Click here to switch to the map view.

The map label for this gene is norM [H]

Identifier: 85373332

GI number: 85373332

Start: 546686

End: 548029

Strand: Reverse

Name: norM [H]

Synonym: ELI_02525

Alternate gene names: 85373332

Gene position: 548029-546686 (Counterclockwise)

Preceding gene: 85373333

Following gene: 85373331

Centisome position: 17.95

GC content: 71.35

Gene sequence:

>1344_bases
ATGGATGTTCGGACACGCCTGTTCCTGACCGACCCGCCCGGGCCGCTGCTGGTGCGCATGGCGACACCCAATTCGCTGGC
CTTCATGATCCAGTCCTTCGTCAGCCTCGGCGAAGTATGGATCATCGGCCAGCTCGGCACCGTCTCGCTGGCGGCGATCG
CGCTGTCCTTCCCGCTGCTGATGCTGACTCAGGCCATGGCCGGCGGCGCGGTCGGCGGGGCGGTGACGTCCTCCATCGCC
CGCGCGCTCGGCAGGGGCGACAGCGAGGCGGCGAACCGGCTGATCTGGCACGCGCTGGCGATCTGCGCGGGCGGCTCGGC
GCTGTTCCTGCTGCTGTTCCTGGCCGCGGGCGAGAGCCTGCTGCGCTTCCTCGGCGGCAGCGGCATCATCCTCGGCCAGG
CGGCGAGCTATTGCCTGATCCTGTTCAGCGGCGGGCTGTTCCTGTGGCTGCTCGGCGTGACCGGCGCGGTGTTTCGCGGG
ATGGGCGACATGAAGACGCCCGCCGCGCTGATGGTGCTGGGCGCCTTCGTGCAAGTCCCGCTGACCGCCGTGCTGGTGCT
CGGCCTGCTCGGCGCGCCGCGCCTGGGCATTGCCGGGGCGGCGGTCTCGGCGGTGGCGACCGGCTTCCTCGTCAGCACCG
TCATGCTGTTCCTGCTGACCCGCCCCGGGCGCATCATCCGGCTGGAGCGCGGCGCGCTGGTGTTCGAGCGGCGGCTGTTT
CGCGATATCTTCGCGGTCGCCGCGCCCGCCTCGCTCTCGCCGCTCCTGACCATCCTCATCATCCTCAGCCTGACCGCCAT
GATCGCCCGCTTCGGCGAAGCGGCGCTGGCGGGCTACGGCATCGGCTCGCGGATCGAGTTCCTGCTGATCCCGCTGGTGT
TCGGCATCGGCGCGGCGATGACTTCGCTGGTGGGGCTTGCCATCGGCGCTGGCGACATCGCCCGGGCGGAGCGGATCGGC
TGGACCGGCGGCGCTATGGCCGCGGCGCTGGCGGGCGTGGTCGGCGCGCTGCTGACGCTGTTCCCCGACCGCTTCATCGG
CGCCTTCACGCAGGACCCGGAGGCATTCGCCGCAGCGCGCTCCTACGTCCGCATTGTCGGCCCGTTCTACGCTTTCCAGG
GCCTCGGCCTGGCGCTCTATTTCGCCAGCCAGGGCGCGGGCTACATGTTCTGGCCGGTCGCCGCGACGATCGCGCGCGTG
GCGCTGGCGCTGGGCGGCGGCTGGTGGCTCGGCTTCCGGCTGGAATGCGGCCTCGACGGCATCTACATCGCCGCCGCCGC
CGCGATGGCGATCTACGGCCTGATGATGGCGGGCTCGGTCAAACTGGGGGCGTGGCGGGAGTGA

Upstream 100 bases:

>100_bases
TGGCGAAACAGCCCCGCCATTGGCAAGCGCGCAGTTTCGTTTTGCAACCGAGCCGGACCACCCCTAGGCATGGCGCAAGC
AGGAAGGGGCGACAGGGTTG

Downstream 100 bases:

>100_bases
AGCGGCCGTCCCGGACCGACCGGCTGCGAGCATAAAAATCGCGTGGATGCCGAGCGCGCGGAATTTGGCTATCAGCCCAC
CATGTCTCTCCTTCGCGAAA

Product: cation efflux pump (multidrug resistance protein)

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MDVRTRLFLTDPPGPLLVRMATPNSLAFMIQSFVSLGEVWIIGQLGTVSLAAIALSFPLLMLTQAMAGGAVGGAVTSSIA
RALGRGDSEAANRLIWHALAICAGGSALFLLLFLAAGESLLRFLGGSGIILGQAASYCLILFSGGLFLWLLGVTGAVFRG
MGDMKTPAALMVLGAFVQVPLTAVLVLGLLGAPRLGIAGAAVSAVATGFLVSTVMLFLLTRPGRIIRLERGALVFERRLF
RDIFAVAAPASLSPLLTILIILSLTAMIARFGEAALAGYGIGSRIEFLLIPLVFGIGAAMTSLVGLAIGAGDIARAERIG
WTGGAMAAALAGVVGALLTLFPDRFIGAFTQDPEAFAAARSYVRIVGPFYAFQGLGLALYFASQGAGYMFWPVAATIARV
ALALGGGWWLGFRLECGLDGIYIAAAAAMAIYGLMMAGSVKLGAWRE

Sequences:

>Translated_447_residues
MDVRTRLFLTDPPGPLLVRMATPNSLAFMIQSFVSLGEVWIIGQLGTVSLAAIALSFPLLMLTQAMAGGAVGGAVTSSIA
RALGRGDSEAANRLIWHALAICAGGSALFLLLFLAAGESLLRFLGGSGIILGQAASYCLILFSGGLFLWLLGVTGAVFRG
MGDMKTPAALMVLGAFVQVPLTAVLVLGLLGAPRLGIAGAAVSAVATGFLVSTVMLFLLTRPGRIIRLERGALVFERRLF
RDIFAVAAPASLSPLLTILIILSLTAMIARFGEAALAGYGIGSRIEFLLIPLVFGIGAAMTSLVGLAIGAGDIARAERIG
WTGGAMAAALAGVVGALLTLFPDRFIGAFTQDPEAFAAARSYVRIVGPFYAFQGLGLALYFASQGAGYMFWPVAATIARV
ALALGGGWWLGFRLECGLDGIYIAAAAAMAIYGLMMAGSVKLGAWRE
>Mature_447_residues
MDVRTRLFLTDPPGPLLVRMATPNSLAFMIQSFVSLGEVWIIGQLGTVSLAAIALSFPLLMLTQAMAGGAVGGAVTSSIA
RALGRGDSEAANRLIWHALAICAGGSALFLLLFLAAGESLLRFLGGSGIILGQAASYCLILFSGGLFLWLLGVTGAVFRG
MGDMKTPAALMVLGAFVQVPLTAVLVLGLLGAPRLGIAGAAVSAVATGFLVSTVMLFLLTRPGRIIRLERGALVFERRLF
RDIFAVAAPASLSPLLTILIILSLTAMIARFGEAALAGYGIGSRIEFLLIPLVFGIGAAMTSLVGLAIGAGDIARAERIG
WTGGAMAAALAGVVGALLTLFPDRFIGAFTQDPEAFAAARSYVRIVGPFYAFQGLGLALYFASQGAGYMFWPVAATIARV
ALALGGGWWLGFRLECGLDGIYIAAAAAMAIYGLMMAGSVKLGAWRE

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 46227; Mature: 46227

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVRTRLFLTDPPGPLLVRMATPNSLAFMIQSFVSLGEVWIIGQLGTVSLAAIALSFPLL
CCCCEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHH
MLTQAMAGGAVGGAVTSSIARALGRGDSEAANRLIWHALAICAGGSALFLLLFLAAGESL
HHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHH
LRFLGGSGIILGQAASYCLILFSGGLFLWLLGVTGAVFRGMGDMKTPAALMVLGAFVQVP
HHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LTAVLVLGLLGAPRLGIAGAAVSAVATGFLVSTVMLFLLTRPGRIIRLERGALVFERRLF
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHH
RDIFAVAAPASLSPLLTILIILSLTAMIARFGEAALAGYGIGSRIEFLLIPLVFGIGAAM
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHHH
TSLVGLAIGAGDIARAERIGWTGGAMAAALAGVVGALLTLFPDRFIGAFTQDPEAFAAAR
HHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
SYVRIVGPFYAFQGLGLALYFASQGAGYMFWPVAATIARVALALGGGWWLGFRLECGLDG
HHHHHHHHHHHHHHCCEEEEEECCCCCEEHHHHHHHHHHHHHHHCCCEEEEEEEECCCCH
IYIAAAAAMAIYGLMMAGSVKLGAWRE
HHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDVRTRLFLTDPPGPLLVRMATPNSLAFMIQSFVSLGEVWIIGQLGTVSLAAIALSFPLL
CCCCEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHH
MLTQAMAGGAVGGAVTSSIARALGRGDSEAANRLIWHALAICAGGSALFLLLFLAAGESL
HHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHH
LRFLGGSGIILGQAASYCLILFSGGLFLWLLGVTGAVFRGMGDMKTPAALMVLGAFVQVP
HHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LTAVLVLGLLGAPRLGIAGAAVSAVATGFLVSTVMLFLLTRPGRIIRLERGALVFERRLF
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHH
RDIFAVAAPASLSPLLTILIILSLTAMIARFGEAALAGYGIGSRIEFLLIPLVFGIGAAM
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHHH
TSLVGLAIGAGDIARAERIGWTGGAMAAALAGVVGALLTLFPDRFIGAFTQDPEAFAAAR
HHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
SYVRIVGPFYAFQGLGLALYFASQGAGYMFWPVAATIARVALALGGGWWLGFRLECGLDG
HHHHHHHHHHHHHHCCEEEEEECCCCCEEHHHHHHHHHHHHHHHCCCEEEEEEEECCCCH
IYIAAAAAMAIYGLMMAGSVKLGAWRE
HHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]