Click here to switch to the map view.

The map label for this gene is etfA [H]

Identifier: 85375527

GI number: 85375527

Start: 2721237

End: 2722166

Strand: Reverse

Name: etfA [H]

Synonym: ELI_13500

Alternate gene names: 85375527

Gene position: 2722166-2721237 (Counterclockwise)

Preceding gene: 85375528

Following gene: 85375520

Centisome position: 89.18

GC content: 64.95

Gene sequence:

>930_bases
ATGAAGACATTGGTTTGGGTCGAGCACGACAACAACGAAATGAAGGACGCGACGCTGTCCGCCGTCACCGCCGCATCGCA
GCTGGGCGAAGTCCACCTGCTGGTCGCTGGCTCGGGCTGCGCGGGCGTGGCCGATGCCGCCGCCAAGATTGCGGGCGTGG
GCAAGGTTCACCTGGCCGACGACCCGGCATACGAGCACGCGCTCGCTGAGAACGTCGCGCCGCTGATCGTCGATCAGATG
GGCCATCACGATGCCTTCGTCGCGCCTGCCACCACGACCGGCAAGAACATCGCGCCGCGCGTCGCTGCGCTGCTCGACGT
CATGCAGATTTCGGACATTCTCTCGGTCGAAGGCGACAAGACCTTCACCCGCCCGATCTATGCCGGCAACGCCATCGCGA
CCGTGCAATCGAGCGACGAGAAGCTCGTCATCACGGTGCGCGGCACTGCTTTCGACAAAGCCGAAGCCGAAGGCGGCTCG
GGCACGGTCGAGGCTGTAAGCGGCCCGACCGGCGAAGGCCTCTCGCAATTCGTCAGCCAGGAAATCGCCGAGAGCGAGCG
CCCCGAGCTGACCAGCGCCAAGGTCATCGTCTCGGGCGGCCGCGCGCTCAAGGACGCCGAGACCTTCGAGCAATATATCA
CGCCGCTCGCCGACAAGCTCGGCGCAGGCATCGGCGCCTCGCGCGCCGCGGTCGATGCTGGCTACGTGCCCAACGACTAC
CAGGTCGGCCAGACCGGCAAGATCGTCGCCCCGGAAGTCTATATCGCGATCGGTATTTCGGGCGCGATCCAGCACCTGGC
CGGCATGAAGGACTCCAAAACCATCATCGCCATCAACAAGGACGAGGACGCCCCGATCTTCCAGGTGGCCGACATCGGCC
TGGTCGGCGATCTCTACAAGGTCGTGCCGGAGCTGATGGAAAAGCTCTGA

Upstream 100 bases:

>100_bases
GAGCTTGTCGAAGGGTTGTCCTTACTTTGAGGGCATCGGGACAGAAAAAAGTACAGGGCTTCGACAAGCTCAGCCCGAAC
GGAAATTGAGGTAGATCCAC

Downstream 100 bases:

>100_bases
GCCGAAACACCGCAATCATCGAAAAAGCCCGGGCCTCACCCCCCGGGCTTTTTTTCGCCTCACGTCAGGCTGATCACCGC
GTGGATCGTGAGCCCCACCA

Product: electron transfer flavoprotein alpha-subunit, (ETFLS)

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MKTLVWVEHDNNEMKDATLSAVTAASQLGEVHLLVAGSGCAGVADAAAKIAGVGKVHLADDPAYEHALAENVAPLIVDQM
GHHDAFVAPATTTGKNIAPRVAALLDVMQISDILSVEGDKTFTRPIYAGNAIATVQSSDEKLVITVRGTAFDKAEAEGGS
GTVEAVSGPTGEGLSQFVSQEIAESERPELTSAKVIVSGGRALKDAETFEQYITPLADKLGAGIGASRAAVDAGYVPNDY
QVGQTGKIVAPEVYIAIGISGAIQHLAGMKDSKTIIAINKDEDAPIFQVADIGLVGDLYKVVPELMEKL

Sequences:

>Translated_309_residues
MKTLVWVEHDNNEMKDATLSAVTAASQLGEVHLLVAGSGCAGVADAAAKIAGVGKVHLADDPAYEHALAENVAPLIVDQM
GHHDAFVAPATTTGKNIAPRVAALLDVMQISDILSVEGDKTFTRPIYAGNAIATVQSSDEKLVITVRGTAFDKAEAEGGS
GTVEAVSGPTGEGLSQFVSQEIAESERPELTSAKVIVSGGRALKDAETFEQYITPLADKLGAGIGASRAAVDAGYVPNDY
QVGQTGKIVAPEVYIAIGISGAIQHLAGMKDSKTIIAINKDEDAPIFQVADIGLVGDLYKVVPELMEKL
>Mature_309_residues
MKTLVWVEHDNNEMKDATLSAVTAASQLGEVHLLVAGSGCAGVADAAAKIAGVGKVHLADDPAYEHALAENVAPLIVDQM
GHHDAFVAPATTTGKNIAPRVAALLDVMQISDILSVEGDKTFTRPIYAGNAIATVQSSDEKLVITVRGTAFDKAEAEGGS
GTVEAVSGPTGEGLSQFVSQEIAESERPELTSAKVIVSGGRALKDAETFEQYITPLADKLGAGIGASRAAVDAGYVPNDY
QVGQTGKIVAPEVYIAIGISGAIQHLAGMKDSKTIIAINKDEDAPIFQVADIGLVGDLYKVVPELMEKL

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=310, Percent_Identity=54.8387096774194, Blast_Score=322, Evalue=2e-88,
Organism=Homo sapiens, GI189181759, Length=269, Percent_Identity=55.7620817843866, Blast_Score=288, Evalue=5e-78,
Organism=Escherichia coli, GI1786226, Length=254, Percent_Identity=31.1023622047244, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787990, Length=249, Percent_Identity=32.5301204819277, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87082157, Length=266, Percent_Identity=31.203007518797, Blast_Score=99, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17506929, Length=311, Percent_Identity=57.2347266881029, Blast_Score=323, Evalue=5e-89,
Organism=Saccharomyces cerevisiae, GI6325261, Length=283, Percent_Identity=48.7632508833922, Blast_Score=262, Evalue=5e-71,
Organism=Drosophila melanogaster, GI17136898, Length=311, Percent_Identity=56.9131832797428, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24652801, Length=311, Percent_Identity=56.9131832797428, Blast_Score=329, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 32032; Mature: 32032

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLVWVEHDNNEMKDATLSAVTAASQLGEVHLLVAGSGCAGVADAAAKIAGVGKVHLAD
CCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCEEEECC
DPAYEHALAENVAPLIVDQMGHHDAFVAPATTTGKNIAPRVAALLDVMQISDILSVEGDK
CHHHHHHHHHCCHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
TFTRPIYAGNAIATVQSSDEKLVITVRGTAFDKAEAEGGSGTVEAVSGPTGEGLSQFVSQ
CCCCEEECCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHH
EIAESERPELTSAKVIVSGGRALKDAETFEQYITPLADKLGAGIGASRAAVDAGYVPNDY
HHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCC
QVGQTGKIVAPEVYIAIGISGAIQHLAGMKDSKTIIAINKDEDAPIFQVADIGLVGDLYK
EECCCCCEECCEEEEEEECHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHH
VVPELMEKL
HHHHHHHHC
>Mature Secondary Structure
MKTLVWVEHDNNEMKDATLSAVTAASQLGEVHLLVAGSGCAGVADAAAKIAGVGKVHLAD
CCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCEEEECC
DPAYEHALAENVAPLIVDQMGHHDAFVAPATTTGKNIAPRVAALLDVMQISDILSVEGDK
CHHHHHHHHHCCHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
TFTRPIYAGNAIATVQSSDEKLVITVRGTAFDKAEAEGGSGTVEAVSGPTGEGLSQFVSQ
CCCCEEECCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHH
EIAESERPELTSAKVIVSGGRALKDAETFEQYITPLADKLGAGIGASRAAVDAGYVPNDY
HHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCC
QVGQTGKIVAPEVYIAIGISGAIQHLAGMKDSKTIIAINKDEDAPIFQVADIGLVGDLYK
EECCCCCEECCEEEEEEECHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHH
VVPELMEKL
HHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8599534; 12597275 [H]