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The map label for this gene is ilvC

Identifier: 85373928

GI number: 85373928

Start: 1143578

End: 1144597

Strand: Reverse

Name: ilvC

Synonym: ELI_05505

Alternate gene names: 85373928

Gene position: 1144597-1143578 (Counterclockwise)

Preceding gene: 85373929

Following gene: 85373927

Centisome position: 37.5

GC content: 62.84

Gene sequence:

>1020_bases
GTGAAAGTTTATTACGACGCCGATGCCGATCTTGGACTGATCACGGACAAGAAGATCGCCGTGCTCGGCTATGGCAGCCA
GGGGCACGCCCATGCACAGAATCTGCGTGACAGCGGGATCAAAGAGGTAGCAATCGCGCTGCGCGACGGCTCTTCCAGCG
CGAAGAAAGCGCAGGATGCTGGCTTCAAGGTGCTCAGCAATTCCGACGCTGCCGAGTGGGCCGATATCCTGATGATCCTC
GCCCCCGACGAGCACCAGGCGGCGATCTGGGCGGATGACCTTGCGGGCAACATGAAGCCGGGCAGCGCCCTCGCCTTCGC
CCACGGGCTCAACATCCACTTCGGCCTGATCGAACCACCCGCCGAGATCGACGTCATCATGATCGCGCCGAAGGGTCCTG
GTCATACTGTCCGCAGCGAGTATCAGCGCGGCGGCGGCGTGCCCTGCCTCATCGCCGTCCACCAGGATTCGAGCGGCAAT
GCCAAGGACATCGCCCTCGCCTATGCCAGCGGTGTCGGCGGCGGGCGCAGCGGCATTATCGAGACCAACTTCCGCGAGGA
ATGCGAGACCGACCTGTTCGGCGAGCAGGCCGTGCTGTGCGGCGGGATCACGCACCTGATCCAAGCCGGCTTCGAGACGC
TGACCGAGGCCGGATATGCACCGGAGATGGCCTATTTCGAGTGCCTGCACGAGACCAAGCTGATCGTCGACCTGCTCTAC
GAAGGCGGCATCGCCAATATGCGCTACTCGATCAGCAACACCGCCGAGTATGGCGACATCACCACCGGCCCGCGCATCAT
CACCGATGAGACCAAGGCCGAAATGAAGCGCGTTCTCGGCGATATCCAGTCGGGCCGCTTCGTGAAGAACTTCGTCCTCG
ACAACCGCGCCGGCCAGCCCGAACTCAAGGCTGCCCGCAAGCGCGCCGAAGCGCATCCGATCGAACAGACCGGTGCCAAG
CTGCGCGCAATGATGCCGTGGATCGGCAAGAACAAGCTGGTCGACAAGGACAGGAACTAG

Upstream 100 bases:

>100_bases
AAGTTTCGTCATCCCAGCGAAAGCTGGGATCTCGCGTTGCAAGGCGCGACCGAGGATAACCAGATCCCGGCTTTCGCTGG
GATGACGTGAGGGAAGAACA

Downstream 100 bases:

>100_bases
CGCGTCCTTAAGCGCCAGATCGGAACCACCCCTGTCCCGCCCGGTTGATGCCGGGACGGGACATTTTTTTTTCGGAGGTT
CGCATGAAAAAGCCGCTTTT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MKVYYDADADLGLITDKKIAVLGYGSQGHAHAQNLRDSGIKEVAIALRDGSSSAKKAQDAGFKVLSNSDAAEWADILMIL
APDEHQAAIWADDLAGNMKPGSALAFAHGLNIHFGLIEPPAEIDVIMIAPKGPGHTVRSEYQRGGGVPCLIAVHQDSSGN
AKDIALAYASGVGGGRSGIIETNFREECETDLFGEQAVLCGGITHLIQAGFETLTEAGYAPEMAYFECLHETKLIVDLLY
EGGIANMRYSISNTAEYGDITTGPRIITDETKAEMKRVLGDIQSGRFVKNFVLDNRAGQPELKAARKRAEAHPIEQTGAK
LRAMMPWIGKNKLVDKDRN

Sequences:

>Translated_339_residues
MKVYYDADADLGLITDKKIAVLGYGSQGHAHAQNLRDSGIKEVAIALRDGSSSAKKAQDAGFKVLSNSDAAEWADILMIL
APDEHQAAIWADDLAGNMKPGSALAFAHGLNIHFGLIEPPAEIDVIMIAPKGPGHTVRSEYQRGGGVPCLIAVHQDSSGN
AKDIALAYASGVGGGRSGIIETNFREECETDLFGEQAVLCGGITHLIQAGFETLTEAGYAPEMAYFECLHETKLIVDLLY
EGGIANMRYSISNTAEYGDITTGPRIITDETKAEMKRVLGDIQSGRFVKNFVLDNRAGQPELKAARKRAEAHPIEQTGAK
LRAMMPWIGKNKLVDKDRN
>Mature_339_residues
MKVYYDADADLGLITDKKIAVLGYGSQGHAHAQNLRDSGIKEVAIALRDGSSSAKKAQDAGFKVLSNSDAAEWADILMIL
APDEHQAAIWADDLAGNMKPGSALAFAHGLNIHFGLIEPPAEIDVIMIAPKGPGHTVRSEYQRGGGVPCLIAVHQDSSGN
AKDIALAYASGVGGGRSGIIETNFREECETDLFGEQAVLCGGITHLIQAGFETLTEAGYAPEMAYFECLHETKLIVDLLY
EGGIANMRYSISNTAEYGDITTGPRIITDETKAEMKRVLGDIQSGRFVKNFVLDNRAGQPELKAARKRAEAHPIEQTGAK
LRAMMPWIGKNKLVDKDRN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=292, Percent_Identity=36.6438356164384, Blast_Score=143, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323387, Length=304, Percent_Identity=29.2763157894737, Blast_Score=119, Evalue=7e-28,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_ERYLH (Q2NAU8)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_457990.1
- ProteinModelPortal:   Q2NAU8
- SMR:   Q2NAU8
- STRING:   Q2NAU8
- GeneID:   3870498
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_05505
- NMPDR:   fig|314225.3.peg.1964
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   AMKQCLK
- PhylomeDB:   Q2NAU8
- ProtClustDB:   PRK05479
- BioCyc:   ELIT314225:ELI_05505-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36482; Mature: 36482

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVYYDADADLGLITDKKIAVLGYGSQGHAHAQNLRDSGIKEVAIALRDGSSSAKKAQDA
CEEEECCCCCEEEEECCEEEEEEECCCCCHHHHHHHHCCHHEEEEEEECCCCHHHHHHHC
GFKVLSNSDAAEWADILMILAPDEHQAAIWADDLAGNMKPGSALAFAHGLNIHFGLIEPP
CEEEECCCCHHHHEEEEEEECCCCCCEEEEEHHHCCCCCCCCEEEEEECCEEEEEEECCC
AEIDVIMIAPKGPGHTVRSEYQRGGGVPCLIAVHQDSSGNAKDIALAYASGVGGGRSGII
CCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEEEECCCCCCCCCEE
ETNFREECETDLFGEQAVLCGGITHLIQAGFETLTEAGYAPEMAYFECLHETKLIVDLLY
ECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMRYSISNTAEYGDITTGPRIITDETKAEMKRVLGDIQSGRFVKNFVLDNRAGQP
CCCCCEEEEEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCEEEHHHHCCCCCCH
ELKAARKRAEAHPIEQTGAKLRAMMPWIGKNKLVDKDRN
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKVYYDADADLGLITDKKIAVLGYGSQGHAHAQNLRDSGIKEVAIALRDGSSSAKKAQDA
CEEEECCCCCEEEEECCEEEEEEECCCCCHHHHHHHHCCHHEEEEEEECCCCHHHHHHHC
GFKVLSNSDAAEWADILMILAPDEHQAAIWADDLAGNMKPGSALAFAHGLNIHFGLIEPP
CEEEECCCCHHHHEEEEEEECCCCCCEEEEEHHHCCCCCCCCEEEEEECCEEEEEEECCC
AEIDVIMIAPKGPGHTVRSEYQRGGGVPCLIAVHQDSSGNAKDIALAYASGVGGGRSGII
CCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEEEECCCCCCCCCEE
ETNFREECETDLFGEQAVLCGGITHLIQAGFETLTEAGYAPEMAYFECLHETKLIVDLLY
ECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMRYSISNTAEYGDITTGPRIITDETKAEMKRVLGDIQSGRFVKNFVLDNRAGQP
CCCCCEEEEEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCEEEHHHHCCCCCCH
ELKAARKRAEAHPIEQTGAKLRAMMPWIGKNKLVDKDRN
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA