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The map label for this gene is dapL [H]

Identifier: 85857917

GI number: 85857917

Start: 74014

End: 75180

Strand: Direct

Name: dapL [H]

Synonym: SYN_00168

Alternate gene names: 85857917

Gene position: 74014-75180 (Clockwise)

Preceding gene: 85857916

Following gene: 85857918

Centisome position: 2.33

GC content: 58.44

Gene sequence:

>1167_bases
GTGCAGATTGCGGAGCGTTTAGGAAAAATTCCCCCTTACCTGTTCATGGAGTTGCGGAAAAAGATCAATAAGGCGAAGGC
CGAGGGCGTGGACGTCATCAGTCTGGCCATCGGCGACCCGGTGGAACCTACGCCGGATTCCATAATCGAGGAACTCTGCC
GCCAGGCGCACGTCCCCGAGAATCACCGGTATCCCACAGATGAGGAAAAAGGGATGCTGGCCTACCGGCAGGAGGTGGCC
CGCTGGTACCGGGAGCGCTACGGCGTCACTCTCGATCCCGAAAAGGAAATCCTGGGGCTTATCGGTTCGAAGGAAGGATG
CCATCACTTTGTGCTGGCCTGCATCAACCCCGGTGACATCGTTCTCATGACCGATCCGGGCTATCCGGCCTATCGTTCCA
GCATTCTCATGGCCGGCGGAGAACCCTGGAATGTTCCGATTCTGCCCGAAAACGATTATCTTCCCGTTTTCGAAGACATC
CCTTCCAACATCCTGAAGCGGGCGCGGGGGATGTTCCTCAACTATCCCAACAACCCGACGGGGGCCTGCGCAACCCGGCC
TTTCCTGGACCGGCTGGTGGCCTTCGCGAGGGAGACCGGAATCGCCGTCTGCTATGACAATCCTTATGGGGAGATGGTTT
TTGAGGGGCAGGAACGTTTGAGCTTCCTGATGGCCGATGGGGCTAAGGAGGTCGGCGTGGAACTCAATTCCCTGTCCAAA
CCGTTCAACATGACGGGCTGGCGGATTGGGATGGCTTCGGGAAACCAGGAAATCCTTGCCGCCATGAGCAAGGTCAAGGA
AAATACCGACTCGGGAATCTTCAATCCCATTCAGTACGCGGGAATTCACGCCCTCCGTCATGAGGGAGCTTCGATTGACC
GGATGCGGGCGATCTATGCCAGGCGGCGGGCGCTGGTTCTGGAGACGCTCAAGAAGATCGGCATAAACTTCGAACCGCCC
AAGGGCACCTTTTATCTCTGGGTGCCGGTTCCTGCGGGAATGACTTCCCTGGAGTTCACCAATCGACTTTTCGAGAAGAC
CGCGGTCGTCGTGGCTTCCGGTACGGCCTATGGCCAGTACGGCGAAGGCTTCATCCGCATCTCGCTGACCGTGCCCGATG
ACCGGCTGGCAGAGGCCATGGCCCGGATCGGGAAGGAGTTCGCCTGA

Upstream 100 bases:

>100_bases
CGTTTACATGGAAGGCCGGGTCCGGGTGATTTACGAGGGCCGGCTCTGGGAAGAGGCCTGGCAGGAGAACGGAAATTAAA
CGATTAAAGGAGAGAGAACG

Downstream 100 bases:

>100_bases
TTGCGAGCAGTGATCCCTGCCCCTTCGGAAGGTTTGGTTCGACGTTTAATGTTCTCACCGTAATATTCCGACCTTGAACA
TTGAACGTAGCGCCCCCCGT

Product: class I/II aminotransferase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MQIAERLGKIPPYLFMELRKKINKAKAEGVDVISLAIGDPVEPTPDSIIEELCRQAHVPENHRYPTDEEKGMLAYRQEVA
RWYRERYGVTLDPEKEILGLIGSKEGCHHFVLACINPGDIVLMTDPGYPAYRSSILMAGGEPWNVPILPENDYLPVFEDI
PSNILKRARGMFLNYPNNPTGACATRPFLDRLVAFARETGIAVCYDNPYGEMVFEGQERLSFLMADGAKEVGVELNSLSK
PFNMTGWRIGMASGNQEILAAMSKVKENTDSGIFNPIQYAGIHALRHEGASIDRMRAIYARRRALVLETLKKIGINFEPP
KGTFYLWVPVPAGMTSLEFTNRLFEKTAVVVASGTAYGQYGEGFIRISLTVPDDRLAEAMARIGKEFA

Sequences:

>Translated_388_residues
MQIAERLGKIPPYLFMELRKKINKAKAEGVDVISLAIGDPVEPTPDSIIEELCRQAHVPENHRYPTDEEKGMLAYRQEVA
RWYRERYGVTLDPEKEILGLIGSKEGCHHFVLACINPGDIVLMTDPGYPAYRSSILMAGGEPWNVPILPENDYLPVFEDI
PSNILKRARGMFLNYPNNPTGACATRPFLDRLVAFARETGIAVCYDNPYGEMVFEGQERLSFLMADGAKEVGVELNSLSK
PFNMTGWRIGMASGNQEILAAMSKVKENTDSGIFNPIQYAGIHALRHEGASIDRMRAIYARRRALVLETLKKIGINFEPP
KGTFYLWVPVPAGMTSLEFTNRLFEKTAVVVASGTAYGQYGEGFIRISLTVPDDRLAEAMARIGKEFA
>Mature_388_residues
MQIAERLGKIPPYLFMELRKKINKAKAEGVDVISLAIGDPVEPTPDSIIEELCRQAHVPENHRYPTDEEKGMLAYRQEVA
RWYRERYGVTLDPEKEILGLIGSKEGCHHFVLACINPGDIVLMTDPGYPAYRSSILMAGGEPWNVPILPENDYLPVFEDI
PSNILKRARGMFLNYPNNPTGACATRPFLDRLVAFARETGIAVCYDNPYGEMVFEGQERLSFLMADGAKEVGVELNSLSK
PFNMTGWRIGMASGNQEILAAMSKVKENTDSGIFNPIQYAGIHALRHEGASIDRMRAIYARRRALVLETLKKIGINFEPP
KGTFYLWVPVPAGMTSLEFTNRLFEKTAVVVASGTAYGQYGEGFIRISLTVPDDRLAEAMARIGKEFA

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=317, Percent_Identity=23.6593059936909, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI169881279, Length=317, Percent_Identity=23.6593059936909, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI56713256, Length=311, Percent_Identity=22.508038585209, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI56713254, Length=311, Percent_Identity=22.508038585209, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI169881281, Length=228, Percent_Identity=23.6842105263158, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1788722, Length=385, Percent_Identity=34.5454545454545, Blast_Score=264, Evalue=6e-72,
Organism=Escherichia coli, GI1786816, Length=364, Percent_Identity=23.9010989010989, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788627, Length=375, Percent_Identity=24, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71994476, Length=294, Percent_Identity=26.530612244898, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71994472, Length=294, Percent_Identity=26.530612244898, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17567369, Length=358, Percent_Identity=25.1396648044693, Blast_Score=104, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6322401, Length=315, Percent_Identity=22.8571428571429, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28573069, Length=387, Percent_Identity=21.9638242894057, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24646114, Length=387, Percent_Identity=21.9638242894057, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28573067, Length=387, Percent_Identity=21.9638242894057, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28573065, Length=387, Percent_Identity=21.9638242894057, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 43284; Mature: 43284

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIAERLGKIPPYLFMELRKKINKAKAEGVDVISLAIGDPVEPTPDSIIEELCRQAHVPE
CCHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCC
NHRYPTDEEKGMLAYRQEVARWYRERYGVTLDPEKEILGLIGSKEGCHHFVLACINPGDI
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCE
VLMTDPGYPAYRSSILMAGGEPWNVPILPENDYLPVFEDIPSNILKRARGMFLNYPNNPT
EEEECCCCCHHHCCEEEECCCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCC
GACATRPFLDRLVAFARETGIAVCYDNPYGEMVFEGQERLSFLMADGAKEVGVELNSLSK
CCCCCHHHHHHHHHHHHHCCEEEEEECCCCCEEECCHHHHHHHHHCCCHHHCCCHHHCCC
PFNMTGWRIGMASGNQEILAAMSKVKENTDSGIFNPIQYAGIHALRHEGASIDRMRAIYA
CCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
RRRALVLETLKKIGINFEPPKGTFYLWVPVPAGMTSLEFTNRLFEKTAVVVASGTAYGQY
HHHHHHHHHHHHHCCEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHEEEEECCCCCCCC
GEGFIRISLTVPDDRLAEAMARIGKEFA
CCCEEEEEEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQIAERLGKIPPYLFMELRKKINKAKAEGVDVISLAIGDPVEPTPDSIIEELCRQAHVPE
CCHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCC
NHRYPTDEEKGMLAYRQEVARWYRERYGVTLDPEKEILGLIGSKEGCHHFVLACINPGDI
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCE
VLMTDPGYPAYRSSILMAGGEPWNVPILPENDYLPVFEDIPSNILKRARGMFLNYPNNPT
EEEECCCCCHHHCCEEEECCCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCC
GACATRPFLDRLVAFARETGIAVCYDNPYGEMVFEGQERLSFLMADGAKEVGVELNSLSK
CCCCCHHHHHHHHHHHHHCCEEEEEECCCCCEEECCHHHHHHHHHCCCHHHCCCHHHCCC
PFNMTGWRIGMASGNQEILAAMSKVKENTDSGIFNPIQYAGIHALRHEGASIDRMRAIYA
CCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
RRRALVLETLKKIGINFEPPKGTFYLWVPVPAGMTSLEFTNRLFEKTAVVVASGTAYGQY
HHHHHHHHHHHHHCCEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHEEEEECCCCCCCC
GEGFIRISLTVPDDRLAEAMARIGKEFA
CCCEEEEEEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA