Click here to switch to the map view.

The map label for this gene is lpxD [H]

Identifier: 85375484

GI number: 85375484

Start: 2675264

End: 2676157

Strand: Direct

Name: lpxD [H]

Synonym: ELI_13285

Alternate gene names: 85375484

Gene position: 2675264-2676157 (Clockwise)

Preceding gene: 85375483

Following gene: 85375485

Centisome position: 87.64

GC content: 60.4

Gene sequence:

>894_bases
ATGACTTGGCGTCTTTCCGACTTTGCTGGCATCGCCGGCCTGCGCGTCGAGCGTGACGGGTCGTTCGAAACTACCGGCAA
GCTGTCGACGCCTCTCGATGGCCTGTGCGTACCGCTTCGCTCGGCGCAGTATGCGGTGGGGGTCAGCAAAAATCCGCGAA
TCGCAGCGGTCATCACAAAGCCCGAGATCGTCGAGAGGTTGGGCGAACATGTGGCTGTGGCTGTGGCGGACGATCCGGAC
GCGGCGCATTCGGAAATTCACGCCCGACTGGCTGAAAACCACGCACAAGAATTGCGGTCGGTGCCCAACGAAATCGACTC
TTCCGCGCGGATCGACCCGTCTGCCCATATTGCCGATCACGGTGTGACAATCGGCCCCAATGCCTGGATCGGGCCGCACT
GCGCCATCACGCCGGGGGTGAACGTTGGCGAAGGCTGCGTGCTCCACAGCGGAACTGCCCTGGGTGTGCCGGGCTTCAAC
ACGGGGATCATCGGTGGCAGGCTGAAGATCGTTCCGCAAATGGGTGGTGTAAGGCTTGGACCGCATGTCGAAATGCTCGC
CAATTGTACGGTCGCCCGTGGCATTTTCGGCGGACACACGTCGCTAGGCGAAGAGACGGTGGCAGACAATCTGGTCTACA
TCGCACATGACGTGCAAATCGGACGCCGGGTCCAGATCTGCGCGCTCGTCAATGTGCTTGGCCGCACGATTGTCGGCGAT
GAAGCCTATCTGGGCCCATCTTGTGTCGTGAAAAACGGATTGGTGTTGGGCGCACGAGCGCGCGTCAACATCGGTGCAGT
TGTCACGACCGATCTTGCCGAAGACGCGATCGTCAGTGGCAATTTCGCCGTTCCCCACGATCGTTTCCTCGATCACATCC
GTTCCATCCGATAA

Upstream 100 bases:

>100_bases
TTCTGGACGCAGTTCGCGGCGGCGACGGCTGCCGCACCGGACCGGAAGAAGCCATTCCGGTACTGCGTCTTCTGCATGCG
GCGGAAGCAGCCGCAGAGGC

Downstream 100 bases:

>100_bases
TCTGGATCAGACATGCAATTCATCGATCTCAAATCGCAATACCTGGAGCTGCAGGATGAAATACGCCAGCGAATCGACGA
CGTTCTCGATCGGCAGGCTT

Product: UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MTWRLSDFAGIAGLRVERDGSFETTGKLSTPLDGLCVPLRSAQYAVGVSKNPRIAAVITKPEIVERLGEHVAVAVADDPD
AAHSEIHARLAENHAQELRSVPNEIDSSARIDPSAHIADHGVTIGPNAWIGPHCAITPGVNVGEGCVLHSGTALGVPGFN
TGIIGGRLKIVPQMGGVRLGPHVEMLANCTVARGIFGGHTSLGEETVADNLVYIAHDVQIGRRVQICALVNVLGRTIVGD
EAYLGPSCVVKNGLVLGARARVNIGAVVTTDLAEDAIVSGNFAVPHDRFLDHIRSIR

Sequences:

>Translated_297_residues
MTWRLSDFAGIAGLRVERDGSFETTGKLSTPLDGLCVPLRSAQYAVGVSKNPRIAAVITKPEIVERLGEHVAVAVADDPD
AAHSEIHARLAENHAQELRSVPNEIDSSARIDPSAHIADHGVTIGPNAWIGPHCAITPGVNVGEGCVLHSGTALGVPGFN
TGIIGGRLKIVPQMGGVRLGPHVEMLANCTVARGIFGGHTSLGEETVADNLVYIAHDVQIGRRVQICALVNVLGRTIVGD
EAYLGPSCVVKNGLVLGARARVNIGAVVTTDLAEDAIVSGNFAVPHDRFLDHIRSIR
>Mature_296_residues
TWRLSDFAGIAGLRVERDGSFETTGKLSTPLDGLCVPLRSAQYAVGVSKNPRIAAVITKPEIVERLGEHVAVAVADDPDA
AHSEIHARLAENHAQELRSVPNEIDSSARIDPSAHIADHGVTIGPNAWIGPHCAITPGVNVGEGCVLHSGTALGVPGFNT
GIIGGRLKIVPQMGGVRLGPHVEMLANCTVARGIFGGHTSLGEETVADNLVYIAHDVQIGRRVQICALVNVLGRTIVGDE
AYLGPSCVVKNGLVLGARARVNIGAVVTTDLAEDAIVSGNFAVPHDRFLDHIRSIR

Specific function: Involved In The Biosynthesis Of Lipid A, A Phosphorylated Glycolipid That Anchors The Lipopolysaccharide To The Outer Membrane Of The Cell. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=194, Percent_Identity=31.4432989690722, Blast_Score=68, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 31181; Mature: 31050

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWRLSDFAGIAGLRVERDGSFETTGKLSTPLDGLCVPLRSAQYAVGVSKNPRIAAVITK
CCEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCEEEEEEEC
PEIVERLGEHVAVAVADDPDAAHSEIHARLAENHAQELRSVPNEIDSSARIDPSAHIADH
HHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCEECCC
GVTIGPNAWIGPHCAITPGVNVGEGCVLHSGTALGVPGFNTGIIGGRLKIVPQMGGVRLG
CEEECCCCCCCCCEEECCCCCCCCCEEEECCCEECCCCCCCCCCCCEEEEEECCCCEEEC
PHVEMLANCTVARGIFGGHTSLGEETVADNLVYIAHDVQIGRRVQICALVNVLGRTIVGD
CCHHHHHCCHHHHCCCCCCCCCCCHHHHCCEEEEEEEECCCCEEHHHHHHHHHHHHEECC
EAYLGPSCVVKNGLVLGARARVNIGAVVTTDLAEDAIVSGNFAVPHDRFLDHIRSIR
CCCCCCHHHHCCCEEEECCCEEEECEEEEECCCCCCEECCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TWRLSDFAGIAGLRVERDGSFETTGKLSTPLDGLCVPLRSAQYAVGVSKNPRIAAVITK
CEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCEEEEEEEC
PEIVERLGEHVAVAVADDPDAAHSEIHARLAENHAQELRSVPNEIDSSARIDPSAHIADH
HHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCEECCC
GVTIGPNAWIGPHCAITPGVNVGEGCVLHSGTALGVPGFNTGIIGGRLKIVPQMGGVRLG
CEEECCCCCCCCCEEECCCCCCCCCEEEECCCEECCCCCCCCCCCCEEEEEECCCCEEEC
PHVEMLANCTVARGIFGGHTSLGEETVADNLVYIAHDVQIGRRVQICALVNVLGRTIVGD
CCHHHHHCCHHHHCCCCCCCCCCCHHHHCCEEEEEEEECCCCEEHHHHHHHHHHHHEECC
EAYLGPSCVVKNGLVLGARARVNIGAVVTTDLAEDAIVSGNFAVPHDRFLDHIRSIR
CCCCCCHHHHCCCEEEECCCEEEECEEEEECCCCCCEECCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12835416 [H]