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The map label for this gene is ctrA [H]

Identifier: 85375673

GI number: 85375673

Start: 2857264

End: 2857959

Strand: Reverse

Name: ctrA [H]

Synonym: ELI_14230

Alternate gene names: 85375673

Gene position: 2857959-2857264 (Counterclockwise)

Preceding gene: 85375674

Following gene: 85375672

Centisome position: 93.63

GC content: 59.77

Gene sequence:

>696_bases
ATGCGTGTACTGCTGATCGAAGACGAGCCGACAACGGCAAAAGCCATCGAGCTGATGCTGACGACCGAAGGCTTCAATGT
CTATTCGACCGACCTCGGTGAGGAAGGCCTCGATCTGGGCAAGCTGTATGATTACGATATCATCCTGCTCGACCTCAACC
TGCCGGATATGCACGGCTACGATGTGCTCAAGAAGCTGCGCGTCGCCAAGGTGCAGACACCGGTCCTGATCCTTTCGGGC
ATTGCCGAAATGGACAGCAAGATCCGCTCGTTCGGCTTCGGTGCCGACGATTACGTGACCAAGCCGTTCCACCGCGAAGA
GCTGGTCGCCCGCATCCACGCCGTGGTGCGCCGTTCGAAGGGCCACAGCCAGTCGATCATCCGCACCGGCAAGCTCGCCG
TGAACCTGGACGCCAAGACCGTCGAAGTCGACGGCGCCCGCGTCCACCTGACCGGCAAGGAATATGCGATGCTCGAGCTG
CTTTCGCTGCGCAAGGGCACGACGCTGACCAAGGAAATGTTCCTCAACCACCTTTACGGCGGGATGGACGAGCCGGAACT
CAAGATCATCGACGTTTTCATCTGCAAGCTGCGCAAGAAATTGAGCCATGCATGCGGCGGCGAGAACTACATCGAAACCG
TCTGGGGCCGCGGCTACGTGCTGCGCGATCCGGACGAACAGTCCGAAGCCGCGTAG

Upstream 100 bases:

>100_bases
TTTTGGTGAGAACTGTCGTGGTTAATCCAAGGCAACACCTCTGAACGAGGGGTTACCGAGCCCACTCGGGGGCGCAAATA
AGGGCAAGGGGGAATACCCG

Downstream 100 bases:

>100_bases
TTCGATTTGCCTCAAGCGCCGGCGGGGCCATCCGGCCCCTCAGGCTTCCGCGCTAACCGCGCGGCGGCCCGTCGGCCTTG
CGGATCGCAAGCGATCCGAA

Product: DNA-binding response regulator CtrA

Products: NA

Alternate protein names: Response regulator SokA [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MRVLLIEDEPTTAKAIELMLTTEGFNVYSTDLGEEGLDLGKLYDYDIILLDLNLPDMHGYDVLKKLRVAKVQTPVLILSG
IAEMDSKIRSFGFGADDYVTKPFHREELVARIHAVVRRSKGHSQSIIRTGKLAVNLDAKTVEVDGARVHLTGKEYAMLEL
LSLRKGTTLTKEMFLNHLYGGMDEPELKIIDVFICKLRKKLSHACGGENYIETVWGRGYVLRDPDEQSEAA

Sequences:

>Translated_231_residues
MRVLLIEDEPTTAKAIELMLTTEGFNVYSTDLGEEGLDLGKLYDYDIILLDLNLPDMHGYDVLKKLRVAKVQTPVLILSG
IAEMDSKIRSFGFGADDYVTKPFHREELVARIHAVVRRSKGHSQSIIRTGKLAVNLDAKTVEVDGARVHLTGKEYAMLEL
LSLRKGTTLTKEMFLNHLYGGMDEPELKIIDVFICKLRKKLSHACGGENYIETVWGRGYVLRDPDEQSEAA
>Mature_231_residues
MRVLLIEDEPTTAKAIELMLTTEGFNVYSTDLGEEGLDLGKLYDYDIILLDLNLPDMHGYDVLKKLRVAKVQTPVLILSG
IAEMDSKIRSFGFGADDYVTKPFHREELVARIHAVVRRSKGHSQSIIRTGKLAVNLDAKTVEVDGARVHLTGKEYAMLEL
LSLRKGTTLTKEMFLNHLYGGMDEPELKIIDVFICKLRKKLSHACGGENYIETVWGRGYVLRDPDEQSEAA

Specific function: Forms part of a two-component regulatory system CtrA/CckA that controls multiple events in the cell cycle, including cell division, stalk synthesis and cell cycle-specific transcription. Binds to a group of cell cycle-regulated promoters critical for DNA

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=33.7719298245614, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=35.6521739130435, Blast_Score=133, Evalue=9e-33,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=33.9366515837104, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=31.6742081447964, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=33.3333333333333, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=29.9559471365639, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=32.15859030837, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=32.4561403508772, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=30.6306306306306, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=30.1369863013699, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=31.5315315315315, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=29.0909090909091, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=24.3362831858407, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=30.8411214953271, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790437, Length=160, Percent_Identity=25.625, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790299, Length=161, Percent_Identity=24.223602484472, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25940; Mature: 25940

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLLIEDEPTTAKAIELMLTTEGFNVYSTDLGEEGLDLGKLYDYDIILLDLNLPDMHGY
CEEEEEECCCCHHHEEEEEEEECCCEEEECCCCCCCCCCCCEECCEEEEEEECCCCCCCH
DVLKKLRVAKVQTPVLILSGIAEMDSKIRSFGFGADDYVTKPFHREELVARIHAVVRRSK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHCC
GHSQSIIRTGKLAVNLDAKTVEVDGARVHLTGKEYAMLELLSLRKGTTLTKEMFLNHLYG
CCCHHHEEECCEEEEECCEEEEECCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHC
GMDEPELKIIDVFICKLRKKLSHACGGENYIETVWGRGYVLRDPDEQSEAA
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCEEECCCCCCCCCC
>Mature Secondary Structure
MRVLLIEDEPTTAKAIELMLTTEGFNVYSTDLGEEGLDLGKLYDYDIILLDLNLPDMHGY
CEEEEEECCCCHHHEEEEEEEECCCEEEECCCCCCCCCCCCEECCEEEEEEECCCCCCCH
DVLKKLRVAKVQTPVLILSGIAEMDSKIRSFGFGADDYVTKPFHREELVARIHAVVRRSK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHCC
GHSQSIIRTGKLAVNLDAKTVEVDGARVHLTGKEYAMLELLSLRKGTTLTKEMFLNHLYG
CCCHHHEEECCEEEEECCEEEEECCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHC
GMDEPELKIIDVFICKLRKKLSHACGGENYIETVWGRGYVLRDPDEQSEAA
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8548829 [H]