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The map label for this gene is yqhE [C]

Identifier: 85373571

GI number: 85373571

Start: 770428

End: 771384

Strand: Direct

Name: yqhE [C]

Synonym: ELI_03720

Alternate gene names: 85373571

Gene position: 770428-771384 (Clockwise)

Preceding gene: 85373570

Following gene: 85373572

Centisome position: 25.24

GC content: 63.32

Gene sequence:

>957_bases
GTGATCGAGACGATACCGCAAGTGGGGTTCGGCCTCTGGAAAGTGCCGGGCGAAGATTGCGAAAGGGTCGTGCTCGAGGC
TATCCGCGCGGGCTATCGCCATTTCGATTGCGCTGCCGACTACGGCAATGAACAGGCCGTCGGCGCAGCTTTTGCCAAGG
CGTTCGCTGACGGGCTGGTGCGGCGCGAAGACCTGTGGATCACCAGCAAGCTCTGGAACACGTTCCATGCCCCCGAGCAT
GTCGAGTTGGCCTGCCGCAAGTCGCTGTCGGACCTGCAGTGCGACTATCTCGACCTCTACCTGGTGCATTTCCCGATCGC
GCTCGCTTTCGTGCCGATCGAAACGCGCTATCCGCCCGAATGGCTGCACGATCCCGATGCTGCCGAGCCGCGGATGAAGC
CGGCCAGGGTGCCGCTGCATAGGACGTGGGCGGCGATGGAGGACCTGCGGCATGCCGGGCTGACGCGGCAGATCGGTGTC
TGCAACTACAACACGGGCTTGCTGCACGACCTGATGCGCTATGCCGAGATCGCGCCGTCGGTGCTGCAGATCGAAGCGCA
TCCCTATCTGACGCAGGAAAAGCTGGTGCGGTTGGCCGGTGACTACGGGCTGCATGTGACCGCTTTCTCGCCGCTTGGCG
CGTTGTCCTATGTCGAGCTGGACATGGCCGGGGCAGGCGACAGCGTGCTGACCGAGCCGGTCGTGACAGCGGCGGCGCAG
GCGCATGGCAAGACACCGGCCCAAGTGGTTTTGCGCTGGGCTATCCAGCGCGGCACGTCGATCATTCCCAAGACCACCAA
GCCAGAACGCATGCGCGAAAATCTCGCCATCGAGGACTTTGCGCTGAGCGAGGAGGAGATGGCGGCGATCAGCGCGCTCG
ACGCCGATCGCCGGTTCAACGATCCCGGCGTTTTCACCGAGGCCGCCTTCAACACTTTCCATCCGATTTACGATTGA

Upstream 100 bases:

>100_bases
CAACCGACGGTGTGCGCTCGGTAGAGATGGGGGCAGCGGCACAGCAAAGCATCGCGACGGGCCAGCCTGTCGCACTCGAT
TTCTCGAAGGGAGCAGCAGC

Downstream 100 bases:

>100_bases
GGCCGCGATGAGCAGCGAGGCGAACGAATTTCCGGGCATCATCGAAGGGCAGGGCGATCTGGCCGGCTTCCTGAGCGCCA
ACAAGGCCGCTGTGGATGAG

Product: aldehyde reductase

Products: aldose; NADH; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MIETIPQVGFGLWKVPGEDCERVVLEAIRAGYRHFDCAADYGNEQAVGAAFAKAFADGLVRREDLWITSKLWNTFHAPEH
VELACRKSLSDLQCDYLDLYLVHFPIALAFVPIETRYPPEWLHDPDAAEPRMKPARVPLHRTWAAMEDLRHAGLTRQIGV
CNYNTGLLHDLMRYAEIAPSVLQIEAHPYLTQEKLVRLAGDYGLHVTAFSPLGALSYVELDMAGAGDSVLTEPVVTAAAQ
AHGKTPAQVVLRWAIQRGTSIIPKTTKPERMRENLAIEDFALSEEEMAAISALDADRRFNDPGVFTEAAFNTFHPIYD

Sequences:

>Translated_318_residues
MIETIPQVGFGLWKVPGEDCERVVLEAIRAGYRHFDCAADYGNEQAVGAAFAKAFADGLVRREDLWITSKLWNTFHAPEH
VELACRKSLSDLQCDYLDLYLVHFPIALAFVPIETRYPPEWLHDPDAAEPRMKPARVPLHRTWAAMEDLRHAGLTRQIGV
CNYNTGLLHDLMRYAEIAPSVLQIEAHPYLTQEKLVRLAGDYGLHVTAFSPLGALSYVELDMAGAGDSVLTEPVVTAAAQ
AHGKTPAQVVLRWAIQRGTSIIPKTTKPERMRENLAIEDFALSEEEMAAISALDADRRFNDPGVFTEAAFNTFHPIYD
>Mature_318_residues
MIETIPQVGFGLWKVPGEDCERVVLEAIRAGYRHFDCAADYGNEQAVGAAFAKAFADGLVRREDLWITSKLWNTFHAPEH
VELACRKSLSDLQCDYLDLYLVHFPIALAFVPIETRYPPEWLHDPDAAEPRMKPARVPLHRTWAAMEDLRHAGLTRQIGV
CNYNTGLLHDLMRYAEIAPSVLQIEAHPYLTQEKLVRLAGDYGLHVTAFSPLGALSYVELDMAGAGDSVLTEPVVTAAAQ
AHGKTPAQVVLRWAIQRGTSIIPKTTKPERMRENLAIEDFALSEEEMAAISALDADRRFNDPGVFTEAAFNTFHPIYD

Specific function: Reduction [C]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI24497577, Length=319, Percent_Identity=39.1849529780564, Blast_Score=222, Evalue=3e-58,
Organism=Homo sapiens, GI5174391, Length=319, Percent_Identity=39.1849529780564, Blast_Score=222, Evalue=3e-58,
Organism=Homo sapiens, GI93277124, Length=313, Percent_Identity=38.9776357827476, Blast_Score=214, Evalue=6e-56,
Organism=Homo sapiens, GI310109920, Length=307, Percent_Identity=37.4592833876222, Blast_Score=195, Evalue=4e-50,
Organism=Homo sapiens, GI5174695, Length=306, Percent_Identity=37.5816993464052, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI45446745, Length=307, Percent_Identity=37.4592833876222, Blast_Score=194, Evalue=7e-50,
Organism=Homo sapiens, GI4503285, Length=307, Percent_Identity=37.4592833876222, Blast_Score=194, Evalue=7e-50,
Organism=Homo sapiens, GI223468663, Length=297, Percent_Identity=38.7205387205387, Blast_Score=194, Evalue=9e-50,
Organism=Homo sapiens, GI24497585, Length=300, Percent_Identity=37.3333333333333, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI5453543, Length=307, Percent_Identity=36.8078175895765, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI24497583, Length=319, Percent_Identity=36.9905956112853, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI4502049, Length=297, Percent_Identity=40.0673400673401, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI310109922, Length=307, Percent_Identity=35.1791530944625, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI291291012, Length=283, Percent_Identity=37.8091872791519, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI300116273, Length=285, Percent_Identity=35.7894736842105, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI300116271, Length=300, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI310109926, Length=107, Percent_Identity=46.7289719626168, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI310109924, Length=163, Percent_Identity=34.9693251533742, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI207028673, Length=107, Percent_Identity=46.7289719626168, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI87082198, Length=303, Percent_Identity=33.6633663366337, Blast_Score=176, Evalue=1e-45,
Organism=Escherichia coli, GI1786400, Length=301, Percent_Identity=31.2292358803987, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17537075, Length=302, Percent_Identity=39.0728476821192, Blast_Score=207, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17537077, Length=301, Percent_Identity=38.8704318936877, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI17566692, Length=310, Percent_Identity=34.1935483870968, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17537079, Length=302, Percent_Identity=32.7814569536424, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17564128, Length=304, Percent_Identity=34.2105263157895, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17550248, Length=303, Percent_Identity=31.6831683168317, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17552492, Length=296, Percent_Identity=28.7162162162162, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17561298, Length=300, Percent_Identity=30.6666666666667, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17561300, Length=296, Percent_Identity=30.4054054054054, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI71998625, Length=294, Percent_Identity=28.9115646258503, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17538386, Length=296, Percent_Identity=28.7162162162162, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17562292, Length=301, Percent_Identity=27.906976744186, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17550246, Length=80, Percent_Identity=40, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321896, Length=314, Percent_Identity=45.859872611465, Blast_Score=292, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6324694, Length=303, Percent_Identity=33.6633663366337, Blast_Score=172, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6320576, Length=300, Percent_Identity=34.3333333333333, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6322556, Length=296, Percent_Identity=29.7297297297297, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319625, Length=302, Percent_Identity=29.1390728476821, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320079, Length=276, Percent_Identity=26.4492753623188, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24657054, Length=294, Percent_Identity=41.4965986394558, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24644950, Length=309, Percent_Identity=39.1585760517799, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI221378297, Length=321, Percent_Identity=38.3177570093458, Blast_Score=210, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24662789, Length=298, Percent_Identity=39.9328859060403, Blast_Score=210, Evalue=8e-55,
Organism=Drosophila melanogaster, GI21356425, Length=295, Percent_Identity=38.6440677966102, Blast_Score=204, Evalue=7e-53,
Organism=Drosophila melanogaster, GI45553081, Length=311, Percent_Identity=34.0836012861736, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24663317, Length=294, Percent_Identity=36.0544217687075, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24662785, Length=315, Percent_Identity=37.1428571428571, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24662781, Length=296, Percent_Identity=38.5135135135135, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI281366140, Length=285, Percent_Identity=34.7368421052632, Blast_Score=174, Evalue=5e-44,
Organism=Drosophila melanogaster, GI20129731, Length=294, Percent_Identity=33.3333333333333, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.1.1.21; 1.1.1.-

Molecular weight: Translated: 35498; Mature: 35498

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIETIPQVGFGLWKVPGEDCERVVLEAIRAGYRHFDCAADYGNEQAVGAAFAKAFADGLV
CCCCCCCCCCCEECCCCHHHHHHHHHHHHHCCHHEEHHHCCCCCHHHHHHHHHHHHHHHH
RREDLWITSKLWNTFHAPEHVELACRKSLSDLQCDYLDLYLVHFPIALAFVPIETRYPPE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEECCCCCHH
WLHDPDAAEPRMKPARVPLHRTWAAMEDLRHAGLTRQIGVCNYNTGLLHDLMRYAEIAPS
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCC
VLQIEAHPYLTQEKLVRLAGDYGLHVTAFSPLGALSYVELDMAGAGDSVLTEPVVTAAAQ
EEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHH
AHGKTPAQVVLRWAIQRGTSIIPKTTKPERMRENLAIEDFALSEEEMAAISALDADRRFN
HCCCCHHHHHHHHHHHHCCEECCCCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHHCCCCC
DPGVFTEAAFNTFHPIYD
CCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MIETIPQVGFGLWKVPGEDCERVVLEAIRAGYRHFDCAADYGNEQAVGAAFAKAFADGLV
CCCCCCCCCCCEECCCCHHHHHHHHHHHHHCCHHEEHHHCCCCCHHHHHHHHHHHHHHHH
RREDLWITSKLWNTFHAPEHVELACRKSLSDLQCDYLDLYLVHFPIALAFVPIETRYPPE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEECCCCCHH
WLHDPDAAEPRMKPARVPLHRTWAAMEDLRHAGLTRQIGVCNYNTGLLHDLMRYAEIAPS
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCC
VLQIEAHPYLTQEKLVRLAGDYGLHVTAFSPLGALSYVELDMAGAGDSVLTEPVVTAAAQ
EEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHH
AHGKTPAQVVLRWAIQRGTSIIPKTTKPERMRENLAIEDFALSEEEMAAISALDADRRFN
HCCCCHHHHHHHHHHHHCCEECCCCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHHCCCCC
DPGVFTEAAFNTFHPIYD
CCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alditol; NAD+; NADP+

Specific reaction: alditol + NAD(P)+ = aldose + NAD(P)H + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA