Click here to switch to the map view.

The map label for this gene is gor [H]

Identifier: 85373803

GI number: 85373803

Start: 1005870

End: 1007219

Strand: Direct

Name: gor [H]

Synonym: ELI_04880

Alternate gene names: 85373803

Gene position: 1005870-1007219 (Clockwise)

Preceding gene: 85373802

Following gene: 85373804

Centisome position: 32.95

GC content: 61.85

Gene sequence:

>1350_bases
ATGGCCGAATACGACTACGACCTCTTCACCATCGGCGGCGGATCGGGCGGCGTGCGCGCCTCCCGCGTCGCGGCCGCCCA
TGGGGCCAGGGTCGCCATTGCCGAAGAGCACCGCATCGGCGGCACCTGTGTCATCCGCGGCTGTGTGCCCAAGAAGATGC
TGGTCTACGGCGCGCATTTCGCGGAGGATCTCGAGGACTGCCAGAAGTTCGGCTGGGAAATCGAAGGCAAGAGCTTCGAC
TGGATCAAGCTGCGCGACAACGTGCTGGCAGATGTCGACCGGCTCGAGGACGCCTATACCGACACGCTCGAAAGCCACGA
TGTCGCAATCTTCAAGGAACGCGCCGAGATCACCGGCGACCATGAGATTACGCTCGCCAGCGGTAAGACGGTCACCGCCA
AATACATCCTGATCGCCACCGGCGCGCGTCCGCGCCTGCCGGAATGCGCAGGGGTCGAGCACGGCATCACGTCCAACGAG
GCCTTCCATCTCGACGAGCTGCCCAAGAAGGTGATCATCGCCGGCGGCGGCTATATCGCCAACGAATTCGCCGGCATCTT
CAACGAATTCGGCAGCAAGGTCTGTATCGTCAATCGCGGCGACCAGTTGCTGCGCGGCTATGACGAAGCACTGCGCGATC
GCCTGCTCCAAATCTCGGTGATGAAAGGCATTGATTTCGAGTTCAACACCGTCTTCGAATACATCAAGCCATGCGAGGAC
GGCGGCTATTTCGTGAAGCTGAAGAACAATGACGAAGAGCGCGTCGATCTCGTCATGTTCGCGATCGGCCGCGTGCCGAA
CACCGAGAAGCTGGGCCTCGACACCGTGGGTGTGGCGCTCGGCGACAATGGCGAAATCAAGGTCGACGAATTCAGCAAGA
CCAGCGTCAATTACATCTATGCCGTCGGTGACGTGACCGACCGCGTTCAGCTGACTCCGGTGGCGATCCGCGAGGGGCAG
GCCTTTGCCGACAGCGTCTTCGGACCGAACGATCCCTATGCCGTCGATCACAGCTGCATTGCGAGCGCGGTGTTCAGCCA
CCCGCCCATCGCCGCCGTCGGCATGACCGAAGGGGAGGCGAAGAACAAGCTGGGCTCGGTGCGCGTCTACCAGTCGGACT
TCCGCCCGATGAAGAACGTGCTCGCCCAGCGCAACGAACGCAGCCTCTTCAAAATGGTCTGCGAAGGCGACAATGATCGC
ATCGTCGGCATCCACATGATCGCGCCCGACGCGCCCGAGATGATGCAGGCTGCGGCCATTGCGGTGAAGGCCGGGCTGAC
CAAGGCCGATTTCGATGCGACGACCGCGATCCACCCGACCATGGCCGAAGAGCTGGTGCTGATGAAGTAG

Upstream 100 bases:

>100_bases
TGCGGCGCAAGCGGATCGGCGGCGGCGGACAGCGGCGCGGCTGACGGTTGGCAAGAGACATCGGCCACGCCATATCGCTC
GCCAATCAGGAGACGAATGC

Downstream 100 bases:

>100_bases
TGCGTGACACCCTCATCGAGGTTCCGCTAGCTGCCGAAGAAGCAAGCTACACCATCCTTCTCCAACTGGGAGACGGATGC
GCAGGCTTCGCACGCCGTGC

Product: pyruvate/2-oxoglutarate dehydrogenase complex

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MAEYDYDLFTIGGGSGGVRASRVAAAHGARVAIAEEHRIGGTCVIRGCVPKKMLVYGAHFAEDLEDCQKFGWEIEGKSFD
WIKLRDNVLADVDRLEDAYTDTLESHDVAIFKERAEITGDHEITLASGKTVTAKYILIATGARPRLPECAGVEHGITSNE
AFHLDELPKKVIIAGGGYIANEFAGIFNEFGSKVCIVNRGDQLLRGYDEALRDRLLQISVMKGIDFEFNTVFEYIKPCED
GGYFVKLKNNDEERVDLVMFAIGRVPNTEKLGLDTVGVALGDNGEIKVDEFSKTSVNYIYAVGDVTDRVQLTPVAIREGQ
AFADSVFGPNDPYAVDHSCIASAVFSHPPIAAVGMTEGEAKNKLGSVRVYQSDFRPMKNVLAQRNERSLFKMVCEGDNDR
IVGIHMIAPDAPEMMQAAAIAVKAGLTKADFDATTAIHPTMAEELVLMK

Sequences:

>Translated_449_residues
MAEYDYDLFTIGGGSGGVRASRVAAAHGARVAIAEEHRIGGTCVIRGCVPKKMLVYGAHFAEDLEDCQKFGWEIEGKSFD
WIKLRDNVLADVDRLEDAYTDTLESHDVAIFKERAEITGDHEITLASGKTVTAKYILIATGARPRLPECAGVEHGITSNE
AFHLDELPKKVIIAGGGYIANEFAGIFNEFGSKVCIVNRGDQLLRGYDEALRDRLLQISVMKGIDFEFNTVFEYIKPCED
GGYFVKLKNNDEERVDLVMFAIGRVPNTEKLGLDTVGVALGDNGEIKVDEFSKTSVNYIYAVGDVTDRVQLTPVAIREGQ
AFADSVFGPNDPYAVDHSCIASAVFSHPPIAAVGMTEGEAKNKLGSVRVYQSDFRPMKNVLAQRNERSLFKMVCEGDNDR
IVGIHMIAPDAPEMMQAAAIAVKAGLTKADFDATTAIHPTMAEELVLMK
>Mature_448_residues
AEYDYDLFTIGGGSGGVRASRVAAAHGARVAIAEEHRIGGTCVIRGCVPKKMLVYGAHFAEDLEDCQKFGWEIEGKSFDW
IKLRDNVLADVDRLEDAYTDTLESHDVAIFKERAEITGDHEITLASGKTVTAKYILIATGARPRLPECAGVEHGITSNEA
FHLDELPKKVIIAGGGYIANEFAGIFNEFGSKVCIVNRGDQLLRGYDEALRDRLLQISVMKGIDFEFNTVFEYIKPCEDG
GYFVKLKNNDEERVDLVMFAIGRVPNTEKLGLDTVGVALGDNGEIKVDEFSKTSVNYIYAVGDVTDRVQLTPVAIREGQA
FADSVFGPNDPYAVDHSCIASAVFSHPPIAAVGMTEGEAKNKLGSVRVYQSDFRPMKNVLAQRNERSLFKMVCEGDNDRI
VGIHMIAPDAPEMMQAAAIAVKAGLTKADFDATTAIHPTMAEELVLMK

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=462, Percent_Identity=41.5584415584416, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI148277071, Length=469, Percent_Identity=34.3283582089552, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI148277065, Length=469, Percent_Identity=34.3283582089552, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI33519430, Length=469, Percent_Identity=34.3283582089552, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI33519428, Length=469, Percent_Identity=34.3283582089552, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI33519426, Length=469, Percent_Identity=34.3283582089552, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI22035672, Length=474, Percent_Identity=32.7004219409283, Blast_Score=215, Evalue=8e-56,
Organism=Homo sapiens, GI291045266, Length=469, Percent_Identity=33.0490405117271, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI291045268, Length=467, Percent_Identity=31.6916488222698, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI91199540, Length=454, Percent_Identity=27.7533039647577, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1789915, Length=429, Percent_Identity=37.7622377622378, Blast_Score=294, Evalue=8e-81,
Organism=Escherichia coli, GI87082354, Length=454, Percent_Identity=28.1938325991189, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1786307, Length=454, Percent_Identity=26.431718061674, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87081717, Length=449, Percent_Identity=26.9487750556793, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71983419, Length=432, Percent_Identity=36.8055555555556, Blast_Score=262, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI71983429, Length=432, Percent_Identity=36.8055555555556, Blast_Score=262, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17557007, Length=468, Percent_Identity=34.4017094017094, Blast_Score=240, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI71982272, Length=485, Percent_Identity=32.5773195876289, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=27.3318872017354, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6325166, Length=465, Percent_Identity=35.9139784946237, Blast_Score=270, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6325240, Length=483, Percent_Identity=27.3291925465839, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6321091, Length=464, Percent_Identity=25.8620689655172, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=33.5456475583864, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=33.5456475583864, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=33.6170212765957, Blast_Score=228, Evalue=9e-60,
Organism=Drosophila melanogaster, GI17737741, Length=474, Percent_Identity=32.2784810126582, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI21358499, Length=461, Percent_Identity=27.114967462039, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49057; Mature: 48926

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEYDYDLFTIGGGSGGVRASRVAAAHGARVAIAEEHRIGGTCVIRGCVPKKMLVYGAHF
CCCCCEEEEEEECCCCCCCHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCHHHEECHHH
AEDLEDCQKFGWEIEGKSFDWIKLRDNVLADVDRLEDAYTDTLESHDVAIFKERAEITGD
HHHHHHHHHCCCEECCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCC
HEITLASGKTVTAKYILIATGARPRLPECAGVEHGITSNEAFHLDELPKKVIIAGGGYIA
CEEEEECCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHCCCEEEEECCCCHH
NEFAGIFNEFGSKVCIVNRGDQLLRGYDEALRDRLLQISVMKGIDFEFNTVFEYIKPCED
HHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHCCCCC
GGYFVKLKNNDEERVDLVMFAIGRVPNTEKLGLDTVGVALGDNGEIKVDEFSKTSVNYIY
CCEEEEECCCCHHHHEEEEEECCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCEEEEE
AVGDVTDRVQLTPVAIREGQAFADSVFGPNDPYAVDHSCIASAVFSHPPIAAVGMTEGEA
EECCCCCCEEEEEEEEECCCHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCHH
KNKLGSVRVYQSDFRPMKNVLAQRNERSLFKMVCEGDNDRIVGIHMIAPDAPEMMQAAAI
HHCCCCEEEEHHHHHHHHHHHHCCCCHHHHHHEECCCCCEEEEEEEECCCCHHHHHHHHH
AVKAGLTKADFDATTAIHPTMAEELVLMK
HHHCCCCCCCCCCCEEECCHHHHHHEECC
>Mature Secondary Structure 
AEYDYDLFTIGGGSGGVRASRVAAAHGARVAIAEEHRIGGTCVIRGCVPKKMLVYGAHF
CCCCEEEEEEECCCCCCCHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCHHHEECHHH
AEDLEDCQKFGWEIEGKSFDWIKLRDNVLADVDRLEDAYTDTLESHDVAIFKERAEITGD
HHHHHHHHHCCCEECCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCC
HEITLASGKTVTAKYILIATGARPRLPECAGVEHGITSNEAFHLDELPKKVIIAGGGYIA
CEEEEECCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHCCCEEEEECCCCHH
NEFAGIFNEFGSKVCIVNRGDQLLRGYDEALRDRLLQISVMKGIDFEFNTVFEYIKPCED
HHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHCCCCC
GGYFVKLKNNDEERVDLVMFAIGRVPNTEKLGLDTVGVALGDNGEIKVDEFSKTSVNYIY
CCEEEEECCCCHHHHEEEEEECCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCEEEEE
AVGDVTDRVQLTPVAIREGQAFADSVFGPNDPYAVDHSCIASAVFSHPPIAAVGMTEGEA
EECCCCCCEEEEEEEEECCCHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCHH
KNKLGSVRVYQSDFRPMKNVLAQRNERSLFKMVCEGDNDRIVGIHMIAPDAPEMMQAAAI
HHCCCCEEEEHHHHHHHHHHHHCCCCHHHHHHEECCCCCEEEEEEEECCCCHHHHHHHHH
AVKAGLTKADFDATTAIHPTMAEELVLMK
HHHCCCCCCCCCCCEEECCHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]