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The map label for this gene is guaB [H]

Identifier: 85374246

GI number: 85374246

Start: 1470160

End: 1471686

Strand: Reverse

Name: guaB [H]

Synonym: ELI_07095

Alternate gene names: 85374246

Gene position: 1471686-1470160 (Counterclockwise)

Preceding gene: 85374247

Following gene: 85374245

Centisome position: 48.21

GC content: 64.96

Gene sequence:

>1527_bases
GTGCGGGCTTCCGGTTACAGGGCGGCGCACGATTCTCTCCTTCTGACCTCGGAAAGCCGCCTCGTGCCTATCAAAGACAT
CCCCCTCGGCCTCACCTTCGACGACGTCTTGCTGCGTCCTGCGGAAAGCGAAGTCCTGCCCAGCATGGCGGACACGCGCA
CGAAGCTGACGCGCGAGATCGCGCTCAACATCCCGGTGATCTCCGCCGCAATGGATACAGTGACGGAAGCGGACATGGCG
ATCGCGATGGCGCAGATGGGCGGGATCGGCGTGCTGCACCGCAATCTCAAGATCAAGGAACAGGTCGCCGCCGTTCGCGC
GGTCAAGCGCTTCGAAAGCGGCATGGTGGTCAACCCGATCACGATCTCGCCCGAAGCGACGCTGGGCCAGGCGCAGGCGA
TCATGGACCAGCACCAGATCAGCGGCATCCCGGTGACCGACAAAGGCGGCAAGCTGGTCGGCATCCTGACCAACCGCGAC
GTCCGCTTCGCCGAAAATCCGGGTCAGCCCGTCCGTGAACTGATGACGACGGACGATCTGGCTACCGTCCCGCTCGGCAC
GGGCGAGAACGAAGCGCGGCGGCTGTTGCACCAGCGGAGGATCGAAAAGCTGGTGGTGGTCGACGATGCCTATCGCTGCA
TCGGTCTCATCACCGTCAAGGATATCGAGAAAGCGGTCACCTATCCCGAAGCCACCAAGGACGAAAGCGGCCGGTTGCGT
GTCGCGGCCGCCACGACCGTGGGTGACAAGGGTTTCGAGCGGACCGAGCGGCTGATCGATGCCGAAGTCGATGTCGTCAT
CATCGACACTGCGCACGGTCATAACAAGGACGTCGCGCTTGCGGTCGAGCGGGTCAAGAAACTCTCCAACGCGGTGCAGG
TCGTCGCCGGCAATGTCGCGACGGCGGAAGCGACCAAGGCGCTGATCGGTGCCGGCGCGGACGCGGTGAAGGTAGGCATC
GGACCGGGCTCGATCTGCACCACTCGGGTGGTGGCCGGCGTCGGCGTACCACAGCTCACCGCGATCATGGACAGCGCGGA
AGAAGCGGCGAAGTCGGGCGTGCCGGTGATCGGCGACGGCGGACTGCGCACCAGCGGCGATGCGGCCAAGGCGCTCGCTG
CCGGGGCCTCGAGCGTGATGATCGGGTCCATGCTGGCAGGGACGGAAGAGGCTCCGGGCGAGACTTTCATCTACCAGGGA
CGCAGCTACAAGAGCTATCGCGGCATGGGTAGCGTGAGCGCGATGGCGCGCGGCAGTGCCGATCGCTACTTCCAGCAGGA
CGTCTCCGCGCTCAAGCTCGTGCCGGAAGGTATCGAGGGACAGGTGCCTTACAAAGGGCCCGCGAAAGACGTCGTCCACC
AGCTCGTCGGCGGGATCAAGGCGGCGATGGGCTATACCGGCAGCGCGACGATCGAGGACCTACGCACCCGTGCGGAATTC
GTGCGCATCACCAATGCGGGCCTGGCCGAAAGCCACGTCCACGACGTGGCGATCACGCGGGAAGCGCCGAATTATCCCAC
ACGATGA

Upstream 100 bases:

>100_bases
CCAGCATTTCGGCAGCGTGCAGAAATACCAGCCGGGCGAGCGGACGGAAGGCGCGCCGGCGGCCGATAACGGGGACGAGT
GATCTTGGCCCCTAGCTAAG

Downstream 100 bases:

>100_bases
CATCCATCATGTCATCGTGTGAGTCCTCGCGAAGGACAAGCGCATGACCCCCGCCGCGCGGGTTCAAGCCGCAATCGACA
TCCTCGACCGCGTGATCGAT

Product: IMP dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MRASGYRAAHDSLLLTSESRLVPIKDIPLGLTFDDVLLRPAESEVLPSMADTRTKLTREIALNIPVISAAMDTVTEADMA
IAMAQMGGIGVLHRNLKIKEQVAAVRAVKRFESGMVVNPITISPEATLGQAQAIMDQHQISGIPVTDKGGKLVGILTNRD
VRFAENPGQPVRELMTTDDLATVPLGTGENEARRLLHQRRIEKLVVVDDAYRCIGLITVKDIEKAVTYPEATKDESGRLR
VAAATTVGDKGFERTERLIDAEVDVVIIDTAHGHNKDVALAVERVKKLSNAVQVVAGNVATAEATKALIGAGADAVKVGI
GPGSICTTRVVAGVGVPQLTAIMDSAEEAAKSGVPVIGDGGLRTSGDAAKALAAGASSVMIGSMLAGTEEAPGETFIYQG
RSYKSYRGMGSVSAMARGSADRYFQQDVSALKLVPEGIEGQVPYKGPAKDVVHQLVGGIKAAMGYTGSATIEDLRTRAEF
VRITNAGLAESHVHDVAITREAPNYPTR

Sequences:

>Translated_508_residues
MRASGYRAAHDSLLLTSESRLVPIKDIPLGLTFDDVLLRPAESEVLPSMADTRTKLTREIALNIPVISAAMDTVTEADMA
IAMAQMGGIGVLHRNLKIKEQVAAVRAVKRFESGMVVNPITISPEATLGQAQAIMDQHQISGIPVTDKGGKLVGILTNRD
VRFAENPGQPVRELMTTDDLATVPLGTGENEARRLLHQRRIEKLVVVDDAYRCIGLITVKDIEKAVTYPEATKDESGRLR
VAAATTVGDKGFERTERLIDAEVDVVIIDTAHGHNKDVALAVERVKKLSNAVQVVAGNVATAEATKALIGAGADAVKVGI
GPGSICTTRVVAGVGVPQLTAIMDSAEEAAKSGVPVIGDGGLRTSGDAAKALAAGASSVMIGSMLAGTEEAPGETFIYQG
RSYKSYRGMGSVSAMARGSADRYFQQDVSALKLVPEGIEGQVPYKGPAKDVVHQLVGGIKAAMGYTGSATIEDLRTRAEF
VRITNAGLAESHVHDVAITREAPNYPTR
>Mature_508_residues
MRASGYRAAHDSLLLTSESRLVPIKDIPLGLTFDDVLLRPAESEVLPSMADTRTKLTREIALNIPVISAAMDTVTEADMA
IAMAQMGGIGVLHRNLKIKEQVAAVRAVKRFESGMVVNPITISPEATLGQAQAIMDQHQISGIPVTDKGGKLVGILTNRD
VRFAENPGQPVRELMTTDDLATVPLGTGENEARRLLHQRRIEKLVVVDDAYRCIGLITVKDIEKAVTYPEATKDESGRLR
VAAATTVGDKGFERTERLIDAEVDVVIIDTAHGHNKDVALAVERVKKLSNAVQVVAGNVATAEATKALIGAGADAVKVGI
GPGSICTTRVVAGVGVPQLTAIMDSAEEAAKSGVPVIGDGGLRTSGDAAKALAAGASSVMIGSMLAGTEEAPGETFIYQG
RSYKSYRGMGSVSAMARGSADRYFQQDVSALKLVPEGIEGQVPYKGPAKDVVHQLVGGIKAAMGYTGSATIEDLRTRAEF
VRITNAGLAESHVHDVAITREAPNYPTR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=478, Percent_Identity=39.5397489539749, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI156616279, Length=478, Percent_Identity=39.5397489539749, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI34328930, Length=478, Percent_Identity=39.5397489539749, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI34328928, Length=478, Percent_Identity=39.5397489539749, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI217035152, Length=473, Percent_Identity=39.323467230444, Blast_Score=305, Evalue=6e-83,
Organism=Homo sapiens, GI217035148, Length=478, Percent_Identity=38.9121338912134, Blast_Score=303, Evalue=4e-82,
Organism=Homo sapiens, GI66933016, Length=480, Percent_Identity=38.125, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI217035150, Length=478, Percent_Identity=37.0292887029289, Blast_Score=278, Evalue=7e-75,
Organism=Homo sapiens, GI50541956, Length=248, Percent_Identity=38.3064516129032, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI50541954, Length=248, Percent_Identity=38.3064516129032, Blast_Score=170, Evalue=4e-42,
Organism=Homo sapiens, GI50541952, Length=248, Percent_Identity=38.3064516129032, Blast_Score=170, Evalue=4e-42,
Organism=Homo sapiens, GI50541948, Length=248, Percent_Identity=38.3064516129032, Blast_Score=170, Evalue=4e-42,
Organism=Homo sapiens, GI156104880, Length=265, Percent_Identity=35.4716981132075, Blast_Score=164, Evalue=3e-40,
Organism=Escherichia coli, GI1788855, Length=480, Percent_Identity=56.4583333333333, Blast_Score=501, Evalue=1e-143,
Organism=Escherichia coli, GI1786293, Length=248, Percent_Identity=37.5, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71994385, Length=497, Percent_Identity=34.20523138833, Blast_Score=261, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI71994389, Length=424, Percent_Identity=36.7924528301887, Blast_Score=247, Evalue=9e-66,
Organism=Caenorhabditis elegans, GI17560440, Length=271, Percent_Identity=34.6863468634686, Blast_Score=164, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6323585, Length=486, Percent_Identity=39.0946502057613, Blast_Score=323, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6322012, Length=484, Percent_Identity=38.4297520661157, Blast_Score=314, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6323464, Length=484, Percent_Identity=38.8429752066116, Blast_Score=309, Evalue=6e-85,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=37.2781065088757, Blast_Score=229, Evalue=9e-61,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=38.7931034482759, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641071, Length=479, Percent_Identity=37.3695198329854, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24641073, Length=479, Percent_Identity=37.3695198329854, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI28571163, Length=438, Percent_Identity=38.1278538812785, Blast_Score=278, Evalue=9e-75,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53617; Mature: 53617

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRASGYRAAHDSLLLTSESRLVPIKDIPLGLTFDDVLLRPAESEVLPSMADTRTKLTREI
CCCCCCCCCCCCEEEECCCCEEEECCCCCCCCHHHHHCCCCHHHHCCCHHHHHHHHHHHH
ALNIPVISAAMDTVTEADMAIAMAQMGGIGVLHRNLKIKEQVAAVRAVKRFESGMVVNPI
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHCCCEECCE
TISPEATLGQAQAIMDQHQISGIPVTDKGGKLVGILTNRDVRFAENPGQPVRELMTTDDL
EECCCCCHHHHHHHHHHHHCCCCCEECCCCEEEEEEECCCEEECCCCCHHHHHHHCCCCC
ATVPLGTGENEARRLLHQRRIEKLVVVDDAYRCIGLITVKDIEKAVTYPEATKDESGRLR
EEECCCCCCHHHHHHHHHHHHHEEEEEECCCEEEEEEEHHHHHHHHCCCCCCCCCCCCEE
VAAATTVGDKGFERTERLIDAEVDVVIIDTAHGHNKDVALAVERVKKLSNAVQVVAGNVA
EEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
TAEATKALIGAGADAVKVGIGPGSICTTRVVAGVGVPQLTAIMDSAEEAAKSGVPVIGDG
HHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECC
GLRTSGDAAKALAAGASSVMIGSMLAGTEEAPGETFIYQGRSYKSYRGMGSVSAMARGSA
CCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEECCCCCHHHCCCCCHHHHHCCCH
DRYFQQDVSALKLVPEGIEGQVPYKGPAKDVVHQLVGGIKAAMGYTGSATIEDLRTRAEF
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
VRITNAGLAESHVHDVAITREAPNYPTR
EEECCCCCCHHHHHEEEEEECCCCCCCC
>Mature Secondary Structure
MRASGYRAAHDSLLLTSESRLVPIKDIPLGLTFDDVLLRPAESEVLPSMADTRTKLTREI
CCCCCCCCCCCCEEEECCCCEEEECCCCCCCCHHHHHCCCCHHHHCCCHHHHHHHHHHHH
ALNIPVISAAMDTVTEADMAIAMAQMGGIGVLHRNLKIKEQVAAVRAVKRFESGMVVNPI
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHCCCEECCE
TISPEATLGQAQAIMDQHQISGIPVTDKGGKLVGILTNRDVRFAENPGQPVRELMTTDDL
EECCCCCHHHHHHHHHHHHCCCCCEECCCCEEEEEEECCCEEECCCCCHHHHHHHCCCCC
ATVPLGTGENEARRLLHQRRIEKLVVVDDAYRCIGLITVKDIEKAVTYPEATKDESGRLR
EEECCCCCCHHHHHHHHHHHHHEEEEEECCCEEEEEEEHHHHHHHHCCCCCCCCCCCCEE
VAAATTVGDKGFERTERLIDAEVDVVIIDTAHGHNKDVALAVERVKKLSNAVQVVAGNVA
EEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
TAEATKALIGAGADAVKVGIGPGSICTTRVVAGVGVPQLTAIMDSAEEAAKSGVPVIGDG
HHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECC
GLRTSGDAAKALAAGASSVMIGSMLAGTEEAPGETFIYQGRSYKSYRGMGSVSAMARGSA
CCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEECCCCCHHHCCCCCHHHHHCCCH
DRYFQQDVSALKLVPEGIEGQVPYKGPAKDVVHQLVGGIKAAMGYTGSATIEDLRTRAEF
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
VRITNAGLAESHVHDVAITREAPNYPTR
EEECCCCCCHHHHHEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA