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The map label for this gene is xseA

Identifier: 85375369

GI number: 85375369

Start: 2569090

End: 2570523

Strand: Reverse

Name: xseA

Synonym: ELI_12710

Alternate gene names: 85375369

Gene position: 2570523-2569090 (Counterclockwise)

Preceding gene: 85375371

Following gene: 85375368

Centisome position: 84.21

GC content: 67.99

Gene sequence:

>1434_bases
ATGTCCGATCTGATCGCTCAATCTCGCGCAGGCGACAACGCCGAGCCGCTTTCCGTCAGCGCCTTGTCCCAAATGCTCAA
GCGCACGGTCGAGGACCGCTTCGGCTATGTCCGCCTGCGCGGTGAATTGTCCGGCGTGAAGCGGGCCGCGAGCGGTCACA
TGTATTGCTCGCTCAAGGACGAGAAGGCCGTGATCGACGGGGTGATGTGGAAGGGCACCACCGCGCGCCTCGCGTTCCAG
CCGGAAGACGGGCTGGAAGTGATCGCGACTGGCAAGCTCACCACTTATCCGGGTCGCTCGAAATACCAGATCGTGCTGGA
AAGCTTGGAAATGGCGGGCGAGGGCGCATTGCTGGCGCTGCTCGAGAAGACCCGCCAGCGGCTCGAAGCGGAAGGCCTGT
TCGCGCGTGATCGCAAGCGGCCACTGCCGTTCCTGCCGCGCACGATCGGGGTCGTGACCTCGCCGACCGGGGCGGTGATC
CGCGATATCCTGCACCGGCTGGCGGATCGTTTTCCCAGCCATGTGCTGGTCTGGCCGGTGCTGGTGCAGGGGCAGGGCGC
GGCCGAGCAGGTCAGCGCGGCGATCCGGGGTTTCGGGGCCATAAAAGCTGGGGGCGAGGTCCCAAGGCCGGACCTGTTGA
TCGTCGCGCGCGGGGGCGGCTCGATTGAGGATTTGTGGAGCTTCAACGAAGAGATGGTCGTGCGCGCCATCGCCGACAGC
CCGATCCCGGTGATCAGCGCGGTCGGGCACGAGACCGACACCACGCTGGCGGACTATGCCGCCGATCGCCGCGCGCCGAC
GCCCACGGCCGCCGCCGAAATCGCGGTGCCGGTGAAGGGGGAACTGGCCGCGACGCTCAATGACTATGCGGCCCGCCAGC
AACGCGGCGTGCTGCGGCCGCTATCGCTGGGGCGTGAACGACTGGAGGCGCGGGTCCAGCGCCTGCCGACCATCGAAACC
CTGCTACAGCCACAGGCGCAAAAGCTCGACGAAAGGGTTGAGCGATTGCGGGGTGCGCTCAGGGATCGCGCGGCGAAGGG
ACGCGAGGCGTTGGCGACGCAACGGTTGTCGCCCACTATGCTCCAACGTGCCGAGCGCGAGGCGCGGCGCAAGCTCGACC
AGGTTCGTTTGGCCCCCGCGCTGGTGGAGCGGCGCGCGGCGCGCGATGGCGAGCGGCTGGCGGGTCTCTCGCGCGTGCTG
GCCACACTCAATCCGCGCGCCCCGCTCGAGCGTGGCTATGCACTGGTGCGCGATGCCGACGGCAAGCTGGTCCGCGCCAA
GGGGGAGGCGACGAAGCAGGCGCGGCTGGCAGTCGAATTCGCCGATGGCAGTCTCGATGTCGTGCCGGCGGGAAAAGCCG
CCGCCGCGCCGAAACGCGTGAAAAAATCGCCTCCGCCGGGCACGTCTGGCGCGCAGGAAGATTTGTTCGGTTAA

Upstream 100 bases:

>100_bases
CACGAACGGGTAGAGAAGCCACCTCCTAACCGTTCGCCCTGAGCCTGTCGAAGGGCCGTCCTTCTTTGAGCACAAGTGTG
TGGAGAGCAGTGCGCCCACG

Downstream 100 bases:

>100_bases
TCCTGTGCTGCTAAAGAGATACCCATGTTGATGTCCTCTCGAAACGAGCCCGCGCGGCTCGAATACGGCCCCAATGGCTT
TCGCGTCCTGCGCACGGGGC

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MSDLIAQSRAGDNAEPLSVSALSQMLKRTVEDRFGYVRLRGELSGVKRAASGHMYCSLKDEKAVIDGVMWKGTTARLAFQ
PEDGLEVIATGKLTTYPGRSKYQIVLESLEMAGEGALLALLEKTRQRLEAEGLFARDRKRPLPFLPRTIGVVTSPTGAVI
RDILHRLADRFPSHVLVWPVLVQGQGAAEQVSAAIRGFGAIKAGGEVPRPDLLIVARGGGSIEDLWSFNEEMVVRAIADS
PIPVISAVGHETDTTLADYAADRRAPTPTAAAEIAVPVKGELAATLNDYAARQQRGVLRPLSLGRERLEARVQRLPTIET
LLQPQAQKLDERVERLRGALRDRAAKGREALATQRLSPTMLQRAEREARRKLDQVRLAPALVERRAARDGERLAGLSRVL
ATLNPRAPLERGYALVRDADGKLVRAKGEATKQARLAVEFADGSLDVVPAGKAAAAPKRVKKSPPPGTSGAQEDLFG

Sequences:

>Translated_477_residues
MSDLIAQSRAGDNAEPLSVSALSQMLKRTVEDRFGYVRLRGELSGVKRAASGHMYCSLKDEKAVIDGVMWKGTTARLAFQ
PEDGLEVIATGKLTTYPGRSKYQIVLESLEMAGEGALLALLEKTRQRLEAEGLFARDRKRPLPFLPRTIGVVTSPTGAVI
RDILHRLADRFPSHVLVWPVLVQGQGAAEQVSAAIRGFGAIKAGGEVPRPDLLIVARGGGSIEDLWSFNEEMVVRAIADS
PIPVISAVGHETDTTLADYAADRRAPTPTAAAEIAVPVKGELAATLNDYAARQQRGVLRPLSLGRERLEARVQRLPTIET
LLQPQAQKLDERVERLRGALRDRAAKGREALATQRLSPTMLQRAEREARRKLDQVRLAPALVERRAARDGERLAGLSRVL
ATLNPRAPLERGYALVRDADGKLVRAKGEATKQARLAVEFADGSLDVVPAGKAAAAPKRVKKSPPPGTSGAQEDLFG
>Mature_476_residues
SDLIAQSRAGDNAEPLSVSALSQMLKRTVEDRFGYVRLRGELSGVKRAASGHMYCSLKDEKAVIDGVMWKGTTARLAFQP
EDGLEVIATGKLTTYPGRSKYQIVLESLEMAGEGALLALLEKTRQRLEAEGLFARDRKRPLPFLPRTIGVVTSPTGAVIR
DILHRLADRFPSHVLVWPVLVQGQGAAEQVSAAIRGFGAIKAGGEVPRPDLLIVARGGGSIEDLWSFNEEMVVRAIADSP
IPVISAVGHETDTTLADYAADRRAPTPTAAAEIAVPVKGELAATLNDYAARQQRGVLRPLSLGRERLEARVQRLPTIETL
LQPQAQKLDERVERLRGALRDRAAKGREALATQRLSPTMLQRAEREARRKLDQVRLAPALVERRAARDGERLAGLSRVLA
TLNPRAPLERGYALVRDADGKLVRAKGEATKQARLAVEFADGSLDVVPAGKAAAAPKRVKKSPPPGTSGAQEDLFG

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=454, Percent_Identity=35.9030837004405, Blast_Score=247, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_ERYLH (Q2N6Q7)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_459431.1
- STRING:   Q2N6Q7
- GeneID:   3871684
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_12710
- NMPDR:   fig|314225.3.peg.483
- eggNOG:   COG1570
- HOGENOM:   HBG634411
- OMA:   RLLIANM
- PhylomeDB:   Q2N6Q7
- ProtClustDB:   PRK00286
- BioCyc:   ELIT314225:ELI_12710-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 51621; Mature: 51490

Theoretical pI: Translated: 10.53; Mature: 10.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLIAQSRAGDNAEPLSVSALSQMLKRTVEDRFGYVRLRGELSGVKRAASGHMYCSLKD
CCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHCCCEEEEECC
EKAVIDGVMWKGTTARLAFQPEDGLEVIATGKLTTYPGRSKYQIVLESLEMAGEGALLAL
CHHHHHCEEECCCCEEEEECCCCCCEEEEECCEEECCCCCHHHHHHHHHHHCCCCHHHHH
LEKTRQRLEAEGLFARDRKRPLPFLPRTIGVVTSPTGAVIRDILHRLADRFPSHVLVWPV
HHHHHHHHHHCCCHHHCCCCCCCCCCHHHCEEECCHHHHHHHHHHHHHHHCCCCEEEEEE
LVQGQGAAEQVSAAIRGFGAIKAGGEVPRPDLLIVARGGGSIEDLWSFNEEMVVRAIADS
EECCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHCCC
PIPVISAVGHETDTTLADYAADRRAPTPTAAAEIAVPVKGELAATLNDYAARQQRGVLRP
CCCHHHHCCCCCCCHHHHHHHCCCCCCCCCHHEEEECCCCHHHHHHHHHHHHHHCCCCCH
LSLGRERLEARVQRLPTIETLLQPQAQKLDERVERLRGALRDRAAKGREALATQRLSPTM
HHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHH
LQRAEREARRKLDQVRLAPALVERRAARDGERLAGLSRVLATLNPRAPLERGYALVRDAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHCEEEEECCC
GKLVRAKGEATKQARLAVEFADGSLDVVPAGKAAAAPKRVKKSPPPGTSGAQEDLFG
CCEEEECCCCCCCEEEEEEECCCCEEEEECCCHHCCCHHHCCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
SDLIAQSRAGDNAEPLSVSALSQMLKRTVEDRFGYVRLRGELSGVKRAASGHMYCSLKD
CCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHCCCEEEEECC
EKAVIDGVMWKGTTARLAFQPEDGLEVIATGKLTTYPGRSKYQIVLESLEMAGEGALLAL
CHHHHHCEEECCCCEEEEECCCCCCEEEEECCEEECCCCCHHHHHHHHHHHCCCCHHHHH
LEKTRQRLEAEGLFARDRKRPLPFLPRTIGVVTSPTGAVIRDILHRLADRFPSHVLVWPV
HHHHHHHHHHCCCHHHCCCCCCCCCCHHHCEEECCHHHHHHHHHHHHHHHCCCCEEEEEE
LVQGQGAAEQVSAAIRGFGAIKAGGEVPRPDLLIVARGGGSIEDLWSFNEEMVVRAIADS
EECCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHCCC
PIPVISAVGHETDTTLADYAADRRAPTPTAAAEIAVPVKGELAATLNDYAARQQRGVLRP
CCCHHHHCCCCCCCHHHHHHHCCCCCCCCCHHEEEECCCCHHHHHHHHHHHHHHCCCCCH
LSLGRERLEARVQRLPTIETLLQPQAQKLDERVERLRGALRDRAAKGREALATQRLSPTM
HHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHH
LQRAEREARRKLDQVRLAPALVERRAARDGERLAGLSRVLATLNPRAPLERGYALVRDAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHCEEEEECCC
GKLVRAKGEATKQARLAVEFADGSLDVVPAGKAAAAPKRVKKSPPPGTSGAQEDLFG
CCEEEECCCCCCCEEEEEEECCCCEEEEECCCHHCCCHHHCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA