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The map label for this gene is acsA [H]

Identifier: 85373759

GI number: 85373759

Start: 962638

End: 964578

Strand: Reverse

Name: acsA [H]

Synonym: ELI_04660

Alternate gene names: 85373759

Gene position: 964578-962638 (Counterclockwise)

Preceding gene: 85373760

Following gene: 85373754

Centisome position: 31.6

GC content: 62.6

Gene sequence:

>1941_bases
ATGAGCGATCAATCCGAGTGGGTACAGCGGCCAGCGAGCGCGCTGAAGGGCACCAATTGCACGGCCGAGCAATATGAGAA
AATGTATGCCAGCAGCCTGCAGGACAGTGATGCCTTCTGGGCCAAGCAGGCCGAGCGGATCGACTGGTTCCAGAAGCCGT
CGAAGATTGCCAACTGGAGCTTCGACCCCGTCGATATCAAGTGGTTCGAAGACGGCACGCTCAACATTTGCCACAACGCC
GTCGATAGGCATGTCGAGGCCGGCAATGGGGATCGGACAGCGATCATCTTCGAGCCAGACTCGCCCGATGGCGAAGTGCG
CACGTTCAGCTACGCGGATGTCCAGCGCGAAGTCATCCGCATGGCCAACACGCTCAAGAAACTCGGCGTCGCCAAGGGCG
ATCGCGTCACGATCTACATGCCGATGGTGCCCGAAGGCGCCTTCGCGATGCTTGCCTGCGCGCGGATCGGGGCGATCCAC
TCGGTGATCTTCGGTGGCTTCTCTCCCGATGCCATCGCCGGACGGGTGGACGACTGCGAGAGCGACTGGATCGTCACTGC
CGACGAGGGCCTGCGCGGGTCGAAGACTATCCCGCTCAAGGCCAATGTCGATTCGGCGCTGGAAAAAGTCTCCGCCAAGG
GCGTGCTGGTGCTGCGTCATACCGGCGGCGACGTGTCGATGACCGATGGCCGCGACCATTGGTATCACGAGCTGTCCGCA
GAGGTGTCCGATGAATGCCTGTGCGAGCCGATGAACGCCGAGGATCCGCTCTTCATCCTCTATACCTCAGGCTCGACCGG
CAAACCCAAGGGCGTGCTGCACACCACCGGGGGCTATGCCGTCTGGACCGAGACCACCTTCCGCTACATCTTCGACTACC
GCGACGGCGAGGTGTTCTGGTGCACCGCCGATATCGGCTGGGTCACCGGGCACAGTTATATCGTTTACGGCCCCCTGCAG
AACGGCGCGACTGCGCTGATGTTCGAAGGCGTGCCGAACTACCCCGATCACGACCGCTTCTGGCAGGTTTGCGCCAAGCA
CAAGGTCAATATCTTCTACACCGCCCCGACCGCGATCCGCGCGCTGATGCGCGAAGGCGACCATCACGTCGAGAAGCACG
ACCTCTCATCATTGCGCCTGCTCGGCAGCGTCGGCGAACCAATCAATCCCGAGGCCTGGCGCTGGTATCACGAGACCGTC
GGCAAAGAGAGAATTCCCATCATCGATACGTGGTGGCAGACCGAAACCGGCGGCTGCATGATCACCACCCTGCCCGCCGC
GCACGATATGAAGCCGGGAAGCGCAGGCAAGCCATTCTTCGGCGTCCAGCCGCAACTGGTCGACAACGAAGGTGCTGAGC
TGGAGGGCGCGGCCAGCGGGAACCTGTGCATCACGCATAGCTGGCCCGGCCAGGCGCGCACGGTCTATGGCGATCACGAG
CGCTTCATCCAGACCTATTTCAGCACCTACCCGGGCAAGTACTTCACCGGCGACGGCTGCCGACGCGACGAGGACGGCTA
TTATTGGATCACCGGCCGCGTCGACGATGTTATCAACGTCTCCGGCCACCGCATGGGCACCGCCGAAGTCGAAAGCGCGC
TTGTGCTGCATCCGAAGGTCAGCGAAGCGGCGGTCGTCGGCTTCCCGCACGATATCAAGGGCCAGGGCATCTATTGCTAC
GTCACCCTGATGGACGGAGTCGAGGAAAGCGACGAGCTGAGCGCCGAACTGCGCCAGTGGGTGCGCAAGGAAATCGGCCC
GATCGCGACGCCAGACCACTTGCATTTCACGCCCGCCCTGCCCAAGACCCGCAGCGGCAAGATCATGCGCCGCATCCTGC
GCAAGATCGGCGAGAACGAATTCGGATCGCTCGGCGACACTTCGACGCTGGCGGATCCGGGTGTCGTCGATGCGCTGATC
GAGGGGCGGAAGAACCGGTAG

Upstream 100 bases:

>100_bases
CTTGAAAAGCGCGAACCCAACTTCACTGGTGGCTAGCTGGTATCAGCAAGCCGTTTCGACACTCTGACACCAAGCATCAG
GCACCGCGCCGGGAGACACA

Downstream 100 bases:

>100_bases
CCAATTGAAAGGAGACCCGTTCGCTCTGAGCCTGTCGAAGGGCAGCCACAGCGTTGCAACTGCGGTTGGCCTGTGGCCAG
CTCCGCTACCGACAGGCTCA

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 646; Mature: 645

Protein sequence:

>646_residues
MSDQSEWVQRPASALKGTNCTAEQYEKMYASSLQDSDAFWAKQAERIDWFQKPSKIANWSFDPVDIKWFEDGTLNICHNA
VDRHVEAGNGDRTAIIFEPDSPDGEVRTFSYADVQREVIRMANTLKKLGVAKGDRVTIYMPMVPEGAFAMLACARIGAIH
SVIFGGFSPDAIAGRVDDCESDWIVTADEGLRGSKTIPLKANVDSALEKVSAKGVLVLRHTGGDVSMTDGRDHWYHELSA
EVSDECLCEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYAVWTETTFRYIFDYRDGEVFWCTADIGWVTGHSYIVYGPLQ
NGATALMFEGVPNYPDHDRFWQVCAKHKVNIFYTAPTAIRALMREGDHHVEKHDLSSLRLLGSVGEPINPEAWRWYHETV
GKERIPIIDTWWQTETGGCMITTLPAAHDMKPGSAGKPFFGVQPQLVDNEGAELEGAASGNLCITHSWPGQARTVYGDHE
RFIQTYFSTYPGKYFTGDGCRRDEDGYYWITGRVDDVINVSGHRMGTAEVESALVLHPKVSEAAVVGFPHDIKGQGIYCY
VTLMDGVEESDELSAELRQWVRKEIGPIATPDHLHFTPALPKTRSGKIMRRILRKIGENEFGSLGDTSTLADPGVVDALI
EGRKNR

Sequences:

>Translated_646_residues
MSDQSEWVQRPASALKGTNCTAEQYEKMYASSLQDSDAFWAKQAERIDWFQKPSKIANWSFDPVDIKWFEDGTLNICHNA
VDRHVEAGNGDRTAIIFEPDSPDGEVRTFSYADVQREVIRMANTLKKLGVAKGDRVTIYMPMVPEGAFAMLACARIGAIH
SVIFGGFSPDAIAGRVDDCESDWIVTADEGLRGSKTIPLKANVDSALEKVSAKGVLVLRHTGGDVSMTDGRDHWYHELSA
EVSDECLCEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYAVWTETTFRYIFDYRDGEVFWCTADIGWVTGHSYIVYGPLQ
NGATALMFEGVPNYPDHDRFWQVCAKHKVNIFYTAPTAIRALMREGDHHVEKHDLSSLRLLGSVGEPINPEAWRWYHETV
GKERIPIIDTWWQTETGGCMITTLPAAHDMKPGSAGKPFFGVQPQLVDNEGAELEGAASGNLCITHSWPGQARTVYGDHE
RFIQTYFSTYPGKYFTGDGCRRDEDGYYWITGRVDDVINVSGHRMGTAEVESALVLHPKVSEAAVVGFPHDIKGQGIYCY
VTLMDGVEESDELSAELRQWVRKEIGPIATPDHLHFTPALPKTRSGKIMRRILRKIGENEFGSLGDTSTLADPGVVDALI
EGRKNR
>Mature_645_residues
SDQSEWVQRPASALKGTNCTAEQYEKMYASSLQDSDAFWAKQAERIDWFQKPSKIANWSFDPVDIKWFEDGTLNICHNAV
DRHVEAGNGDRTAIIFEPDSPDGEVRTFSYADVQREVIRMANTLKKLGVAKGDRVTIYMPMVPEGAFAMLACARIGAIHS
VIFGGFSPDAIAGRVDDCESDWIVTADEGLRGSKTIPLKANVDSALEKVSAKGVLVLRHTGGDVSMTDGRDHWYHELSAE
VSDECLCEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYAVWTETTFRYIFDYRDGEVFWCTADIGWVTGHSYIVYGPLQN
GATALMFEGVPNYPDHDRFWQVCAKHKVNIFYTAPTAIRALMREGDHHVEKHDLSSLRLLGSVGEPINPEAWRWYHETVG
KERIPIIDTWWQTETGGCMITTLPAAHDMKPGSAGKPFFGVQPQLVDNEGAELEGAASGNLCITHSWPGQARTVYGDHER
FIQTYFSTYPGKYFTGDGCRRDEDGYYWITGRVDDVINVSGHRMGTAEVESALVLHPKVSEAAVVGFPHDIKGQGIYCYV
TLMDGVEESDELSAELRQWVRKEIGPIATPDHLHFTPALPKTRSGKIMRRILRKIGENEFGSLGDTSTLADPGVVDALIE
GRKNR

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=670, Percent_Identity=51.3432835820895, Blast_Score=675, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=683, Percent_Identity=50.3660322108346, Blast_Score=671, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=621, Percent_Identity=47.8260869565217, Blast_Score=602, Evalue=1e-172,
Organism=Homo sapiens, GI13375727, Length=628, Percent_Identity=38.375796178344, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI38505220, Length=553, Percent_Identity=29.6564195298373, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI42544132, Length=522, Percent_Identity=29.6934865900383, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI122937307, Length=515, Percent_Identity=28.1553398058252, Blast_Score=193, Evalue=5e-49,
Organism=Homo sapiens, GI115511026, Length=524, Percent_Identity=28.4351145038168, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI31982927, Length=627, Percent_Identity=23.1259968102073, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI58082049, Length=516, Percent_Identity=25.7751937984496, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI157311624, Length=517, Percent_Identity=25.9187620889749, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI157311622, Length=517, Percent_Identity=25.9187620889749, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI42544134, Length=342, Percent_Identity=26.6081871345029, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI187761345, Length=389, Percent_Identity=28.7917737789203, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI187761343, Length=389, Percent_Identity=28.7917737789203, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI195947378, Length=439, Percent_Identity=25.5125284738041, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI156151445, Length=559, Percent_Identity=21.4669051878354, Blast_Score=83, Evalue=9e-16,
Organism=Escherichia coli, GI1790505, Length=639, Percent_Identity=64.0062597809077, Blast_Score=846, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=628, Percent_Identity=38.8535031847134, Blast_Score=415, Evalue=1e-117,
Organism=Escherichia coli, GI221142682, Length=537, Percent_Identity=24.7672253258845, Blast_Score=138, Evalue=1e-33,
Organism=Escherichia coli, GI145693145, Length=534, Percent_Identity=23.0337078651685, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1788107, Length=563, Percent_Identity=24.866785079929, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1786810, Length=519, Percent_Identity=20.2312138728324, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71983001, Length=657, Percent_Identity=47.79299847793, Blast_Score=612, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI71982997, Length=657, Percent_Identity=47.79299847793, Blast_Score=611, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI17569507, Length=599, Percent_Identity=21.3689482470785, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17558820, Length=514, Percent_Identity=23.7354085603113, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71985884, Length=577, Percent_Identity=23.2235701906412, Blast_Score=103, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI32563687, Length=529, Percent_Identity=23.062381852552, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17557194, Length=563, Percent_Identity=23.6234458259325, Blast_Score=99, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17538037, Length=546, Percent_Identity=23.2600732600733, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17559526, Length=554, Percent_Identity=22.7436823104693, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17560140, Length=525, Percent_Identity=20.3809523809524, Blast_Score=82, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6323182, Length=648, Percent_Identity=46.9135802469136, Blast_Score=594, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6319264, Length=643, Percent_Identity=46.1897356143079, Blast_Score=564, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6319699, Length=367, Percent_Identity=25.0681198910082, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24667955, Length=665, Percent_Identity=51.1278195488722, Blast_Score=693, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=54.9822064056939, Blast_Score=635, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=55.5769230769231, Blast_Score=598, Evalue=1e-171,
Organism=Drosophila melanogaster, GI21355225, Length=614, Percent_Identity=36.4820846905537, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI21355181, Length=538, Percent_Identity=24.5353159851301, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI18859661, Length=528, Percent_Identity=24.0530303030303, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19922652, Length=510, Percent_Identity=23.921568627451, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24581924, Length=526, Percent_Identity=21.6730038022814, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24656500, Length=375, Percent_Identity=24.2666666666667, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24648260, Length=361, Percent_Identity=23.8227146814404, Blast_Score=76, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71778; Mature: 71647

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQSEWVQRPASALKGTNCTAEQYEKMYASSLQDSDAFWAKQAERIDWFQKPSKIANWS
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHCCCC
FDPVDIKWFEDGTLNICHNAVDRHVEAGNGDRTAIIFEPDSPDGEVRTFSYADVQREVIR
CCCEEEEEECCCCHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCEEEEEHHHHHHHHHH
MANTLKKLGVAKGDRVTIYMPMVPEGAFAMLACARIGAIHSVIFGGFSPDAIAGRVDDCE
HHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCC
SDWIVTADEGLRGSKTIPLKANVDSALEKVSAKGVLVLRHTGGDVSMTDGRDHWYHELSA
CCEEEECCCCCCCCCEEEEECCHHHHHHHHCCCCEEEEEECCCCEEECCCCHHHHHHHHH
EVSDECLCEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYAVWTETTFRYIFDYRDGEVFW
HCCHHHHCCCCCCCCCEEEEEECCCCCCCCCEEECCCCEEEEECCEEEEEEEECCCEEEE
CTADIGWVTGHSYIVYGPLQNGATALMFEGVPNYPDHDRFWQVCAKHKVNIFYTAPTAIR
EECCCCEEECCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECHHHHH
ALMREGDHHVEKHDLSSLRLLGSVGEPINPEAWRWYHETVGKERIPIIDTWWQTETGGCM
HHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCEE
ITTLPAAHDMKPGSAGKPFFGVQPQLVDNEGAELEGAASGNLCITHSWPGQARTVYGDHE
EEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCEECCCCCCEEEEECCCCCCEEEECCHH
RFIQTYFSTYPGKYFTGDGCRRDEDGYYWITGRVDDVINVSGHRMGTAEVESALVLHPKV
HHHHHHHHHCCCCEECCCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHCCEEEECCCC
SEAAVVGFPHDIKGQGIYCYVTLMDGVEESDELSAELRQWVRKEIGPIATPDHLHFTPAL
CCEEEECCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCC
PKTRSGKIMRRILRKIGENEFGSLGDTSTLADPGVVDALIEGRKNR
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
>Mature Secondary Structure 
SDQSEWVQRPASALKGTNCTAEQYEKMYASSLQDSDAFWAKQAERIDWFQKPSKIANWS
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHCCCC
FDPVDIKWFEDGTLNICHNAVDRHVEAGNGDRTAIIFEPDSPDGEVRTFSYADVQREVIR
CCCEEEEEECCCCHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCEEEEEHHHHHHHHHH
MANTLKKLGVAKGDRVTIYMPMVPEGAFAMLACARIGAIHSVIFGGFSPDAIAGRVDDCE
HHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCC
SDWIVTADEGLRGSKTIPLKANVDSALEKVSAKGVLVLRHTGGDVSMTDGRDHWYHELSA
CCEEEECCCCCCCCCEEEEECCHHHHHHHHCCCCEEEEEECCCCEEECCCCHHHHHHHHH
EVSDECLCEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYAVWTETTFRYIFDYRDGEVFW
HCCHHHHCCCCCCCCCEEEEEECCCCCCCCCEEECCCCEEEEECCEEEEEEEECCCEEEE
CTADIGWVTGHSYIVYGPLQNGATALMFEGVPNYPDHDRFWQVCAKHKVNIFYTAPTAIR
EECCCCEEECCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECHHHHH
ALMREGDHHVEKHDLSSLRLLGSVGEPINPEAWRWYHETVGKERIPIIDTWWQTETGGCM
HHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCEE
ITTLPAAHDMKPGSAGKPFFGVQPQLVDNEGAELEGAASGNLCITHSWPGQARTVYGDHE
EEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCEECCCCCCEEEEECCCCCCEEEECCHH
RFIQTYFSTYPGKYFTGDGCRRDEDGYYWITGRVDDVINVSGHRMGTAEVESALVLHPKV
HHHHHHHHHCCCCEECCCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHCCEEEECCCC
SEAAVVGFPHDIKGQGIYCYVTLMDGVEESDELSAELRQWVRKEIGPIATPDHLHFTPAL
CCEEEECCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCC
PKTRSGKIMRRILRKIGENEFGSLGDTSTLADPGVVDALIEGRKNR
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA