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The map label for this gene is recQ [H]

Identifier: 85375229

GI number: 85375229

Start: 2421535

End: 2423340

Strand: Reverse

Name: recQ [H]

Synonym: ELI_12010

Alternate gene names: 85375229

Gene position: 2423340-2421535 (Counterclockwise)

Preceding gene: 85375236

Following gene: 85375228

Centisome position: 79.39

GC content: 67.44

Gene sequence:

>1806_bases
GTGGGCGCAGACACTCTCGACCTGGATTCATCCGCCGCACTGGACGATGCGCGCCAGCGCTTGCGCGAAGTGTTCGGCCA
TGACGATTTCCGTGGCCGCCAGCCGGACGTGCTGGTGCGCGTTCTCGCCGGGCAATCGACGCTGGCGGTGATGCCGACCG
GCGCGGGCAAGTCGCTGACCTATCAGCTGCCGGCCACCATGCTGCATGGTACTTGCGTGGTGATCTCGCCACTGATCGCC
CTGATGCACGACCAGCTGCGCGCGGCGCGGGCAGATGGCATTCGCGCGGCAACGCTGACCAGCGCGGATTCCGACTGGCG
CGAGACGATGGACGCCTTCCGTGCGGGCGAACTGGACCTGCTCTACGTCGCACCCGAGCGGGCGAGCCAGCCGAGCTTTT
GCGACCTCCTGACCGCAGCCCCGCTGGCGCTGTTCGCCATCGACGAAGCGCACTGCGTTTCGGAATGGGGGCACGATTTC
CGCCCCGACTACCGCCAGCTGCGCCCCCTGATGGATCGCTTCGGCGATATTCCGCGGCTGGCGCTGACCGCGACCGCGGA
TGCGCATACGCGGGCCGATATCCTCGAGCAGCTGGGCATCCCGCAAGACGGGCTGGTGGTCGCGGGCTTCGACCGGCCCA
GTATCCACTACGCCATCCGTCATCGCGACAACCCGGTGCGACAACTGACCACGCTGATGGGCGAACAGCCGGGTCCGGGC
ATCGTTTATGCGCCGACCCGCCGCAAGGTTGAGGACCTGGCCGCCAAGCTCGCTGCGGCGACCGGGCGCGAGGTGCTGCC
TTATCATGCGGGGCTCGACCCGCATGTGCGGGCGGAGAACCAGGCGCGGTTCGTCGCGAGCGAGGACATGGTGATGGTCG
CGACCATCGCCTTCGGAATGGGGATCGACAAGCCGGATGTGCGCTTCGTCGCTCATGCAAGCATCCCGAAATCGATCGAG
GCCTATTATCAGGAAACGGGCCGCGCGGGCCGAGATGGCGACCCTTCGCTGGCGCTGATGCTGTGGGGCGCGGAGGATTT
CGCCCGCGCAAGGATGCGGCTCGCCGAAGTGCCCGAAGACAGGCAGGCGGGTGACCGCCAGCGGCTCGATTCGCTCGCCA
GCCTGGTCGAGACGGCGGGGTGCCGCCGCGCGGTGCTACTCAGGCATTTCGGTGAAGACCCGCCCGGGCAATGCGGCAAT
TGCGACAATTGCCTCGATGCGCCGGGCGTGGTCGACGTGACCGAACTGGCGCGCAAGTTCCTCAGTGCAGCCTATCGCAC
GGGGCAGAGCTTTGGCTTCGGCCATTTGCAGAAGGTGCTCACCGGGGCGGAAGACGACCGCGTGCGCCAGCGGGAGCACG
ACCGGCTGAGCGTATTCGGGATCGTCGATGGCGAGGATGCGGCAATGCTGCGCCCGGTCAGCCGGGCCTTGCAGGCGCGC
GGTTCGTTGGTCGCGACCGAGCACGGCGGGCTGGCGCTGGGCGGCGATGCCAAGGACATCCTCAAGGGCGATACTCCGGT
GATGATCGTCAAGCCGCCGAAGAAAGAGCGCCGCAGCAGGCGTAGCCGCGCTGGCGGGGTCAACCCTGTCGGCGATCCGC
TGTTCGATGCCTTGCGCGAACTCAGGCGAGAGCTGGCGGTCGAAGGGCAGGTGCCACCCTACGTCATCTTCCACGATGCG
ACCTTGCGCGAAATGGCGGTGACGCGGCCTGCCAGCCTATCCGAACTCGGCGCGATCGGCGGCGTAGGGGCCAAGAAGCT
CGACGCCTATGGCGAGCGCTTTCTCGACTGCATCCGGAGACACTGA

Upstream 100 bases:

>100_bases
GTGCGGTTGCTCGCAGTTTAGACGGGGAGGCGGGCGTGGGCCAAGGGAAAACTGGCACCTTCGCCCTTGTCTGGCCTTGG
CGATGTGTCATGGCACATGC

Downstream 100 bases:

>100_bases
CACCGGATTGACGGAATTTGTTTGACTTGCGGGCCGTCCGATATAAAGATGATATCATAGTTATATCGAAAGGACTGATC
CGATGGTCAATGTTTTGGAC

Product: DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 601; Mature: 600

Protein sequence:

>601_residues
MGADTLDLDSSAALDDARQRLREVFGHDDFRGRQPDVLVRVLAGQSTLAVMPTGAGKSLTYQLPATMLHGTCVVISPLIA
LMHDQLRAARADGIRAATLTSADSDWRETMDAFRAGELDLLYVAPERASQPSFCDLLTAAPLALFAIDEAHCVSEWGHDF
RPDYRQLRPLMDRFGDIPRLALTATADAHTRADILEQLGIPQDGLVVAGFDRPSIHYAIRHRDNPVRQLTTLMGEQPGPG
IVYAPTRRKVEDLAAKLAAATGREVLPYHAGLDPHVRAENQARFVASEDMVMVATIAFGMGIDKPDVRFVAHASIPKSIE
AYYQETGRAGRDGDPSLALMLWGAEDFARARMRLAEVPEDRQAGDRQRLDSLASLVETAGCRRAVLLRHFGEDPPGQCGN
CDNCLDAPGVVDVTELARKFLSAAYRTGQSFGFGHLQKVLTGAEDDRVRQREHDRLSVFGIVDGEDAAMLRPVSRALQAR
GSLVATEHGGLALGGDAKDILKGDTPVMIVKPPKKERRSRRSRAGGVNPVGDPLFDALRELRRELAVEGQVPPYVIFHDA
TLREMAVTRPASLSELGAIGGVGAKKLDAYGERFLDCIRRH

Sequences:

>Translated_601_residues
MGADTLDLDSSAALDDARQRLREVFGHDDFRGRQPDVLVRVLAGQSTLAVMPTGAGKSLTYQLPATMLHGTCVVISPLIA
LMHDQLRAARADGIRAATLTSADSDWRETMDAFRAGELDLLYVAPERASQPSFCDLLTAAPLALFAIDEAHCVSEWGHDF
RPDYRQLRPLMDRFGDIPRLALTATADAHTRADILEQLGIPQDGLVVAGFDRPSIHYAIRHRDNPVRQLTTLMGEQPGPG
IVYAPTRRKVEDLAAKLAAATGREVLPYHAGLDPHVRAENQARFVASEDMVMVATIAFGMGIDKPDVRFVAHASIPKSIE
AYYQETGRAGRDGDPSLALMLWGAEDFARARMRLAEVPEDRQAGDRQRLDSLASLVETAGCRRAVLLRHFGEDPPGQCGN
CDNCLDAPGVVDVTELARKFLSAAYRTGQSFGFGHLQKVLTGAEDDRVRQREHDRLSVFGIVDGEDAAMLRPVSRALQAR
GSLVATEHGGLALGGDAKDILKGDTPVMIVKPPKKERRSRRSRAGGVNPVGDPLFDALRELRRELAVEGQVPPYVIFHDA
TLREMAVTRPASLSELGAIGGVGAKKLDAYGERFLDCIRRH
>Mature_600_residues
GADTLDLDSSAALDDARQRLREVFGHDDFRGRQPDVLVRVLAGQSTLAVMPTGAGKSLTYQLPATMLHGTCVVISPLIAL
MHDQLRAARADGIRAATLTSADSDWRETMDAFRAGELDLLYVAPERASQPSFCDLLTAAPLALFAIDEAHCVSEWGHDFR
PDYRQLRPLMDRFGDIPRLALTATADAHTRADILEQLGIPQDGLVVAGFDRPSIHYAIRHRDNPVRQLTTLMGEQPGPGI
VYAPTRRKVEDLAAKLAAATGREVLPYHAGLDPHVRAENQARFVASEDMVMVATIAFGMGIDKPDVRFVAHASIPKSIEA
YYQETGRAGRDGDPSLALMLWGAEDFARARMRLAEVPEDRQAGDRQRLDSLASLVETAGCRRAVLLRHFGEDPPGQCGNC
DNCLDAPGVVDVTELARKFLSAAYRTGQSFGFGHLQKVLTGAEDDRVRQREHDRLSVFGIVDGEDAAMLRPVSRALQARG
SLVATEHGGLALGGDAKDILKGDTPVMIVKPPKKERRSRRSRAGGVNPVGDPLFDALRELRRELAVEGQVPPYVIFHDAT
LREMAVTRPASLSELGAIGGVGAKKLDAYGERFLDCIRRH

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=625, Percent_Identity=31.68, Blast_Score=271, Evalue=2e-72,
Organism=Homo sapiens, GI110735439, Length=498, Percent_Identity=34.9397590361446, Blast_Score=259, Evalue=7e-69,
Organism=Homo sapiens, GI169218196, Length=498, Percent_Identity=34.9397590361446, Blast_Score=258, Evalue=9e-69,
Organism=Homo sapiens, GI14591902, Length=420, Percent_Identity=35.7142857142857, Blast_Score=255, Evalue=9e-68,
Organism=Homo sapiens, GI14591904, Length=420, Percent_Identity=35.7142857142857, Blast_Score=255, Evalue=9e-68,
Organism=Homo sapiens, GI148612816, Length=454, Percent_Identity=35.2422907488987, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI51242947, Length=398, Percent_Identity=37.1859296482412, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI51242943, Length=398, Percent_Identity=37.1859296482412, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI284005309, Length=343, Percent_Identity=37.0262390670554, Blast_Score=175, Evalue=1e-43,
Organism=Escherichia coli, GI48994977, Length=608, Percent_Identity=42.4342105263158, Blast_Score=465, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI32564293, Length=672, Percent_Identity=31.25, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI25145561, Length=420, Percent_Identity=41.1904761904762, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI71987997, Length=459, Percent_Identity=35.2941176470588, Blast_Score=252, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI71987993, Length=459, Percent_Identity=35.2941176470588, Blast_Score=252, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17552866, Length=461, Percent_Identity=33.4056399132321, Blast_Score=204, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6323844, Length=472, Percent_Identity=35.8050847457627, Blast_Score=300, Evalue=5e-82,
Organism=Drosophila melanogaster, GI24646066, Length=635, Percent_Identity=32.5984251968504, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24664226, Length=427, Percent_Identity=36.768149882904, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24664230, Length=427, Percent_Identity=36.768149882904, Blast_Score=231, Evalue=2e-60,
Organism=Drosophila melanogaster, GI62472181, Length=427, Percent_Identity=36.768149882904, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI21358123, Length=368, Percent_Identity=36.4130434782609, Blast_Score=184, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 65530; Mature: 65399

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS50967 HRDC ; PS00104 EPSP_SYNTHASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGADTLDLDSSAALDDARQRLREVFGHDDFRGRQPDVLVRVLAGQSTLAVMPTGAGKSLT
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCEE
YQLPATMLHGTCVVISPLIALMHDQLRAARADGIRAATLTSADSDWRETMDAFRAGELDL
EECCHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCEEE
LYVAPERASQPSFCDLLTAAPLALFAIDEAHCVSEWGHDFRPDYRQLRPLMDRFGDIPRL
EEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCE
ALTATADAHTRADILEQLGIPQDGLVVAGFDRPSIHYAIRHRDNPVRQLTTLMGEQPGPG
EEEECCCHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHCCCCCCC
IVYAPTRRKVEDLAAKLAAATGREVLPYHAGLDPHVRAENQARFVASEDMVMVATIAFGM
EEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEHHHHHHC
GIDKPDVRFVAHASIPKSIEAYYQETGRAGRDGDPSLALMLWGAEDFARARMRLAEVPED
CCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCH
RQAGDRQRLDSLASLVETAGCRRAVLLRHFGEDPPGQCGNCDNCLDAPGVVDVTELARKF
HHCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
LSAAYRTGQSFGFGHLQKVLTGAEDDRVRQREHDRLSVFGIVDGEDAAMLRPVSRALQAR
HHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHC
GSLVATEHGGLALGGDAKDILKGDTPVMIVKPPKKERRSRRSRAGGVNPVGDPLFDALRE
CCEEEECCCCEEECCCHHHHHCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHH
LRRELAVEGQVPPYVIFHDATLREMAVTRPASLSELGAIGGVGAKKLDAYGERFLDCIRR
HHHHHCCCCCCCCEEEEECCHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHC
H
C
>Mature Secondary Structure 
GADTLDLDSSAALDDARQRLREVFGHDDFRGRQPDVLVRVLAGQSTLAVMPTGAGKSLT
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCEE
YQLPATMLHGTCVVISPLIALMHDQLRAARADGIRAATLTSADSDWRETMDAFRAGELDL
EECCHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCEEE
LYVAPERASQPSFCDLLTAAPLALFAIDEAHCVSEWGHDFRPDYRQLRPLMDRFGDIPRL
EEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCE
ALTATADAHTRADILEQLGIPQDGLVVAGFDRPSIHYAIRHRDNPVRQLTTLMGEQPGPG
EEEECCCHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHCCCCCCC
IVYAPTRRKVEDLAAKLAAATGREVLPYHAGLDPHVRAENQARFVASEDMVMVATIAFGM
EEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEHHHHHHC
GIDKPDVRFVAHASIPKSIEAYYQETGRAGRDGDPSLALMLWGAEDFARARMRLAEVPED
CCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCH
RQAGDRQRLDSLASLVETAGCRRAVLLRHFGEDPPGQCGNCDNCLDAPGVVDVTELARKF
HHCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
LSAAYRTGQSFGFGHLQKVLTGAEDDRVRQREHDRLSVFGIVDGEDAAMLRPVSRALQAR
HHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHC
GSLVATEHGGLALGGDAKDILKGDTPVMIVKPPKKERRSRRSRAGGVNPVGDPLFDALRE
CCEEEECCCCEEECCCHHHHHCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHH
LRRELAVEGQVPPYVIFHDATLREMAVTRPASLSELGAIGGVGAKKLDAYGERFLDCIRR
HHHHHCCCCCCCCEEEEECCHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHC
H
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]