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The map label for this gene is pccB [H]

Identifier: 85373805

GI number: 85373805

Start: 1008467

End: 1009999

Strand: Direct

Name: pccB [H]

Synonym: ELI_04890

Alternate gene names: 85373805

Gene position: 1008467-1009999 (Clockwise)

Preceding gene: 85373804

Following gene: 85373806

Centisome position: 33.04

GC content: 62.43

Gene sequence:

>1533_bases
ATGTCCGCCAATATCGCCGAAATGGAACGTCGCCGCGAAGCTGCCCATCTGGGCGGAGGCCAGAAGCGGATCGATGCGCA
GCATGCCAAGGGCAAGCTGACTGCGCGCGAGCGGCTCGATGTGCTGCTGGACGAGGATAGCTTCGAAGAGCTCGATACCT
ACGTGGAGCATAATTGCGTCGATTTCGGCATGGCGGATCAGAAGATCCCGGGCGACGGCGTGGTCACCGGCAGCGGCACG
ATCAACGGGCGGCTGGTCTATGTCTTCAGCCAGGACTTCACCGTCTTCGGCGGCTCGCTGTCGAAGCGCCATGCGGAGAA
GATCTGCAAGGTGATGGACACCGCGATGAAGGTCGGTGCGCCGGTGATCGGCCTCAACGATTCCGGCGGCGCGCGCATCC
AGGAAGGCGTTGCGTCGCTCGGCGGCTATGCCGAAGTGTTCCAGCGCAATGTGCTCGCCAGCGGCGTGGTGCCGCAGATC
AGCCTCATCATGGGGCCCTGCGCGGGCGGGGCGGTCTATAGCCCCGCGATGACCGACTTCATCTTCATGGTGGAGGACAG
CTCCTATATGTTCGTCACCGGGCCGGAGGTGGTGAAGACCGTCACCAACGAGACCGTGACGCAGGAAGAGCTGGGCGGGG
CGAAGACCCACACCACCAAGACTTCGGTCGCAGATAACGCATTCGAAAACGATATCGAAGCGCTGCTGGCGACCCGCAAT
TTCTTCGATTTCCTGCCGCTCAGCAATCGCGAGCAGGTCCCCGAGCGACCCACGGCGGATCCGTTCGACCGCGAGGAACA
CAGCCTCGACACGCTGATCCCGGCCAATGCCAACCAGCCTTACGACATGCACGAAGTCATCCGCAAAGTGGTGGACGAAG
GCGATTTCTTCGAAGTCCAGCCGGCGCATGCGGCGAACATCCTGTGCGGGTTCGGCCGGGTCGAGGGCCGCACCGTGGGC
GTAGTCGCCAACCAGCCGATGGTGCTGGCTGGCGTGCTCGACATCAATTCGTCGAAGAAGGCCGCGCGCTTCGTGCGCTT
CTGCGATGCCTTCGAGATCCCGATCCTGACCTTCGTCGACGTCCCCGGCTTCCTGCCCGGAACAGCGCAGGAGCATAACG
GCATCATCAAGCACGGCGCAAAACTGCTGTTCGCCTATGCCGAGGCGACCGTGCCCAAGATCACCGTCATCACCCGCAAG
GCTTATGGCGGCGCGTACGATGTGATGGCCTCGAAGCACTTGCGCGGCGACTTGAACTACGCCTGGCCCACTGCCGAGAT
CGCCGTGATGGGCGCCAAGGGCGCGGTGGAGATCATCTTCCGCCAGGACCGCGACGATCCCGACAAGATCGCCGAGAAAA
CCAAGGAATACGAAGACCGATTCGCCAACCCCTTCGTGGCGGCGAGCCGCGGCTATATCGACGAGGTGATCTACCCGCAC
TCGACGCGGAAGCGCATCGCGCTGGGGCTAAGGAAACTGCGGACGAAGAGCCTCGAGAACCCTTGGAAGAAGCATGATAA
TATTCCGTTGTGA

Upstream 100 bases:

>100_bases
ACATGGGGTGGTGAAGGTCTAGGTCTGCAACGATCACAATCGGTTGACGCTGCGGCAATGCGCTGGCTAGGCGCAATGCA
AACGCACACAGGGGAACTGC

Downstream 100 bases:

>100_bases
GGTGAATTATGAACTGCCGTCACTGTGAGAGCGAATTGGCTGAGCAAGCCAAATTCTGCAGCGAGTGCGGACGAAAAGTC
ATAGAGGGGACTCCTGCAAG

Product: propionyl-CoA carboxylase beta subunit

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MSANIAEMERRREAAHLGGGQKRIDAQHAKGKLTARERLDVLLDEDSFEELDTYVEHNCVDFGMADQKIPGDGVVTGSGT
INGRLVYVFSQDFTVFGGSLSKRHAEKICKVMDTAMKVGAPVIGLNDSGGARIQEGVASLGGYAEVFQRNVLASGVVPQI
SLIMGPCAGGAVYSPAMTDFIFMVEDSSYMFVTGPEVVKTVTNETVTQEELGGAKTHTTKTSVADNAFENDIEALLATRN
FFDFLPLSNREQVPERPTADPFDREEHSLDTLIPANANQPYDMHEVIRKVVDEGDFFEVQPAHAANILCGFGRVEGRTVG
VVANQPMVLAGVLDINSSKKAARFVRFCDAFEIPILTFVDVPGFLPGTAQEHNGIIKHGAKLLFAYAEATVPKITVITRK
AYGGAYDVMASKHLRGDLNYAWPTAEIAVMGAKGAVEIIFRQDRDDPDKIAEKTKEYEDRFANPFVAASRGYIDEVIYPH
STRKRIALGLRKLRTKSLENPWKKHDNIPL

Sequences:

>Translated_510_residues
MSANIAEMERRREAAHLGGGQKRIDAQHAKGKLTARERLDVLLDEDSFEELDTYVEHNCVDFGMADQKIPGDGVVTGSGT
INGRLVYVFSQDFTVFGGSLSKRHAEKICKVMDTAMKVGAPVIGLNDSGGARIQEGVASLGGYAEVFQRNVLASGVVPQI
SLIMGPCAGGAVYSPAMTDFIFMVEDSSYMFVTGPEVVKTVTNETVTQEELGGAKTHTTKTSVADNAFENDIEALLATRN
FFDFLPLSNREQVPERPTADPFDREEHSLDTLIPANANQPYDMHEVIRKVVDEGDFFEVQPAHAANILCGFGRVEGRTVG
VVANQPMVLAGVLDINSSKKAARFVRFCDAFEIPILTFVDVPGFLPGTAQEHNGIIKHGAKLLFAYAEATVPKITVITRK
AYGGAYDVMASKHLRGDLNYAWPTAEIAVMGAKGAVEIIFRQDRDDPDKIAEKTKEYEDRFANPFVAASRGYIDEVIYPH
STRKRIALGLRKLRTKSLENPWKKHDNIPL
>Mature_509_residues
SANIAEMERRREAAHLGGGQKRIDAQHAKGKLTARERLDVLLDEDSFEELDTYVEHNCVDFGMADQKIPGDGVVTGSGTI
NGRLVYVFSQDFTVFGGSLSKRHAEKICKVMDTAMKVGAPVIGLNDSGGARIQEGVASLGGYAEVFQRNVLASGVVPQIS
LIMGPCAGGAVYSPAMTDFIFMVEDSSYMFVTGPEVVKTVTNETVTQEELGGAKTHTTKTSVADNAFENDIEALLATRNF
FDFLPLSNREQVPERPTADPFDREEHSLDTLIPANANQPYDMHEVIRKVVDEGDFFEVQPAHAANILCGFGRVEGRTVGV
VANQPMVLAGVLDINSSKKAARFVRFCDAFEIPILTFVDVPGFLPGTAQEHNGIIKHGAKLLFAYAEATVPKITVITRKA
YGGAYDVMASKHLRGDLNYAWPTAEIAVMGAKGAVEIIFRQDRDDPDKIAEKTKEYEDRFANPFVAASRGYIDEVIYPHS
TRKRIALGLRKLRTKSLENPWKKHDNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=506, Percent_Identity=67.3913043478261, Blast_Score=716, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=525, Percent_Identity=64.9523809523809, Blast_Score=703, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=525, Percent_Identity=32.3809523809524, Blast_Score=230, Evalue=2e-60,
Organism=Escherichia coli, GI1788655, Length=194, Percent_Identity=28.8659793814433, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI25147359, Length=504, Percent_Identity=66.0714285714286, Blast_Score=716, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=504, Percent_Identity=66.0714285714286, Blast_Score=715, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=518, Percent_Identity=30.6949806949807, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI24586065, Length=514, Percent_Identity=31.9066147859922, Blast_Score=239, Evalue=4e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55903; Mature: 55772

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANIAEMERRREAAHLGGGQKRIDAQHAKGKLTARERLDVLLDEDSFEELDTYVEHNCV
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHEEECCCCHHHHHHHHHCCCE
DFGMADQKIPGDGVVTGSGTINGRLVYVFSQDFTVFGGSLSKRHAEKICKVMDTAMKVGA
ECCCCCCCCCCCCEEECCCCCCCEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHCC
PVIGLNDSGGARIQEGVASLGGYAEVFQRNVLASGVVPQISLIMGPCAGGAVYSPAMTDF
CEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEHHEECCCCCCCEECCCCEEE
IFMVEDSSYMFVTGPEVVKTVTNETVTQEELGGAKTHTTKTSVADNAFENDIEALLATRN
EEEEECCCEEEEECHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FFDFLPLSNREQVPERPTADPFDREEHSLDTLIPANANQPYDMHEVIRKVVDEGDFFEVQ
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHCCCCEEEEC
PAHAANILCGFGRVEGRTVGVVANQPMVLAGVLDINSSKKAARFVRFCDAFEIPILTFVD
CCHHHHHEEECCCCCCEEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEC
VPGFLPGTAQEHNGIIKHGAKLLFAYAEATVPKITVITRKAYGGAYDVMASKHLRGDLNY
CCCCCCCCCHHCCCHHHHHHHHEEHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCC
AWPTAEIAVMGAKGAVEIIFRQDRDDPDKIAEKTKEYEDRFANPFVAASRGYIDEVIYPH
CCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHCCCC
STRKRIALGLRKLRTKSLENPWKKHDNIPL
CHHHHHHHHHHHHHHHHHCCHHHHCCCCCC
>Mature Secondary Structure 
SANIAEMERRREAAHLGGGQKRIDAQHAKGKLTARERLDVLLDEDSFEELDTYVEHNCV
CCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHEEECCCCHHHHHHHHHCCCE
DFGMADQKIPGDGVVTGSGTINGRLVYVFSQDFTVFGGSLSKRHAEKICKVMDTAMKVGA
ECCCCCCCCCCCCEEECCCCCCCEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHCC
PVIGLNDSGGARIQEGVASLGGYAEVFQRNVLASGVVPQISLIMGPCAGGAVYSPAMTDF
CEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEHHEECCCCCCCEECCCCEEE
IFMVEDSSYMFVTGPEVVKTVTNETVTQEELGGAKTHTTKTSVADNAFENDIEALLATRN
EEEEECCCEEEEECHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FFDFLPLSNREQVPERPTADPFDREEHSLDTLIPANANQPYDMHEVIRKVVDEGDFFEVQ
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHCCCCEEEEC
PAHAANILCGFGRVEGRTVGVVANQPMVLAGVLDINSSKKAARFVRFCDAFEIPILTFVD
CCHHHHHEEECCCCCCEEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEC
VPGFLPGTAQEHNGIIKHGAKLLFAYAEATVPKITVITRKAYGGAYDVMASKHLRGDLNY
CCCCCCCCCHHCCCHHHHHHHHEEHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCC
AWPTAEIAVMGAKGAVEIIFRQDRDDPDKIAEKTKEYEDRFANPFVAASRGYIDEVIYPH
CCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHCCCC
STRKRIALGLRKLRTKSLENPWKKHDNIPL
CHHHHHHHHHHHHHHHHHCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]