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The map label for this gene is yggV [C]

Identifier: 85374028

GI number: 85374028

Start: 1242794

End: 1243423

Strand: Reverse

Name: yggV [C]

Synonym: ELI_06005

Alternate gene names: 85374028

Gene position: 1243423-1242794 (Counterclockwise)

Preceding gene: 85374029

Following gene: 85374027

Centisome position: 40.74

GC content: 65.08

Gene sequence:

>630_bases
GTGACGCGCCGCCTCGGCTCAGGCTCGCTGGTCATTGCCACGCACAACGCGGGCAAGCTGAAAGAGATTTCAGCGCTGCT
GGAGCCGTATGGCGTCAAATGCATCAGCGCCGGCTCGTTGGGCCTTCCGGAGCCTGCCGAGACCGGCACGACCTTTGTCG
AGAACGCTCTGATCAAGGCGCGCGCCGCGGCCGAAGCGTCCGGCATGGCGGCGCTGGCCGACGACAGCGGCCTGTCGGTC
GATGCGCTGGAGGGGCGGCCCGGTGTCTACACCGCCGATTGGGCCGAGCGGCAATGGTTCGAAGGCAAGCCGGGACGCGA
CTGGTACATGGCTATGGGCAAGGTAGAGGGCATGTTGCAACAACTCGGCCCGGACACCGATCGGAATGCTGCGTTTCATT
GTGTCCTCGCGCTGGCGTGGCCCGATGGCGAGCACGCGATCTACGAAGGCAAATGCCCCGGTTCGCTGACCTGGCCTCCG
CGCGGCAAGCTGGGCTTTGGCTACGACCCCGTTTTTGTGCCGACTGGGCGCGGCCAAACATTCGCCGAAATCGACCCGGA
AGAGAAGCACGCCATCAGCCATCGCGCCGATGCTTTCGCCAAGCTGGTCGCGAAACAGTTTGGCAGCTAG

Upstream 100 bases:

>100_bases
CCGAAGGCGCGACCTATGACGAGGAAGGCTTGATGCGCCTGCTCCGCCTCGCCCAGATCGGTTGCGCGCAGATCTTCAAG
TCGCAGGACGAGGCGACGAA

Downstream 100 bases:

>100_bases
ACTGCGGCCATGGCCCGCGCGCTCTACATCCATTGGCCCTTCTGCGCGAAGAAGTGCCCCTATTGCGATTTCAACAGCCA
CGTGCGCGCCAGCGTCGATC

Product: putative deoxyribonucleotide triphosphate pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase [H]

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MTRRLGSGSLVIATHNAGKLKEISALLEPYGVKCISAGSLGLPEPAETGTTFVENALIKARAAAEASGMAALADDSGLSV
DALEGRPGVYTADWAERQWFEGKPGRDWYMAMGKVEGMLQQLGPDTDRNAAFHCVLALAWPDGEHAIYEGKCPGSLTWPP
RGKLGFGYDPVFVPTGRGQTFAEIDPEEKHAISHRADAFAKLVAKQFGS

Sequences:

>Translated_209_residues
MTRRLGSGSLVIATHNAGKLKEISALLEPYGVKCISAGSLGLPEPAETGTTFVENALIKARAAAEASGMAALADDSGLSV
DALEGRPGVYTADWAERQWFEGKPGRDWYMAMGKVEGMLQQLGPDTDRNAAFHCVLALAWPDGEHAIYEGKCPGSLTWPP
RGKLGFGYDPVFVPTGRGQTFAEIDPEEKHAISHRADAFAKLVAKQFGS
>Mature_208_residues
TRRLGSGSLVIATHNAGKLKEISALLEPYGVKCISAGSLGLPEPAETGTTFVENALIKARAAAEASGMAALADDSGLSVD
ALEGRPGVYTADWAERQWFEGKPGRDWYMAMGKVEGMLQQLGPDTDRNAAFHCVLALAWPDGEHAIYEGKCPGSLTWPPR
GKLGFGYDPVFVPTGRGQTFAEIDPEEKHAISHRADAFAKLVAKQFGS

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions [H]

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family [H]

Homologues:

Organism=Homo sapiens, GI15626999, Length=211, Percent_Identity=30.8056872037915, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI31657144, Length=158, Percent_Identity=32.2784810126582, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1789324, Length=196, Percent_Identity=40.8163265306122, Blast_Score=143, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17556833, Length=195, Percent_Identity=32.3076923076923, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322529, Length=205, Percent_Identity=28.2926829268293, Blast_Score=82, Evalue=6e-17,
Organism=Drosophila melanogaster, GI19920712, Length=197, Percent_Identity=31.9796954314721, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002637
- InterPro:   IPR020922 [H]

Pfam domain/function: PF01725 Ham1p_like [H]

EC number: =3.6.1.15 [H]

Molecular weight: Translated: 22290; Mature: 22159

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRLGSGSLVIATHNAGKLKEISALLEPYGVKCISAGSLGLPEPAETGTTFVENALIKA
CCCCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHH
RAAAEASGMAALADDSGLSVDALEGRPGVYTADWAERQWFEGKPGRDWYMAMGKVEGMLQ
HHHHCCCCCEEEECCCCCEEEEECCCCCEEECCHHHHHCCCCCCCCHHHHHHHHHHHHHH
QLGPDTDRNAAFHCVLALAWPDGEHAIYEGKCPGSLTWPPRGKLGFGYDPVFVPTGRGQT
HHCCCCCCCCEEEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCE
FAEIDPEEKHAISHRADAFAKLVAKQFGS
EECCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TRRLGSGSLVIATHNAGKLKEISALLEPYGVKCISAGSLGLPEPAETGTTFVENALIKA
CCCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHH
RAAAEASGMAALADDSGLSVDALEGRPGVYTADWAERQWFEGKPGRDWYMAMGKVEGMLQ
HHHHCCCCCEEEECCCCCEEEEECCCCCEEECCHHHHHCCCCCCCCHHHHHHHHHHHHHH
QLGPDTDRNAAFHCVLALAWPDGEHAIYEGKCPGSLTWPPRGKLGFGYDPVFVPTGRGQT
HHCCCCCCCCEEEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCE
FAEIDPEEKHAISHRADAFAKLVAKQFGS
EECCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]