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The map label for this gene is dnaX [H]

Identifier: 85857923

GI number: 85857923

Start: 80085

End: 81851

Strand: Direct

Name: dnaX [H]

Synonym: SYN_00163

Alternate gene names: 85857923

Gene position: 80085-81851 (Clockwise)

Preceding gene: 85857922

Following gene: 85857924

Centisome position: 2.52

GC content: 59.2

Gene sequence:

>1767_bases
ATGGACTACCTTGTTTTAGCCCGCAAATGGAGGCCTCAGGTCTTTGAGGACGTCGTCGGCCAGCAGCATGTCGTCCAGAC
CCTGAAGAATGCCATCCGTCAGGAGCGCATTGCCCACGCCTTTCTGTTCAGTGGGCCGCGCGGTGTCGGCAAGACCTCCA
TTGCCCGCATTCTGGCCAAGGCCATCAATTGTGAACAGGGGCCTGCCGGGACACCGTGCAATGTCTGTACAAACTGCCGT
GAAATCACGGAAGGCATTTCCATGGATGTCCGGGAAATCGATGGCGCCTCCAATCGGGGTATCGACGAAATTCGGGAGCT
CCGCGAACGGATCCGTTTCCTGCCCGTTTCCTGCCGTTATAAGGTCTATATCATCGATGAAGTGCACATGCTGACTCGGG
AAGCCTTCAACGCTCTGCTGAAGACCCTCGAGGAACCCCCTCCCCATGTCGTTTTCATTTTTGCCACAACAGAGACCCAT
AAAGTGCCGGCAACCATCCTTTCCCGCTGTCAGTGCTTTGAGTTCCGCCGCCTTTCCCTGCGTCAGATTGCAGAGCAGCT
GCGGAAGATCGCCGAGACGGAAAAGATCCGGATCAGCGATGCCGGCCTTGCCTGGATTGCCGAAGCGGGGGACGGCAGCA
TGCGGGACTCCGAGAGCATCTTTGATCAAGTGATTTCCTATGCCGGAACGGCGATCGAAGACGAGGCCGTTGAGGAGCTG
CTCGGCCGGACCGACCGTCGCTTTCTCTTCCAGCTTTCCGAGGCGGTCCTGCGCCGCGATGCCGGACAATGTCTCCGGAT
TGTGGAGGAGGGGTATTACGCCGGCCTGGACATGACGTATTTTTATACGCTTCTTCTCCACCATTTCCGTAATCTTCTCC
TGGTGAAGATCGTCGGGCCGCAGCAGGAGCTCCTGGATCTGCCCGGCAACGACCTGTCCGGCATCGAGGCGCAGGTGGCG
GAGGTCTCGCGGGAGACTCTGCAGCAGCTTCTGGATATCCTGCTGGCGGAAGAGGAAAGCGCGCGACGGAGCCACAACCC
CCGGCTTCACTTGGAAGCGATCGTCTGCCGCATGGCCGGTCTGCCGCCAGCTCTTCCCATCGAAGAGATTCTCTCCCGCA
TGGAGGACCTGGAAACCCGGCTGGCGTCTTCCGCGCCTTGCCTTTCGGAAACGGTTCCCGGGGCCGCCTCCTTTTCGCCT
TCCAAACCGGGAAATTCAACGACAGTGAGAGAGCGTCCGTTGACACTGCCAATCGTCCGGACAGAGGACCGGAGCGTAAG
GGAACCGATGGCGGAATTGCAGGGGGCGGTCAGGGATCCGGCGCATGCCGGGGGGGATGTCTGGGCGGATTTCAAAGCCC
ATGTGAAGAAGCATTCGATCCTGCTGGCCTCCAAGATCGAGCAGGGCGAATGTCTCGGCTGTGAAAACGGCCATCTGCGC
ATCGGGTTTCGCAAGGGGAGCGTTTTTTTTGAGGACCTCAACGAACCGGAGCAGAAGAGCCGGCTGAGCGAGCTTGCCGG
ATCCTTTTTCAAAACCGCCGTGACGGTGGACATCGAGCCCGTGGAGACGGAATCCGACGGTCGGGGCTCCGGGGGGAGAT
TGTCGGAGGCCATGGCCCGGAAAAATCAGGCGGAAGAGCTCCGTCGGGAAGCCCTGAATCATCCCCTTCTGCAGAAAGTC
TTGAGCGTCTTTGAAGGAGCGGAGGTTCAGGAGATTAAAGTCCTGCCCCCTCAGAGGCCATCGACCGATGTGAAGTCTGA
AGGATAA

Upstream 100 bases:

>100_bases
TGTTTCAGACCGGGAAGCTCCCTCTTCCGATTCTGATCTTACCCGTTTTTCGGAGAGGGGAAGATGGAATTGTCTGCCGT
TTTTTTCCCCAGGAGCCCTT

Downstream 100 bases:

>100_bases
GCCGGAAGGAGCCGCAATCGGGTTCCGGGCGGCATGAGTGTGCAGTTTTATTATCAAGTGATAAGGATAAGGAGGTAAGT
TTTTTTGGCGCCCAATATTG

Product: DNA polymerase III subunit gamma/tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 588; Mature: 588

Protein sequence:

>588_residues
MDYLVLARKWRPQVFEDVVGQQHVVQTLKNAIRQERIAHAFLFSGPRGVGKTSIARILAKAINCEQGPAGTPCNVCTNCR
EITEGISMDVREIDGASNRGIDEIRELRERIRFLPVSCRYKVYIIDEVHMLTREAFNALLKTLEEPPPHVVFIFATTETH
KVPATILSRCQCFEFRRLSLRQIAEQLRKIAETEKIRISDAGLAWIAEAGDGSMRDSESIFDQVISYAGTAIEDEAVEEL
LGRTDRRFLFQLSEAVLRRDAGQCLRIVEEGYYAGLDMTYFYTLLLHHFRNLLLVKIVGPQQELLDLPGNDLSGIEAQVA
EVSRETLQQLLDILLAEEESARRSHNPRLHLEAIVCRMAGLPPALPIEEILSRMEDLETRLASSAPCLSETVPGAASFSP
SKPGNSTTVRERPLTLPIVRTEDRSVREPMAELQGAVRDPAHAGGDVWADFKAHVKKHSILLASKIEQGECLGCENGHLR
IGFRKGSVFFEDLNEPEQKSRLSELAGSFFKTAVTVDIEPVETESDGRGSGGRLSEAMARKNQAEELRREALNHPLLQKV
LSVFEGAEVQEIKVLPPQRPSTDVKSEG

Sequences:

>Translated_588_residues
MDYLVLARKWRPQVFEDVVGQQHVVQTLKNAIRQERIAHAFLFSGPRGVGKTSIARILAKAINCEQGPAGTPCNVCTNCR
EITEGISMDVREIDGASNRGIDEIRELRERIRFLPVSCRYKVYIIDEVHMLTREAFNALLKTLEEPPPHVVFIFATTETH
KVPATILSRCQCFEFRRLSLRQIAEQLRKIAETEKIRISDAGLAWIAEAGDGSMRDSESIFDQVISYAGTAIEDEAVEEL
LGRTDRRFLFQLSEAVLRRDAGQCLRIVEEGYYAGLDMTYFYTLLLHHFRNLLLVKIVGPQQELLDLPGNDLSGIEAQVA
EVSRETLQQLLDILLAEEESARRSHNPRLHLEAIVCRMAGLPPALPIEEILSRMEDLETRLASSAPCLSETVPGAASFSP
SKPGNSTTVRERPLTLPIVRTEDRSVREPMAELQGAVRDPAHAGGDVWADFKAHVKKHSILLASKIEQGECLGCENGHLR
IGFRKGSVFFEDLNEPEQKSRLSELAGSFFKTAVTVDIEPVETESDGRGSGGRLSEAMARKNQAEELRREALNHPLLQKV
LSVFEGAEVQEIKVLPPQRPSTDVKSEG
>Mature_588_residues
MDYLVLARKWRPQVFEDVVGQQHVVQTLKNAIRQERIAHAFLFSGPRGVGKTSIARILAKAINCEQGPAGTPCNVCTNCR
EITEGISMDVREIDGASNRGIDEIRELRERIRFLPVSCRYKVYIIDEVHMLTREAFNALLKTLEEPPPHVVFIFATTETH
KVPATILSRCQCFEFRRLSLRQIAEQLRKIAETEKIRISDAGLAWIAEAGDGSMRDSESIFDQVISYAGTAIEDEAVEEL
LGRTDRRFLFQLSEAVLRRDAGQCLRIVEEGYYAGLDMTYFYTLLLHHFRNLLLVKIVGPQQELLDLPGNDLSGIEAQVA
EVSRETLQQLLDILLAEEESARRSHNPRLHLEAIVCRMAGLPPALPIEEILSRMEDLETRLASSAPCLSETVPGAASFSP
SKPGNSTTVRERPLTLPIVRTEDRSVREPMAELQGAVRDPAHAGGDVWADFKAHVKKHSILLASKIEQGECLGCENGHLR
IGFRKGSVFFEDLNEPEQKSRLSELAGSFFKTAVTVDIEPVETESDGRGSGGRLSEAMARKNQAEELRREALNHPLLQKV
LSVFEGAEVQEIKVLPPQRPSTDVKSEG

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI194306571, Length=275, Percent_Identity=26.1818181818182, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI194306567, Length=275, Percent_Identity=26.1818181818182, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI6677723, Length=272, Percent_Identity=26.4705882352941, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI4506491, Length=246, Percent_Identity=27.2357723577236, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI31881687, Length=246, Percent_Identity=27.2357723577236, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI31563534, Length=213, Percent_Identity=27.6995305164319, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786676, Length=373, Percent_Identity=40.7506702412869, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1787119, Length=197, Percent_Identity=28.9340101522843, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17541988, Length=212, Percent_Identity=28.3018867924528, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17554730, Length=279, Percent_Identity=24.3727598566308, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71986063, Length=325, Percent_Identity=22.4615384615385, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322528, Length=284, Percent_Identity=26.4084507042254, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324039, Length=235, Percent_Identity=25.531914893617, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324478, Length=234, Percent_Identity=25.2136752136752, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324111, Length=205, Percent_Identity=29.7560975609756, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19921076, Length=269, Percent_Identity=26.3940520446097, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17647857, Length=216, Percent_Identity=27.7777777777778, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI18859927, Length=296, Percent_Identity=24.3243243243243, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 65660; Mature: 65660

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYLVLARKWRPQVFEDVVGQQHVVQTLKNAIRQERIAHAFLFSGPRGVGKTSIARILAK
CCCEEEEHHCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
AINCEQGPAGTPCNVCTNCREITEGISMDVREIDGASNRGIDEIRELRERIRFLPVSCRY
HHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEE
KVYIIDEVHMLTREAFNALLKTLEEPPPHVVFIFATTETHKVPATILSRCQCFEFRRLSL
EEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
RQIAEQLRKIAETEKIRISDAGLAWIAEAGDGSMRDSESIFDQVISYAGTAIEDEAVEEL
HHHHHHHHHHHHHCCEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHH
LGRTDRRFLFQLSEAVLRRDAGQCLRIVEEGYYAGLDMTYFYTLLLHHFRNLLLVKIVGP
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHEEEEEEECC
QQELLDLPGNDLSGIEAQVAEVSRETLQQLLDILLAEEESARRSHNPRLHLEAIVCRMAG
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHC
LPPALPIEEILSRMEDLETRLASSAPCLSETVPGAASFSPSKPGNSTTVRERPLTLPIVR
CCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
TEDRSVREPMAELQGAVRDPAHAGGDVWADFKAHVKKHSILLASKIEQGECLGCENGHLR
CCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCEE
IGFRKGSVFFEDLNEPEQKSRLSELAGSFFKTAVTVDIEPVETESDGRGSGGRLSEAMAR
EEEEECCEEHHHCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCHHHHHHHH
KNQAEELRREALNHPLLQKVLSVFEGAEVQEIKVLPPQRPSTDVKSEG
HHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MDYLVLARKWRPQVFEDVVGQQHVVQTLKNAIRQERIAHAFLFSGPRGVGKTSIARILAK
CCCEEEEHHCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
AINCEQGPAGTPCNVCTNCREITEGISMDVREIDGASNRGIDEIRELRERIRFLPVSCRY
HHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEE
KVYIIDEVHMLTREAFNALLKTLEEPPPHVVFIFATTETHKVPATILSRCQCFEFRRLSL
EEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
RQIAEQLRKIAETEKIRISDAGLAWIAEAGDGSMRDSESIFDQVISYAGTAIEDEAVEEL
HHHHHHHHHHHHHCCEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHH
LGRTDRRFLFQLSEAVLRRDAGQCLRIVEEGYYAGLDMTYFYTLLLHHFRNLLLVKIVGP
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHEEEEEEECC
QQELLDLPGNDLSGIEAQVAEVSRETLQQLLDILLAEEESARRSHNPRLHLEAIVCRMAG
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHC
LPPALPIEEILSRMEDLETRLASSAPCLSETVPGAASFSPSKPGNSTTVRERPLTLPIVR
CCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
TEDRSVREPMAELQGAVRDPAHAGGDVWADFKAHVKKHSILLASKIEQGECLGCENGHLR
CCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCEE
IGFRKGSVFFEDLNEPEQKSRLSELAGSFFKTAVTVDIEPVETESDGRGSGGRLSEAMAR
EEEEECCEEHHHCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCHHHHHHHH
KNQAEELRREALNHPLLQKVLSVFEGAEVQEIKVLPPQRPSTDVKSEG
HHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]