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The map label for this gene is algR [H]

Identifier: 85375406

GI number: 85375406

Start: 2600426

End: 2601166

Strand: Reverse

Name: algR [H]

Synonym: ELI_12895

Alternate gene names: 85375406

Gene position: 2601166-2600426 (Counterclockwise)

Preceding gene: 85375407

Following gene: 85375405

Centisome position: 85.22

GC content: 66.53

Gene sequence:

>741_bases
ATGAGCGATGACAAGGATGTATCGCTGCGCACGCTGATCGTCGATGACGAACCGCTCGCGGTCGAGCGCATGCAGGTGAT
CTGCGCCAAGCTGCCCAAGCTCAATGTGGTCGGCACCGCCAGCGACGGCGAAGCGGCGCTGCGGCTGGTCGATGCGCTGA
CGCCCGATCTTGTCCTGCTCGACATGACGATGCCCGGCCTCGACGGGCTCGCGGTCGCGCGCAAGCTCGGCAGGCTGGAC
GCTCCGCCGGCGGTGATCTTCGTGACGGCGCACGATCATTTCGCGGTCGAGGCCTTCGACCTCGAAGCAATCGATTACGT
GTTGAAGCCCGTCGCGCAGGACCGGCTCGAGCGCGCGATCGAGCGCGCCATTGCGCGGCGCGGCGAGGCTCGTCCGGAGA
AGGAAAGCGAGTGGCTGCAGGAGCTCTGGGTCCCGCACCGCAGCGAATTGATCCGGATCGAGACAAGCCAGGTCTCGCGC
ATCGATGCCGAGCGCGATTACGTCCGCCTCTATGTCGGCGATCGCACCTACCTGCTGCTGCAGACCATCGCGGGCCTCGA
AGAACGGCTCGACCCAGCTGAATTCATCCGCATCCACCGCTCCACGATCCTGCGCAAGGACGGCATCCGCGGCCTGCGCC
ACGACGGCCTCGGCGTGTGGTCGGTCGAACTGGAAGACGGCGAAGCGCTGCGGATCGGGCGGACCTATCTGCCCAAGGTC
AAGGCGATGGCCGGGCGCTGA

Upstream 100 bases:

>100_bases
TCGAAGCGCGGTTCGGGCGCGATGCCACCATCACGGCAGGCCCGGTCGAAGACGGCTATGTCACCGAATTGCGTCTGCCG
CTCGAGAGAAAGGCCGCATC

Downstream 100 bases:

>100_bases
AGCGCCCTTGTTTTTTGCTTTTCGCACCCGCATCCGTGGGTGCGTCCTCGGTGCTGGTCCTCCCTTCGGTCGGGCACCTG
CGGGGCGGGCGGTCGCCCTT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MSDDKDVSLRTLIVDDEPLAVERMQVICAKLPKLNVVGTASDGEAALRLVDALTPDLVLLDMTMPGLDGLAVARKLGRLD
APPAVIFVTAHDHFAVEAFDLEAIDYVLKPVAQDRLERAIERAIARRGEARPEKESEWLQELWVPHRSELIRIETSQVSR
IDAERDYVRLYVGDRTYLLLQTIAGLEERLDPAEFIRIHRSTILRKDGIRGLRHDGLGVWSVELEDGEALRIGRTYLPKV
KAMAGR

Sequences:

>Translated_246_residues
MSDDKDVSLRTLIVDDEPLAVERMQVICAKLPKLNVVGTASDGEAALRLVDALTPDLVLLDMTMPGLDGLAVARKLGRLD
APPAVIFVTAHDHFAVEAFDLEAIDYVLKPVAQDRLERAIERAIARRGEARPEKESEWLQELWVPHRSELIRIETSQVSR
IDAERDYVRLYVGDRTYLLLQTIAGLEERLDPAEFIRIHRSTILRKDGIRGLRHDGLGVWSVELEDGEALRIGRTYLPKV
KAMAGR
>Mature_245_residues
SDDKDVSLRTLIVDDEPLAVERMQVICAKLPKLNVVGTASDGEAALRLVDALTPDLVLLDMTMPGLDGLAVARKLGRLDA
PPAVIFVTAHDHFAVEAFDLEAIDYVLKPVAQDRLERAIERAIARRGEARPEKESEWLQELWVPHRSELIRIETSQVSRI
DAERDYVRLYVGDRTYLLLQTIAGLEERLDPAEFIRIHRSTILRKDGIRGLRHDGLGVWSVELEDGEALRIGRTYLPKVK
AMAGR

Specific function: Positive regulator of the algD gene, which codes for a GDP-mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway [H]

COG id: COG3279

COG function: function code KT; Response regulator of the LytR/AlgR family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082052, Length=245, Percent_Identity=28.9795918367347, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788724, Length=220, Percent_Identity=25.9090909090909, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788550, Length=117, Percent_Identity=36.7521367521368, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR007492
- InterPro:   IPR001789 [H]

Pfam domain/function: PF04397 LytTR; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 27648; Mature: 27517

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50930 HTH_LYTTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDKDVSLRTLIVDDEPLAVERMQVICAKLPKLNVVGTASDGEAALRLVDALTPDLVLL
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEE
DMTMPGLDGLAVARKLGRLDAPPAVIFVTAHDHFAVEAFDLEAIDYVLKPVAQDRLERAI
EECCCCCCHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHH
ERAIARRGEARPEKESEWLQELWVPHRSELIRIETSQVSRIDAERDYVRLYVGDRTYLLL
HHHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEHHHHHHCCCCCCEEEEEECCCHHHHH
QTIAGLEERLDPAEFIRIHRSTILRKDGIRGLRHDGLGVWSVELEDGEALRIGRTYLPKV
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEECCHHCCHH
KAMAGR
HHHCCC
>Mature Secondary Structure 
SDDKDVSLRTLIVDDEPLAVERMQVICAKLPKLNVVGTASDGEAALRLVDALTPDLVLL
CCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEE
DMTMPGLDGLAVARKLGRLDAPPAVIFVTAHDHFAVEAFDLEAIDYVLKPVAQDRLERAI
EECCCCCCHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHH
ERAIARRGEARPEKESEWLQELWVPHRSELIRIETSQVSRIDAERDYVRLYVGDRTYLLL
HHHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEHHHHHHCCCCCCEEEEEECCCHHHHH
QTIAGLEERLDPAEFIRIHRSTILRKDGIRGLRHDGLGVWSVELEDGEALRIGRTYLPKV
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEECCHHCCHH
KAMAGR
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2493441; 10984043; 2544550; 8159168 [H]