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The map label for this gene is kdpD [H]

Identifier: 85373331

GI number: 85373331

Start: 545108

End: 546643

Strand: Reverse

Name: kdpD [H]

Synonym: ELI_02520

Alternate gene names: 85373331

Gene position: 546643-545108 (Counterclockwise)

Preceding gene: 85373332

Following gene: 85373330

Centisome position: 17.91

GC content: 61.26

Gene sequence:

>1536_bases
GTGGATGCCGAGCGCGCGGAATTTGGCTATCAGCCCACCATGTCTCTCCTTCGCGAAAGCCCGGAACGCAGCAACCTCGC
GGTAAGCCTCGCCATCGACTTCGGGGTGTTCTTCATCGCCGCCCTTGTCACATGGCTGGCGCAATATTTCGACCGGCCGA
TAACCGCCGTTCTGGCGTTTCTCACCGGCGTCATCATGATTGCCGTCCATTCCGGCATGACCCGCGCCGTCATCGGGGCC
GTGGCGGCATCGATCGTCTACAATTTCTTCCTCAGCGAACCGGTCTATCAATTCGGCGTCACCACTGCCGACGAAACCAT
CCCGCTGGTCGCGTTCAATGTCAGCGCTCTCCTCGTCGGATTCGTCGTCGGCAGGCTCAGCGATTATGCCAGTGATGCGC
AGACGGCACGCGCAGAGACGCAGTTCCTGCTCACCCTGAGCGACAAGCTGCAATCCGCCATCAGCTTCGAAGATGTCGAA
CTGGCGATAAACAGGGCTCTGCCGATGCAGGGGCTGGAAAGCGTCAAGGTCTATCTCTCGCGCGGCGATGCCTATGTCCG
GCCGACGACCGGCGAGGTCGAGATGGAATCATTCAGCGCCTTGATCGCCGAAAACACCGATCATCCGCCCGGGTCCCGCG
CCAAGATTCTCGAACTCCTCGGCGCGCGGGGGTCGCTGGGACTGGTCAAATTCCAGCTTGTCCATACCGCCAAGGGGGAA
GATGTCGCCTTGCGCCTGCAGTCGATAACTGCCTTGATTGCGGTCGCCATCGAACGGTGTCTCTTGCTCGACGAACTCGC
CGAAGCGCGCACTGCAGCCCGAAGCGAAGAGCTCAAGGACGCAATACTGGCATCGGTGTCTCACGATCTGCGAACGCCGA
TCACCGTTATCGAAACCGCCGCCAGCGCGCTCAAGTCAAGCGACGTGTCGCTCGATGGAGAACAGCGGCATAAAATGCTG
GTTTCCATTGTCGAGCAATGCCACCGGCTGGACCGCTACACCAACCAATTGCTCGATGTCGGCCGCATCCAGGCGGGAAT
TTCGAAACTTCGCATGGGAACGGTCGACCTCGCCGAAATCGCCCAGCTGGCCATCCGCCACGTTCGCTCTGGCAAGCCCG
AAGTGGTGTTCGAACGCAATTTCCCCCGGGAACGATGTCTGGTTTCCGGAAATGAAGGAATGCTGGAGAACGCCCTGTTC
AACCTGTTCGACAATGCCGCCAAATTCGGCGGTGCCGACGGCCCGGTCACAGTCGAGATCGCTATCGAGGGACGGTACGC
CCGGCTCAGTGTCAGCGATCGCGGGCCGGGCATCCCGGCGCATGAACTGGACACGGTTTTCAAGCGGTTCCACAAGAGCG
GACGCAATACTGCCAATGGCGGCGCCGGGCTCGGCCTCTTCATCGCACGCGGCTTTATCGAAGCAGCCAACGGATCGATC
GCGATCGAATCGCCCGTCGATGGACAGCACGGCACCCGCGCCACCGTACGGCTCGACCTGGCGCGCGAGCCGGAACTGCG
AGAGGCTGCGGCATGA

Upstream 100 bases:

>100_bases
GGCGATCTACGGCCTGATGATGGCGGGCTCGGTCAAACTGGGGGCGTGGCGGGAGTGAAGCGGCCGTCCCGGACCGACCG
GCTGCGAGCATAAAAATCGC

Downstream 100 bases:

>100_bases
ACATCCTCGTTGTGGATGACGAACCTTCGATCCTCGAAGCACTGCGCCCTGTCCTGGCGGCCCGCGGTTACAGCGTACTC
ACCGCGGGGGACGGCAAGGC

Product: sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MDAERAEFGYQPTMSLLRESPERSNLAVSLAIDFGVFFIAALVTWLAQYFDRPITAVLAFLTGVIMIAVHSGMTRAVIGA
VAASIVYNFFLSEPVYQFGVTTADETIPLVAFNVSALLVGFVVGRLSDYASDAQTARAETQFLLTLSDKLQSAISFEDVE
LAINRALPMQGLESVKVYLSRGDAYVRPTTGEVEMESFSALIAENTDHPPGSRAKILELLGARGSLGLVKFQLVHTAKGE
DVALRLQSITALIAVAIERCLLLDELAEARTAARSEELKDAILASVSHDLRTPITVIETAASALKSSDVSLDGEQRHKML
VSIVEQCHRLDRYTNQLLDVGRIQAGISKLRMGTVDLAEIAQLAIRHVRSGKPEVVFERNFPRERCLVSGNEGMLENALF
NLFDNAAKFGGADGPVTVEIAIEGRYARLSVSDRGPGIPAHELDTVFKRFHKSGRNTANGGAGLGLFIARGFIEAANGSI
AIESPVDGQHGTRATVRLDLAREPELREAAA

Sequences:

>Translated_511_residues
MDAERAEFGYQPTMSLLRESPERSNLAVSLAIDFGVFFIAALVTWLAQYFDRPITAVLAFLTGVIMIAVHSGMTRAVIGA
VAASIVYNFFLSEPVYQFGVTTADETIPLVAFNVSALLVGFVVGRLSDYASDAQTARAETQFLLTLSDKLQSAISFEDVE
LAINRALPMQGLESVKVYLSRGDAYVRPTTGEVEMESFSALIAENTDHPPGSRAKILELLGARGSLGLVKFQLVHTAKGE
DVALRLQSITALIAVAIERCLLLDELAEARTAARSEELKDAILASVSHDLRTPITVIETAASALKSSDVSLDGEQRHKML
VSIVEQCHRLDRYTNQLLDVGRIQAGISKLRMGTVDLAEIAQLAIRHVRSGKPEVVFERNFPRERCLVSGNEGMLENALF
NLFDNAAKFGGADGPVTVEIAIEGRYARLSVSDRGPGIPAHELDTVFKRFHKSGRNTANGGAGLGLFIARGFIEAANGSI
AIESPVDGQHGTRATVRLDLAREPELREAAA
>Mature_511_residues
MDAERAEFGYQPTMSLLRESPERSNLAVSLAIDFGVFFIAALVTWLAQYFDRPITAVLAFLTGVIMIAVHSGMTRAVIGA
VAASIVYNFFLSEPVYQFGVTTADETIPLVAFNVSALLVGFVVGRLSDYASDAQTARAETQFLLTLSDKLQSAISFEDVE
LAINRALPMQGLESVKVYLSRGDAYVRPTTGEVEMESFSALIAENTDHPPGSRAKILELLGARGSLGLVKFQLVHTAKGE
DVALRLQSITALIAVAIERCLLLDELAEARTAARSEELKDAILASVSHDLRTPITVIETAASALKSSDVSLDGEQRHKML
VSIVEQCHRLDRYTNQLLDVGRIQAGISKLRMGTVDLAEIAQLAIRHVRSGKPEVVFERNFPRERCLVSGNEGMLENALF
NLFDNAAKFGGADGPVTVEIAIEGRYARLSVSDRGPGIPAHELDTVFKRFHKSGRNTANGGAGLGLFIARGFIEAANGSI
AIESPVDGQHGTRATVRLDLAREPELREAAA

Specific function: Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals [H]

COG id: COG2205

COG function: function code T; Osmosensitive K+ channel histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=473, Percent_Identity=28.3298097251586, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=30.9322033898305, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1788393, Length=243, Percent_Identity=27.1604938271605, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790346, Length=214, Percent_Identity=29.9065420560748, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788713, Length=226, Percent_Identity=27.4336283185841, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI145693157, Length=283, Percent_Identity=25.7950530035336, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=245, Percent_Identity=26.9387755102041, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790436, Length=246, Percent_Identity=26.0162601626016, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082128, Length=213, Percent_Identity=28.169014084507, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI48994928, Length=220, Percent_Identity=27.7272727272727, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR003852
- InterPro:   IPR006016 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF02702 KdpD; PF00582 Usp [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55241; Mature: 55241

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAERAEFGYQPTMSLLRESPERSNLAVSLAIDFGVFFIAALVTWLAQYFDRPITAVLAF
CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LTGVIMIAVHSGMTRAVIGAVAASIVYNFFLSEPVYQFGVTTADETIPLVAFNVSALLVG
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEHHHHHHHHH
FVVGRLSDYASDAQTARAETQFLLTLSDKLQSAISFEDVELAINRALPMQGLESVKVYLS
HHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHC
RGDAYVRPTTGEVEMESFSALIAENTDHPPGSRAKILELLGARGSLGLVKFQLVHTAKGE
CCCEEECCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEEECCCCC
DVALRLQSITALIAVAIERCLLLDELAEARTAARSEELKDAILASVSHDLRTPITVIETA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ASALKSSDVSLDGEQRHKMLVSIVEQCHRLDRYTNQLLDVGRIQAGISKLRMGTVDLAEI
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
AQLAIRHVRSGKPEVVFERNFPRERCLVSGNEGMLENALFNLFDNAAKFGGADGPVTVEI
HHHHHHHHHCCCCCEEEECCCCHHHCEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEE
AIEGRYARLSVSDRGPGIPAHELDTVFKRFHKSGRNTANGGAGLGLFIARGFIEAANGSI
EEECEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCE
AIESPVDGQHGTRATVRLDLAREPELREAAA
EEECCCCCCCCCEEEEEEECCCCCCHHHHCC
>Mature Secondary Structure
MDAERAEFGYQPTMSLLRESPERSNLAVSLAIDFGVFFIAALVTWLAQYFDRPITAVLAF
CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LTGVIMIAVHSGMTRAVIGAVAASIVYNFFLSEPVYQFGVTTADETIPLVAFNVSALLVG
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEHHHHHHHHH
FVVGRLSDYASDAQTARAETQFLLTLSDKLQSAISFEDVELAINRALPMQGLESVKVYLS
HHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHC
RGDAYVRPTTGEVEMESFSALIAENTDHPPGSRAKILELLGARGSLGLVKFQLVHTAKGE
CCCEEECCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEEECCCCC
DVALRLQSITALIAVAIERCLLLDELAEARTAARSEELKDAILASVSHDLRTPITVIETA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ASALKSSDVSLDGEQRHKMLVSIVEQCHRLDRYTNQLLDVGRIQAGISKLRMGTVDLAEI
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
AQLAIRHVRSGKPEVVFERNFPRERCLVSGNEGMLENALFNLFDNAAKFGGADGPVTVEI
HHHHHHHHHCCCCCEEEECCCCHHHCEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEE
AIEGRYARLSVSDRGPGIPAHELDTVFKRFHKSGRNTANGGAGLGLFIARGFIEAANGSI
EEECEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCE
AIESPVDGQHGTRATVRLDLAREPELREAAA
EEECCCCCCCCCEEEEEEECCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1532388; 8905232; 9278503; 7499326 [H]