTIGFITPMSHKFCSECNRLRMTADGKLRGCLYDKREIDLKKALQSKPSDEDLKQLFI
CCCCEEEECCCCHHHHHHHHHEEECCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHH
EAILLKPYEHHMDAGWGKDNPRKMSQIGG
HHHHHCCHHHHCCCCCCCCCCHHHHHCCC
>Mature Secondary Structure
MIDMLDTYNRNINYLRISVTDRCNLRCRYCMPEEGISKLDHREILSLEDIVRSVKVAAGV
CCCCCHHCCCCCEEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GIRKIRLTGGEPLVRKDIARLIGFISEVPEIDDIAMTTNGVLFADMAEQLKAAGLDRVNF
CEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCEEHHHHHHHHHHCCCCCCCC
SMDTMVSEKFRYISRRDHLADVRKAIFKALELGLEPVKINTVVIRGFNDDELLDFADLAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHHHHH
DFPLHIRFIEFMPIGDLLFWKKDRMITSEQIKEKIEQRYELTPTKLVKGSGPARYFKLAG
CCCEEEEEEEEEECCHHHEECCCCCCCHHHHHHHHHHHHCCCHHHEECCCCCCEEEEECC
GRGTIGFITPMSHKFCSECNRLRMTADGKLRGCLYDKREIDLKKALQSKPSDEDLKQLFI
CCCCEEEECCCCHHHHHHHHHEEECCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHH
EAILLKPYEHHMDAGWGKDNPRKMSQIGG
HHHHHCCHHHHCCCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA